Nature Communications - 24 June 2015

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Produced with support from:  Genentech, A Member of the Roche Group        Nature Communications - now fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Editorial View all Editorials     Towards an unbiased view of science OPEN Authors at Nature Communications now have the option to choose double-blind peer review 22 June 2015 | doi: 10.1038/ncomms8774       Latest Articles View all Articles     Using the transit of Venus to probe the upper planetary atmosphere OPEN Fabio Reale, Angelo F. Gambino, Giuseppina Micela, Antonio Maggio, Thomas Widemann and Giuseppe Piccioni The atmosphere of a transiting planet shields the stellar radiation enabling size and density stratification to be estimated. Here, the authors study Venus and show that the measured radius depends on the wavelength used, which has implications for Venus’s ionosphere and may help in planning future missions. 23 June 2015 | doi: 10.1038/ncomms8563 Earth Sciences  Atmospheric science  Geology and geophysics  Earth-like aqueous debris-flow activity on Mars at high orbital obliquity in the last million years OPEN T. de Haas, E. Hauber, S. J. Conway, H. van Steijn, A. Johnsson and M. G. Kleinhans It is thought that water flowed on the surface of Mars in the geological past during periods of high orbital obliquity. Here, the authors assess how much liquid water was present and suggest that debris flows occurred at Earth-like frequencies during high-obliquity periods in the past million years. 23 June 2015 | doi: 10.1038/ncomms8543 Earth Sciences  Geology and geophysics  Regional climate impacts of a possible future grand solar minimum OPEN Sarah Ineson, Amanda C. Maycock, Lesley J. Gray, Adam A. Scaife, Nick J. Dunstone, Jerald W. Harder, Jeff R. Knight, Mike Lockwood, James C. Manners and Richard A. Wood Regional surface climate response to a future decline in solar activity remains uncertain. Here, via numerical simulations, the authors show that a return to Maunder Minimum-like lows by 2050 could lead to some areas of significantly reduced surface warming via modulation of the North Atlantic Oscillation. 23 June 2015 | doi: 10.1038/ncomms8535 Earth Sciences  Atmospheric science  Climate science  Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota OPEN Chih-Jung Chang, Chuan-Sheng Lin, Chia-Chen Lu, Jan Martel, Yun-Fei Ko, David M. Ojcius, Shun-Fu Tseng, Tsung-Ru Wu, Yi-Yuan Margaret Chen, John D. Young and Hsin-Chih Lai Ganoderma lucidum is a medicinal mushroom used in Traditional Chinese Medicine with putative anti-diabetic properties. Here, the authors show that polysaccharides from a water extract of this mushroom exert beneficial metabolic effects by modulating the composition of the gut microbiota in mice. 23 June 2015 | doi: 10.1038/ncomms8489 Biological Sciences  Medical research  Microbiology  Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites Alison N. Thorburn, Craig I. McKenzie, Sj Shen, Dragana Stanley, Laurence Macia, Linda J. Mason, Laura K. Roberts, Connie H. Y. Wong, Raymond Shim, Remy Robert, Nina Chevalier, Jian K. Tan, Eliana Mariño, Rob J. Moore, Lee Wong, Malcolm J. McConville, Dedreia L. Tull, Lisa G. Wood, Vanessa E. Murphy, Joerg Mattes et al. Growing evidence suggests that environmental rather than genetic factors are major contributors to asthma development. Here the authors show that high intake of dietary fibre by pregnant mice increases resistance of their progeny to the development of allergic airways disease. 23 June 2015 | doi: 10.1038/ncomms8320 Biological Sciences  Immunology  A metabolic stress-inducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolism Yang Xu, Munaf Zalzala, Jiesi Xu, Yuanyuan Li, Liya Yin and Yanqiao Zhang The nuclear hormone receptor HNF4α is important for liver function. Here, Xu et al. show that miR-34a regulates expression of HNF4α and is increased under conditions of metabolic stress, suggesting miR-34a promotes the development of non-alcoholic fatty liver disease. 23 June 2015 | doi: 10.1038/ncomms8466 Biological Sciences  Medical research  Aquaporin-3-mediated hydrogen peroxide transport is required for NF-κB signalling in keratinocytes and development of psoriasis Mariko Hara-Chikuma, Hiroki Satooka, Sachiko Watanabe, Tetsuya Honda, Yoshiki Miyachi, Takeshi Watanabe and A. S. Verkman Aquaporin-3 (AQP3) mediates cellular uptake of water and hydrogen peroxide (H2O2). Here, the authors show that TNF-induced H2O2 enters keratinocytes via AQP3, eliciting NF-κB activation and the development of psoriasis, and identify AQP3 as a potential therapeutic target for this inflammatory immune-mediated disease. 23 June 2015 | doi: 10.1038/ncomms8454 Biological Sciences  Cell biology  Medical research  Arbitrary lattice symmetries via block copolymer nanomeshes OPEN Pawel W. Majewski, Atikur Rahman, Charles T. Black and Kevin G. Yager Nanoscale patterning methods based on self-assembly promise to revolutionize the fabrication of high-tech devices, but suffer from a limited number of possible lattice symmetries. Here, the authors use a laser zone annealing technique to pattern block copolymers into any 2D mesh motif they desire. 