Nature Immunology Contents: July 2015 Volume 16 pp 675 - 785

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TABLE OF CONTENTS July 2015 Volume 16, Issue 7 Meeting Report News and Views Research Highlights Review Articles Corrigenda Errata Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Presented by Adaptive Biotechnologies, Nature Immunology, Nature Medicine, Nature Biotechnology, and Nature Genetics IMMUNE PROFILING IN HEALTH AND DISEASE September 9-11, 2015 | Seattle, WA, USA  REGISTER NOW!   Meeting Report Top Innate immune memory: a paradigm shift in understanding host defense   pp675 - 679 Mihai G Netea, Eicke Latz, Kingston H G Mills and Luke A J O'Neill doi:10.1038/ni.3178 Researchers gathered at the Wellcome Trust Genome Campus in Hinxton, Cambridge, for the first Innate Immune Memory Conference dedicated to the adaptive characteristics of innate immunity, to further the understanding of this newly described immunological process that probably has a central role in host defense and inflammation. News and Views Top Sirt-ainly Aire   pp680 - 681 Pärt Peterson doi:10.1038/ni.3195 Sirtuin-1 (Sirt1), a protein deacetylase known for its multiple cellular functions, including roles in metabolism, stress response and aging, is a post-translational modulator of autoimmune regulator (Aire) in central immunotolerance. See also: Article by Chuprin et al. DNA methylation secures CD4+ and CD8+ T cell lineage borders   pp681 - 683 Yongqiang Feng and Alexander Y Rudensky doi:10.1038/ni.3207 Dynamic control of DNA methylation in the Cd4 locus serves an important role in reinforcing the binary fate stability of helper and cytotoxic T cells. See also: Article by Sellars et al. DCs are ready to commit   pp683 - 685 Deborah R Winter and Ido Amit doi:10.1038/ni.3208 Dendritic cell progenitors commit to a specific conventional dendritic cell fate earlier than previously thought, by initiating transcription-factor regulatory circuits unique to their subtype. See also: Article by Grajales-Reyes et al. | Article by Schlitzer et al. How many memories does it take to make an SLE flare?   pp685 - 687 David M Tarlinton and Kenneth G C Smith doi:10.1038/ni.3209 Deep-sequencing analyses of immunoglobulin variable-segment genes from antibody-secreting cells have allowed comparisons of conventional immunization responses to disease flares experienced by patients with systemic lupus erythematosus. Such analyses provide insight into B cell recruitment and differentiation processes yielding expanded clones that contribute to this complex autoimmune disease. See also: Article by Tipton et al. Immunology JOBS of the week Director of the Centre for Cancer Immunology University of Southampton Postdoctoral Researcher in Tumor Immunology and Cancer Immunotherapy University of California Los Angeles PhD Position in Molecular Immunology VIB Postdoctoral Position in Immunology Rosalind Franklin University of Medicine and Science Postdoctoral Position in Tumor Immunology Roswell Park Cancer Institute More Science jobs from Immunology EVENT Frontiers in Basic Immunology 2015 8th Oct - 9th Oct 2015 Maryland, USA More science events from Research Highlights Top Maintaining barriers | ILC2 commitment | Clonal origin | About STATs | Targeting by quartets | Brain lymphatics Review Top The diverse role of RIP kinases in necroptosis and inflammation   pp689 - 697 John Silke, James A Rickard and Motti Gerlic doi:10.1038/ni.3206 Gerlic and colleagues examine the role of cell death, particularly necroptosis, in inflammation, in the context of recent insights into the roles of the key necroptosis effector molecules RIPK1, RIPK3 and MLKL. Advertisement Automated Cell Sorting - Now Available at a Bench near You Take control of the how, when, and where of cell sorting with the S3e™, a benchtop instrument that makes cell sorting accessible to all. Automated setup and real-time sort monitoring eliminate the need for flow cytometry expertise, while a small footprint ensures that the S3e fits in almost any lab. Learn more.   