Scientific Reports Biology Table of Contents e-alert: 30 June 2015

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30 June 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               Biological Sciences               Functional conservation of an ancestral Pellino protein in helminth species ▶     Christopher D. Cluxton, Brian E. Caffrey, Gemma K. Kinsella et al.     The immune system of H. sapiens has innate signaling pathways that arose in ancestral species. This is exemplified by the discovery of the Toll-like receptor (TLR) pathway using …             In Vivo Fluorescence Immunohistochemistry: Localization of Fluorescently Labeled Cetuximab in Squamous Cell Carcinomas ▶     Esther de Boer, Jason M. Warram, Matthew D. Tucker et al.     Anti-EGFR (epidermal growth factor receptor) antibody based treatment strategies have been successfully implemented in head and neck squamous cell carcinoma (HNSCC). Un…             Dietary protein and lifespan across the metamorphic boundary: protein-restricted larvae develop into short-lived adults ▶     A. Runagall-McNaull, R. Bonduriansky, A. J. Crean     Restriction of nutrients in the adult diet extends lifespan across a diverse range of species, but less is known about the long-term effects of developmental dietary restriction. …             Protracted brain development in a rodent model of extreme longevity ▶     Orsolya K. Penz, Janos Fuzik, Aleksandra B. Kurek et al.     Extreme longevity requires the continuous and large-scale adaptation of organ systems to delay senescence. Naked mole rats are the longest-living rodents, whose nervous system …             Chemical and Metabolic Profiling of Si-Ni Decoction Analogous Formulae by High performance Liquid Chromatography-Mass Spectrometry ▶     Qian Chen, Shun Xiao, Zhenhao Li et al.     Along with an indispensable role in healthcare system of China for centuries, Traditional Chinese Medicine (TCM) shows increasing usages as complementary therapy in western …             Bacterial population and biodegradation potential in chronically crude oil-contaminated marine sediments are strongly linked to temperature ▶     Rafael Bargiela, Francesca Mapelli, David Rojo et al.     Two of the largest crude oil-polluted areas in the world are the semi-enclosed Mediterranean and Red Seas, but the effect of chronic pollution remains incompletely understood on …             Identification of BST-2/tetherin-induced hepatitis B virus restriction and hepatocyte-specific BST-2 inactivation ▶     Mingyu Lv, Biao Zhang, Ying Shi et al.     BST-2/tetherin is an interferon-inducible antiviral protein that blocks the release of various enveloped viruses, including HIV-1. Hepatitis B virus (HBV), a major cause of liver …             Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification ▶     Yi-Yu Ke, Vivek Kumar Singh, Mohane Selvaraj Coumar et al.     The inhibition of FMS-like tyrosine kinase 3 (FLT3) activity using small-molecule inhibitors has emerged as a target-based alternative to traditional chemotherapy for the …             Investigation of multipotent postnatal stem cells from human maxillary sinus membrane ▶     JunBing Guo, JunQuan Weng, Qiong Rong et al.     Maxillary sinus membrane (MSM) elevation is a common surgical technique for increasing bone height in the posterior maxilla prior to dental implant placement. However, the …             Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3β ▶     Jun Jiang, Zhi-Hao Wang, Min Qu et al.     Abnormal tau hyperphosphorylation is an early pathological marker of Alzheimer’s disease (AD), however, the upstream factors that regulate tau phosphorylation are not illustrated …             Metabolome progression during early gut microbial colonization of gnotobiotic mice ▶     Angela Marcobal, Tahir Yusufaly, Steven Higginbottom et al.     The microbiome has been implicated directly in host health, especially host metabolic processes and development of immune responses. These are particularly important in infants …             Quantifying the Antiviral Effect of IFN on HIV-1 Replication in Cell Culture ▶     Hiroki Ikeda, Ana Godinho-Santos, Sylvie Rato et al.     