23 June 2015 | doi: 10.1038/ncomms8448 Physical Sciences  Materials science  Nanotechnology  Universal far-from-equilibrium dynamics of a holographic superconductor Julian Sonner, Adolfo del Campo and Wojciech H. Zurek In strongly coupled systems lacking long-lived quasiparticles, conventional methods are inadequate to study the dynamics of phase transitions. Here, the authors use holographic duality to investigate the superconducting transition and show that critical dynamics and formation of topological defects are universal. 23 June 2015 | doi: 10.1038/ncomms8406 Physical Sciences  Condensed matter  Theoretical physics  Maxwell’s demon in biochemical signal transduction with feedback loop OPEN Sosuke Ito and Takahiro Sagawa The connection between information and thermodynamics is embodied in the figure of Maxwell’s demon, a feedback controller. Here, the authors apply thermodynamics of information to signal transduction in chemotaxis of E. coli, predicting that its robustness is quantified by transfer entropy. 23 June 2015 | doi: 10.1038/ncomms8498 Physical Sciences  Theoretical physics  Thymoproteasomes produce unique peptide motifs for positive selection of CD8+ T cells OPEN Katsuhiro Sasaki, Kensuke Takada, Yuki Ohte, Hiroyuki Kondo, Hiroyuki Sorimachi, Keiji Tanaka, Yousuke Takahama and Shigeo Murata Proteasomes digest intracellular proteins into peptides that are then presented to lymphocytes as antigens. Here the authors show that a thymic epithelium-specific proteasome subunit cuts model proteins in a pattern favouring their weak binding to T cell receptor, and thus T cell positive selection. 23 June 2015 | doi: 10.1038/ncomms8484 Biological Sciences  Immunology  Revealing the planar chemistry of two-dimensional heterostructures at the atomic level OPEN Harry Chou, Ariel Ismach, Rudresh Ghosh, Rodney S. Ruoff and Andrei Dolocan The properties of 2D materials such as graphene can vary according to the quality and, for vertical devices, the interfaces between materials. Here, the authors report a method using TOF-SIMS, micro-Raman spectroscopy and atomic force microscopy to give high levels of detail of vertical 2D heterostructures. 23 June 2015 | doi: 10.1038/ncomms8482 Chemical Sciences  Materials science  Nanotechnology  Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport Maria Belen Jaurena, Hugo Juraver-Geslin, Arun Devotta and Jean-Pierre Saint-Jeannet Cranial placode progenitors arise from a common precursor field known as the preplacodal region. Here the authors show that transcription factor Zic1 induces the localized production and transport of retinoic acid at the anterior neural plate, which in turn activates a placode developmental programme in neighbouring cells. 23 June 2015 | doi: 10.1038/ncomms8476 Biological Sciences  Developmental biology  Spatial and temporal imaging of long-range charge transport in perovskite thin films by ultrafast microscopy OPEN Zhi Guo, Joseph S. Manser, Yan Wan, Prashant V. Kamat and Libai Huang Determining the mechanism of charge carrier transport in solar cells is important for their development towards higher efficiencies. Here, the authors elucidate the spatial and temporal diffusion of charge carriers in hybrid perovskite thin films through ultrafast transient absorption microscopy. 23 June 2015 | doi: 10.1038/ncomms8471 Physical Sciences  Applied physics  Materials science  Optical physics  Early aqueous activity on the ordinary and carbonaceous chondrite parent bodies recorded by fayalite Patricia M. Doyle, Kaori Jogo, Kazuhide Nagashima, Alexander N. Krot, Shigeru Wakita, Fred J. Ciesla and Ian D. Hutcheon The parent bodies of many chondritic meteorites experienced aqueous alteration, the chronology of which helps constrain their histories. Here, the authors synthesize a fayalite standard and report reliable ages of secondary fayalite, from which model accretion ages are determined and the place of accretion is inferred. 23 June 2015 | doi: 10.1038/ncomms8444 Earth Sciences  Geology and geophysics  Planetary sciences  A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae OPEN Jose Luis Ramirez, Giselle de Almeida Oliveira, Eric Calvo, Jesmond Dalli, Romain A. Colas, Charles N. Serhan, Jose M. Ribeiro and Carolina Barillas-Mury A soluble factor induced by Plasmodium infection promotes hemocyte differentiation and increases mosquitoe resistance to subsequent infections. Here the authors show that this factor consists of a Lipocalin/Lipoxin A4 complex, and that insects can metabolize arachidonic acid to produce lipoxins. 23 June 2015 | doi: 10.1038/ncomms8403 Biological Sciences  Immunology  Molecular biology  PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling OPEN Laura Braccini, Elisa Ciraolo, Carlo C. Campa, Alessia Perino, Dario L. Longo, Gianpaolo Tibolla, Marco Pregnolato, Yanyan Cao, Beatrice Tassone, Federico Damilano, Muriel Laffargue, Enzo Calautti, Marco Falasca, Giuseppe D. Norata, Jonathan M. Backer and Emilio Hirsch The kinase PI3K is crucial for insulin signalling in the liver but the roles of individual PI3K isoforms are largely unclear. Using mice that lack class II PI3K isoform γ (PI3K-C2γ), the authors here show that PI3K-C2γ selectively activates endosomal Akt2 by regulating the localized production of PIP2. 