Nature Communications - 22 July 2015

Advertisement WHITE PAPER: The Role Of rasH2 In An Evolving Pharmaceutical Carcinogenicity Landscape  Changes to the ICH S1 guidelines have been proposed potentially transforming how pharmaceutical carcinogenicity evaluations are conducted.  Download To Learn More About: The background and limitations of existing protocols The potential impact of proposed changes to ICH S1 guidelines. How the rasH2 transgenic mouse meets the proposed guidelines Download Now     Weekly Content Alert Nature Communications is now fully open access. Read more. 22 July 2015  Featured image: Farmer et al. show that short, warm winters reduce population recruitment and embryo hatching success in Lake Erie yellow perch. Latest content: Articles Corrigenda Erratum Journal homepage Recommend to library Web feed   Advertisement Presented by Adaptive Biotechnologies, Nature Immunology, Nature Medicine, Nature Biotechnology, and Nature Genetics IMMUNE PROFILING IN HEALTH AND DISEASE September 9-11, 2015 | Seattle, WA, USA  REGISTER NOW!       Nature Communications - now fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Articles View all Articles     Nanoparticles with photoinduced precipitation for the extraction of pollutants from water and soil OPEN Ferdinand Brandl, Nicolas Bertrand, Eliana Martins Lima and Robert Langer Nanoparticles can act as absorbent materials for environmental clean-up due to their high surface-to-volume ratio, but subsequent removal can be difficult. Here, the authors report nanoparticles that aggregate upon UV radiation, allowing them to absorb pollutants from water and subsequently be removed in the aggregated state. 21 July 2015 | doi: 10.1038/ncomms8765 Chemical Sciences  Materials science  Nanotechnology  Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery OPEN Charles Robb Flynn, Vance L. Albaugh, Steven Cai, Joyce Cheung-Flynn, Phillip E. Williams, Robert M. Brucker, Seth R. Bordenstein, Yan Guo, David H. Wasserman and Naji N. Abumrad Gastric bypass surgery is one of the most effective interventions to achieve durable weight loss. Here, Flynn et al. show that, in mice, bile diversion to the small intestine results in beneficial and sustained metabolic improvements similar to Roux-en-Y gastric bypass surgery. 21 July 2015 | doi: 10.1038/ncomms8715 Biological Sciences  Medical research  Drivers of the US CO2 emissions 1997–2013 OPEN Kuishuang Feng, Steven J. Davis, Laixiang Sun and Klaus Hubacek US CO2 emissions dropped ∼11% between 2007 and 2013; a trend widely attributed to the increased use of natural gas over coal, yet the drivers behind this decline remain unquantified. Here, the authors analyse the drivers and show that the recent economic downturn is primarily responsible for the emissions drop. 21 July 2015 | doi: 10.1038/ncomms8714 Earth Sciences  Climate science  A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus OPEN Ying Wu, MyungSam Cho, David Shore, Manki Song, JungAh Choi, Tao Jiang, Yong-Qiang Deng, Melissa Bourgeois, Lynn Almli, Hua Yang, Li-Mei Chen, Yi Shi, Jianxu Qi, An Li, Kye Sook Yi, MinSeok Chang, Jin Soo Bae, HyunJoo Lee, JiYoung Shin, James Stevens et al. Monoclonal antibodies with broadly neutralizing activity are being developed as potential treatment of influenza infections. Here, the authors describe a broadly neutralizing antibody with an unusual mode of binding to viral haemagglutinin, which has been isolated from patients convalescent from pandemic H1N1 influenza infection. 21 July 2015 | doi: 10.1038/ncomms8708 Biological Sciences  Immunology  Virology  Eliminating material constraints for nonlinearity with plasmonic metamaterials OPEN Andres D. Neira, Nicolas Olivier, Mazhar E. Nasir, Wayne Dickson, Gregory A. Wurtz and Anatoly V. Zayats Nonlinear optical properties of conventional materials have limited spectral tuneability as they are defined by the material properties themselves. Here, the authors demonstrate that strong nonlinearity can be achieved in metamaterials where negligible nonlinearity of the constituent materials exists. 21 July 2015 | doi: 10.1038/ncomms8757 Physical Sciences  Condensed matter  Materials science  Optical physics  Towards a mechanistic understanding of carbon stabilization in manganese oxides OPEN Karen Johnson, Graham Purvis, Elisa Lopez-Capel, Caroline Peacock, Neil Gray, Thomas Wagner, Christian März, Leon Bowen, Jesus Ojeda, Nina Finlay, Steve Robertson, Fred Worrall and Chris Greenwell Minerals are known to stabilize organic carbon in sediments, affecting biogeochemical cycles and global climate, but the mechanism is not understood. Here, the authors suggest that manganese oxides can trap organic carbon and may act as a ‘mineral pump’, transforming carbon between labile and refractory forms. 21 July 2015 | doi: 10.1038/ncomms8628 Earth Sciences  Biogeochemistry  Residue-specific structures and membrane locations of pH-low insertion peptide by solid-state nuclear magnetic resonance OPEN Nicolas S. Shu, Michael S. Chung, Lan Yao, Ming An and Wei Qiang The pH-low insertion peptides (pHLIPs) respond to environmental pH variations by forming transmembrane α-helices. Here, the authors present the residue-specific structures and membrane locations of pHLIPs at different pH levels to probe the mechanism of their pH-dependant membrane insertion. 21 July 2015 | doi: 10.1038/ncomms8787 Biological Sciences  Biochemistry  Transient signal generation in a self-assembled nanosystem fueled by ATP OPEN Cristian Pezzato and Leonard J. Prins Natural and synthetic systems have fundamentally different approaches to signal generation. Here, the authors report a strategy that enables transient signal generation in a self-assembled system and show that it can be used to mimic several key features of natural signalling pathways. 21 July 2015 | doi: 10.1038/ncomms8790 Chemical Sciences  Materials science  Nanotechnology  Organic chemistry  Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst OPEN Daniel B. Graham, Christine E. Becker, Aivi Doan, Gautam Goel, Eduardo J. Villablanca, Dan Knights, Amanda Mok, Aylwin C.Y. Ng, John G. Doench, David E. Root, Clary B. Clish and Ramnik J. Xavier Phagocytes employ multiple bactericidal mechanisms to kill microorganisms, including the generation of toxic superoxide and other reactive oxygen species. Here the authors utilize a multi-omics approach to identify and characterize new regulatory nodes implicated in mucosal immunity that control phagocyte oxidative burst. 