Nature Immunology Contents: August 2015 Volume 16 pp 787 - 889

If you are unable to see the message below, click here to view.

Advertisement Your personal assistant for Cell Behavior Quantification BeQuanti is a software package designed to automatically detect and quantify cell interaction underflow. BeQuanti dramatically speeds up your research process performing fine detailed and reliable analysis of several cell adhesion parameters.  Learn more   Get the trial version today  TABLE OF CONTENTS August 2015 Volume 16, Issue 8 Commentary News and Views Correspondence Research Highlights Review Articles Errata Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Microbiology: Call for Papers Launching in January 2016, Nature Microbiology is now open for submissions and inviting high-quality submissions. The journal will cover all aspects of microorganisms be it their evolution, physiology and cell biology, their interactions with each other, with a host, with an environment, or their societal significance.  Submit your next research paper to the journal.     Commentary Top Balancing family life with a science career   pp787 - 790 Akiko Iwasaki doi:10.1038/ni.3199 Women are underrepresented in the science and engineering fields. Difficulties in balancing family life and work have a big role in women's opting out of scientific career paths. Institutions and funding agencies need to work harder to reverse this disparity. News and Views Top DPP4 in anti-tumor immunity: going beyond the enzyme   pp791 - 792 Kei Ohnuma, Ryo Hatano and Chikao Morimoto doi:10.1038/ni.3210 Effective anti-tumor immune therapy in solid tumors relies on the presence of effector T cells. Inhibition of the dipeptidylpeptidase DPP4 (CD26) enhances chemokine CXCL10-mediated infiltration of lymphocytes into the tumor parenchyma, which results in diminished tumor growth. See also: Article by Barreira da Silva et al. XBP1, a determinant of the eosinophil lineage   pp793 - 794 Zhong-Jian Shen and James S Malter doi:10.1038/ni.3214 Targeted deletion of the transcription factor XBP1 in hematopoietic stem cells selectively prevents eosinophil maturation in the bone marrow without affecting other lineages of the immune system. See also: Article by Bettigole et al. NLRP3 moonlights in TH2 polarization   pp794 - 796 Jenny P Y Ting and Jonathan A Harton doi:10.1038/ni.3223 As the cytosolic guardian for many microbial and sterile inflammatory insults, NLRP3 is best appreciated for its innate immunological role mediating inflammasome activation. Now NLRP3 debuts as a transcription factor key for TH2 polarization. See also: Article by Bruchard et al. Tuning up FALCs: immunological shielding in the body cavities   pp796 - 798 Christian Perez-Shibayama and Burkhard Ludewig doi:10.1038/ni.3228 Fat-associated lymphoid clusters (FALCs) are non-classical secondary lymphoid organs of the body cavities. The formation and maturation of FALCs are driven by tumor-necrosis factor and are further enhanced by invariant natural killer T cells. See also: Article by Bénézech et al. Immunology JOBS of the week Director of the Centre for Cancer Immunology University of Southampton Postdoctoral Researcher in Tumor Immunology and Cancer Immunotherapy University of California Los Angeles PhD Position in Molecular Immunology VIB Postdoctoral Position in Immunology Rosalind Franklin University of Medicine and Science Postdoctoral Position in Tumor Immunology Roswell Park Cancer Institute More Science jobs from Immunology EVENT Frontiers in Basic Immunology 2015 8th Oct - 9th Oct 2015 Maryland, USA More science events from Correspondence Top A new mouse strain for the analysis of invariant NKT cell function   pp799 - 800 Shilpi Chandra, Meng Zhao, Alison Budelsky, Alvaro de Mingo Pulido, Jeremy Day et al. doi:10.1038/ni.3203 Research Highlights Top Harmine-izing immunity | Inflammatory ripples | Retroviral PAMP sensor | TH1 complementation | Natural resistance | Thymoproteasome bias Review Top Guarding the frontiers: the biology of type III interferons   pp802 - 809 Andreas Wack, Ewa Terczyńska-Dyla and Rune Hartmann doi:10.1038/ni.3212 Type I and III interferons share similar antiviral properties, but there are some important distinctions. Hartmann and colleagues review the specialized functions of type III interferons, including