23 June 2015 | doi: 10.1038/ncomms8400 Biological Sciences  Cell biology  Medical research  Interlayer orientation-dependent light absorption and emission in monolayer semiconductor stacks OPEN Hoseok Heo, Ji Ho Sung, Soonyoung Cha, Bo-Gyu Jang, Joo-Youn Kim, Gangtae Jin, Donghun Lee, Ji-Hoon Ahn, Myoung-Jae Lee, Ji Hoon Shim, Hyunyong Choi and Moon-Ho Jo Single atomic layers of transition metal dichalcogenides have outstanding electrical and optical properties. Here, the authors show that light absorption and emission from stacks of different transition metal dichalcogenide monolayers can be tuned by rotating the crystals. 23 June 2015 | doi: 10.1038/ncomms8372 Physical Sciences  Materials science  Optical physics  Colloidal metasurfaces displaying near-ideal and tunable light absorbance in the infrared OPEN Matthew J. Rozin, David A. Rosen, Tyler J. Dill and Andrea R. Tao Metasurfaces are arrays of subwavelength structures that are tailored to produce specific optical responses. Rozin et al. show that large-area metasurfaces can be readily fabricated by self-assembly of colloidal nanocrystals of different geometries, producing tunable reflectance and absorbance properties. 23 June 2015 | doi: 10.1038/ncomms8325 Physical Sciences  Materials science  Nanotechnology  Optical physics  High-quality sandwiched black phosphorus heterostructure and its quantum oscillations OPEN Xiaolong Chen, Yingying Wu, Zefei Wu, Yu Han, Shuigang Xu, Lin Wang, Weiguang Ye, Tianyi Han, Yuheng He, Yuan Cai and Ning Wang Black phosphorus is an atomically thin material that exhibits excellent properties for electronics applications, but these degrade in atmospheric conditions. Here, the authors demonstrate the fabrication of stable, ultra-clean and high-mobility black phosphorus sandwiched between the layers of boron nitride. 23 June 2015 | doi: 10.1038/ncomms8315 Physical Sciences  Materials science  Nanotechnology  Strongly correlated two-dimensional plasma explored from entropy measurements A. Y. Kuntsevich, Y. V. Tupikov, V. M. Pudalov and I. S. Burmistrov Electrons trapped to a two-dimensional plane can exhibit many exotic properties. Here, the authors use a technique that measures entropy per electron to explore the evolution of such a system from the Fermi liquid regime to a previously unexplored regime of a strongly correlated charged plasma. 23 June 2015 | doi: 10.1038/ncomms8298 The bacterial tubulin FtsZ requires its intrinsically disordered linker to direct robust cell wall construction Kousik Sundararajan, Amanda Miguel, Samantha M. Desmarais, Elizabeth L. Meier, Kerwyn Casey Huang and Erin D. Goley The bacterial division protein FtsZ recruits cell wall synthesis enzymes to the cytokinetic ring. Sundararajan et al. show that FtsZ deletion variants alter peptidoglycan structure without detectable effects on enzyme recruitment, suggesting an additional role in the regulation of cell wall metabolism. 23 June 2015 | doi: 10.1038/ncomms8281 Biological Sciences  Biochemistry  Microbiology  Bifunctional non-noble metal oxide nanoparticle electrocatalysts through lithium-induced conversion for overall water splitting OPEN Haotian Wang, Hyun-Wook Lee, Yong Deng, Zhiyi Lu, Po-Chun Hsu, Yayuan Liu, Dingchang Lin and Yi Cui There is intensive research underway in developing electrocatalysts for water splitting. Here, the authors present a lithium-induced conversion reaction method to develop an active and stable bifunctional catalyst for overall water splitting, outperforming the combination of noble metal catalysts. 23 June 2015 | doi: 10.1038/ncomms8261 Chemical Sciences  Catalysis  Materials science  Nanotechnology  Orbitofrontal lesions eliminate signalling of biological significance in cue-responsive ventral striatal neurons Nisha K. Cooch, Thomas A. Stalnaker, Heather M. Wied, Sheena Bali-Chaudhary, Michael A. McDannald, Tzu-Lan Liu and Geoffrey Schoenbaum The ventral striatum (VS) has long been proposed as crucial for integrating biologically significant associative information to drive actions. Here, the authors demonstrate that orbitofrontal cortical inputs to the VS play a critical role in biasing activity to represent reward value. 23 June 2015 | doi: 10.1038/ncomms8195 Biological Sciences  Neuroscience  Controlling dispersion forces between small particles with artificially created random light fields OPEN Georges Brügger, Luis S. Froufe-Pérez, Frank Scheffold and Juan José Sáenz Natural dispersion forces acting between molecules and particles arise from electromagnetic fields generated by quantum and thermal fluctuations. Here, Brügger et al. show that isotropic dispersion forces between colloidal particles can be induced, controlled and tuned with artificial, fluctuating laser light fields. 22 June 2015 | doi: 10.1038/ncomms8460 Physical Sciences  Condensed matter  Optical physics  Physical chemistry  Robust electron pairing in the integer quantum hall effect regime H K. Choi, I. Sivan, A. Rosenblatt, M. Heiblum, V. Umansky and D. Mahalu Electron pairing is a rare phenomenon which can result in exotic behaviour such as superconductivity. Here, the authors evidence robust electron pairing in the quantum Hall edge states of a Fabry–Perot interferometer via Aharonov–Bohm conductance oscillations and quantum shot noise measurements. 