21 July 2015 | doi: 10.1038/ncomms8838 Biological Sciences  Biochemistry  Genetics  Immunology  Active suppression of intestinal CD4+TCRαβ+ T-lymphocyte maturation during the postnatal period OPEN Natalia Torow, Kai Yu, Kasra Hassani, Jenny Freitag, Olga Schulz, Marijana Basic, Anne Brennecke, Tim Sparwasser, Norbert Wagner, André Bleich, Matthias Lochner, Siegfried Weiss, Reinhold Förster, Oliver Pabst and Mathias W. Hornef The mechanisms governing the ontogeny and maturation of the mucosal immune system during the postnatal period are not well understood. Here the authors characterize the homing kinetic, anatomical distribution and maturation of early intestinal CD4 T cells and provide insights into active T-cell suppression during the postnatal period. 21 July 2015 | doi: 10.1038/ncomms8725 Biological Sciences  Immunology  Topological data analysis of contagion maps for examining spreading processes on networks Dane Taylor, Florian Klimm, Heather A. Harrington, Miroslav Kramár, Konstantin Mischaikow, Mason A. Porter and Peter J. Mucha The spreading dynamics of a contagion depend on the structure of an underlying network, and long-range edges due to airline transportation or media communication can significantly alter such dynamics. Here the authors use contagion dynamics on networks to produce point clouds for this analysis. 21 July 2015 | doi: 10.1038/ncomms8723 Physical Sciences  Theoretical physics  Intestinal CD169+ macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes OPEN Kenichi Asano, Naomichi Takahashi, Mikiko Ushiki, Misa Monya, Fumiaki Aihara, Erika Kuboki, Shigetaka Moriyama, Mayumi Iida, Hiroshi Kitamura, Chun-Hong Qiu, Takashi Watanabe and Masato Tanaka Macrophages and dendritic cells residing in the lamina propria are involved in controlling mucosal immune balance. Here, the authors identify CD169+ macrophages as contributors to the inflammation of DSS colitis through their role in mediating the recruitment of monocytes by secreting the cytokine CCL8. 21 July 2015 | doi: 10.1038/ncomms8802 Biological Sciences  Immunology  Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation OPEN Jeong-Hwan Yoon, Katsuko Sudo, Masahiko Kuroda, Mitsuyasu Kato, In-Kyu Lee, Jin Soo Han, Susumu Nakae, Takeshi Imamura, Juryun Kim, Ji Hyeon Ju, Dae-Kee Kim, Koichi Matsuzaki, Michael Weinstein, Isao Matsumoto, Takayuki Sumida and Mizuko Mamura TGF-ß and IL-6 are the essential cytokines for mediating the differentiation of IL-17-producing CD4+ T helper cells (TH17). Here, Yoon et al. provide more insights into this process and describe the opposing roles of TGFß-signalling intermediates Smad2 and Smad3 as STAT3 cofactors in Th17 differentiation. 21 July 2015 | doi: 10.1038/ncomms8600 Biological Sciences  Immunology  Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity Johannes Zuegg, Craig Muldoon, George Adamson, Declan McKeveney, Giang Le Thanh, Rajaratnam Premraj, Bernd Becker, Mu Cheng, Alysha G. Elliott, Johnny X. Huang, Mark S. Butler, Megha Bajaj, Joachim Seifert, Latika Singh, Nicola F. Galley, David I. Roper, Adrian J. Lloyd, Christopher G. Dowson, Ting-Jen Cheng, Wei-Chieh Cheng et al. The inhibition of bacterial glycosyltransferase has the potential to be an effective therapeutic target against drug resistance bacteria. Here, the authors present a novel class of inhibitor compounds based on a monosaccharide scaffold, which are able to eliminate bacterial infections in mice. 21 July 2015 | doi: 10.1038/ncomms8719 Biological Sciences  Chemical biology  Medicinal chemistry  Large-scale genomics unveil polygenic architecture of human cortical surface area OPEN Chi-Hua Chen, Qian Peng, Andrew J. Schork, Min-Tzu Lo, Chun-Chieh Fan, Yunpeng Wang, Rahul S. Desikan, Francesco Bettella, Donald J. Hagler, null null, Connor McCabe, Linda Chang, Natacha Akshoomoff, Erik Newman, Thomas Ernst, Peter Van Zijl, Joshua Kuperman, Sarah Murray, Cinnamon Bloss, Mark Appelbaum et al. How genetic variation contributes to brain morphology is still poorly understood. Here Chen et al. combine brain imaging with single-nucleotide polymorphism data to discover that a substantial degree of cortical variation is derived from underlying genetic differences. 20 July 2015 | doi: 10.1038/ncomms8549 Biological Sciences  Genetics  Neuroscience  Identification of phases, symmetries and defects through local crystallography OPEN Alex Belianinov, Qian He, Mikhail Kravchenko, Stephen Jesse, Albina Borisevich and Sergei V. Kalinin High-resolution microscopy methods provide a rich source of information, and allow highly precise measurements of atomic coordinates. Here, the authors report a method for quantitative analysis of material structures using multivariate statistical analysis to identify and distinguish various phases, defects and symmetries. 20 July 2015 | doi: 10.1038/ncomms8801 Chemical Sciences  Analytical chemistry  Condensed matter  Materials science  Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos OPEN Thomas Jank, Stephanie Eckerle, Marcus Steinemann, Christoph Trillhaase, Marianne Schimpl, Sebastian Wiese, Daan M. F. van Aalten, Wolfgang Driever and Klaus Aktories Yersinia ruckeri is the source of redmouth disease in fish. Here the authors analysed the Yersinia toxin Afp18 and show that it acts to inhibit RhoA activation by glycosylating a distinct tyrosine residue inducing a signalling incompetent structural conformation. 20 July 2015 | doi: 10.1038/ncomms8807 Biological Sciences  Cell biology  Molecular biology  Solubility design leading to high figure of merit in low-cost Ce-CoSb3 skutterudites OPEN Yinglu Tang, Riley Hanus, Sinn-wen Chen and G. Jeffrey Snyder Thermoelectric materials have the potential to convert waste heat into electricity. Although some of the more viable thermoelectric materials are based on expensive rare earth elements, here the authors replace Yb with low-cost Ce by engineering Ce solubility, thereby making Ce-CoSb3 a competitive thermoelectric. 20 July 2015 | doi: 10.1038/ncomms8584 Physical Sciences  Materials science  Mesoscale infraslow spontaneous membrane potential fluctuations recapitulate high-frequency activity cortical motifs Allen W. Chan, Majid H. Mohajerani, Jeffrey M. LeDue, Yu Tian Wang and Timothy H. Murphy The brain exists in a state of constant activity but little is known about very low frequency forms of activity. Here, the authors use high-speed, wide-field, voltage-sensitive dye imaging to investigate the presence and functional structure of infraslow spontaneous activity in anaesthetized and awake mouse cortex. 