Type-I interferons (IFNs) induce the expression of hundreds of cellular genes, some of which have direct antiviral activities. Although IFNs restrict different steps of HIV …             Microbial population dynamics in response to Pectobacterium atrosepticum infection in potato tubers ▶     Viia Kõiv, Märt Roosaare, Eve Vedler et al.     Endophytes are microbes and fungi that live inside plant tissues without damaging the host. Herein we examine the dynamic changes in the endophytic bacterial community in potato (…             Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates ▶     Heeseung Lee, Mei-Chuan Ko     How neuropeptides in the primate spinal cord regulate itch and pain is largely unknown. Here we elucidate the sensory functions of spinal opioid-related peptides and …             The antimicrobial propeptide hCAP-18 plasma levels in neutropenia of various aetiologies: a prospective study ▶     Ying Ye, Göran Carlsson, Jenny M. T. Karlsson-Sjöberg et al.     The underlying cause of neutropenia may be difficult to determine due to similar clinical presentation in many neutropenic conditions. The neutrophil protein hCAP-18 (pro-LL-37) …             Cortical actin networks induce spatio-temporal confinement of phospholipids in the plasma membrane – a minimally invasive investigation by STED-FCS ▶     Débora M. Andrade, Mathias P. Clausen, Jan Keller et al.     Important discoveries in the last decades have changed our view of the plasma membrane organisation. Specifically, the cortical cytoskeleton has emerged as a key modulator of the …             Fast, multi-frequency, and quantitative nanomechanical mapping of live cells using the atomic force microscope ▶     Alexander X. Cartagena-Rivera, Wen-Horng Wang, Robert L. Geahlen et al.     A longstanding goal in cellular mechanobiology has been to link dynamic biomolecular processes underpinning disease or morphogenesis to spatio-temporal changes in nanoscale …             Detection and mapping of illicit drugs and their metabolites in fingermarks by MALDI MS and compatibility with forensic techniques ▶     G. Groeneveld, M. de Puit, S. Bleay et al.     Despite the proven capabilities of Matrix Assisted Laser Desorption Ionisation Mass Spectrometry (MALDI MS) in laboratory settings, research is still needed to integrate this …             Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus ▶     Tahir Ali, Gwang Ho Yoon, Shahid Ali Shah et al.     The pathological hallmarks of Alzheimer’s disease (AD) include amyloid beta (Aβ) accumulation, neurofibrillary tangle formation, synaptic dysfunction and neuronal loss. In this …             Quantitative analysis of the human T cell palmitome ▶     Eliot Morrison, Benno Kuropka, Stefanie Kliche et al.     Palmitoylation is a reversible post-translational modification used to inducibly compartmentalize proteins in cellular membranes, affecting the function of receptors and …             Discovery of a non-cationic cell penetrating peptide derived from membrane-interacting human proteins and its potential as a protein delivery carrier ▶     Hyo Young Kim, Soo Young Yum, Goo Jang et al.     Cell penetrating peptides (CPPs) are peptides that can be translocated into cells and used as a carrier platform for the intracellular uptake of cargo molecules. Subject to the …             Functional annotation of HOT regions in the human genome: implications for human disease and cancer ▶     Hao Li, Hebing Chen, Feng Liu et al.     Advances in genome-wide association studies (GWAS) and large-scale sequencing studies have resulted in an impressive and growing list of disease- and trait-associated genetic …             Using an in-vitro biofilm model to assess the virulence potential of Bacterial Vaginosis or non-Bacterial Vaginosis Gardnerella vaginalis isolates ▶     Joana Castro, Patrícia Alves, Cármen Sousa et al.     Gardnerella vaginalis is the most common species found in bacterial vaginosis (BV). However, it is also present in a significant proportion of healthy women and G. vaginalis …             Temperature affects the silicate morphology in a diatom ▶     N. Javaheri, R. Dries, A. Burson et al.     Silica deposition by diatoms, a common component of the phytoplankton, has attracted considerable interest given the importance in ecology and materials science. There has …             SNP rs2057482 in HIF1A gene predicts clinical outcome of aggressive hepatocellular carcinoma patients after surgery ▶     Xu Guo, Deyang Li, Yibing Chen et al.     