Nature Reviews Genetics Contents August 2015 Volume 16 Number 8 pp 435-496

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TABLE OF CONTENTS
August 2015 Volume 16 Number 8
Impact Factor 39.794 *	In this issue Comment Research Highlights Reviews Also this month Article series: Disease mechanisms  Featured article: Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders Neelroop N. Parikshak, Michael J. Gandal & Daniel H. Geschwind
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Comment: Start me up: ways to encourage sharing of genomic information with research participants Misha Angrist p435 | doi:10.1038/nrg3981 Personalized and precision medicine initiatives explicitly call for researchers to treat research participants as partners. One way to realize that goal is by returning individual research results to participants. I propose a number of concrete steps that could facilitate that process. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Viral evolution: Keeping a watchful eye on Ebola p437 | doi:10.1038/nrg3983 PDF Chromatin: Histone influences on chromosomal translocations p438 | doi:10.1038/nrg3979 PDF Evolutionary genetics: Becoming human —identifying human accelerated regulatory DNA p438 | doi:10.1038/nrg3985 PDF Molecular evolution: Warm and wild lizard sex changes p440 | doi:10.1038/nrg3977 PDF Human evolution: Kennewick Man's genome p440 | doi:10.1038/nrg3984 PDF IN BRIEF Human genetics: Gene expression and functional brain networks | Microbial genetics: Bimodal regulation of genetic competence | Stem cells: Chimpanzee induced pluripotent stem cells | Genetic testing: Low-cost clinical testing for Mendelian diseases PDF Genetics JOBS of the week Postdoctoral Position in Functional Cancer Genomics Institute of Oncology Research Postdoctoral Associate in Genomics and Bioinformatics, USC University of Southern California Visiting Investigator Memorial Sloan Kettering Cancer Center (MSKCC) More Science jobs from Genetics EVENT Nature Genetics and the Wellcome Trust Present: The Genomics of Common Diseases 2015 02.09.15 Cambridge, UK More science events from
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REVIEWS		Top
Article series: Disease mechanisms Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders Neelroop N. Parikshak, Michael J. Gandal & Daniel H. Geschwind p441 | doi:10.1038/nrg3934 The study of the genetic basis of neurodevelopmental disorders and neurodegenerative diseases has progressed through recent large-scale association studies as well as the application of a range of high-throughput molecular methods. In this Review, the authors examine systems biology approaches and demonstrate how gene networks provide an organizing framework to integrate the analysis of large-scale genetic and molecular profiling data sets to characterize the genetic basis of phenotypes that affect the central nervous system. Abstract | Full Text | PDF | Supplementary information
Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms Diarmaid Hughes & Dan I. Andersson p459 | doi:10.1038/nrg3922 The emergence of drug resistance is a major challenge for controlling diverse infectious diseases and cancer. In this Review, the authors discuss the mechanisms and evolutionary consequences of drug resistance. They highlight commonalities and distinctions across diverse pathogens and systems, and the implications for optimizing the current use and future development of drug therapies. Abstract | Full Text | PDF
Horizontal gene transfer: building the web of life Shannon M. Soucy, Jinling Huang & Johann Peter Gogarten p472 | doi:10.1038/nrg3962 The extent of horizontal gene transfer (HGT) is now becoming apparent. In this Review, the authors describe the mechanisms of HGT using examples from recent findings of HGT between prokaryotes and eukaryotes (including the human microbiome), and also between multicellular eukaryotes. They further describe the acquisition of novel traits via HGT in an evolutionary context. Abstract | Full Text | PDF | Supplementary information
Pervasive robustness in biological systems Marie-Anne Felix & Michalis Barkoulas p483 | doi:10.1038/nrg3949 Robustness of a phenotypic trait is characterized as lack of, or low, variance in that phenotype under a particular genetic or environmental perturbation. The authors review recent studies characterizing robustness, provide guidance in reporting robust features and insights into how variation propagates across biological systems. Abstract | Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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