Articles Top Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection   pp698 - 707 Pedro P Hernández, Tanel Mahlak&otide;iv, Ines Yang, Vera Schwierzeck, Nam Nguyen et al. doi:10.1038/ni.3180 Epithelial surfaces are the main entry point for viruses and thus are important immunological sites. Diefenbach and colleagues show that the related cytokines IL-22 and IFN-λ act together in the control of enterovirus infection. Batf3 maintains autoactivation of Irf8 for commitment of a CD8α+ conventional DC clonogenic progenitor   pp708 - 717 Gary E Grajales-Reyes, Arifumi Iwata, Jörn Albring, Xiaodi Wu, Roxane Tussiwand et al. doi:10.1038/ni.3197 The transcription factors Batf3 and IRF8 are required for the development of CD8α+ conventional dendritic cells (cDCs). Murphy and colleagues characterize the Batf3-IRF8 interactions that allow differentiation toward CD8α+ cDCs. See also: News and Views by Winter & Amit Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow   pp718 - 728 Andreas Schlitzer, V Sivakamasundari, Jinmiao Chen, Hermi Rizal Bin Sumatoh, Jaring Schreuder et al. doi:10.1038/ni.3200 The progenitor stage of commitment toward the conventional dendritic cell subsets and the transcriptional networks that control it remain poorly understood. Two articles from Ginhoux and colleagues and Murphy and colleagues offer insight into these processes. See also: News and Views by Winter & Amit The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways   pp729 - 736 Mohammad Samie and Peter Cresswell doi:10.1038/ni.3196 Dendritic cells present exogenous antigens to T cells on MHC class I or MHC class II. Cresswell and colleagues show that the transcription factor TFEB inhibits exogenous antigen presentation by MHC class I and enhances presentation by MHC class II by promoting phagosomal acidification. The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance   pp737 - 745 Anna Chuprin, Ayelet Avin, Yael Goldfarb, Yonatan Herzig, Ben Levi et al. doi:10.1038/ni.3194 Dysfunction of the deacetylase Sirt1 has been associated with certain metabolic diseases. Abramson and colleagues show that Sirt1 has high expression in the thymus, where it deacetylates the transcriptional regulator Aire and is essential for Aire's ability to switch on the expression of tissue-specific genes. See also: News and Views by Peterson Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages   pp746 - 754 MacLean Sellars, Jun R Huh, Kenneth Day, Priya D Issuree, Carolina Galan et al. doi:10.1038/ni.3198 Cd4 expression in helper and cytotoxic T cells is locked in by gene-expression programs that define lineage identity. Littman and colleagues define stage-specific methylation and demethylation events that regulate the heritable expression of Cd4. See also: News and Views by Feng & Rudensky Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus   pp755 - 765 Christopher M Tipton, Christopher F Fucile, Jaime Darce, Asiya Chida, Travis Ichikawa et al. doi:10.1038/ni.3175 Patients with systemic lupus erythematosus (SLE) experience flares of autoantibody secretion. Sanz and colleagues track the plasma cell repertoires of patients with SLE and find a sizeable polyclonal contribution by newly activated autoreactive B cells. See also: News and Views by Tarlinton & Smith Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia   pp766 - 774 Srividya Swaminathan, Lars Klemm, Eugene Park, Elli Papaemmanuil, Anthony Ford et al. doi:10.1038/ni.3160 Secondary mutations can drive the transformation of pre-leukemic clones that carry ETV6-RUNX1 translocations. Muschen and colleagues show that repeated inflammatory episodes induce aberrant coexpression of the DNA recombinases RAG and AID to promote the development of acute lymphoblastic leukemia. The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth   pp775 - 784 Claudia Bossen, Caroline S Murre, Aaron N Chang, Robert Mansson, Hans-Reimer Rodewald et al. doi:10.1038/ni.3170 B lineage development requires the transcription factors E2A, EBF1, Foxo1 and Ikaros. Murre and colleagues show that these factors gain access to lineage-specific enhancer sites by the action of the chromatin remodeler Brg1. Corrigenda Top Corrigendum: A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus   p785 Wanwisa Dejnirattisai, Wiyada Wongwiwat, Sunpetchuda Supasa, Xiaokang Zhang, Xinghong Dai et al. doi:10.1038/ni0715-785a Corrigendum: The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation   p785 Qiao Zhang, Hong Kuang, Cong Chen, Jie Yan, Hanh Chi Do-Umehara et al. doi:10.1038/ni0715-785b Errata Top Erratum: The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis   p785 Michio Onizawa, Shigeru Oshima, Ulf Schulze-Topphoff, Juan A Oses-Prieto, Timothy Lu et al. doi:10.1038/ni0715-785c Erratum: Responsiveness of B cells is regulated by the hinge region of IgD   p785 Rudolf Übelhart, Eva Hug, Martina P Bach, Thomas Wossning, Marcus Dühren-von Minden et al. doi:10.1038/ni0715-785d Top Advertisement Nature Collections  TARGETING IL-17 IN INFLAMMATORY DISEASE  This Collection highlights the opportunities and potential benefits of interleukin-17-targeted therapies for chronic inflammatory diseases. 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