Hypoxia-inducible factor 1α (HIF-1α) plays an important role in tumor growth and metastasis. Genetic variations of HIF1A gene have been shown to influence the developing risk and …             Gap formation following climatic events in spatially structured plant communities ▶     Jinbao Liao, Hans J. De Boeck, Zhenqing Li et al.     Gaps play a crucial role in maintaining species diversity, yet how community structure and composition influence gap formation is still poorly understood. We apply a spatially …             MiR-19a regulates PTEN expression to mediate glycogen synthesis in hepatocytes ▶     Lin Dou, Xiangyu Meng, Xiaofang Sui et al.     MiR-19a, a member of mir-17-92 microRNA clusters, has been demonstrated to promote cell proliferation and angiogenesis via regulating the PI3K/AKT pathway, the major insulin …             Spider wrapping silk fibre architecture arising from its modular soluble protein precursor ▶     Marie-Laurence Tremblay, Lingling Xu, Thierry Lefèvre et al.     Spiders store spidroins in their silk glands as high concentration aqueous solutions, spinning these dopes into fibres with outstanding mechanical properties. Aciniform (or …             Structural and Physical Basis for Anti-IgE Therapy ▶     Jon D. Wright, Hsing-Mao Chu, Chun-Hsiang Huang et al.     Omalizumab, an anti-IgE antibody, used to treat severe allergic asthma and chronic idiopathic urticaria, binds to IgE in blood or membrane-bound on B lymphocytes but not to IgE …             Musical training, individual differences and the cocktail party problem ▶     Jayaganesh Swaminathan, Christine R. Mason, Timothy M. Streeter et al.     Are musicians better able to understand speech in noise than non-musicians? Recent findings have produced contradictory results. Here we addressed this question by asking …             Single-copy gene based 50 K SNP chip for genetic studies and molecular breeding in rice ▶     Nisha Singh, Pawan Kumar Jayaswal, Kabita Panda et al.     Single nucleotide polymorphism (SNP) is the most abundant DNA sequence variation present in plant genomes. Here, we report the design and validation of a unique genic-SNP …             Insulin-like factor regulates neural induction through an IGF1 receptor-independent mechanism ▶     Yoshikazu Haramoto, Shuji Takahashi, Tomomi Oshima et al.     Insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) signalling is required for normal embryonic growth and development. Previous reports indicated that the …             Out-of-sync: disrupted neural activity in emotional circuitry during film viewing in melancholic depression ▶     Christine C. Guo, Vinh T. Nguyen, Matthew P. Hyett et al.     While a rich body of research in controlled experiments has established changes in the neural circuitry of emotion in major depressive disorders, little is known as to how such …             Association genetics in Populus reveals the interactions between Pt-miR397a and its target genes ▶     Jinhui Chen, Beibei Chen, Xiaohui Yang et al.     Recent studies have revealed associations between single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes and diseases. However, association studies to decipher the …             Decay in survival motor neuron and plastin 3 levels during differentiation of iPSC-derived human motor neurons ▶     María G Boza-Morán, Rebeca Martínez-Hernández, Sara Bernal et al.     Spinal muscular atrophy (SMA) is a neuromuscular disease caused by mutations in Survival Motor Neuron 1 (SMN1), leading to degeneration of alpha motor neurons (MNs) but also …             Pupillary light reflex to light inside the natural blind spot ▶     Kentaro Miyamoto, Ikuya Murakami     When a light stimulus covers the human natural blind spot (BS), perceptual filling-in corrects for the missing information inside the BS. Here, we examined whether a filled-in …             Preparation of Graphene-Modified Acupuncture Needle and Its Application in Detecting Neurotransmitters ▶     Lina Tang, Danxin Du, Fan Yang et al.     