22 June 2015 | doi: 10.1038/ncomms8435 Physical Sciences  Applied physics  Condensed matter  A two-dimensional spin liquid in quantum kagome ice Juan Carrasquilla, Zhihao Hao and Roger G. Melko Two-dimensional quantum spin liquid states, which retain spin disorder down to low temperatures, have never been realized experimentally. Here, the authors use quantum Monte Carlo methods to predict a new route to this state in rare-earth pyrochlore quantum spin ices under an applied (111) magnetic field. 22 June 2015 | doi: 10.1038/ncomms8421 Physical Sciences  Theoretical physics  High-performance flexible perovskite solar cells exploiting Zn2SnO4 prepared in solution below 100 °C OPEN Seong Sik Shin, Woon Seok Yang, Jun Hong Noh, Jae Ho Suk, Nam Joong Jeon, Jong Hoon Park, Ju Seong Kim, Won Mo Seong and Sang Il Seok There has been impressive progress in the development of perovskite solar cells in recent years, but the best performing systems tend to be fabricated on glass surfaces. Here, the authors present a cell built on a polymer substrate, allowing flexibility whilst maintaining high efficiency. 22 June 2015 | doi: 10.1038/ncomms8410 Physical Sciences  Applied physics  Materials science  Optical physics  Peptidyl-prolyl isomerization targets rice Aux/IAAs for proteasomal degradation during auxin signalling Hongwei Jing, Xiaolu Yang, Jian Zhang, Xuehui Liu, Huakun Zheng, Guojun Dong, Jinqiang Nian, Jian Feng, Bin Xia, Qian Qian, Jiayang Li and Jianru Zuo Auxin signalling requires the degradation of Aux/IAA transcriptional repressors which is mediated by their interaction with F-box proteins. Jing et al. show that in rice, OsIAA11 interaction with the F-box protein TIR1 is enhanced by cyclophilin-dependent cis/trans isomerisation of the repressor. 22 June 2015 | doi: 10.1038/ncomms8395 Biological Sciences  Cell biology  Plant sciences  A piRNA-like small RNA interacts with and modulates p-ERM proteins in human somatic cells OPEN Yuping Mei, Yuyan Wang, Priti Kumari, Amol Carl Shetty, David Clark, Tyler Gable, Alexander D. MacKerell, Mark Z. Ma, David J. Weber, Austin J. Yang, Martin J. Edelman and Li Mao PIWI-interacting RNAs (piRNAs) suppress transposon and gene expression during development. Here, the authors identify many piRNAs and piRNA-like small RNAs in 11 human cell lines, and show that one piRNA-like small RNA binds to phosphorylated ERM proteins to regulate cancer cell migration and invasion. 22 June 2015 | doi: 10.1038/ncomms8316 Biological Sciences  Cell biology  Molecular biology  Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1–BAP1 complex OPEN Anand Balasubramani, Antti Larjo, Jed A. Bassein, Xing Chang, Ryan B. Hastie, Susan M. Togher, Harri Lähdesmäki and Anjana Rao Premature truncations of ASXL1, a subunit of a deubiquitinase complex, are frequent in myeloid leukemia. Here, the authors show that expression of truncated ASXL1 in a haematopoietic precursor cell line enhances the deubiquitinase activity and leads to differentiation to the mast cell lineage. 22 June 2015 | doi: 10.1038/ncomms8307 Biological Sciences  Cancer  Molecular biology  The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication OPEN Bertil Macao, Jay P. Uhler, Triinu Siibak, Xuefeng Zhu, Yonghong Shi, Wenwen Sheng, Monica Olsson, James B. Stewart, Claes M. Gustafsson and Maria Falkenberg Mitochondrial DNA (mtDNA) polymerase γ has a 3′–5′ exonuclease proofreading activity. Here, the authors show it is required for creating ligatable ends during mtDNA replication, and inactivation of the activity in mice causes strand-specific nicks in DNA and the formation of linear mtDNA fragments. 22 June 2015 | doi: 10.1038/ncomms8303 Biological Sciences  Cell biology  Molecular biology  A primase subunit essential for efficient primer synthesis by an archaeal eukaryotic-type primase Bing Liu, Songying Ouyang, Kira S. Makarova, Qiu Xia, Yanping Zhu, Zhimeng Li, Li Guo, Eugene V. Koonin, Zhi-Jie Liu and Li Huang Archaea encode an eukaryotic-type primase comprising a catalytic subunit PriS and a noncatalytic subunit PriL. Here, the authors identify in an archaeon Sulfolobus solfataricus an essential noncatalytic subunit of primase, PriX, that forms PriSLX trimer and increases the efficiency of primer synthesis. 22 June 2015 | doi: 10.1038/ncomms8300 Biological Sciences  Biochemistry  Molecular biology  TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin Yasushi Masuda, Hidehisa Takahashi, Shigeo Sato, Chieri Tomomori-Sato, Anita Saraf, Michael P. Washburn, Laurence Florens, Ronald C. Conaway, Joan W. Conaway and Shigetsugu Hatakeyama Many proteins are assembled into damaged chromatins to repair DNA double-strand breaks (DSBs). Here, the authors show that TRIM29 binds to modified histone H3 and H4 tails following DSB formation and functions as a scaffold protein to assemble DNA repair proteins into chromatin. 22 June 2015 | doi: 10.1038/ncomms8299 Biological Sciences  Cell biology  Molecular biology  Spin transport and Hanle effect in silicon nanowires using graphene tunnel barriers O. M. J. van ’t Erve, A. L. Friedman, C. H. Li, J. T. Robinson, J. Connell, L. J. Lauhon and B. T. Jonker Graphene forms low-resistance tunnel barriers for spin injection from a ferromagnet into silicon. Here, the authors fabricate silicon nanowire non-local spin valves with graphene tunnel barriers, evidencing spin accumulation and transport via Hanle spin precession measurements. 