Nature Reviews Molecular Cell Biology contents July 2015 Volume 16 Number 7 pp 389-449

If you are unable to see the message below, click here to view.

TABLE OF CONTENTS
July 2015 Volume 16 Number 7
Impact Factor 37.806 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Cell death and autophagy Poster: Stem cell states: naive to primed pluripotency  Featured article: Swiss army knives: non-canonical functions of nuclear Drosha and Dicer Kaspar Burger & Monika Gullerova
Subscribe   Facebook   RSS   Recommend to library   Twitter
Advertisement
Helmholtz Zentrum München and Nature Medicine are pleased to announce: THE 3RD ANNUAL HELMHOLTZ-NATURE MEDICINE DIABETES CONFERENCE September 19-21, 2015 | Munich, Germany  REGISTER NOW!
RESEARCH HIGHLIGHTS Top Autophagy: Selecting ER for eating p389 | doi:10.1038/nrm4013 Two studies identify receptors that target the endoplasmic reticulum for autophagy-mediated degradation. PDF Circadian rhythms: Translating the clock p390 | doi:10.1038/nrm4008 The major circadian transcription factor BMAL1 has independent circadian translational activity, which is regulated by the mTOR pathway kinase S6K1. PDF Mechanotransduction: Adhesion forces promote transcription p390 | doi:10.1038/nrm4017 Mechanical forces activate YAP1 and β-catenin transcriptional activity in a cadherin-dependent manner. PDF JOURNAL CLUB From hippos to yorkies in one pathway p392 | doi:10.1038/nrm4011 Barry Thompson reminds us how Yorkie was discovered as the transcriptional coactivator downstream of Hippo signalling. PDF Unfolded protein response: Regulatory ribosomal ubiquitylation p392 | doi:10.1038/nrm4016 The ubiquitylation of specific Lys residues of 40S ribosomal proteins is stimulated by the unfolded protein response to contribute to translational regulation. PDF IN BRIEF RNA metabolism: Methyladenosine promotes translation | Splicing: Unmasking exitrons | Chromosomes: Finding the right size | Cell adhesion: Sticking three cells together | Techniques: microRNA switches to isolate specific cells | DNA damage response: Damage by Helicobacter pylori PDF Molecular Cell Biology JOBS of the week Stem Cell / Translational Medicine Post-Doctoral Fellowship - Molecular Biology and Epigenetics Rutgers New Jersey Medical School PhD Position in Molecular Cell Biology University of Duisburg-Essen Postdoctoral Research Worker King's College London Postdoctoral Fellow Cleveland Clinic Director "elect" of the Imagine Institute Institut Imagine More Science jobs from Molecular Cell Biology EVENT Future of Biomedicine 2015 02.09.15 Russian Federation More science events from
REVIEWS		Top
Article series: Cell death and autophagy p53 in survival, death and metabolic health: a lifeguard with a licence to kill Flore Kruiswijk, Christiaan F. Labuschagne & Karen H. Vousden p393 | doi:10.1038/nrm4007 The function of p53 as a tumour suppressor has been attributed to its ability to promote cell death or permanently inhibit cell proliferation. However, p53 can also contribute to cell survival by regulating various metabolic pathways to allow cells to adapt to mild metabolic stresses. Abstract | Full Text | PDF
Specifying and protecting germ cell fate Susan Strome & Dustin Updike p406 | doi:10.1038/nrm4009 Recent studies in different species have increased our understanding of the factors and molecular mechanisms that underlie the specification of germ cells, which are the specialized cells that generate gametes. Moreover, studies are elucidating how these cells ensure that only germline-appropriate transcripts are translated to protect germ cell identity. Abstract | Full Text | PDF
Swiss army knives: non-canonical functions of nuclear Drosha and Dicer Kaspar Burger & Monika Gullerova p417 | doi:10.1038/nrm3994 Recent studies have revealed that the RNase III enzymes Drosha and Dicer (including newly discovered Dicer isoforms) have non-canonical nuclear RNAi functions in various organisms. These include the regulation of transcription initiation and termination, and the processing of various RNA species. Abstract | Full Text | PDF | Supplementary information
Control of mammalian gene expression by selective mRNA export Vihandha O. Wickramasinghe & Ronald A. Laskey p431 | doi:10.1038/nrm4010 Recent studies have shown that nuclear export of mRNAs, which is a crucial step in the regulation of gene expression, can be selective in mammalian cells. Selective transport involves transcription-export complexes TREX and TREX-2 and controls biological processes such as DNA repair, haematopoiesis, proliferation and maintenance of pluripotency. Abstract | Full Text | PDF
PERSPECTIVES		Top
ESSAY Discovering centromere proteins: from cold white hands to the A, B, C of CENPs William C. Earnshaw p443 | doi:10.1038/nrm4001 William Earnshaw describes the events that led to the discovery and cloning of the first kinetochore proteins 30 years ago using autoimmune sera from patients with scleroderma-spectrum disease. He also discusses our current appreciation of the complexity of this remarkable structure. Abstract | Full Text | PDF
Advertisement
Noncoding RNAs in Endocrinology  Noncoding RNAs have important roles in the development and regulation of the endocrine system. This web collection on noncoding RNAs in endocrinology highlights current and future applications of noncoding RNAs as diagnostic and prognostic biomarkers and as therapeutic targets for personalized management of patients with a wide range of endocrine diseases. Access the collection online.
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2014 Journal Citation Report (Thomson Reuters, )

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.