Scientific Reports Biology Table of Contents e-alert: 7 July 2015

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07 July 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               Biological Sciences               RASA: Robust Alternative Splicing Analysis for Human Transcriptome Arrays ▶     Junhee Seok, Weihong Xu, Ronald W. Davis et al.     Human transcriptome arrays (HTA) have recently been developed for high-throughput alternative splicing analysis by measuring signals not only from exons but also from exon-exon …             Coral transplantation triggers shift in microbiome and promotion of coral disease associated potential pathogens ▶     Jordan M. Casey, Sean R. Connolly, Tracy D. Ainsworth     By cultivating turf algae and aggressively defending their territories, territorial damselfishes in the genus Stegastes play a major role in shaping coral-algal dynamics on coral …             Waste-Activated Sludge Fermentation for Polyacrylamide Biodegradation Improved by Anaerobic Hydrolysis and Key Microorganisms Involved in Biological Polyacrylamide Removal ▶     Xiaohu Dai, Fan Luo, Dong Zhang et al.     During the anaerobic digestion of dewatered sludge, polyacrylamide (PAM), a chemical conditioner, can usually be consumed as a carbon and nitrogen source along with other organic …             Balancing the Expression and Production of a Heterodimeric Protein: Recombinant Agkisacutacin as a Novel Antithrombotic Drug Candidate ▶     Yugang Guo, Jing Wu, Hao Jia et al.     Agkisacucetin extracted from the venom of Agkistrodon acutus has been demonstrated to be a promising antithrombotic drug candidate in clinical studies due to its function as a …             Two-photon directed evolution of green fluorescent proteins ▶     Caleb R. Stoltzfus, Lauren M. Barnett, Mikhail Drobizhev et al.     Directed evolution has been used extensively to improve the properties of a variety of fluorescent proteins (FPs). Evolutionary strategies, however, have not yet been used to …             Synergistic activity of polarised osteoblasts inside condensations cause their differentiation ▶     Himanshu Kaul, Brian K. Hall, Chris Newby et al.     Condensation of pre-osteogenic, or pre-chondrogenic, cells is the first of a series of processes that initiate skeletal development. We present a validated, novel, …             Multidimensional High-Resolution Magic Angle Spinning and Solution-State NMR Characterization of 13C-labeled Plant Metabolites and Lignocellulose ▶     Tetsuya Mori, Yuuri Tsuboi, Nobuhiro Ishida et al.     Lignocellulose, which includes mainly cellulose, hemicellulose, and lignin, is a potential resource for the production of chemicals and for other applications. For effective …             Formation and manipulation of cell spheroids using a density adjusted PEG/DEX aqueous two phase system ▶     Chungmin Han, Shuichi Takayama, Jaesung Park     Various spheroid formation techniques have been widely developed for efficient and reliable 3-D cell culture research. Although those efforts improved many aspects of spheroid …             Hybrid male sterility and genome-wide misexpression of male reproductive proteases ▶     Suzanne Gomes, Alberto Civetta     Hybrid male sterility is a common barrier to gene flow between species. Previous studies have posited a link between misregulation of spermatogenesis genes in interspecies …             SiNG-PCRseq: Accurate inter-sequence quantification achieved by spiking-in a neighbor genome for competitive PCR amplicon sequencing ▶     Soo A. Oh, Inchul Yang, Yoonsoo Hahn et al.     Despite the recent technological advances in DNA quantitation by sequencing, accurate delineation of the quantitative relationship among different DNA sequences is yet to be …             Motif analysis in directed ordered networks and applications to food webs ▶     Pavel V. Paulau, Christoph Feenders, Bernd Blasius     The analysis of small recurrent substructures, so called network motifs, has become a standard tool of complex network science to unveil the design principles underlying the …             Tulane virus recognizes sialic acids as cellular receptors ▶     Ming Tan, Chao Wei, Pengwei Huang et al.     The recent discovery that human noroviruses (huNoVs) recognize sialic acids (SAs) in addition to histo-blood group antigens (HBGAs) pointed to a new direction in studying …             N-Myc and STAT Interactor regulates autophagy and chemosensitivity in breast cancer cells ▶     Brandon J. Metge, Aparna Mitra, Dongquan Chen et al.     We have previously reported that expression of NMI (N-myc and STAT interactor) is compromised in invasive breast cancers. We also demonstrated that loss of NMI expression …             Antimicrobial Peptides: Insights into Membrane Permeabilization, Lipopolysaccharide Fragmentation and Application in Plant Disease Control ▶     Aritreyee Datta, Anirban Ghosh, Cristina Airoldi et al.     