19 June 2015 | doi: 10.1038/ncomms8541 Physical Sciences  Applied physics  Condensed matter  Nanotechnology  Emergent vortices in populations of colloidal rollers OPEN Antoine Bricard, Jean-Baptiste Caussin, Debasish Das, Charles Savoie, Vijayakumar Chikkadi, Kyohei Shitara, Oleksandr Chepizhko, Fernando Peruani, David Saintillan and Denis Bartolo Confined populations of interacting motile particles often display collective motion in the form of large-scale vortices, such as fish groups and bacteria colonies. Bricard et al. study a model system with self-propelled colloidal rollers and identify the constituents responsible for emergent vortices. 19 June 2015 | doi: 10.1038/ncomms8470 Physical Sciences  Applied physics  Fluids and plasma physics  Materials science  Probing deformed commutators with macroscopic harmonic oscillators OPEN Mateusz Bawaj, Ciro Biancofiore, Michele Bonaldi, Federica Bonfigli, Antonio Borrielli, Giovanni Di Giuseppe, Lorenzo Marconi, Francesco Marino, Riccardo Natali, Antonio Pontin, Giovanni A. Prodi, Enrico Serra, David Vitali and Francesco Marin A minimal observable length leading to deformed commutation relations is a common feature of theories that aim to merge quantum physics and gravity. Here, the authors analyse the free evolution of micro- and nano-oscillators to lower the limits on the parameters quantifying commutator deformation. 19 June 2015 | doi: 10.1038/ncomms8503 Physical Sciences  Applied physics  Theoretical physics  The limits of chemosensation vary across dimensions OPEN Brendan A. Bicknell, Peter Dayan and Geoffrey J. Goodhill Theoretical studies on chemosensation often invoke a model of three dimensional unbounded diffusion, but many biological problems involve two-dimensional diffusion in a bounded domain. Here Bicknell et al. present a model for chemosensation that covers bounded domains of any dimension, and apply it to biological problems in two dimensions. 19 June 2015 | doi: 10.1038/ncomms8468 Biological Sciences  Biophysics  Optoelectronic crystal of artificial atoms in strain-textured molybdenum disulphide OPEN Hong Li, Alex W. Contryman, Xiaofeng Qian, Sina Moeini Ardakani, Yongji Gong, Xingli Wang, Jeffery M. Weisse, Chi Hwan Lee, Jiheng Zhao, Pulickel M. Ajayan, Ju Li, Hari C. Manoharan and Xiaolin Zheng Periodically strained monolayer molybdenum disulphide funnels photogenerated electron-hole pairs across an electric field induced by a spatially graded band gap, mimicking a crystal of artificial atoms. Here, the authors experimentally demonstrate the artificial crystal in strain-textured molybdenum disulphide. 19 June 2015 | doi: 10.1038/ncomms8381 Physical Sciences  Materials science  Nanotechnology  Pressure induced metallization with absence of structural transition in layered molybdenum diselenide OPEN Zhao Zhao, Haijun Zhang, Hongtao Yuan, Shibing Wang, Yu Lin, Qiaoshi Zeng, Gang Xu, Zhenxian Liu, G. K. Solanki, K. D. Patel, Yi Cui, Harold Y. Hwang and Wendy L. Mao Controlling the properties of transition metal chalcogenides enables the study of new condensed-matter phenomena and the development of potential applications. Here, the authors continuously tune the crystal and electronic structure of molybdenum diselenide away from the pristine state using pressure. 19 June 2015 | doi: 10.1038/ncomms8312 Physical Sciences  Condensed matter  Materials science  Atomically thin resonant tunnel diodes built from synthetic van der Waals heterostructures OPEN Yu-Chuan Lin, Ram Krishna Ghosh, Rafik Addou, Ning Lu, Sarah M. Eichfeld, Hui Zhu, Ming-Yang Li, Xin Peng, Moon J. Kim, Lain-Jong Li, Robert M. Wallace, Suman Datta and Joshua A. Robinson The family of two-dimensional materials is ever growing, but greater functionality can be realized by combining them together. Here, the authors report the direct synthesis of multijunction heterostructures made from graphene, tungsten diselenide and either molybdenum disulphide or molybdenum diselenide. 19 June 2015 | doi: 10.1038/ncomms8311 Physical Sciences  Applied physics  Materials science  Direct interaction between centralspindlin and PRC1 reinforces mechanical resilience of the central spindle OPEN Kian-Yong Lee, Behrooz Esmaeili, Ben Zealley and Masanori Mishima The central spindle is an anti parallel bundle of microtubules that forms between segregating chromosomes and links the two halves of the mitotic spindle. Lee et al. reveal that interaction between two microtubule bundling proteins at the central spindle confers robustness to cortical pulling forces. 19 June 2015 | doi: 10.1038/ncomms8290 Biological Sciences  Biophysics  Cell biology  The solvation of electrons by an atmospheric-pressure plasma OPEN Paul Rumbach, David M. Bartels, R. Mohan Sankaran and David B. Go Free, or solvated, electrons in a solution are known to form at the interface between a liquid and a gas. Here, the authors use absorption spectroscopy in a total internal reflection geometry to probe solvated electrons generated at a plasma in contact with the surface of an aqueous solution 19 June 2015 | doi: 10.1038/ncomms8248 Physical Sciences  Fluids and plasma physics  Physical chemistry  Light-induced crawling of crystals on a glass surface OPEN Emi Uchida, Reiko Azumi and Yasuo Norikane Creating the motion of nanosized or microsized objects is essential for building robots at small scales. Here, Uchida et al. move photoresponsive organic crystals on a glass substrate using two lamps, which crystallize and melt the crystal front and the rear, respectively, to generate the moving force. 