We report a unique nanosensing platform by combining modern nanotechnology with traditional acupuncture needle to prepare graphene-modified acupuncture needle (G-AN), and using …             Preparation by alkaline treatment and detailed characterisation of empty hepatitis B virus core particles for vaccine and gene therapy applications ▶     Arnis Strods, Velta Ose, Janis Bogans et al.     Hepatitis B virus (HBV) core (HBc) virus-like particles (VLPs) are one of the most powerful protein engineering tools utilised to expose immunological epitopes and/or …             Effect of Variation in hemorheology between human and animal blood on the binding efficacy of vascular-targeted carriers ▶     K. Namdee, M. Carrasco-Teja, M. B. Fish et al.     Animal models are extensively used to evaluate the in vivo functionality of novel drug delivery systems (DDS). However, many variations likely exist in vivo between the animals …             Environmental enrichment and abstinence attenuate ketamine-induced cardiac and renal toxicity ▶     Xingxing Li, Shuangyan Li, Wenhui Zheng et al.     The current study was designed to investigate the effect of abstinence in combination with environmental enrichment (EE) on cardiac and renal toxicity induced by 2 weeks of …             Quantification of recombinant immunotoxin delivery to solid tumors allows for direct comparison of in vivo and in vitro results ▶     Emily Mason-Osann, Kevin Hollevoet, Gerhard Niederfellner et al.     Solid tumors present challenges for delivery of protein therapeutics; current methods cannot quantify the functional effects of these agents. RG7787 (anti-mesothelin recombinant …             Repurposing ebselen for treatment of multidrug-resistant staphylococcal infections ▶     Shankar Thangamani, Waleed Younis, Mohamed N. Seleem     Novel antimicrobials and new approaches to developing them are urgently needed. Repurposing already-approved drugs with well-characterized toxicology and pharmacology is a novel …             The effect of land-use on the diversity and mass-abundance relationships of understory avian insectivores in Sri Lanka and southern India ▶     Rachakonda Sreekar, Umesh Srinivasan, Christos Mammides et al.     Understory avian insectivores are especially sensitive to deforestation, although regional differences in how these species respond to human disturbance may be linked to varying …             Nitrogen limitation as a driver of genome size evolution in a group of karst plants ▶     Ming Kang, Jing Wang, Hongwen Huang     Genome size is of fundamental biological importance with significance in predicting structural and functional attributes of organisms. Although abundant evidence has shown that …             Gender differences in brain structure and resting-state functional connectivity related to narcissistic personality ▶     Wenjing Yang, Lingli Cun, Xue Du et al.     Although cognitive and personality studies have observed gender differences in narcissism, the neural bases of these differences remain unknown. The current study combined the …             Synthesis, characterization and apoptotic activity of quinazolinone Schiff base derivatives toward MCF-7 cells via intrinsic and extrinsic apoptosis pathways ▶     Maryam Zahedifard, Fadhil Lafta Faraj, Mohammadjavad Paydar et al.     The current study investigated the cytotoxic effect of 3-(5-chloro-2-hydroxybenzylideneamino)-2-(5-chloro-2-hydroxyphenyl)-2,3-dihydroquinazolin-41(H)-one (A) and …             The stage-classified matrix models project a significant increase in biomass carbon stocks in China’s forests between 2005 and 2050 ▶     Huifeng Hu, Shaopeng Wang, Zhaodi Guo et al.     China’s forests are characterized by young age, low carbon (C) density and a large plantation area, implying a high potential for increasing C sinks in the future. Using data of …             Acrylamide toxic effects on mouse oocyte quality and fertility in vivo ▶     Xing Duan, Qiao-Chu Wang, Kun-Lin Chen et al.     Acrylamide is an industrial chemical that has attracted considerable attention due to its presumed carcinogenic, neurotoxic, and cytotoxic effects. In this study we investigated …             Universal Approach to FRAP Analysis of Arbitrary Bleaching Patterns ▶     Daniel Blumenthal, Leo Goldstien, Michael Edidin et al.     