Nature Reviews Genetics Contents July 2015 Volume 16 Number 7 pp 373-433

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TABLE OF CONTENTS
July 2015 Volume 16 Number 7
Impact Factor 39.794 *	In this issue Comment Research Highlights Reviews Also this month Article series: Study designs Applications of next-generation sequencing Non-coding RNA  Featured article: Reconstructing ancient genomes and epigenomes Ludovic Orlando, M. Thomas P. Gilbert & Eske Willerslev
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Comment: An ecosystem of cancer cell line factories to support a cancer dependency map Jesse S. Boehm & Todd R. Golub p373 | doi:10.1038/nrg3967 Jesse Boehm and Todd Golub call for an international effort to establish >10,000 cancer cell line models as a community resource. Cancer cell line factories will facilitate the creation of a cancer dependency map, connecting cancer genomics to therapeutic dependencies. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Human genetics: GTEx pilot quantifies eQTL variation across tissues and individuals p375 | doi:10.1038/nrg3969 PDF Genome stability: Chromothripsis and micronucleus formation p376 | doi:10.1038/nrg3970 PDF Technology: A drop in single-cell challenges p376 | doi:10.1038/nrg3972 PDF Genome organization: Disorder — from chromatin to limb development p378 | doi:10.1038/nrg3968 PDF Marine microbiology: Deep sequencing of the global oceans p378 | doi:10.1038/nrg3971 PDF IN BRIEF Genetic testing: Clinical whole-genome sequencing | Human evolution: Out-of-Africa migration routes | Pathogen genetics: Rapid typing of S. Enteritidis clinical isolates PDF Genetics JOBS of the week Postdoctoral Researcher in Tumor Immunology and Cancer Immunotherapy University of California Los Angeles Post-Doctoral Fellow University of Oslo Post-doctoral Position In Motor Neuron Disease University of Arkansas for Medical Sciences postdoctoral fellow Medical College of Wisconsin Research Assistant Professor | Pancreatic beta-cell University of Pennsylvania, Department of Genetics More Science jobs from Genetics EVENT Yeast Genetics & Genomics 21.07.15 Cold Spring Harbour, USA More science events from
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REVIEWS		Top
Article series: Study designs Methods for the directed evolution of proteins Michael S. Packer & David R. Liu p379 | doi:10.1038/nrg3927 Directed evolution uses laboratory-based evolution to enhance the properties of biomolecules, primarily to generate proteins with optimized or novel activities. This Review discusses the diverse range of technologies for the directed evolution of proteins, particularly methods for generating diversity in the gene library and approaches for screening and selecting for variants with desired properties. The relative strengths and limitations of these approaches are highlighted to guide readers to appropriate strategies. Abstract | Full Text | PDF
Article series: Applications of next-generation sequencing Reconstructing ancient genomes and epigenomes Ludovic Orlando, M. Thomas P. Gilbert & Eske Willerslev p395 | doi:10.1038/nrg3935 Sequencing genomes of ancient specimens, including human ancestors, can provide rich insights into evolutionary histories. However, ancient DNA samples are frequently degraded, damaged and contaminated with ancient and modern DNA from various sources. This Review describes the methodological and bioinformatic advances that allow these challenges to be overcome in order to process and sequence ancient samples for genome reconstruction, as well as recent progress in characterizing ancient epigenomes. Abstract | Full Text | PDF
Determinants of the rate of protein sequence evolution Jianzhi Zhang & Jian-Rong Yang p409 | doi:10.1038/nrg3950 The rate and mechanism of protein sequence evolution are fundamental questions in the field of molecular evolution. This Review examines theoretical models and empirical testing based on recent analyses of large-scale genomic data sets that have offered new insights into the determinants of the rate of protein evolution. Abstract | Full Text | PDF | Supplementary information
Article series: Non-coding RNA Towards a molecular understanding of microRNA-mediated gene silencing Stefanie Jonas & Elisa Izaurralde p421 | doi:10.1038/nrg3965 MicroRNAs (miRNAs) repress gene expression both through initiating mRNA degradation and through translational repression. This Review describes how molecular studies and structural data are revealing key insights into both mechanisms of miRNA-mediated gene repression in animals, including their intricate interplay, and are posing new questions for future research. Abstract | Full Text | PDF
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