18 June 2015 | doi: 10.1038/ncomms8310 Physical Sciences  Materials science  Nanotechnology  Exosome-delivered microRNAs modulate the inflammatory response to endotoxin OPEN Margaret Alexander, Ruozhen Hu, Marah C. Runtsch, Dominique A. Kagele, Timothy L. Mosbruger, Tanya Tolmachova, Miguel C. Seabra, June L. Round, Diane M. Ward and Ryan M. O’Connell Response to inflammatory stimuli such as endotoxin is coordinated at many levels. Here, the authors show that two microRNAs known to regulate inflammatory response inside the cell are secreted by dendritic cells and modulate inflammatory signalling in the neighbouring cells. 18 June 2015 | doi: 10.1038/ncomms8321 Biological Sciences  Immunology  Inefficient microbial production of refractory dissolved organic matter in the ocean Helena Osterholz, Jutta Niggemann, Helge-Ansgar Giebel, Meinhard Simon and Thorsten Dittmar The extent to which the microbial carbon pump contributes to the generation of marine refractory dissolved organic matter (RDOM) remains a matter of debate. Here, the authors report results from a 3-year mesocosm study, and show that most of the microbial DOM is different from RDOM in the ocean. 18 June 2015 | doi: 10.1038/ncomms8422 Earth Sciences  Biogeochemistry  Microbiology  Oceanography  Multivalency governs HP1α association dynamics with the silent chromatin state OPEN Sinan Kilic, Andreas L. Bachmann, Louise C. Bryan and Beat Fierz Chromatin effector proteins often employ multivalent interactions with histone post-translational modifications. Here by using chemically defined nucleosome array and single-molecule microscopy, the authors show that effector multivalency prolongs chromatin retention and accelerates the association rate. 18 June 2015 | doi: 10.1038/ncomms8313 Biological Sciences  Biochemistry  Molecular biology  A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours Madhuri Kalathur, Alberto Toso, Jingjing Chen, Ajinkya Revandkar, Claudia Danzer-Baltzer, Ilaria Guccini, Abdullah Alajati, Manuela Sarti, Sandra Pinton, Lara Brambilla, Diletta Di Mitri, Giuseppina Carbone, R Garcia-Escudero, Alessandro Padova, Letizia Magnoni, Alessia Tarditi, Laura Maccari, Federico Malusa, Ravi Kiran Reddy Kalathur, Lorenzo A. Pinna et al. It has been proposed that the identification of genes regulating senescence in the absence of PTEN might help develop pro-senescence compounds for the treatment of cancer. Here, the authors use a combination of chemical and shRNA functional screen and identify CK2 as a potential target. 18 June 2015 | doi: 10.1038/ncomms8227 Biological Sciences  Cancer  Cell biology  Molecular biology  Kumada–Grignard-type biaryl couplings on water OPEN Anish Bhattacharjya, Piyatida Klumphu and Bruce H. Lipshutz Organomagnesium reagents have been a staple for carbon–carbon bond formations for over a century, but are notoriously sensitive to water. Here, the authors show a Kumada-type coupling of aryl halides on water, with a potential intermediary of an in situ formed Grignard reagent. 18 June 2015 | doi: 10.1038/ncomms8401 Chemical Sciences  Catalysis  Organic chemistry  Parts-per-million level loading organocatalysed enantioselective silylation of alcohols OPEN Sang Yeon Park, Ji-Woong Lee and Choong Eui Song Organocatalytic methods typically do not approach the extremely low loadings that can be achieved with some metal catalysed processes. Here, the authors report a remarkably powerful organocatalyst capable of performing asymmetric silylations with sub parts-per-million level loadings. 18 June 2015 | doi: 10.1038/ncomms8512 Chemical Sciences  Catalysis  Organic chemistry  Role of redox centre in charge transport investigated by novel self-assembled conjugated polymer molecular junctions OPEN Zongrui Wang, Huanli Dong, Tao Li, Rune Hviid, Ye Zou, Zhongming Wei, Xiaolong Fu, Erjing Wang, Yonggang Zhen, Kasper Nørgaard, Bo W. Laursen and Wenping Hu To date, conjugated polymers have not yet been used in molecular junctions despite the fact that they transport charge more efficiently than small-molecular systems. Here, Wang et al. showcase the self-assembly of conjugated polymers into ultrathin films in a planar manner for device construction. 18 June 2015 | doi: 10.1038/ncomms8478 Chemical Sciences  Materials science  Nanotechnology  Physical chemistry  The impact of DNA intercalators on DNA and DNA-processing enzymes elucidated through force-dependent binding kinetics OPEN Andreas S. Biebricher, Iddo Heller, Roel F. H. Roijmans, Tjalle P. Hoekstra, Erwin J. G. Peterman and Gijs J. L. Wuite DNA intercalators, a type of fluorescent probes widely used to visualize DNA, can perturb DNA structure and stability. Here, the authors show how DNA-binding affinity can be tuned using DNA tension, ionic strength and dye species, and how this can be used to minimize DNA structural perturbations. 18 June 2015 | doi: 10.1038/ncomms8304 Biological Sciences  Biochemistry  Molecular biology  Tissue landscape alters adjacent cell fates during Drosophila egg development Lathiena A. Manning, Ann Marie Weideman, Bradford E. Peercy and Michelle Starz-Gaiano How diffusible signals determine cell fate is a vital and still unresolved developmental biology issue. Using the Drosophila egg chamber as a model system, here the authors apply novel imaging and mathematical approaches to show that cell differentiation depends on irregular tissue domains that lead to asymmetric distributions of morphogens. 