The recent increase in multidrug resistance against bacterial infections has become a major concern to human health and global food security. Synthetic antimicrobial peptides …             Forward genetic screen for auxin-deficient mutants by cytokinin ▶     Lei Wu, Pan Luo, Dong-Wei Di et al.     Identification of mutants with impairments in auxin biosynthesis and dynamics by forward genetic screening is hindered by the complexity, redundancy and necessity of the pathways …             Validation of Placebo in a Manual Therapy Randomized Controlled Trial ▶     Aleksander Chaibi, Jūratė Šaltytė Benth, Michael Bjørn Russell     At present, no consensus exists among clinical and academic experts regarding an appropriate placebo for randomized controlled trials (RCTs) of spinal manipulative therapy (SMT). …             Novel ZnO hollow-nanocarriers containing paclitaxel targeting folate-receptors in a malignant pH-microenvironment for effective monitoring and promoting breast tumor regression ▶     Nagaprasad Puvvada, Shashi Rajput, B.N. Prashanth Kumar et al.     Low pH in the tumor micromilieu is a recognized pathological feature of cancer. This attribute of cancerous cells has been targeted herein for the controlled release of …             INC280, an orally available small molecule inhibitor of c-MET, reduces migration and adhesion in ovarian cancer cell models ▶     Kim Moran-Jones, Laura M. Brown, Goli Samimi     5-year survival rates for ovarian cancer are approximately 40%, and for women diagnosed at late stage (the majority), just 27%. This indicates a dire need for new treatments to …             Motion-induced blindness continues outside visual awareness and without attention ▶     Kevin C. Dieter, Duje Tadin, Joel Pearson     Visual phenomena demonstrating striking perceptual disappearances of salient stimuli have fascinated researchers because of their utility in identifying neural processes that …             DNA methylation as a potential diagnosis indicator for rapid discrimination of rare cancer cells and normal cells ▶     Xingyu Si, Yaoyao Zhao, Chengdui Yang et al.     The global DNA methylation degree may be a ubiquitous and early biomarker to distinguish cancer cells from benign cells. However, its usefulness in clinical diagnosis was …             Conformational Entropy of Intrinsically Disordered Proteins from Amino Acid Triads ▶     Anupaul Baruah, Pooja Rani, Parbati Biswas     This work quantitatively characterizes intrinsic disorder in proteins in terms of sequence composition and backbone conformational entropy. Analysis of the normalized relative …             Brain size as a driver of avian escape strategy ▶     Diogo S. M. Samia, Anders Pape Møller, Daniel T. Blumstein     After detecting an approaching predator, animals make a decision when to flee. Prey will initiate flight soon after detecting a predator so as to minimize attentional costs …             Proteasome Accessory Factor C (pafC) Is a novel gene Involved in Mycobacterium Intrinsic Resistance to broad-spectrum antibiotics - Fluoroquinolones ▶     Qiming Li, Longxiang Xie, Quanxin Long et al.     Antibiotics resistance poses catastrophic threat to global public health. Novel insights into the underlying mechanisms of action will inspire better measures to control drug …             Revisiting the intraperoxisomal pathway of mammalian PEX7 ▶     Tony A. Rodrigues, Cláudia P. Grou, Jorge E. Azevedo     Newly synthesized peroxisomal proteins containing a cleavable type 2 targeting signal (PTS2) are transported to the peroxisome by a cytosolic PEX5-PEX7 complex. There, the …             Temporal Genetic Dynamics of an Invasive Species, Frankliniella occidentalis (Pergande), in an Early Phase of Establishment ▶     Xian-Ming Yang, Heng Lou, Jing-Tao Sun et al.     Many species can successfully colonize new areas despite their propagules having low genetic variation. We assessed whether the decreased genetic diversity could result in …             In vivo bioimaging with tissue-specific transcription factor activated luciferase reporters ▶     Suzanne M. K. Buckley, Juliette M. K. M. Delhove, Dany P. Perocheau et al.     The application of transcription factor activated luciferase reporter cassettes in vitro is widespread but potential for in vivo application has not yet been realized. …             Comparative assessment of vaccine vectors encoding ten malaria antigens identifies two protective liver-stage candidates ▶     Rhea J. Longley, Ahmed M. Salman, Matthew G. Cottingham et al.     The development of an efficacious Plasmodium falciparum malaria vaccine remains a top priority for global health. Vaccination with irradiated sporozoites is able to provide …             Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs ▶     Eugene K. Lee, Yosuke K. Kurokawa, Robin Tu et al.     Current preclinical screening methods do not adequately detect cardiotoxicity. Using human induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs), more physiologically …             Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies ▶     Anu-Maarit Moilanen, Reetta Riikonen, Riikka Oksala et al.     