20 July 2015 | doi: 10.1038/ncomms8738 Biological Sciences  Neuroscience  Quantitative X-ray phase-contrast microtomography from a compact laser-driven betatron source OPEN J. Wenz, S. Schleede, K. Khrennikov, M. Bech, P. Thibault, M. Heigoldt, F. Pfeiffer and S. Karsch With excellent resolving power and tissue contrast, X-ray phase-contrast imaging holds great promise but the source requirements have limited its use. Here, Wenz et al. show a phase-contrast microtomogram of a biological sample using X-ray radiation driven by a high-power laser. 20 July 2015 | doi: 10.1038/ncomms8568 Physical Sciences  Applied physics  Optical physics  High density terahertz frequency comb produced by coherent synchrotron radiation OPEN S. Tammaro, O. Pirali, P. Roy, J.-F. Lampin, G. Ducournau, A. Cuisset, F. Hindle and G. Mouret There is considerable interest in generating broadband frequency combs at terahertz frequencies. Here, Tammaro et al. achieve this using coherent synchrotron radiation where the electron bunches emit quasi-synchronous terahertz pulses with high power, broad frequency, zero frequency offset, and high density. 20 July 2015 | doi: 10.1038/ncomms8733 Physical Sciences  Applied physics  Optical physics  Non-wetting surface-driven high-aspect-ratio crystalline grain growth for efficient hybrid perovskite solar cells OPEN Cheng Bi, Qi Wang, Yuchuan Shao, Yongbo Yuan, Zhengguo Xiao and Jinsong Huang The performance of hybrid perovskite solar cells is diminished by charge recombination, which commonly occurs at grain boundaries. Here, the authors employ a non-wetting hole transport layer which promotes the growth of highly crystalline films with fewer grain boundaries, leading to improved device efficiencies. 20 July 2015 | doi: 10.1038/ncomms8747 Physical Sciences  Applied physics  Materials science  Atomic view of the histidine environment stabilizing higher-pH conformations of pH-dependent proteins OPEN Céline Valéry, Stéphanie Deville-Foillard, Christelle Lefebvre, Nuria Taberner, Pierre Legrand, Florian Meneau, Cristelle Meriadec, Camille Delvaux, Thomas Bizien, Emmanouil Kasotakis, Carmen Lopez-Iglesias, Andrew Gall, Stéphane Bressanelli, Marie-Hélène Le Du, Maïté Paternostre and Franck Artzner In biological systems, large pH-induced conformational changes can be observed in certain proteins, a phenomenon poorly understood at the molecular level. Here the authors describe a peptide with the ability to self-organize into either small or large nanotubes in a pH-dependent manner and detail the mechanism driving the transition. 20 July 2015 | doi: 10.1038/ncomms8771 Biological Sciences  Chemical biology  A portable expression resource for engineering cross-species genetic circuits and pathways OPEN Manish Kushwaha and Howard M. Salis Organism-specific genetic parts are often used to express circuits and pathways, limiting their portability. Here the authors engineer a cross-species expression resource, without using host-specific parts, to control protein and pathway expression in non-model bacteria. 17 July 2015 | doi: 10.1038/ncomms8832 Biological Sciences  Bioengineering  Microbiology  Inside-out Ca2+ signalling prompted by STIM1 conformational switch OPEN Guolin Ma, Ming Wei, Lian He, Chongxu Liu, Bo Wu, Shenyuan L. Zhang, Ji Jing, Xiaowen Liang, Alessandro Senes, Peng Tan, Siwei Li, Aomin Sun, Yunchen Bi, Ling Zhong, Hongjiang Si, Yuequan Shen, Minyong Li, Mi-Sun Lee, Weibin Zhou, Junfeng Wang et al. Depletion of calcium from intracellular stores induces interaction between the endoplasmic reticulum STIM1 protein and the plasma membrane ORAI1 channel that facilitates cellular calcium entry. Here Ma et al. characterize a STIM1 gain-of-function mutant and propose a conformational switch that controls ORAI1 gating. 17 July 2015 | doi: 10.1038/ncomms8826 Biological Sciences  Biophysics  Cell biology  Insect glycerol transporters evolved by functional co-option and gene replacement OPEN Roderick Nigel Finn, François Chauvigné, Jon Anders Stavang, Xavier Belles and Joan Cerdà Insects can accumulate high levels of glycerol as an adaptive response to dessication and freezing. Here, the authors show that glycerol transporters evolved from water-selective channels that co-opted the glycerol transport function of ancestral aquaglyceroporins in the oldest lineages of insects. 17 July 2015 | doi: 10.1038/ncomms8814 Biological Sciences  Evolution  Genetics  Efficient water reduction with gallium phosphide nanowires OPEN Anthony Standing, Simone Assali, Lu Gao, Marcel A. Verheijen, Dick van Dam, Yingchao Cui, Peter H. L. Notten, Jos E. M. Haverkort and Erik P. A. M. Bakkers Photoelectrochemical hydrogen production from solar energy and water is one possible sustainable fuel option. Here, the authors fabricate wurtzite gallium phosphide nanowires, with a direct bandgap, allowing for enhanced optical absorption; demonstrating an enhancement in the water reduction efficiency. 17 July 2015 | doi: 10.1038/ncomms8824 Chemical Sciences  Catalysis  Nanotechnology  An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response OPEN Yuheng Shi, Bofeng Yuan, Nan Qi, Wenting Zhu, Jingru Su, Xiaoyan Li, Peipei Qi, Dan Zhang and Fajian Hou The cellular protein RIG-I detects viral RNA and activates another protein, MAVS, which then forms filaments and stimulates an antiviral pathway. Here, the authors identify different regions within MAVS involved in activating transcription factors IRF3 and NF-κB, and in MAVS self-inhibition. 17 July 2015 | doi: 10.1038/ncomms8811 Biological Sciences  Immunology  Microbiology  Virology  The development and characterization of synthetic minimal yeast promoters OPEN Heidi Redden and Hal S. Alper Endogenous fungal gene promoters can be hundreds of base pairs long, limiting their use in synthetic biology and biotechnology. Here Redden and Alper screen a library of synthetic promoter elements to generate compact DNA sequences of ∼100 base pairs able to drive high levels of gene expression. 