17 June 2015 | doi: 10.1038/ncomms8356 Biological Sciences  Cell biology  Developmental biology  Photonic sensing of organic solvents through geometric study of dynamic reflection spectrum OPEN Yuqi Zhang, Qianqian Fu and Jianping Ge Photonic sensing is a method for detecting individual chemical species, but can fail when they are sufficiently similar in physical properties. Here, the authors report a method that can distinguish even very closely related species, such as homologues and chemical isomers. 17 June 2015 | doi: 10.1038/ncomms8510 Chemical Sciences  Analytical chemistry  Optical physics  Physical chemistry  Identification of mammalian-adapting mutations in the polymerase complex of an avian H5N1 influenza virus OPEN Andrew S. Taft, Makoto Ozawa, Adam Fitch, Jay V. Depasse, Peter J. Halfmann, Lindsay Hill-Batorski, Masato Hatta, Thomas C. Friedrich, Tiago J. S. Lopes, Eileen A. Maher, Elodie Ghedin, Catherine A. Macken, Gabriele Neumann and Yoshihiro Kawaoka Understanding the factors that enable some bird flu viruses to infect humans is important for the identification of circulating viruses with higher potential to infect us. Here, Taft et al. identify novel mutations in the polymerase of an avian H5N1 virus that help the virus to replicate in human cells and in mice 17 June 2015 | doi: 10.1038/ncomms8491 Biological Sciences  Microbiology  Virology  KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR OPEN Daisuke Kamimura, Kokichi Katsunuma, Yasunobu Arima, Toru Atsumi, Jing-jing Jiang, Hidenori Bando, Jie Meng, Lavannya Sabharwal, Andrea Stofkova, Naoki Nishikawa, Hironao Suzuki, Hideki Ogura, Naoko Ueda, Mineko Tsuruoka, Masaya Harada, Junya Kobayashi, Takanori Hasegawa, Hisahiro Yoshida, Haruhiko Koseki, Ikuo Miura et al. KDEL receptors are known to be involved in retrotransporting chaperones to the endoplasmic reticulum from the Golgi complex. Here the authors unravel a role of KDEL receptor 1 in regulating integrated stress responses in naïve T cells through its association with protein phosphatase 1. 17 June 2015 | doi: 10.1038/ncomms8474 Biological Sciences  Immunology  Rhodium-catalysed C(sp2)–C(sp2) bond formation via C–H/C–F activation OPEN Panpan Tian, Chao Feng and Teck-Peng Loh Fluoroalkenes are found widely in biologically active compounds, but their introduction can be difficult or laborious. Here, the authors report a C–H/C–F activation strategy to introduce monofluoroalkenes into organic molecules in one step with good to excellent yields. 17 June 2015 | doi: 10.1038/ncomms8472 Chemical Sciences  Catalysis  Organic chemistry  Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization Fang-Ke Huang, Shaoqin Han, Bowen Xing, Jianyun Huang, Bingqian Liu, Francois Bordeleau, Cynthia A. Reinhart-King, J. Jillian Zhang and Xin-Yun Huang As metastasis requires cellular machinery of migration and invasion, interfering with these functions is a promising anticancer strategy. Here the authors show that a structurally novel fascin inhibitor blocks filopodia formation, migration and invasion, and effectively inhibits metastasis in mice. 17 June 2015 | doi: 10.1038/ncomms8465 Biological Sciences  Cancer  Cell biology  Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme Brian T. Nasipak, Teresita Padilla-Benavides, Karin M. Green, John D. Leszyk, Wenjie Mao, Silvana Konda, Saïd Sif, Scott A. Shaffer, Yasuyuki Ohkawa and Anthony N. Imbalzano Brg1 is part of the SWI/SNF chromatin remodelling complex that is essential for embryonic development. Here, the authors show that Brg1 is the target of two opposing calcium-regulated molecules involved in myogenesis: calcineurin, which promotes myogenesis, and protein kinase C β (PKCβ), which inhibits it. 17 June 2015 | doi: 10.1038/ncomms8441 Biological Sciences  Cell biology  Developmental biology  The synergetic effect of lithium polysulfide and lithium nitrate to prevent lithium dendrite growth Weiyang Li, Hongbin Yao, Kai Yan, Guangyuan Zheng, Zheng Liang, Yet-Ming Chiang and Yi Cui Lithium dendrite growth is a serious hazard in battery operations. Here, the authors show that when using lithium polysulfide and lithium nitrate as additives in ether-based electrolyte, a stable and uniform solid electrolyte interphase forms on the lithium surface, which prevents dendrite growth. 17 June 2015 | doi: 10.1038/ncomms8436 Chemical Sciences  Materials science  Exponential self-replication enabled through a fibre elongation/breakage mechanism OPEN Mathieu Colomb-Delsuc, Elio Mattia, Jan W. Sadownik and Sijbren Otto Exponential replication is one of the requirements for molecular-level Darwinian evolution, but is difficult to achieve in synthetic systems. Here, the authors show a peptide-functionalized macrocycle that forms supramolecular fibres with exponential growth when subjected to mild agitation. 17 June 2015 | doi: 10.1038/ncomms8427 Chemical Sciences  Materials science  Organic chemistry  Dynamical properties induced by state-dependent delays in photonic systems OPEN Jade Martínez-Llinàs, Xavier Porte, Miguel C. Soriano, Pere Colet and Ingo Fischer Time delays in feedback loops and connections in dynamical systems and complex networks can depend on the state of the system, but these state-dependent delays are poorly understood. Here, the authors use a photonic system to characterize the switching between two loops with different delay times. 