Activation of androgen receptor (AR) is crucial for prostate cancer growth. Remarkably, also castration-resistant prostate cancer (CRPC) is dependent on functional AR, and …             Allogenic iPSC-derived RPE cell transplants induce immune response in pigs: a pilot study ▶     Elliott H Sohn, Chunhua Jiao, Emily Kaalberg et al.     Stem cell strategies focused on replacement of RPE cells for the treatment of geographic atrophy are under intense investigation. Although the eye has long been considered immune …             Structural colour in Chondrus crispus ▶     Chris J. Chandler, Bodo D. Wilts, Silvia Vignolini et al.     The marine world is incredibly rich in brilliant and intense colours. Photonic structures are found in many different species and provide extremely complex optical responses that …             PNPLA3 genetic variants determine hepatic steatosis in non-obese chronic hepatitis C patients ▶     Chung-Feng Huang, Jyh-Jou Chen, Ming-Lun Yeh et al.     The influence of patatin-like phospholipase domain-containing 3 (PNPLA3) genetic variants in the development of liver steatosis in Asian chronic hepatitis C patients remains …             A Novel High-Resolution and Sensitivity-Enhanced Three-Dimensional Solid-State NMR Experiment Under Ultrafast Magic Angle Spinning Conditions ▶     Rongchun Zhang, Manoj Kumar Pandey, Yusuke Nishiyama et al.     Although magic angle spinning (MAS) solid-state NMR is a powerful technique to obtain atomic-resolution insights into the structure and dynamics of a variety of chemical and …             Improved grazing management may increase soil carbon sequestration in temperate steppe ▶     Wenqing Chen, Ding Huang, Nan Liu et al.     Different grazing strategies impact grassland plant production and may also regulate the soil carbon formation. For a site in semiarid temperate steppe, we studied the effect of …             High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification ▶     Samuel A. Kotler, Jeffrey R. Brender, Subramanian Vivekanandan et al.     Alzheimer’s disease is characterized by the misfolding and self-assembly of the amyloidogenic protein amyloid-β (Aβ). The aggregation of Aβ leads to diverse oligomeric states, …             Dominant and novel clades of Candidatus Accumulibacter phosphatis in 18 globally distributed full-scale wastewater treatment plants ▶     Yanping Mao, David W. Graham, Hideyuki Tamaki et al.     Here we employed quantitative real-time PCR (qPCR) assays for polyphosphate kinase 1 (ppk1) and 16S rRNA genes to assess relative abundances of dominant clades of Candidatus …             Regression of Gastric Cancer by Systemic Injection of RNA Nanoparticles Carrying both Ligand and siRNA ▶     Daxiang Cui, Chunlei Zhang, Bing Liu et al.     Gastric cancer is the second leading cause of cancer-related death worldwide. RNA nanotechnology has recently emerged as an important field due to recent finding of its high …             Neuritin reverses deficits in murine novel object associative recognition memory caused by exposure to extremely low-frequency (50 Hz) electromagnetic fields ▶     Qian-Ru Zhao, Jun-Mei Lu, Jin-Jing Yao et al.     Animal studies have shown that electromagnetic field exposure may interfere with the activity of brain cells, thereby generating behavioral and cognitive disturbances. However, …             Systematic characterization of the peroxidase gene family provides new insights into fungal pathogenicity in Magnaporthe oryzae ▶     Albely Afifa Mir, Sook-Young Park, Md. Abu Sadat et al.     Fungal pathogens have evolved antioxidant defense against reactive oxygen species produced as a part of host innate immunity. Recent studies proposed peroxidases as components of …             Pros and cons of methylation-based enrichment methods for ancient DNA ▶     Andaine Seguin-Orlando, Cristina Gamba, Clio Der Sarkissian et al.     The recent discovery that DNA methylation survives in fossil material provides an opportunity for novel molecular approaches in palaeogenomics. Here, we apply to ancient DNA …             Exaggerated perception of facial expressions is increased in individuals with schizotypal traits ▶     Shota Uono, Wataru Sato, Motomi Toichi     Emotional facial expressions are indispensable communicative tools, and social interactions involving facial expressions are impaired in some psychiatric disorders. Recent …             Structural Features of a Bacteroidetes-Affiliated Cellulase Linked with a Polysaccharide Utilization Locus ▶     A.E. Naas, A.K. MacKenzie, B. Dalhus et al.     Previous gene-centric analysis of a cow rumen metagenome revealed the first potentially cellulolytic polysaccharide utilization locus, of which the main catalytic enzyme (AC2a…             Controlled electromechanical cell stimulation on-a-chip ▶     Andrea Pavesi, Giulia Adriani, Marco Rasponi et al.     