Nature Reviews Cancer contents July 2015 Volume 15 Number 7 pp384-448

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TABLE OF CONTENTS
July 2015 Volume 15 Number 7		Advertisement
Impact Factor 37.912 *	In this issue Research Highlights Progress Reviews Perspectives Also this month  Featured article: Applications of the CRISPR–Cas9 system in cancer biology Francisco J. Sánchez-Rivera & Tyler Jacks	Capture Cell Invasion & Migration in Real-Time The xCELLigence Real-Time Cell Analysis (RTCA) DP Instrument offers a Label-Free Trans-well Assay that continuously monitors cell invasion and migration with superior accuracy and reproducibility. For more info & a FREE demo offer,visit www.CIM.aceabio.com
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RESEARCH HIGHLIGHTS Top Metastasis: LOX does some prepping p384 | doi:10.1038/nrc3976 Cox et al. have shown that metastasis of certain breast cancers to bone can be driven by the enzyme lysyl oxidase (LOX), which induces bone lesions that provide a landing site for circulating tumour cells. PDF Multiple myeloma: Mama, I'm coming home p384 | doi:10.1038/nrc3980 Zhu et al. find that the homing of multiple myeloma cells to the bone marrow is promoted by cyclophilin A-CD147 signalling between bone marrow endothelial cells and myeloma cells. PDF RNA splicing: MYC maintains high-fidelity splicing p385 | doi:10.1038/nrc3977 One way that MYC promotes lymphomagenesis is through maintaining correct pre-mRNA splicing. PDF Metastasis: An influential delivery p386 | doi:10.1038/nrc3974 Two recent studies add to the evidence supporting an important role for extracellular vesicles in promoting metastasis and provide a new technique for analysing these vesicles in vivo. PDF Haematological malignancies: Splicing the MDS genome p393 | doi:10.1038/nrc3975 Three papers now present different aspects of a similar story: altered splicing can lead to myelodysplastic syndrome (MDS) and even to progression to acute myeloid leukaemia (AML). PDF Cancer JOBS of the week Director of the Centre for Cancer Immunology University of Southampton Molecular Mechanisms and Translational Research in Kidney Cancer UT Southwestern Medical Center Postdoc – DNA Repair / Cancer Genetics Rutgers University Postdoc position for translational bioinformatics in cancer Baylor College of Medicine (BCM) Postdoctoral Training Fellowship in Cancer Genomics The Francis Crick Institute More Science jobs from Cancer EVENT Basic Epigenetic Mechanisms in Cancer 08.11.15 Berlin, Germany More science events from
PROGRESS		Top
Applications of the CRISPR-Cas9 system in cancer biology Francisco J. Sánchez-Rivera & Tyler Jacks p387 | doi:10.1038/nrc3950 The CRISPR–Cas9 (clustered regularly interspaced short palindromic repeats–CRISPR-associated 9) system provides many avenues for improving how we generate models of cancer. This system has numerous uses, including providing a means to understand the importance of genetic alterations as a tumour evolves, and CRISPR–Cas9 may potentially constitute a therapeutic strategy in the future. Abstract | Full Text | PDF
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REVIEWS		Top
Forging a signature of in vivo senescence Norman E. Sharpless & Charles J. Sherr p397 | doi:10.1038/nrc3960 'Cellular senescence' has been broadened to describe durable states of proliferative arrest induced by disparate stress factors. This Review discusses the limitations of senescence-associated biomarkers and provides suggestions for how to improve the phenotypic description of senescence. Abstract | Full Text | PDF
The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence Holly E. Barker, James T. E. Paget, Aadil A. Khan & Kevin J. Harrington p409 | doi:10.1038/nrc3958 In this Review, Barker and colleagues describe the mechanisms of radioresistance that are mediated by the tumour stroma and explore how these mechanisms can be targeted to improve radiotherapy responses. Abstract | Full Text | PDF | Supplementary information
Probing for a deeper understanding of rhabdomyosarcoma: insights from complementary model systems Venkatesh P. Kashi, Mark E. Hatley & Rene L. Galindo p426 | doi:10.1038/nrc3961 This Review discusses what we have learned about the biology of rhabdomyosarcoma using various model systems, and how these models might be used to discover new targetable pathogenic mechanisms. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Metabolic dysregulation in monogenic disorders and cancer — finding method in madness Ayelet Erez & Ralph J. DeBerardinis p440 | doi:10.1038/nrc3949 Inborn errors of metabolism are inherited monogenic disorders caused by mutations in genes encoding metabolic enzymes that can result in malignancy. This Opinion article discusses how studying these rare diseases might provide insight into how specific metabolic changes contribute to cancer initiation, development, diagnosis and treatment. Abstract | Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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