17 July 2015 | doi: 10.1038/ncomms8810 Biological Sciences  Bioengineering  Molecular biology  Noble metal-comparable SERS enhancement from semiconducting metal oxides by making oxygen vacancies OPEN Shan Cong, Yinyin Yuan, Zhigang Chen, Junyu Hou, Mei Yang, Yanli Su, Yongyi Zhang, Liang Li, Qingwen Li, Fengxia Geng and Zhigang Zhao Surface-enhanced Raman spectroscopy is widely used for rapid and sensitive molecular detection in chemistry and biology, but typically relies on noble metals. Here the authors report a non-stoichiometric semiconducting material with defect-rich surface that displays excellent detection limits and enhancement factors. 17 July 2015 | doi: 10.1038/ncomms8800 Chemical Sciences  Analytical chemistry  Materials science  Physical chemistry  Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1 OPEN Sabine Vettorazzi, Constantin Bode, Lien Dejager, Lucien Frappart, Ekaterina Shelest, Carina Klaßen, Alpaslan Tasdogan, Holger M. Reichardt, Claude Libert, Marion Schneider, Falk Weih, N. Henriette Uhlenhaut, Jean-Pierre David, Markus Gräler, Anna Kleiman and Jan P. Tuckermann Endothelial damage is a major component of acute lung injury pathogenesis. Here the authors show that in a mouse model of acute lung injury, glucocorticoids induce sphingosine kinase 1 production in macrophages, promoting endothelial barrier function and ameliorating the disease. 17 July 2015 | doi: 10.1038/ncomms8796 Biological Sciences  Immunology  Gains and losses of coral skeletal porosity changes with ocean acidification acclimation OPEN Paola Fantazzini, Stefano Mengoli, Luca Pasquini, Villiam Bortolotti, Leonardo Brizi, Manuel Mariani, Matteo Di Giosia, Simona Fermani, Bruno Capaccioni, Erik Caroselli, Fiorella Prada, Francesco Zaccanti, Oren Levy, Zvy Dubinsky, Jaap A. Kaandorp, Pirom Konglerd, Jörg U. Hammel, Yannicke Dauphin, Jean-Pierre Cuif, James C. Weaver et al. Global warming and ocean acidification impact coral ecosystems. Here, the authors show higher skeletal porosity and reduced bulk density at lower pH in corals living along a natural pH gradient in the Mediterranean, which may contribute to reduce population density and increase damage susceptibility. 17 July 2015 | doi: 10.1038/ncomms8785 Biological Sciences  Biogeochemistry  Ecology  Oceanography  PDGFRβ signalling regulates local inflammation and synergizes with hypercholesterolaemia to promote atherosclerosis Chaoyong He, Shayna C. Medley, Taishan Hu, Myron E. Hinsdale, Florea Lupu, Renu Virmani and Lorin E. Olson Platelet-derived growth factor (PDGF) signaling in vascular smooth muscle cells (VSMCs) promotes atherogenesis. Here, the authors show that mutant mice with increased PDGF activity in VSMCs have augmented STAT1-dependent chemokine signals resulting in artery wall inflammation and formation of advanced plaque morphologies clinically relevant in humans. 17 July 2015 | doi: 10.1038/ncomms8770 Biological Sciences  Medical research  PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis OPEN Min-Sik Lee, Man-Hyung Jeong, Hyun-Woo Lee, Hyun-Ji Han, Aram Ko, Stephen M. Hewitt, Jae-Hoon Kim, Kyung-Hee Chun, Joon-Yong Chung, Cheolju Lee, Hanbyoul Cho and Jaewhan Song Mutations and post-translational modifications of the PI3K/AKT pathway inhibitor PTEN are a feature of many cancers, but these have not been associated with cervical cancer. Here, the authors identify a PI3K/AKT-mediated ubiquitination degradation pathway of PTEN that occurs in patients with cervical cancer. 17 July 2015 | doi: 10.1038/ncomms8769 Biological Sciences  Cancer  Cell biology  Long-life Li/polysulphide batteries with high sulphur loading enabled by lightweight three-dimensional nitrogen/sulphur-codoped graphene sponge OPEN Guangmin Zhou, Eunsu Paek, Gyeong S. Hwang and Arumugam Manthiram There is intensive research underway into the cathode development of lithium–sulphur batteries. Here, the authors report a lithium–sulphur battery using nitrogen/sulphur codoped graphene structure which displays excellent electrochemical performance with high sulphur loading. 17 July 2015 | doi: 10.1038/ncomms8760 Chemical Sciences  Materials science  Nanotechnology  Physical chemistry  Quenching of dynamic nuclear polarization by spin–orbit coupling in GaAs quantum dots OPEN John M. Nichol, Shannon P. Harvey, Michael D. Shulman, Arijeet Pal, Vladimir Umansky, Emmanuel I. Rashba, Bertrand I. Halperin and Amir Yacoby Dynamic nuclear polarization is the transfer of electronic angular momentum to nuclear spins and is a potential route for coherently manipulating spin in quantum information. Here, the authors show that spin–orbit coupling can quench dynamic nuclear polarization in a gallium arsenide quantum dot. 17 July 2015 | doi: 10.1038/ncomms8682 Physical Sciences  Condensed matter  Nanotechnology  Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia OPEN June Li, Dianne E. van der Wal, Guangheng Zhu, Miao Xu, Issaka Yougbare, Li Ma, Brian Vadasz, Naadiya Carrim, Renata Grozovsky, Min Ruan, Lingyan Zhu, Qingshu Zeng, Lili Tao, Zhi-min Zhai, Jun Peng, Ming Hou, Valery Leytin, John Freedman, Karin M. Hoffmeister and Heyu Ni et al. Immune thrombocytopenia (ITP) is caused by autoantibody-mediated platelet clearance, but refractoriness to current immunomodulatory therapies is common. Here the authors show that desialylated platelets can be cleared via hepatic Ashwell–Morell receptor, a process that can be attenuated by sialidase inhibitors, suggesting a new therapy for ITP. 17 July 2015 | doi: 10.1038/ncomms8737 Biological Sciences  Immunology  Medical research  Giant narrowband twin-beam generation along the pump-energy propagation direction OPEN Angela M. Pérez, Kirill Yu Spasibko, Polina R. Sharapova, Olga V. Tikhonova, Gerd Leuchs and Maria V. Chekhova Nonlinear interactions such as parametric down-conversion and four-wave mixing are limited by transverse and longitudinal walk-off effects. Here, Pérez et al. demonstrate bright, tunable, diffraction-limited twin-beam radiation by ensuring that signal or idler pulse propagates in the direction or velocity of the pump. 17 July 2015 | doi: 10.1038/ncomms8707 Physical Sciences  Optical physics  Conditional rotation of two strongly coupled semiconductor charge qubits OPEN Hai-Ou Li, Gang Cao, Guo-Dong Yu, Ming Xiao, Guang-Can Guo, Hong-Wen Jiang and Guo-Ping Guo Quantum-information processing requires gates that can operate on multiple qubits. Here, the authors demonstrate a controlled-NOT gate operation on two coupled charge qubits comprising electrons confined in semiconductor double quantum dots. 17 July 2015 | doi: 10.1038/ncomms8681 Physical Sciences  Applied physics  Nanotechnology  Spin–cavity interactions between a quantum dot molecule and a photonic crystal cavity OPEN Patrick M. Vora, Allan S. Bracker, Samuel G. Carter, Timothy M. Sweeney, Mijin Kim, Chul Soo Kim, Lily Yang, Peter G. Brereton, Sophia E. Economou and Daniel Gammon Optical cavities enhance light–matter interactions, and have been used to strongly couple a photon to a single spin. Here, the authors take this a step further by coupling a photon to a two-spin system by embedding an indium arsenide quantum-dot molecule in a photonic crystal cavity. 