The original approach to calculating diffusion coefficients of a fluorescent probe from Fluorescence Recovery After Photobleaching (FRAP) measurements assumes bleaching with a …             Does the passage of seeds through frugivore gut affect their storage: A case study on the endangered plant Euryodendron excelsum ▶     Shen Shikang, Wu Fuqin, Wang Yuehua     Plant-frugivore mutualism serves an important function in multiple ecological processes. Although previous studies have highlighted the effect of frugivore gut passage on fresh …             Considerably Unfolded Transthyretin Monomers Preceed and Exchange with Dynamically Structured Amyloid Protofibrils ▶     Minna Groenning, Raul I. Campos, Daniel Hirschberg et al.     Despite numerous studies, a detailed description of the transthyretin (TTR) self-assembly mechanism and fibril structure in TTR amyloidoses remains unresolved. Here, using a …             RAD51 135G>C substitution increases breast cancer risk in an ethnic-specific manner: a meta-analysis on 21236 cases and 19407 controls ▶     Deepa Sekhar, Singh Pooja, Sandeep Kumar et al.     RAD51 is a homolog of bacterial RecA protein, which plays an important role in preserving stability of the genome. RAD51 interacts with BRCA1 and BRCA2 for homologous …             Function and evolution of Magnaporthe oryzae avirulence gene AvrPib responding to the rice blast resistance gene Pib ▶     Shulin Zhang, Ling Wang, Weihuai Wu et al.     Magnaporthe oryzae (Mo) is the causative pathogen of the damaging disease rice blast. The effector gene AvrPib, which confers avirulence to host carrying resistance gene Pib, was …             GDC 2: Compression of large collections of genomes ▶     Sebastian Deorowicz, Agnieszka Danek, Marcin Niemiec     The fall of prices of the high-throughput genome sequencing changes the landscape of modern genomics. A number of large scale projects aimed at sequencing many human genomes are …             Sox2-CreER mice are useful for fate mapping of mature, but not neonatal, cochlear supporting cells in hair cell regeneration studies ▶     Bradley J. Walters, Tetsuji Yamashita, Jian Zuo     Studies of hair cell regeneration in the postnatal cochlea rely on fate mapping of supporting cells. Here we characterized a Sox2-CreER knock-in mouse line with two independent …             Individual Differences in Newborn Visual Attention Associate with Temperament and Behavioral Difficulties in Later Childhood ▶     Kostas A. Papageorgiou, Teresa Farroni, Mark H. Johnson et al.     Recently it was shown that individual differences in attention style in infants are associated with childhood effortful control, surgency, and hyperactivity-inattention. Here we …             Competition-cooperation relationship networks characterize the competition and cooperation between proteins ▶     Hong Li, Yuan Zhou, Ziding Zhang     By analyzing protein-protein interaction (PPI) networks, one can find that a protein may have multiple binding partners. However, it is difficult to determine whether the …             Molecular and neuronal homology between the olfactory systems of zebrafish and mouse ▶     Luis R. Saraiva, Gaurav Ahuja, Ivan Ivandic et al.     Studies of the two major olfactory organs of rodents, the olfactory mucosa (OM) and the vomeronasal organ (VNO), unraveled the molecular basis of smell in vertebrates. However, …             Revealing patterns of local species richness along environmental gradients with a novel network tool ▶     Mara Baudena, Angel Sánchez, Co-Pierre Georg et al.     How species richness relates to environmental gradients at large extents is commonly investigated aggregating local site data to coarser grains. However, such relationships often …             Unique human orbital morphology compared with that of apes ▶     Eric Denion, Martin Hitier, Vincent Guyader et al.     Humans’ and apes’ convergent (front-facing) orbits allow a large overlap of monocular visual fields but are considered to limit the lateral visual field extent. However, humans …             The first crop plant genetically engineered to release an insect pheromone for defence ▶     Toby J.A. Bruce, Gudbjorg I. Aradottir, Lesley E. Smart et al.     