their ability to mediate antiviral functions at barrier surfaces. Articles Top The transcription factor Foxm1 is essential for the quiescence and maintenance of hematopoietic stem cells   pp810 - 818 Yu Hou, Wen Li, Yue Sheng, Liping Li, Yong Huang et al. doi:10.1038/ni.3204 Hematopoietic stem cells are held in check to maintain their functional activity throughout life. Qian and colleagues show that the transcriptional regulator Foxm1 maintains the quiescence and self-renewal capacity of these cells in vivo. Inflammation-induced formation of fat-associated lymphoid clusters   pp819 - 828 Cécile Bénézech, Nguyet-Thin Luu, Jennifer A Walker, Andrei A Kruglov, Yunhua Loo et al. doi:10.1038/ni.3215 Fat-associated lymphoid clusters are lymphoid tissues that support B-1 cells. Caamano and colleagues show that inflammation that elicits the cytokine TNF and activates natural killer cells contributes to the formation of these clusters in visceral fat. See also: News and Views by Perez-Shibayama & Ludewig The transcription factor XBP1 is selectively required for eosinophil differentiation   pp829 - 837 Sarah E Bettigole, Raphael Lis, Stanley Adoro, Ann-Hwee Lee, Lisa A Spencer et al. doi:10.1038/ni.3225 The transcription factor XBP1 is associated with endoplasmic reticulum stress. Glimcher and colleagues show that XBP1 is expressed during eosinophil differentiation and is uniquely required for the production of granule proteins and eosinophil survival. See also: News and Views by Shen & Malter Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation   pp838 - 849 Xiaodi Su, Yingpu Yu, Yi Zhong, Eugenia G Giannopoulou, Xiaoyu Hu et al. doi:10.1038/ni.3205 Interferon-γ (IFN-γ) primes macrophages to undergo proinflammatory activation. Ivashkiv and colleagues detail the translational and metabolic program triggered in human macrophages after IFN-γ treatment. Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy   pp850 - 858 Rosa Barreira da Silva, Melissa E Laird, Nader Yatim, Laurence Fiette, Molly A Ingersoll et al. doi:10.1038/ni.3201 Post-translational modification of chemokines such as CXCL10 can regulate their activity. Albert and colleagues demonstrate that the endogenous peptidase DPP4 cleaves CXCL10 and thereby interferes with T cell recruitment to tumors. See also: News and Views by Ohnuma et al. The receptor NLRP3 is a transcriptional regulator of TH2 differentiation   pp859 - 870 Mélanie Bruchard, Cédric Rebé, Valentin Derangère, Dieudonnée Togbé, Bernhard Ryffel et al. doi:10.1038/ni.3202 The receptor NLRP3 is central to the formation of inflammasomes in myeloid cells. Ghiringhelli and colleagues demonstrate that NLRP3 also serves an important inflammasome-independent role in CD4+ T cells, in which it helps coordinate TH2 differentiation. See also: News and Views by Ting & Harton Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells   pp871 - 879 Brian J Laidlaw, Weiguo Cui, Robert A Amezquita, Simon M Gray, Tianxia Guan et al. doi:10.1038/ni.3224 The precise factors that control effective memory formation by T cells are unclear. Kaech et al. demonstrate that regulatory T cell-produced IL-10 is critical for the generation of CD8+ memory cells. Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota   pp880 - 888 Cornelia Lindner, Irene Thomsen, Benjamin Wahl, Milas Ugur, Maya K Sethi et al. doi:10.1038/ni.3213 Secretory IgA (SIgA) shapes the gut microbial composition. Pabst and colleagues show that the IgA-secreting plasma cell repertoire, once established, is remarkably resilient to changes in microbial populations that occur upon infection or antibiotic treatment. Errata Top Erratum: TET1 is a tumor suppressor of hematopoietic malignancy   p889 Luisa Cimmino, Meelad M Dawlaty, Delphine Ndiaye-Lobry, Yoon Sing Yap, Sofia Bakogianni et al. doi:10.1038/ni0815-889a Erratum: The diverse role of RIP kinases in necroptosis and inflammation   p889 John Silke, James A Rickard and Motti Gerlic doi:10.1038/ni0815-889b Top Advertisement Nature Genetics in association with the Wellcome Trust present: THE GENOMICS OF COMMON DISEASES 2015 September 2-5, 2015 | Cambridge, UK  REGISTER NOW!   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our customer feedback department Nature Publishing Group | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.