17 July 2015 | doi: 10.1038/ncomms8665 Physical Sciences  Nanotechnology  Optical physics  Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis Eric Linster, Iwona Stephan, Willy V. Bienvenut, Jodi Maple-Grødem, Line M. Myklebust, Monika Huber, Michael Reichelt, Carsten Sticht, Simon Geir Møller, Thierry Meinnel, Thomas Arnesen, Carmela Giglione, Rüdiger Hell and Markus Wirtz N-terminal acetylation is a common protein modification in eukaryotes. Here the authors show that in Arabidopsis, N-terminal acetylation is decreased by drought stress, that abundance of an N-terminal acetyltransferase is reduced by abscisic acid and that constitutive downregulation can confer drought resistance. 17 July 2015 | doi: 10.1038/ncomms8640 Biological Sciences  Biochemistry  Plant sciences  E2F1-dependent miR-421 regulates mitochondrial fragmentation and myocardial infarction by targeting Pink1 Kun Wang, Lu-Yu Zhou, Jian-Xun Wang, Yin Wang, Teng Sun, Bing Zhao, Yong-Jie Yang, Tao An, Bo Long, Na Li, Cui-Yun Liu, Ying Gong, Jin-Ning Gao, Yan-Han Dong, Jian Zhang and Pei-Feng Li Inhibition of mitochondrial fragmentation can block or delay cell death. Here the authors show that the signalling axis E2F1-miR-421-Pink1 represents a major regulator of mitochondrial fission and cardiomyocyte death, identifying potential therapeutic targets for treatment of heart failure. 17 July 2015 | doi: 10.1038/ncomms8619 Biological Sciences  Cell biology  Medical research  Creating semiconductor metafilms with designer absorption spectra OPEN Soo Jin Kim, Pengyu Fan, Ju-Hyung Kang and Mark L. Brongersma Ultrathin semiconductor metafilms can be designed to achieve near-unity absorption in specific spectral regions. Here, Kim et al. engineer nanoscale optical resonances in sub-50-nm-thick germanium nanobeams metafilms to demonstrate near-unity absorption in one or more desired wavelength regions. 17 July 2015 | doi: 10.1038/ncomms8591 Physical Sciences  Materials science  Nanotechnology  Optical physics  Rational design of crystalline supermicroporous covalent organic frameworks with triangular topologies OPEN Sasanka Dalapati, Matthew Addicoat, Shangbin Jin, Tsuneaki Sakurai, Jia Gao, Hong Xu, Stephan Irle, Shu Seki and Donglin Jiang Covalent organic frameworks are currently arousing considerable interest due to their desirable properties for a wide range of applications. Here, Jiang et al. report two such materials with triangular topologies which exhibit high hole mobility arising from extensive π-cloud delocalisation. 16 July 2015 | doi: 10.1038/ncomms8786 Chemical Sciences  Materials science  Organic chemistry  Parallel circuits control temperature preference in Drosophila during ageing OPEN Hsiang-Wen Shih, Chia-Lin Wu, Sue-Wei Chang, Tsung-Ho Liu, Jason Sih-Yu Lai, Tsai-Feng Fu, Chien-Chung Fu and Ann-Shyn Chiang The capacity for thermoregulation deteriorates with age, particularly in cold environments. Here the authors demonstrate in Drosophila that age-related changes in cold avoidance result from a shift in the relative contribution of two parallel mushroom body circuits that are modulated by dopamine. 16 July 2015 | doi: 10.1038/ncomms8775 Biological Sciences  Molecular biology  Neuroscience  Locking GTPases covalently in their functional states OPEN David Wiegandt, Sophie Vieweg, Frank Hofmann, Daniel Koch, Fu Li, Yao-Wen Wu, Aymelt Itzen, Matthias P. Müller and Roger S. Goody The cellular function of small GTPases is regulated by switching between active (GTP-bound) and inactive (GDP-bound) states. Here the authors develop nucleotide analogues that can be covalently linked to GTPases via a strategically placed cysteine residue to lock the target GTPase in defined activation states. 16 July 2015 | doi: 10.1038/ncomms8773 Biological Sciences  Biophysics  Cell biology  Chemical biology  D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2 OPEN An-Ping Lin, Saman Abbas, Sang-Woo Kim, Manoela Ortega, Hakim Bouamar, Yissela Escobedo, Prakash Varadarajan, Yuejuan Qin, Jessica Sudderth, Eduard Schulz, Alexander Deutsch, Sumitra Mohan, Peter Ulz, Peter Neumeister, Dinesh Rakheja, Xiaoli Gao, Andrew Hinck, Susan T. Weintraub, Ralph J. DeBerardinis, Heinz Sill et al. IDH1- and IDH2-mutant cancer cells aberrantly accumulate D2-hydroxyglutarate (D2-HG). Here, Lin et al. find loss-of-function mutations in D2-hydroxyglutarate dehydrogenase (D2HGDH), which converts D2-HG to alpha-ketoglutarate (α-KG), in diffuse large B-cell lymphomas and show that D2HGDH via α-KG regulates the expression and activity of IDH2. 16 July 2015 | doi: 10.1038/ncomms8768 Biological Sciences  Cancer  Genetics  Medical research  Transient brain activity disentangles fMRI resting-state dynamics in terms of spatially and temporally overlapping networks OPEN Fikret Işik Karahanoğlu and Dimitri Van De Ville Growing evidence from neuroimaging studies suggests that the brain is dynamically organized into functionally connected networks. Here, the authors develop a new technique for decomposing spontaneous activity into temporally overlapping building blocks that assemble standard functional networks. 16 July 2015 | doi: 10.1038/ncomms8751 Biological Sciences  Neuroscience  A spectrally tunable all-graphene-based flexible field-effect light-emitting device OPEN Xiaomu Wang, He Tian, Mohammad Ali Mohammad, Cheng Li, Can Wu, Yi Yang and Tian-Ling Ren Wavelength tuning of a light emitting diode (LED) by an external electrical bias would benefit display technologies. Here, Wang et al. demonstrate wavelength-tuning from blue to the near-infrared in an all-graphene-based field effect LED by gate modulation 16 July 2015 | doi: 10.1038/ncomms8767 Physical Sciences  Materials science  Nanotechnology  Chemical structure imaging of a single molecule by atomic force microscopy at room temperature OPEN Kota Iwata, Shiro Yamazaki, Pingo Mutombo, Prokop Hapala, Martin Ondráček, Pavel Jelínek and Yoshiaki Sugimoto Atomic force microscopy is capable of resolving the chemical structure of a single molecule on a surface, usually at low temperatures. Here, the authors demonstrate that the chemical structure of a single molecule strongly adsorbed onto a silicon surface can be determined at room temperature. 