Stem cell research has yielded promising advances in regenerative medicine, but standard assays generally lack the ability to combine different cell stimulations with rapid …             Deciphering the evolution of birdwing butterflies 150 years after Alfred Russel Wallace ▶     Fabien L. Condamine, Emmanuel F. A. Toussaint, Anne-Laure Clamens et al.     One hundred and fifty years after Alfred Wallace studied the geographical variation and species diversity of butterflies in the Indomalayan-Australasian Archipelago, the …             Multiple scale model for cell migration in monolayers: Elastic mismatch between cells enhances motility ▶     Benoit Palmieri, Yony Bresler, Denis Wirtz et al.     We propose a multiscale model for monolayer of motile cells that comprise normal and cancer cells. In the model, the two types of cells have identical properties except for their …             Detoxification mechanisms of honey bees (Apis mellifera) resulting in tolerance of dietary nicotine ▶     Esther E. du Rand, Salome Smit, Mervyn Beukes et al.     Insecticides are thought to be among the major factors contributing to current declines in bee populations. However, detoxification mechanisms in healthy, unstressed honey bees …             Erratum: Near-shore Antarctic pH variability has implications for the design of ocean acidification experiments ▶     Lydia Kapsenberg, Amanda L. Kelley, Emily C. Shaw et al.                 Acyl-CoA N-acyltransferase influences fertility by regulating lipid metabolism and jasmonic acid biogenesis in cotton ▶     Wenfeng Fu, Ying Shen, Juan Hao et al.     Cotton (Gossypium spp.) is an important economic crop and there is obvious heterosis in cotton, fertility has played an important role in this heterosis. However, the genes that …             Detection of UV-induced cyclobutane pyrimidine dimers by near-infrared spectroscopy and aquaphotomics ▶     Noriko Goto, Gyorgy Bazar, Zoltan Kovacs et al.     Ultraviolet (UV) radiation causes cellular DNA damage, among which cyclobutane pyrimidine dimers (CPDs) are responsible for a variety of genetic mutations. Although several …             Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice ▶     Ling-Lei Kong, Xiao-Mei zhuang, Hai-Ying Yang et al.     Triptolide (TP) is the major active principle of Tripterygium wilfordii Hook f. and very effective in treatment of autoimmune diseases. However, TP induced hepatotoxicity limited …             Resistance of R-Ras knockout mice to skin tumour induction ▶     Ulrike May, Stuart Prince, Maria Vähätupa et al.     The R-ras gene encodes a small GTPase that is a member of the Ras family. Despite close sequence similarities, R-Ras is functionally distinct from the prototypic Ras proteins; no …             Cortisol and testosterone increase financial risk taking and may destabilize markets ▶     Carlos Cueva, R. Edward Roberts, Tom Spencer et al.     It is widely known that financial markets can become dangerously unstable, yet it is unclear why. Recent research has highlighted the possibility that endogenous hormones, in …             Uncovering miRNAs involved in crosstalk between nutrient deficiencies in Arabidopsis ▶     Gang Liang, Qin Ai, Diqiu Yu     Integrating carbon (C), nitrogen (N), and sulfur (S) metabolism is essential for the growth and development of living organisms. MicroRNAs (miRNAs) play key roles in regulating …             Heat-Denatured Lysozyme Inactivates Murine Norovirus as a Surrogate Human Norovirus ▶     Hajime Takahashi, Moemi Nakazawa, Chihiro Ohshima et al.     Human norovirus infects humans through the consumption of contaminated food, contact with the excrement or vomit of an infected person, and through airborne droplets that scatter …             Colonization by fragments of the submerged macrophyte Myriophyllum spicatum under different sediment type and density conditions ▶     Feng Li, Lianlian Zhu, Yonghong Xie et al.     In this paper, the effect of plant density, sediment type, and macrophyte fragment size on the fragment colonization ability of Myriophyllum spicatum was evaluated in an outdoor …             A Novel Chimeric Anti-PA Neutralizing Antibody for Postexposure Prophylaxis and Treatment of Anthrax ▶     Siping Xiong, Qi Tang, Xudong Liang et al.     Anthrax is a highly lethal infectious disease caused by the bacterium Bacillus anthracis, and the associated shock is closely related to the lethal toxin (LeTx) produced by the …             External control of reactions in microdroplets ▶     Samaneh Mashaghi, Antoine M. van Oijen     Scale reduction of chemical reactions enables novel screening and synthesis approaches that facilitate a highly parallelized and combinatorial exploration of chemical space. …             Novel macromolecules derived from coumarin: synthesis and antioxidant activity ▶     Ahmed A. Al-Amiery, Yasameen K. Al-Majedy, Abdul Amir H. Kadhum et al.     