EMBO reports Table of Contents for July 2015; Vol. 16, No. 7

July 2015 | Volume 16, Number 7 Submit Table of Contents Correspondence Science & Society Scientific Reports Articles Volume 16, Number 7 Correspondence Levelling the lingo playing field English is the relatively undisputed lingua franca of science. Would it be better to allow non‐native speaking authors to declare their English language skills upfront so that readers can focus on the science in a paper, rather than the prose? Andrea Ballabeni Published online 10.06.2015 Science & Society The big, the bad and the ugly: Extreme animals as inspiration for biomedical research Animal models have advanced biomedical research, but they have important limits. The tools of comparative genomics should now allow us to expand our bestiary to study non‐model organisms and how they deal with aging and cancer, eventually applying this knowledge to human health. João Pedro de Magalhães Published online 03.06.2015 The case of the gene: Postgenomics between modernity and postmodernity Molecular biology has made huge advances in understanding how life works. Central to this endeavour has been the concept of the gene, which has undergone multiple revisions from an all‐powerful, phenotype‐defining entity to a much more complex and fluid player in the program of life. Laurence Perbal Published online 08.06.2015 CSI on steroids: DNA‐based phenotyping is helping police derive visual information from crime scene samples to aid in the hunt for suspects Academic researchers and companies are developing forensic DNA phenotyping as a new tool for criminal investigators, as DNA from samples at crime scenes contain potentially useful information about a suspect's hair or eye colour, race, age or facial characteristics. Howard Wolinsky Published online 15.06.2015 Web 2.0 and academic debate: Social media challenges traditions in scientific publishing The use of social media has already affected and often improved science communication and discussion among researchers. It has the potential to further impact upon and change science publishing and the way research is conducted and analysed. Philip Hunter Published online 10.06.2015 Scientific Reports DAZL regulates Tet1 translation in murine embryonic stem cells This study reports that by enhancing Tet1 mRNA translation, the RNA‐binding protein DAZL regulates TET1‐mediated cytosine hydroxymethylation in ESCs during active reprogramming to a pluripotent ground state. Maaike Welling, Hsu‐Hsin Chen, Javier Muñoz, Michael U Musheev, Lennart Kester, Jan Philipp Junker, Nikolai Mischerikow, Mandana Arbab, Ewart Kuijk, Lev Silberstein, Peter V Kharchenko, Mieke Geens, Christof Niehrs, Hilde van de Velde, Alexander van Oudenaarden, Albert JR Heck, and Niels Geijsen Published online 15.06.2015 Paternal H3K4 methylation is required for minor zygotic gene activation and early mouse embryonic development In the mouse zygote, transcriptional properties are asymmetric between male and female pronuclei. This study shows that in the male pronucleus, minor zygotic gene activation requires Mll3/4‐dependent H3K4 monomethylation likely at enhancers. Keisuke Aoshima, Erina Inoue, Hirofumi Sawa, and Yuki Okada Published online 29.04.2015 Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1‐Mdm35 complex This study reports the structural basis of Ups1‐Mdm35‐mediated phosphatidic acid binding and transfer from the outer to the inner mitochondrial membrane, thus shedding new light on the mechanism of intramitochondrial phospholipid transport by the MSF1/PRELI family proteins. Fang Yu, Fangyuan He, Hongyan Yao, Chengyuan Wang, Jianchuan Wang, Jianxu Li, Xiaofeng Qi, Hongwei Xue, Jianping Ding, and Peng Zhang Published online 12.06.2015 Structural insight into the TRIAP1/PRELI‐like domain family of mitochondrial phospholipid transfer complexes The structures of TRIAP1 and its complex with SLMO1 reveal how the PRELI domain is chaperoned during mitochondrial import. Access to an internal phospholipid binding cavity is likely regulated by conformationally adaptable loops. Xeni Miliara, James A Garnett, Takashi Tatsuta, Ferdos Abid Ali, Heather Baldie, Inmaculada Pérez‐Dorado, Peter Simpson, Ernesto Yague, Thomas Langer, and Stephen Matthews Published online 12.06.2015 Articles Atrx promotes heterochromatin formation at retrotransposons Atrx contributes to retrotransposon silencing in ES cells by promoting inaccessible heterochromatin formation. The data also suggest that retrotransposon silencing requires the histone chaperone Daxx but is independent of histone H3.3. Dennis Sadic, Katharina Schmidt, Sophia Groh, Ivan Kondofersky, Joachim Ellwart, Christiane Fuchs, Fabian J Theis, and Gunnar Schotta Published online 26.05.2015 DCC functions as an accelerator of thalamocortical axonal growth downstream of spontaneous thalamic activity This study identifies the Netrin‐1 receptor DCC as an accelerator for thalamic axon growth. Dcc transcription is regulated by spontaneous calcium activity in thalamocortical neurons, and an AP‐1‐binding site in the Dcc promoter that is crucial for the activity‐dependent regulation of this gene is described. Mar Castillo‐Paterna, Verónica Moreno‐Juan, Anton Filipchuk, Luis Rodríguez‐Malmierca, Rafael Susín, and Guillermina López‐Bendito Published online 06.05.2015 Transcription factor p63 bookmarks and regulates dynamic enhancers during epidermal differentiation The key epithelial transcription factor p63 functions as a placeholder to bookmark genomic loci for gene regulation in epithelial development. The data suggest that different sets of co‐regulators are required to activate proliferation and differentiation genes during epidermal differentiation and developmental genes in other epithelial tissues. Evelyn N Kouwenhoven, Martin Oti, Hanna Niehues, Simon J van Heeringen, Joost Schalkwijk, Hendrik G Stunnenberg, Hans van Bokhoven, and Huiqing Zhou Published online 01.06.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.