16 July 2015 | doi: 10.1038/ncomms8766 Chemical Sciences  Inorganic chemistry  Nanotechnology  GABA depolarizes immature neurons and inhibits network activity in the neonatal neocortex in vivo Knut Kirmse, Michael Kummer, Yury Kovalchuk, Otto W. Witte, Olga Garaschuk and Knut Holthoff GABA depolarizes immature neurons in the central nervous system, yet the mode of GABA action in the developing brain is unknown. Here the authors demonstrate that in vivo GABA acts as a depolarizing neurotransmitter imposing inhibitory control on network activity in the mouse postnatal day 3–4 neocortex. 16 July 2015 | doi: 10.1038/ncomms8750 Biological Sciences  Neuroscience  A generic concept to overcome bandgap limitations for designing highly efficient multi-junction photovoltaic cells OPEN Fei Guo, Ning Li, Frank W. Fecher, Nicola Gasparini, Cesar Omar Ramirez Quiroz, Carina Bronnbauer, Yi Hou, Vuk V. Radmilović, Velimir R. Radmilović, Erdmann Spiecker, Karen Forberich and Christoph J. Brabec The efficiency of a single-junction photovoltaic cell is constrained by the Shockley-Queisser limit. Here, the authors adopt a triple-junction configuration which relaxes material and current-matching constraints, providing a generic strategy for advancing the efficiency roadmap of photovoltaic technologies. 16 July 2015 | doi: 10.1038/ncomms8730 Physical Sciences  Materials science  Nanotechnology  High-quality EuO thin films the easy way via topotactic transformation OPEN Thomas Mairoser, Julia A. Mundy, Alexander Melville, Daniel Hodash, Paul Cueva, Rainer Held, Artur Glavic, Jürgen Schubert, David A. Muller, Darrell G. Schlom and Andreas Schmehl In the absence of matching substrates, the growth of oxide thin films can be challenging. Here, the authors demonstrate the growth of EuO thin films via a topotactic reaction, where a chemical reaction transforms a single crystal of one phase into that of another. 16 July 2015 | doi: 10.1038/ncomms8716 Physical Sciences  Materials science  Uphill diffusion and overshooting in the adsorption of binary mixtures in nanoporous solids OPEN Alexander Lauerer, Tomas Binder, Christian Chmelik, Erich Miersemann, Jürgen Haase, Douglas M. Ruthven and Jörg Kärger During the transient adsorption of a binary mixture in a nanoporous host, the concentration of one component may temporarily exceed its equilibrium value, with molecules diffusing in the direction of increasing concentration. Here, the authors use microimaging to examine this process in a real system. 16 July 2015 | doi: 10.1038/ncomms8697 Chemical Sciences  Materials science  Physical chemistry  Determination of band alignment in the single-layer MoS2/WSe2 heterojunction OPEN Ming-Hui Chiu, Chendong Zhang, Hung-Wei Shiu, Chih-Piao Chuu, Chang-Hsiao Chen, Chih-Yuan S. Chang, Chia-Hao Chen, Mei-Yin Chou, Chih-Kang Shih and Lain-Jong Li The alignment of the bandgap of adjacent materials in a heterostructure largely determines the electronic properties of a device. Here, the authors measure the conduction and valance band offsets at the interface between two two-dimensional materials: molybdenum disulphide and tungsten diselenide. 16 July 2015 | doi: 10.1038/ncomms8666 Physical Sciences  Materials science  Nanotechnology  Highly indistinguishable photons from deterministic quantum-dot microlenses utilizing three-dimensional in situ electron-beam lithography OPEN M. Gschrey, A. Thoma, P. Schnauber, M. Seifried, R. Schmidt, B. Wohlfeil, L. Krüger, J. -H. Schulze, T. Heindel, S. Burger, F. Schmidt, A. Strittmatter, S. Rodt and S. Reitzenstein Single indistinguishable photon sources with high flux rates and purity are needed in quantum communications. Here, Gschrey et al. use three-dimensional electron-beam lithography to pattern deterministic quantum-dot microlenses and demonstrate enhanced photon-extraction efficiency and photon indistinguishability. 16 July 2015 | doi: 10.1038/ncomms8662 Physical Sciences  Applied physics  Condensed matter  Nanotechnology  Thermodynamic picture of ultrafast charge transport in graphene OPEN Zoltán Mics, Klaas-Jan Tielrooij, Khaled Parvez, Søren A. Jensen, Ivan Ivanov, Xinliang Feng, Klaus Müllen, Mischa Bonn and Dmitry Turchinovich A linear energy–momentum relation of graphene results in a high direct-current electron mobility, but this is not necessarily true at terahertz frequencies. Here, the authors show that its ultrafast conductivity is dependent on a highly nonlinear interplay between heating and cooling of the electron gas. 16 July 2015 | doi: 10.1038/ncomms8655 Physical Sciences  Condensed matter  Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety OPEN Guo-Qiang Wang, Cheng Cen, Chong Li, Shuai Cao, Ning Wang, Zheng Zhou, Xue-Mei Liu, Yu Xu, Na-Xi Tian, Ying Zhang, Jun Wang, Li-Ping Wang and Yun Wang The medial prefrontal cortex (mPFC) is implicated in pain regulation, yet the underlying mechanisms are poorly understood. Here the authors establish a critical role for mPFC in regulating pain sensation and pain-related anxiety, mediated by activation of the cyclin-dependent kinase 5 signalling pathway. 