The rational design of 4-hydroxycoumarins with tailor-made antioxidant activities is required nowadays due to the wide variety of pharmacologically significant, structurally …             Re-visiting the nature and relationships between neurological signs and neurocognitive functions in first-episode schizophrenia: An invariance model across time ▶     Raymond C. K. Chan, Shan Dai, Simon S. Y. Lui et al.     The present study examined different types of neurological signs in patients with first-episode schizophrenia and their relationships with neurocognitive functions. Both …             The sexually driven epidemic in youths in China’s southwestern border region was caused by dynamic emerging multiple recombinant HIV-1 strains ▶     Huamian Wei, Hui Xing, Jenny H. Hsi et al.     Dehong prefecture, Yunnan province on China’s southwestern border was the gateway of the country’s AIDS epidemic. Studies on HIV-1 molecular epidemiology will provide key …             Host Responses and Regulation by NFκB Signaling in the Liver and Liver Epithelial Cells Infected with A Novel Tick-borne Bunyavirus ▶     Qiyu Sun, Cong Jin, Lili Zhu et al.     Infection in humans by severe fever with thrombocytopenia syndrome virus (SFTSV), a novel bunyavirus transmitted by ticks, is often associated with pronounced liver damage, …             Herbal formula, Scutellariae radix and Rhei rhizoma attenuate dimethylnitrosamine-induced liver fibrosis in a rat model ▶     Tai-Long Pan, Pei-Wen Wang, Chun-Hsun Huang et al.     The bioactive components extracted from Scutellariae radix and Rhei rhizoma (SR) have been commonly used to treat liver diseases. The aim of this study was to verify the …             Circuital characterisation of space-charge motion with a time-varying applied bias ▶     Chul Kim, Eun-Yi Moon, Jungho Hwang et al.     Understanding the behaviour of space-charge between two electrodes is important for a number of applications. The Shockley-Ramo theorem and equivalent circuit models are useful …             QiShenYiQi Pills, a compound in Chinese medicine, protects against pressure overload-induced cardiac hypertrophy through a multi-component and multi-target mode ▶     Yuan-Yuan Chen, Quan Li, Chun-Shui Pan et al.     The present study aimed to explore the holistic mechanism for the antihypertrophic effect of a compound in Chinese medicine, QiShenYiQi Pills (QSYQ) and the contributions of its …             Identification of urine protein biomarkers with the potential for early detection of lung cancer ▶     Hongjuan Zhang, Jing Cao, Lin Li et al.     Lung cancer is the leading cause of cancer-related deaths and has an overall 5-year survival rate lower than 15%. Large-scale clinical trials have demonstrated a significant …             A germline mutation in SRRM2, a splicing factor gene, is implicated in papillary thyroid carcinoma predisposition ▶     Jerneja Tomsic, Huiling He, Keiko Akagi et al.     Papillary thyroid carcinoma (PTC) displays strong but so far largely uncharacterized heritability. Here we studied genetic predisposition in a family with six affected …             A New Oviraptorid Dinosaur (Dinosauria: Oviraptorosauria) from the Late Cretaceous of Southern China and Its Paleobiogeographical Implications ▶     Junchang Lü, Hanyong Pu, Yoshitsugu Kobayashi et al.     The Ganzhou area of Jiangxi Province, southern China is becoming one of the most productive oviraptorosaurian localities in the world. A new oviraptorid dinosaur was unearthed …             Carbon Quantum Dots for Zebrafish Fluorescence Imaging ▶     Yan-Fei Kang, Yu-Hao Li, Yang-Wu Fang et al.     Carbon quantum dots (C-QDs) are becoming a desirable alternative to metal-based QDs and dye probes owing to their high biocompatibility, low toxicity, ease of preparation, and …             High-frame rate four dimensional optoacoustic tomography enables visualization of cardiovascular dynamics and mouse heart perfusion ▶     Xosé Luís Deán-Ben, Steven James Ford, Daniel Razansky     Functional imaging of mouse models of cardiac health and disease provides a major contribution to our fundamental understanding of the mammalian heart. However, imaging murine …             Molecular evolution of haemagglutinin (H) gene in measles virus ▶     Hirokazu Kimura, Mika Saitoh, Miho Kobayashi et al.     We studied the molecular evolution of the haemagglutinin (H) gene (full length) in all genotypes (24 genotypes, 297 strains) of measles virus (MeV). The gene’s evolutionary …             Corrigendum: Ecto-domain phosphorylation promotes functional recovery from spinal cord injury ▶     Kenji Suehiro, Yuka Nakamura, Shuai Xu et al.                 Corrigendum: Biomineralization mediated by anaerobic methane-consuming cell consortia ▶     Ying Chen, Yi-Liang Li, Gen-Tao Zhou et al.                 Redox Linked Flavin Sites in Extracellular Decaheme Proteins Involved in Microbe-Mineral Electron Transfer. ▶     Marcus J. Edwards, Gaye F. White, Michael Norman et al.     