Insect pheromones offer potential for managing pests of crop plants. Volatility and instability are problems for deployment in agriculture but could be solved by expressing genes …             Hypertrophic scar contracture is mediated by the TRPC3 mechanical force transducer via NFkB activation ▶     Hisako Ishise, Barrett Larson, Yutaka Hirata et al.     Wound healing process is a complex and highly orchestrated process that ultimately results in the formation of scar tissue. Hypertrophic scar contracture is considered to be a …             Endoplasmic reticulum stress impairment in the spinal dorsal horn of a neuropathic pain model ▶     Enji Zhang, Min-Hee Yi, Nara Shin et al.     Endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases, but its role in neuropathic pain remains unclear. In this study, we examined the ER stress …             iRhom1 regulates proteasome activity via PAC1/2 under ER stress ▶     WonJae Lee, YoungDoo Kim, Jisu Park et al.     Proteasome is a protein degradation complex that plays a major role in maintaining cellular homeostasis. Despite extensive efforts to identify protein substrates that are …             Identification of cytokine-induced modulation of microRNA expression and secretion as measured by a novel microRNA specific qPCR assay ▶     Vladimir Benes, Paul Collier, Claus Kordes et al.     microRNAs are an abundant class of small non-coding RNAs that control gene expression post-transcriptionally. Importantly, microRNA activity participates in the regulation of …             Adenosine accelerates the healing of diabetic ischemic ulcers by improving autophagy of endothelial progenitor cells grown on a biomaterial ▶     Wen Chen, Yangxiao Wu, Li Li et al.     Endothelial progenitor cells (EPCs) seeded on biomaterials can effectively promote diabetic ischemic wound healing. However, the function of transplanted EPCs is negatively …             Phosphorylation of Beet black scorch virus coat protein by PKA is required for assembly and stability of virus particles ▶     Xiaofei Zhao, Xiaoling Wang, Kai Dong et al.     Plant virus coat proteins (CPs) play a fundamental role in protection of genomic RNAs, virion assembly, and viral movement. Although phosphorylation of several CPs during virus …             Influence of carbapenem resistance on mortality of patients with Pseudomonas aeruginosa infection: a meta-analysis ▶     Qianqian Liu, Xiaoqing Li, Wenzhang Li et al.     Treatment of infectious diseases caused by the carbapenem-resistant Pseudomonas aeruginosa (CRPA) is becoming more challenging with each passing year. We conducted a …             Phytotoxic Mechanism of Nanoparticles: Destruction of Chloroplasts and Vascular Bundles and Alteration of Nutrient Absorption ▶     Le Van Nhan, Chuanxin Ma, Yukui Rui et al.     This study focused on determining the phytotoxic mechanism of CeO2 nanoparticles (NPs): destroying chloroplasts and vascular bundles and altering absorption of nutrients on …             Scattering of Sculpted Light in Intact Brain Tissue, with implications for Optogenetics ▶     Itia A. Favre-Bulle, Daryl Preece, Timo A. Nieminen et al.     Optogenetics uses light to control and observe the activity of neurons, often using a focused laser beam. As brain tissue is a scattering medium, beams are distorted and spread …             Altered regional activity and inter-regional functional connectivity in psychogenic non-epileptic seizures ▶     Rong Li, Yibo Li, Dongmei An et al.     Although various imaging studies have focused on detecting the cerebral function underlying psychogenic non-epileptic seizures (PNES), the nature of PNES remains poorly …             Differential gene retention as an evolutionary mechanism to generate biodiversity and adaptation in yeasts ▶     Guillaume Morel, Lieven Sterck, Dominique Swennen et al.     The evolutionary history of the characters underlying the adaptation of microorganisms to food and biotechnological uses is poorly understood. We undertook comparative genomics …             Nanopore sensing of individual transcription factors bound to DNA ▶     Allison Squires, Evrim Atas, Amit Meller     Transcription factor (TF)-DNA interactions are the primary control point in regulation of gene expression. Characterization of these interactions is essential for understanding …             An Alternative Phosphorylation Switch in Integrin β2 (CD18) Tail for Dok1 Binding ▶     Sebanti Gupta, Joel Chia-Yeong Chit, Chen Feng et al.     