16 July 2015 | doi: 10.1038/ncomms8660 Biological Sciences  Neuroscience  The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming Liem Phan, Ping-Chieh Chou, Guermarie Velazquez-Torres, Ismael Samudio, Kenneth Parreno, Yaling Huang, Chieh Tseng, Thuy Vu, Chris Gully, Chun-Hui Su, Edward Wang, Jian Chen, Hyun-Ho Choi, Enrique Fuentes-Mattei, Ji-Hyun Shin, Christine Shiang, Brian Grabiner, Marzenna Blonska, Stephen Skerl, Yiping Shao et al. The transcription factor c-Myc is a master regulator of cellular metabolism and has an important role in tumorigenesis. Phan et al. show that 14-3-3σ, an inhibitor of cell cycle progression, also suppresses tumour-promoting metabolic programmes by promoting the degradation of c-Myc. 16 July 2015 | doi: 10.1038/ncomms8530 Biological Sciences  Cancer  Medical research  Transition of dislocation nucleation induced by local stress concentration in nanotwinned copper OPEN N. Lu, K. Du, L. Lu and H. Q. Ye Metallic materials with a nanometre-scaled lamella structure can have properties that are very different from their coarser-grained counterparts. Here, the authors demonstrate how dislocations in such a material—nanotwinned copper—can nucleate in two distinctly different mechanisms depending on local stress 16 July 2015 | doi: 10.1038/ncomms8648 Physical Sciences  Materials science  Hot photocarrier dynamics in organic solar cells P. A. Lane, P. D. Cunningham, J. S. Melinger, O. Esenturk and E. J. Heilweil An optically excited electrical current flows through an organic solar cell by charge transfer between electron donors and acceptors. Here, the authors use terahertz photoconductivity measurements to show that any energy in excess of that needed to create these carriers can influence charge mobility 16 July 2015 | doi: 10.1038/ncomms8558 Physical Sciences  Materials science  Optical physics  Interneuron- and GABAA receptor-specific inhibitory synaptic plasticity in cerebellar Purkinje cells OPEN Qionger He, Ian Duguid, Beverley Clark, Patrizia Panzanelli, Bijal Patel, Philip Thomas, Jean-Marc Fritschy and Trevor G. Smart Rebound potentiation (RP), a form of inhibitory plasticity in the cerebellum, is characterized by an increase in GABAergic synaptic currents. Here the authors demonstrate that RP is both interneuron input-specific and GABAA receptor subunit-specific and serves to regulate Purkinje cell firing patterns. 16 July 2015 | doi: 10.1038/ncomms8364 Biological Sciences  Biophysics  Cell biology  Neuroscience  Short winters threaten temperate fish populations OPEN Troy M. Farmer, Elizabeth A. Marschall, Konrad Dabrowski and Stuart A. Ludsin Reductions in winter duration under climate change may have negative consequences for ectotherms adapted to seasonal temperature regimes. Here Farmer et al. show how short winters have, in part, caused failed lake fishery recruitment by altering spawning phenology and lowering the quality of eggs and larvae. 15 July 2015 | doi: 10.1038/ncomms8724 Biological Sciences  Climate science  Ecology  Zoology  Intrinsically stretchable and transparent thin-film transistors based on printable silver nanowires, carbon nanotubes and an elastomeric dielectric OPEN Jiajie Liang, Lu Li, Dustin Chen, Tibor Hajagos, Zhi Ren, Shu-Yu Chou, Wei Hu and Qibing Pei Stretchable displays need stretchable electronics to control them. Here, the authors create transparent and deformable thin-film transistors comprised of silver nanowire-based electrodes, a carbon nanotube network channel and a polyurethane-co-polyethylene oxide dielectric made using solution-based techniques. 15 July 2015 | doi: 10.1038/ncomms8647 Physical Sciences  Applied physics  Materials science  SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation OPEN Leo T. -H. Tang, Tim J. Craig and Jeremy M. Henley Synapsins anchor synaptic vesicles (SVs) to the actin cytoskeleton to establish the reserve vesicle pool. Here Tang et al. show that SUMOylation of synapsin 1a enhances its interaction with SVs to promote efficient reclustering following stimulation, and a mutation linked to autism and epilepsy leads to defective SUMOylation. 15 July 2015 | doi: 10.1038/ncomms8728 Biological Sciences  Cell biology  Neuroscience  Molecular interactions on single-walled carbon nanotubes revealed by high-resolution transmission microscopy OPEN Tomokazu Umeyama, Jinseok Baek, Yuta Sato, Kazu Suenaga, Fawzi Abou-Chahine, Nikolai V. Tkachenko, Helge Lemmetyinen and Hiroshi Imahori Probing local molecular properties is crucial for the rational designs of functional organic materials. Here, Umeyama et al. prepare a dimeric structure of a model π-aromatic compound on the sidewall of a carbon nanotube to be visualized by transmission electron microscopy at a single-molecule level. 15 July 2015 | doi: 10.1038/ncomms8732 Physical Sciences  Condensed matter  Materials science  Plant species’ origin predicts dominance and response to nutrient enrichment and herbivores in global grasslands OPEN Eric W. Seabloom, Elizabeth T. Borer, Yvonne M. Buckley, Elsa E. Cleland, Kendi F. Davies, Jennifer Firn, W. Stanley Harpole, Yann Hautier, Eric M. Lind, Andrew S. MacDougall, John L. Orrock, Suzanne M. Prober, Peter B. Adler, T. Michael Anderson, Jonathan D. Bakker, Lori A. Biederman, Dana M. Blumenthal, Cynthia S. Brown, Lars A. Brudvig, Marc Cadotte et al. It remains unclear whether exotic and native species are functionally different. Using a global grassland experiment, Seabloom et al. show that native and exotic species respond differently to two globally pervasive environmental changes, addition of mineral nutrients and alteration of herbivore density. 15 July 2015 | doi: 10.1038/ncomms8710 Biological Sciences  Ecology  Plant sciences  Adiponectin regulates psoriasiform skin inflammation by suppressing IL-17 production from γδ-T cells Sayaka Shibata, Yayoi Tada, Carren Sy Hau, Aya Mitsui, Masahiro Kamata, Yoshihide Asano, Makoto Sugaya, Takafumi Kadono, Yosuke Masamoto, Mineo Kurokawa, Toshimasa Yamauchi, Naoto Kubota, Takashi Kadowaki and Shinichi Sato Adiponectin levels are decreased in metabolic syndrome and psoriasis patients. Here the authors show that adiponectin suppresses the pathogenic production of IL-17 of γδ T cells, and adiponectin administration improves psoriasis-like symptoms in a mouse model of the disease. 15 July 2015 | doi: 10.1038/ncomms8687 Biological Sciences  Immunology  Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels OPEN Kazuya Setoh, Chikashi Terao, Shigeo Muro, Takahisa Kawaguchi, Yasuharu Tabara, Meiko Takahashi, Takeo Nakayama, Shinji Kosugi, Akihiro Sekine, Ryo Yamada, Michiaki Mishima and Fumihiko Matsuda Alpha-1 antitrypsin deficiency is a common genetic disorder in Europeans. Here Setoh et al. perform a genome-wide association study of AAT serum levels in a Japanese population and find three missense variants in the metabolism genes ALDH2, HNF1A and GCKR. 15 July 2015 | doi: 10.1038/ncomms8754 Biological Sciences  Genetics  Restoration of rhythmicity in diffusively coupled dynamical networks OPEN Wei Zou, D. V. Senthilkumar, Raphael Nagao, István Z. Kiss, Yang Tang, Aneta Koseska, Jinqiao Duan and Jürgen Kurths Oscillatory behaviour is essential for proper functioning of several processes, yet quenching phenomena can lead to steady states with suppressed oscillations. Here the authors present a scheme to revoke these states in diffusively coupled networks, and demonstrate their approach on a chemical oscillator. 