Extracellular microbe-mineral electron transfer is a major driving force for the oxidation of organic carbon in many subsurface environments. Extracellular multi-heme cytochromes …             Reorganization of corticospinal tract fibers after spinal cord injury in adult macaques ▶     Hiroshi Nakagawa, Taihei Ninomiya, Toshihide Yamashita et al.     Previous studies have shown that sprouting of corticospinal tract (CST) fibers after spinal cord injury (SCI) contributes to recovery of motor functions. However, the …             Trans-spliced Cas9 allows cleavage of HBB and CCR5 genes in human cells using compact expression cassettes ▶     Eli J. Fine, Caleb M. Appleton, Douglas E. White et al.     CRISPR/Cas9 systems have been used in a wide variety of biological studies; however, the large size of CRISPR/Cas9 presents challenges in packaging it within adeno-associated …             Optimizing fluorescent protein trios for 3-Way FRET imaging of protein interactions in living cells ▶     Brandon L. Scott, Adam D. Hoppe     Powerful new methods have extended FRET microscopy to the imaging of three or more interacting proteins inside living cells. Here, we compared widely available fluorescent …             Long-duration animal tracking in difficult lighting conditions ▶     Ulrich Stern, Edward Y. Zhu, Ruo He et al.     High-throughput analysis of animal behavior requires software to analyze videos. Such software typically depends on the experiments’ being performed in good lighting conditions, …             Diversity and evolution of cytochrome P450 monooxygenases in Oomycetes ▶     Mopeli Marshal Sello, Norventia Jafta, David R Nelson et al.     Cytochrome P450 monooxygenases (P450s) are heme-thiolate proteins whose role as drug targets against pathogens, as well as in valuable chemical production and bioremediation, has …             Folic acid supplements and colorectal cancer risk: meta-analysis of randomized controlled trials ▶     Tingting Qin, Mulong Du, Haina Du et al.     Numerous studies have investigated the effects of folic acid supplementation on colorectal cancer risk, but conflicting results were reported. We herein performed a meta-analysis …             New Insight into the Role of the Calvin Cycle: Reutilization of CO2 Emitted through Sugar Degradation ▶     Rie Shimizu, Yudai Dempo, Yasumune Nakayama et al.     Ralstonia eutropha is a facultative chemolithoautotrophic bacterium that uses the Calvin–Benson–Bassham (CBB) cycle for CO2 fixation. This study showed that R. eutropha strain …             A novel alphaproteobacterial ectosymbiont promotes the growth of the hydrocarbon-rich green alga Botryococcus braunii ▶     Yuuhiko Tanabe, Yusuke Okazaki, Masaki Yoshida et al.     Botryococcus braunii is a colony-forming green alga that accumulates large amounts of liquid hydrocarbons within the colony. The utilization of B. braunii for biofuel production …             A systematic analysis of human lipocalin family and its expression in esophageal carcinoma ▶     Ze-Peng Du, Bing-Li Wu, Xuan Wu et al.     The lipocalin proteins (lipocalins) are a large family of small proteins characterized by low sequence similarity and highly conserved crystal structures. Lipocalins have been …             Hydrodynamic chronoamperometry for probing kinetics of anaerobic microbial metabolism – case study of Faecalibacterium prausnitzii ▶     Antonin Prévoteau, Annelies Geirnaert, Jan B.A. Arends et al.     Monitoring in vitro the metabolic activity of microorganisms aids bioprocesses and enables better understanding of microbial metabolism. Redox mediators can be used for this …             The role of miR-100 in regulating apoptosis of breast cancer cells ▶     Yi Gong, Tianliang He, Lu Yang et al.     Breast cancer is a serious health problem worldwide. Inhibition of apoptosis plays a major role in breast cancer tumorigenesis. MicroRNAs (miRNAs) play crucial roles in the …             Low-bias phosphopeptide enrichment from scarce samples using plastic antibodies ▶     Jing Chen, Sudhirkumar Shinde, Markus-Hermann Koch et al.     Phosphospecific enrichment techniques and mass spectrometry (MS) are essential tools for comprehending the cellular phosphoproteome. Here, we report a fast and simple approach …             Heparin interacts with elongation factor 1α of Cryptosporidium parvum and inhibits invasion ▶     Atsuko Inomata, Fumi Murakoshi, Akiko Ishiwa et al.     Cryptosporidium parvum is an apicomplexan parasite that can cause serious watery diarrhea, cryptosporidiosis, in human and other mammals. C. parvum invades gastrointestinal …             Chromosome Scaffold is a Double-Stranded Assembly of Scaffold Proteins ▶     Rawin Poonperm, Hideaki Takata, Tohru Hamano et al.     Chromosome higher order structure has been an enigma for over a century. The most important structural finding has been the presence of a chromosome scaffold composed of …             Signatures of positive selection in East African Shorthorn Zebu: A genome-wide single nucleotide polymorphism analysis ▶     Hussain Bahbahani, Harry Clifford, David Wragg et al.     