Nature Reviews Immunology Contents July 2015 Volume 15 Number 7 pp 401-463

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TABLE OF CONTENTS
July 2015 Volume 15 Number 7		Advertisement
Impact Factor 33.836 *	In this issue Research Highlights Reviews Also this month  Featured article: Transcriptional regulation of innate lymphoid cell fate Nicolas Serafini, Christian A. J. Vosshenrich & James P. Di Santo	Automated Cell Sorting - Now Available at a Bench near You   Take control of the how, when, and where of cell sorting with the S3e™, a benchtop instrument that makes cell sorting accessible to all. Automated setup and real-time sort monitoring eliminate the need for flow cytometry expertise, while a small footprint ensures that the S3e fits in almost any lab. Learn more.
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RESEARCH HIGHLIGHTS Top Plant immunity: Host mimicry of pathogen virulence targets p401 | doi:10.1038/nri3876 An integrated DNA-binding domain in a plant immune receptor functions as a decoy to detect pathogen effectors that target host transcription factors. PDF Mucosal immunology: Message in a bottle p402 | doi:10.1038/nri3872 Outer membrane vesicles access intestinal macrophages in a sulfatase-dependent manner where they induce inflammation in susceptible hosts. PDF Viral infection: Cytokine cooperation p402 | doi:10.1038/nri3873 Interferon-[lambda] and interleukin-22 act synergistically to curtail rotavirus infection of intestinal epithelial cells. PDF Innate immunity: New PAMP discovered p402 | doi:10.1038/nri3880 HBP is a pathogen-associated molecular pattern (PAMP) from Gram-negative bacteria that promotes immunity following cytosolic detection. PDF Neuroimmunology: A brain drain p404 | doi:10.1038/nri3878 Lymphatic vessels have been identified in the central nervous system. PDF B cells: Mediators of central tolerance p404 | doi:10.1038/nri3879 Thymic B cells directly present self-antigen for T cell negative selection. PDF IN BRIEF Monocytes: Pre-emptive regulation | Neuroimmunology: Bugs on the brain | Immunological memory: γδ T cells reach out PDF Immunology JOBS of the week Immunology Postdoctoral Fellowship Position The Scripps Research Institute - Florida Director of the Division of Allergy and Clinical Immunology The Johns Hopkins Department of Medicine PostDoc position Microbial Immunology Leibniz Institute for Natural Product Research and Infection Biology Faculty Position in Immunology Northwestern University Postdoctoral Research Scientist The Babraham Institute More Science jobs from Immunology EVENT Frontiers in Basic Immunology 2015 08.10.15 ,aryland, USA More science events from
REVIEWS		Top
Type I interferons in anticancer immunity Laurence Zitvogel et al. p405 | doi:10.1038/nri3845 Type I interferons (IFNs) are best known for their role in antiviral immunity. As discussed in this Review, recent evidence indicates that these cytokines also have an integral role in natural and therapy-induced anticancer immunity. Harnessing the antineoplastic properties of type I IFNs may lead to the development of ever-more effective anticancer therapies. Abstract | Full Text | PDF
Transcriptional regulation of innate lymphoid cell fate Nicolas Serafini, Christian A. J. Vosshenrich & James P. Di Santo p415 | doi:10.1038/nri3855 Innate lymphoid cells (ILCs) are emerging as key regulators of the immune system, with different ILC subsets showing distinct immunological properties. This Review describes the transcriptional mechanisms that regulate the development and function of the different ILC subsets. The authors also discuss the evolving ILC nomenclature. Abstract | Full Text | PDF
Aicardi-Goutières syndrome and the type I interferonopathies Yanick J. Crow & Nicolas Manel p429 | doi:10.1038/nri3850 This Review describes the type I interferonopathies — a set of Mendelian disorders associated with the upregulation of type I interferon activity. The authors explain how defects in key components of innate immune signalling pathways can lead to these diseases and discuss the immunological insights that have resulted from their study. Abstract | Full Text | PDF
Antibody-independent functions of B cells: a focus on cytokines Ping Shen & Simon Fillatreau p441 | doi:10.1038/nri3857 Although they are better known for their roles in antibody responses, B cells also contribute to immunity by secreting cytokines. Here, the authors discuss the various ways in which B cells can shape the immune response during infection and inflammatory disease by producing both pro-inflammatory and immunosuppressive cytokines. Abstract | Full Text | PDF
Genetic susceptibility to invasive Salmonella disease James J. Gilchrist, Calman A. MacLennan & Adrian V. S. Hill p452 | doi:10.1038/nri3858 Invasive Salmonella disease is severe and represents a major public health problem worldwide. In this Review, the authors summarize our current understanding of host immunity to Salmonella and compare host genetic data from human and mouse studies. Abstract | Full Text | PDF | Supplementary information
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Nature Collections TARGETING IL-17 IN INFLAMMATORY DISEASE  This Collection highlights the opportunities and potential benefits of interleukin-17-targeted therapies for chronic inflammatory diseases. Produced with support from  Eli Lilly and Company
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