Integrins are involved in cell migration and adhesion. A large number of proteins interact with the cytoplasmic tails of integrins. Dok1 is a negative regulator of integrin …             Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration ▶     Masato Koike, Hidetoshi Nojiri, Yusuke Ozawa et al.     Mechanical stress and aging are major risk factors of cartilage degeneration. Human studies have previously reported that oxidative damage increased, while SOD2 protein was …             Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model ▶     R. Alhabbab, P. Blair, R. Elgueta et al.     B cells have been reported to promote graft rejection through alloantibody production. However, there is growing evidence that B cells can contribute to the maintenance of …             Prediction of structural features and application to outer membrane protein identification ▶     Renxiang Yan, Xiaofeng Wang, Lanqing Huang et al.     Protein three-dimensional (3D) structures provide insightful information in many fields of biology. One-dimensional properties derived from 3D structures such as secondary …             Heat stress induced apoptosis is triggered by transcription-independent p53, Ca2+ dyshomeostasis and the subsequent Bax mitochondrial translocation ▶     Z. T. Gu, L. Li, F. WU et al.     In this study, We demonstrated that Bax mitochondrial translocation plays a vital role in the initiation of the mitochondrial signaling pathway upon activation by heat stress. In …             In situ imaging and proteome profiling indicate andrographolide is a highly promiscuous compound ▶     Lin Li, Hadhi Wijaya, Sanjay Samanta et al.     Natural products represent an enormous source of pharmacologically useful compounds, and are often used as the starting point in modern drug discovery. Many biologically …             Reassortment and distinct evolutionary dynamics of Rift Valley Fever virus genomic segments ▶     Caio C. M. Freire, Atila Iamarino, Peinda O. Ly Soumaré et al.     Rift Valley Fever virus (RVFV) is a member of Bunyaviridae family that causes a febrile disease affecting mainly ruminants and occasionally humans in Africa, with symptoms that …             Phosphorylation of Pex11p does not regulate peroxisomal fission in the yeast Hansenula polymorpha ▶     Ann S. Thomas, Arjen M. Krikken, Ida J. van der Klei et al.     Pex11p plays a crucial role in peroxisomal fission. Studies in Saccharomyces cerevisiae and Pichia pastoris indicated that Pex11p is activated by phosphorylation, which results …             Evidence for horizontal transfer of mitochondrial DNA to the plastid genome in a bamboo genus ▶     Peng-Fei Ma, Yu-Xiao Zhang, Zhen-Hua Guo et al.     In flowering plants, three genomes (nuclear, mitochondrial, and plastid) coexist and intracellular horizontal transfer of DNA is prevalent, especially from the plastid to the …             Network-based survival-associated module biomarker and its crosstalk with cell death genes in ovarian cancer ▶     Nana Jin, Hao Wu, Zhengqiang Miao et al.     Ovarian cancer remains a dismal disease with diagnosing in the late, metastatic stages, therefore, there is a growing realization of the critical need to develop effective …             Genome-wide Association Study on Platinum-induced Hepatotoxicity in Non-Small Cell Lung Cancer Patients ▶     Songyu Cao, Cheng Wang, Hongxia Ma et al.     Platinum-based chemotherapy has been shown to improve the survival of advanced non-small cell lung cancer (NSCLC) patients; the platinum-induced toxicity severely impedes the …             dbEMT: an epithelial-mesenchymal transition associated gene resource ▶     Min Zhao, Lei Kong, Yining Liu et al.     As a cellular process that changes epithelial cells to mesenchymal cells, Epithelial-mesenchymal transition (EMT) plays important roles in development and cancer metastasis. …             In-vivo detection of binary PKA network interactions upon activation of endogenous GPCRs ▶     Ruth Röck, Verena Bachmann, Hyo-eun C Bhang et al.     