The small East African Shorthorn Zebu (EASZ) is the main indigenous cattle across East Africa. A recent genome wide SNP analysis revealed an ancient stable African taurine x …             Liquid on Paper: Rapid Prototyping of Soft Functional Components for Paper Electronics ▶     Yu Long Han, Hao Liu, Cheng Ouyang et al.     This paper describes a novel approach to fabricate paper-based electric circuits consisting of a paper matrix embedded with three-dimensional (3D) microchannels and liquid metal. …             Functional BCL-2 regulatory genetic variants contribute to susceptibility of esophageal squamous cell carcinoma ▶     Wenting Pan, Jinyun Yang, Jinyu Wei et al.     B-cell lymphoma-2 (BCL-2) prevents apoptosis and its overexpression could promote cancer cell survival. Multiple functional BCL-2 genetic polymorphisms, such as rs2279115, …             Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase ▶     Theodoros Goulas, Danuta Mizgalska, Irene Garcia-Ferrer et al.     Citrullination is a post-translational modification of higher organisms that deiminates arginines in proteins and peptides. It occurs in physiological processes but also …             Highly homologous proteins exert opposite biological activities by using different interaction interfaces ▶     Anat Iosub Amir, Martijn van Rosmalen, Guy Mayer et al.     We present a possible molecular basis for the opposite activity of two homologues proteins that bind similar ligands and show that this is achieved by fine-tuning of the …             DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects ▶     Kristin Kessler, Ina Wunderlich, Steffen Uebe et al.     Skeletal ciliopathies are a heterogeneous group of autosomal recessive osteochondrodysplasias caused by defects in formation, maintenance and function of the primary cilium. …             Corrigendum: Role of Ran-regulated nuclear-cytoplasmic trafficking of pVHL in the regulation of microtubular stability-mediated HIF-1α in hypoxic cardiomyocytes ▶     Xupin Jiang, Dongxia Zhang, Hengshu Zhang et al.                 Corrigendum: Label-Free Characterization of Emerging Human Neuronal Networks ▶     Mustafa Mir, Taewoo Kim, Anirban Majumder et al.                 The cost of promiscuity: sexual transmission of Nosema microsporidian parasites in polyandrous honey bees ▶     K. E. Roberts, S. E. F. Evison, B. Baer et al.     Multiple mating (and insemination) by females with different males, polyandry, is widespread across animals, due to material and/or genetic benefits for females. It reaches …             Corrigendum: Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations ▶     Josep Sardanyés, Carles Simó, Regina Martínez et al.                 A Statistical Framework to Predict Functional Non-Coding Regions in the Human Genome Through Integrated Analysis of Annotation Data ▶     Qiongshi Lu, Yiming Hu, Jiehuan Sun et al.     Identifying functional regions in the human genome is a major goal in human genetics. Great efforts have been made to functionally annotate the human genome either through …             The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila ▶     Julie L. Hentze, Mikael A. Carlsson, Shu Kondo et al.     Coordinating metabolism and feeding is important to avoid obesity and metabolic diseases, yet the underlying mechanisms, balancing nutrient intake and metabolic expenditure, are …             Cytoplasmic nucleophosmin has elevated T199 phosphorylation upon which G2/M phase progression is dependent ▶     Narisa Chan, Tit Meng Lim     The cytoplasmic mutant of nucleophosmin (NPMc) is found approximately in one-third of acute myeloid leukemia (AML) cases and is highly associated with normal karyotype. Whereas …             Long noncoding RNA expression profiles in gut tissues constitute molecular signatures that reflect the types of microbes ▶     Lunxi Liang, Luoyan Ai, Jin Qian et al.     The gut microbiota is commonly referred to as a hidden organ due to its pivotal effects on host physiology, metabolism, nutrition and immunity. The gut microbes may be shaped by …             Helix 8 of the angiotensin- II type 1A receptor interacts with phosphatidylinositol phosphates and modulates membrane insertion ▶     Daniel J. Hirst, Tzong-Hsien Lee, Leonard K. Pattenden et al.     The carboxyl-terminus of the type 1 angiotensin II receptor (AT1A) regulates receptor activation/deactivation and the amphipathic Helix 8 within the carboxyl-terminus is a high …             Pleistocene glaciations, demographic expansion and subsequent isolation promoted morphological heterogeneity: A phylogeographic study of the alpine Rosa sericea complex (Rosaceae) ▶     Yun-Dong Gao, Yu Zhang, Xin-Fen Gao et al.     