15 July 2015 | doi: 10.1038/ncomms8709 Physical Sciences  Theoretical physics  Rapid epitaxy-free graphene synthesis on silicidated polycrystalline platinum OPEN Vitaliy Babenko, Adrian T. Murdock, Antal A. Koós, Jude Britton, Alison Crossley, Philip Holdway, Jonathan Moffat, Jian Huang, Jack A. Alexander-Webber, Robin J. Nicholas and Nicole Grobert Innovative substrate engineering is necessary to improve the quality of CVD-synthesized graphene. Here the authors demonstrate in situ fabrication of an eutectic Pt-Si alloy that forms a wetting liquid surface on polycrystalline Pt foils, allowing millimetre-sized graphene crystals to grow in minutes. 15 July 2015 | doi: 10.1038/ncomms8536 Physical Sciences  Materials science  Nanotechnology  Food-web stability signals critical transitions in temperate shallow lakes OPEN Jan J. Kuiper, Cassandra van Altena, Peter C. de Ruiter, Luuk P. A. van Gerven, Jan H. Janse and Wolf M. Mooij How mechanisms underlying food-web stability may influence ecosystem regime shifts is not well understood. Combining food-web and ecosystem modelling, Kuiper et al. show that destabilizing reorganization of a small number of key trophic interactions precede catastrophic changes in shallow lake ecosystems. 15 July 2015 | doi: 10.1038/ncomms8727 Biological Sciences  Ecology  Giant colloidal silver crystals for low-loss linear and nonlinear plasmonics OPEN Chun-Yuan Wang, Hung-Ying Chen, Liuyang Sun, Wei-Liang Chen, Yu-Ming Chang, Hyeyoung Ahn, Xiaoqin Li and Shangjr Gwo The typical small sizes of silver microcrystals prevent the full characterization of fundamental plasmonic properties and limits applications. Here, Wang et al. report the synthesis of large colloidal silver crystals with superior nonlinear properties and surface plasmon polariton propagation lengths beyond 100 μm. 15 July 2015 | doi: 10.1038/ncomms8734 Physical Sciences  Materials science  Nanotechnology  Optical physics  Supramolecular motifs in dynamic covalent PEG-hemiaminal organogels OPEN Courtney H. Fox, Gijs M. ter Hurrne, Rudy J. Wojtecki, Gavin O. Jones, Hans W. Horn, E. W. Meijer, Curtis W. Frank, James L. Hedrick and Jeannette M. García Control of supramolecular chemistry and dynamic covalent crosslinking are ideal ways to generate soft materials with desirable mechanical behaviours. Here, the authors report on practical and computational methods used to elucidate the structural properties of PEG-hemiaminal organogel networks. 15 July 2015 | doi: 10.1038/ncomms8417 Chemical Sciences  Materials science  Organic chemistry  An actin-dependent spindle position checkpoint ensures the asymmetric division in mouse oocytes OPEN Aïcha Metchat, Manuel Eguren, Julius M. Hossain, Antonio Z. Politi, Sébastien Huet and Jan Ellenberg In mammalian oocytes, the meiotic spindle is assembled close to the centre of the cell and relocates to the cell periphery prior to chromosome segregation. Here Metchat et al. show that anaphase is delayed until the spindle is positioned close to the cell cortex, providing evidence for a spindle position checkpoint. 15 July 2015 | doi: 10.1038/ncomms8784 Biological Sciences  Cell biology  Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase Fangliang Zhang, Devang M. Patel, Kristen Colavita, Irina Rodionova, Brian Buckley, David A. Scott, Akhilesh Kumar, Svetlana A. Shabalina, Sougata Saha, Mikhail Chernov, Andrei L. Osterman and Anna Kashina The phosphoribosyl pyrophosphate synthase PRPS2 catalyses the first step of de novo purine nucleotide biosynthesis, and has recently been shown to couple protein and nucleotide metabolism. Zhang et al. demonstrate that PRPS2 activity is regulated by tRNA-dependent post-translational addition of arginine. 15 July 2015 | doi: 10.1038/ncomms8517 Biological Sciences  Biochemistry    Nature Communications JOBS of the week Postdoctoral Research Associate University of Liverpool Postdoctoral Research Assistant University of Dundee Tenure-Track Faculty Position University of Cambridge PhD-position (4 years) in Cancer Genetics / Genomics University of Bergen Staff Clinician – Allergic Diseases National Institute of Allergy and Infectious Diseases 2 Postdocs in Alzheimer's / Prion disease research University of Calgary Postdoctoral Research Assistant University of Bristol Research Associate University College London (UCL) W2 Professorship for Medical Physics Martin-Luther-Universität Halle-Wittenberg Research Fellow University of Sussex More Science jobs from Nature Communications EVENT Cancer Diagnostics Conference 16.11.15 San Francisco, USA More science events from       Latest Corrigenda     Corrigendum: The dynamics of methylammonium ions in hybrid organic–inorganic perovskite solar cells Aurelien M.A. Leguy, Jarvist Moore Frost, Andrew P. McMahon, Victoria Garcia Sakai, W. Kockelmann, ChunHung Law, Xiaoe Li, Fabrizia Foglia, Aron Walsh, Brian C. O’Regan, Jenny Nelson, João T. Cabral and Piers R.F. Barnes 20 July 2015 | doi: 10.1038/ncomms8780 Physical Sciences  Applied physics  Physical chemistry      Corrigendum: Topological excitations in a kagome magnet Manuel Pereiro, Dmitry Yudin, Jonathan Chico, Corina Etz, Olle Eriksson and Anders Bergman 20 July 2015 | doi: 10.1038/ncomms8881 Physical Sciences  Condensed matter  Materials science  Nanotechnology        Latest Erratum     Erratum: Facile synthesis of ultrahigh-surface-area hollow carbon nanospheres for enhanced adsorption and energy storage Fei Xu, Zhiwei Tang, Siqi Huang, Luyi Chen, Yeru Liang, Weicong Mai, Hui Zhong, Ruowen Fu and Dingcai Wu 16 July 2015 | doi: 10.1038/ncomms8863 Chemical Sciences  Materials science  Physical chemistry      Advertisement Create your own profile on the Nature Index  Register to get the most from the Nature Index by creating your own profile and receiving monthly updates. •   Add your principal institution and affiliated institutions •   Add your papers •   Bookmark pages •   Create your own indexes You can also register using existing ORCID, OpenID and social media accounts.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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