Membrane receptor-sensed input signals affect and modulate intracellular protein-protein interactions (PPIs). Consequent changes occur to the compositions of protein complexes, …             Quantifying the Number of Discriminable Coincident Dendritic Input Patterns through Dendritic Tree Morphology ▶     Antonio G. Zippo, Gabriele E. M. Biella     Current developments in neuronal physiology are unveiling novel roles for dendrites. Experiments have shown mechanisms of non-linear synaptic NMDA dependent activations, able to …             Constructal thermodynamics combined with infrared experiments to evaluate temperature differences in cells ▶     Umberto Lucia, Giuseppe Grazzini, Bartolomeo Montrucchio et al.     The aim of this work was to evaluate differences in energy flows between normal and immortalized cells when these distinct biological systems are exposed to environmental …             Amniotic fluid stem cells provide considerable advantages in epidermal regeneration: B7H4 creates a moderate inflammation microenvironment to promote wound repair ▶     Qing Sun, Fang Li, Hong Li et al.     The current treatments for severe skin injury all involve skin grafting. However, there is a worldwide shortage of donor skin tissue. In this study, we examined the advantages of …             Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess ▶     Sara Samino, Maria Vinaixa, Marta Díaz et al.     Hyperinsulinaemic androgen excess (HIAE) in prepubertal and pubertal girls usually precedes a broader pathological phenotype in adulthood that is associated with anovulatory …             Divergence of dim-light vision among bats (order: Chiroptera) as estimated by molecular and electrophysiological methods ▶     He-Qun Liu, Jing-Kuan Wei, Bo Li et al.     Dim-light vision is present in all bats, but is divergent among species. Old-World fruit bats (Pteropodidae) have fully developed eyes; the eyes of insectivorous bats are …             Prognostic significance of kynurenine 3-monooxygenase and effects on proliferation, migration, and invasion of human hepatocellular carcinoma ▶     Haojie Jin, Yurong Zhang, Haiyan You et al.     Kynurenine 3-monooxygenase (KMO) is a pivotal enzyme in the kynurenine pathway of tryptophan degradation and plays a critical role in Huntington’s and Alzheimer’s diseases. This …             Kinetics of protein-ligand unbinding via smoothed potential molecular dynamics simulations ▶     Luca Mollica, Sergio Decherchi, Syeda Rehana Zia et al.     Drug discovery is expensive and high-risk. Its main reasons of failure are lack of efficacy and toxicity of a drug candidate. Binding affinity for the biological target has been …             Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression ▶     Juliana Falivene, Yanina Ghiglione, Natalia Laufer et al.     The aim of this study was to analyze Th17 and Treg subsets and their correlation with anti-HIV T-cell responses and clinical parameters during (acute/early) primary HIV infection …             An integrated approach to reveal miRNAs’ impacts on the functional consequence of copy number alterations in cancer ▶     Kening Li, Yongjing Liu, Yuanshuai Zhou et al.     Copy number alteration (CNA) is known to induce gene expression changes mainly through dosage effect, and therefore affect the initiation and progression of tumor. However, tumor …             Effect of papain-based gel on type I collagen - spectroscopy applied for microstructural analysis ▶     Zenildo Santos Silva Júnior, Sergio Brossi Botta, Patricia Aparecida Ana et al.     Considering the improvement of biomaterials that facilitate atraumatic restorative techniques in dentistry, a papain-based gel can be used in the chemomechanical removal of …             Temperature-induced shifts in hibernation behavior in experimental amphibian populations ▶     Xu Gao, Changnan Jin, Diego Llusia et al.     Phenological shifts are primary responses of species to recent climate change. Such changes might lead to temporal mismatches in food webs and exacerbate species vulnerability. …             Unsupervised segmentation of low-contrast multichannel images: discrimination of tissue components in microscopic images of unstained specimens ▶     Ivica Kopriva, Marijana Popović Hadžija, Mirko Hadžija et al.     Low-contrast images, such as color microscopic images of unstained histological specimens, are composed of objects with highly correlated spectral profiles. 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