While most temperate plants probably underwent glacial constriction to refugia and interglacial expansion, another type of interglacial refugia might have existed to maintain …             Pyridine-type alkaloid composition affects bacterial community composition of floral nectar ▶     Yana Aizenberg-Gershtein, Ido Izhaki, Rakesh Santhanam et al.     Pyridine-type alkaloids are most common in Nicotiana species. To study the effect of alkaloid composition on bacterial community composition in floral nectar, we compared the …             Enzymatic measurement of phosphatidylglycerol and cardiolipin in cultured cells and mitochondria ▶     Shin-ya Morita, Tomohiro Terada     Phosphatidylglycerol (PG) and cardiolipin (CL) are synthesized in mitochondria and regulate numerous biological functions. In this study, a novel fluorometric method was …             Acceleration of protein folding by four orders of magnitude through a single amino acid substitution ▶     Daniel J. A. Roderer, Martin A. Schärer, Marina Rubini et al.     Cis prolyl peptide bonds are conserved structural elements in numerous protein families, although their formation is energetically unfavorable, intrinsically slow and often …             Photothermal ablation of bone metastasis of breast cancer using PEGylated multi-walled carbon nanotubes ▶     Zhen Lin, Yi Liu, Xueming Ma et al.     This study investigates therapeutic efficacy of photothermal therapy (PTT) in an orthotropic xenograft model of bone metastasis of breast cancer. The near-infrared (NIR) …             Corrigendum: Carnival or football, is there a real risk for acquiring dengue fever in Brazil during holidays seasons? ▶     Maíra Aguiar, Filipe Rocha, José Eduardo Marques Pessanha et al.                 Corrigendum: Generation of the SCN1A epilepsy mutation in hiPS cells using the TALEN technique ▶     Wanjuan Chen, Jingxin Liu, Longmei Zhang et al.                 A Herpesvirus Specific Motif of Epstein-Barr Virus DNA Polymerase Is Required for the Efficient Lytic Genome Synthesis ▶     Yohei Narita, Atsuko Sugimoto, Daisuke Kawashima et al.     Epstein-Barr virus (EBV) is associated with several malignancies, including Burkitt lymphoma and nasopharyngeal carcinoma. To overcome such disorders, understanding the molecular …             Consequences of Nosema apis infection for male honey bees and their fertility ▶     Yan Peng, Barbara Baer-Imhoof, A. Harvey Millar et al.     The queens of eusocial bees, ants and wasps mate only during a very short period early in life and males therefore produce ejaculates consisting of large numbers of high quality …             A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome ▶     Rama Soundararajan, Anurag N. Paranjape, Valentin Barsan et al.     Currently, very few prognosticators accurately predict metastasis in cancer patients. In order to complete the metastatic cascade and successfully colonize distant sites, …             Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma ▶     Stacey L. Lehman, Sandra Ryeom, Constantinos Koumenis     The tumor microenvironment is characterized by deficiencies in oxygen and nutrients, such as glucose and amino acids. Activation of the GCN2 arm of the Integrated Stress Response …             Matrix Metalloproteinase-3 -1171 5A/6A Polymorphism (rs35068180) is Associated with Risk of Periodontitis ▶     Cheng Ding, Xing Chen, Peng-tao Zhang et al.     Matrix metalloproteinase-3 (MMP3) plays a key role in tissue degradation in periodontitis. The relationship between the MMP3 -1171 5A/6A polymorphism (rs35068180) and …             A Novel Audiovisual Brain-Computer Interface and Its Application in Awareness Detection ▶     Fei Wang, Yanbin He, Jiahui Pan et al.     Currently, detecting awareness in patients with disorders of consciousness (DOC) is a challenging task, which is commonly addressed through behavioral observation scales such as …             Phenotypic and evolutionary implications of modulating the ERK-MAPK cascade using the dentition as a model ▶     Pauline Marangoni, Cyril Charles, Paul Tafforeau et al.     The question of phenotypic convergence across a signalling pathway has important implications for both developmental and evolutionary biology. The ERK-MAPK cascade is known to …             SPECT/CT Imaging of High-Risk Atherosclerotic Plaques using Integrin-Binding RGD Dimer Peptides ▶     Jung Sun Yoo, Jonghwan Lee, Jae Ho Jung et al.     Vulnerable atherosclerotic plaques with unique biological signatures are responsible for most major cardiovascular events including acute myocardial infarction and stroke. …             Whole genome amplification with SurePlex results in better copy number alteration detection using sequencing data compared to the MALBAC method ▶     Lieselot Deleye, Dieter De Coninck, Christodoulos Christodoulou et al.     Current whole genome amplification (WGA) methods lead to amplification bias resulting in over- and under-represented regions in the genome. 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