17 June 2015 | doi: 10.1038/ncomms8425 Physical Sciences  Applied physics  Optical physics  Theoretical physics  Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours OPEN Tan A. Ince, Aurea D. Sousa, Michelle A. Jones, J. Chuck Harrell, Elin S. Agoston, Marit Krohn, Laura M. Selfors, Wenbin Liu, Ken Chen, Mao Yong, Peter Buchwald, Bin Wang, Katherine S. Hale, Evan Cohick, Petra Sergent, Abigail Witt, Zhanna Kozhekbaeva, Sizhen Gao, Agoston T. Agoston, Melissa A. Merritt et al. Despite methodological improvements, it remains extremely difficult to routinely establish cell lines from human primary tumours. Here, the authors develop a culture medium that allows efficient cell line establishment and use this to generate 25 ovarian cancer cell lines. 17 June 2015 | doi: 10.1038/ncomms8419 Biological Sciences  Cancer  Cell biology  Artificial membrane-binding proteins stimulate oxygenation of stem cells during engineering of large cartilage tissue OPEN James P. K. Armstrong, Rameen Shakur, Joseph P. Horne, Sally C. Dickinson, Craig T. Armstrong, Katherine Lau, Juned Kadiwala, Robert Lowe, Annela Seddon, Stephen Mann, J. L. Ross Anderson, Adam W. Perriman and Anthony P. Hollander Avoiding central cell necrosis at the centre of large engineered tissue constructs is an important issue for in vitro tissue engineering. Here, the authors demonstrate that this problem may be overcome by oxygenating human mesenchymal stem cells with artificial membrane-binding proteins. 17 June 2015 | doi: 10.1038/ncomms8405 Biological Sciences  Bioengineering  Materials science  NELL-1 in the treatment of osteoporotic bone loss OPEN Aaron W. James, Jia Shen, Xinli Zhang, Greg Asatrian, Raghav Goyal, Jin H. Kwak, Lin Jiang, Benjamin Bengs, Cymbeline T. Culiat, A. Simon Turner, Howard B. Seim III, Benjamin M. Wu, Karen Lyons, John S. Adams, Kang Ting and Chia Soo The growth factor NELL-1 induces bone formation during development, but its role in osteoporosis is unknown. This study shows that NELL-1 binding to integrin ß1 induces Wnt/ß-catenin signalling in the bone and restores bone mineral density in osteoporotic mice and sheep, suggesting the therapeutic potential of NELL-1 for the treatment of bone loss. 17 June 2015 | doi: 10.1038/ncomms8362 Biological Sciences  Medical research  Surface determination through atomically resolved secondary-electron imaging OPEN J. Ciston, H. G. Brown, A. J. D’Alfonso, P. Koirala, C. Ophus, Y. Lin, Y. Suzuki, H. Inada, Y. Zhu, L. J. Allen and L. D. Marks Technical difficulties have so far limited the application of high-resolution secondary-electron microscopy in imaging surface structures. Here, the authors report a successful determination of surface reconstruction of strontium titanate, using the secondary-electron microscopy along with other techniques. 17 June 2015 | doi: 10.1038/ncomms8358 Chemical Sciences  Applied physics  Materials science  The ZNF304-integrin axis protects against anoikis in cancer Burcu Aslan, Paloma Monroig, Ming-Chuan Hsu, Guillermo Armaiz Pena, Cristian Rodriguez-Aguayo, Vianey Gonzalez-Villasana, Rajesha Rupaimoole, Archana Sidalaghatta Nagaraja, Selanere Mangala, Hee-Dong Han, Erkan Yuca, Sherry Y. Wu, Cristina Ivan, Tyler J. Moss, Prahlad T. Ram, Huamin Wang, Alexandra Gol-Chambers, Ozgur Ozkayar, Pinar Kanlikilicer, Enrique Fuentes-Mattei et al. Ovarian cancer is often accompanied by metastases at the time of diagnosis and has a poor survival rate. In this study, Aslan et al. identify a role for ZNF304 in ovarian cancer metastasis and show that the protein transcriptionally regulates β1 integrin, resulting in a reduction in programmed cell death. 17 June 2015 | doi: 10.1038/ncomms8351 Biological Sciences  Cancer  Cell biology  Medical research  Conjugated polyelectrolyte hole transport layer for inverted-type perovskite solar cells OPEN Hyosung Choi, Cheng-Kang Mai, Hak-Beom Kim, Jaeki Jeong, Seyeong Song, Guillermo C. Bazan, Jin Young Kim and Alan J. Heeger There is intensive research underway into the development of hole transport layers for perovskite solar cells. Here, the authors report an inverted-type perovskite solar cell with low-temperature solution-processable conjugated polyelectrolyte as the hole transport layer, which exhibits an efficiency of over 12%. 17 June 2015 | doi: 10.1038/ncomms8348 Chemical Sciences  Materials science  Physical chemistry  Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model OPEN Beatrice Bissig-Choisat, Lili Wang, Xavier Legras, Pradip K. Saha, Leon Chen, Peter Bell, Francis P. Pankowicz, Matthew C. Hill, Mercedes Barzi, Claudia Kettlun Leyton, Hon-Chiu Eastwood Leung, Robert L. Kruse, Ryan W. Himes, John A. Goss, James M. Wilson, Lawrence Chan, William R. Lagor and Karl-Dimiter Bissig Familial hypercholesterolemia (FH) is a congenital disease associated with high plasma cholesterol levels. Here, the authors recapitulate FH in chimeric mice, in which livers are repopulated with hepatocytes from an FH patient, and successfully correct the disease using adenovirus-mediated gene therapy. 17 June 2015 | doi: 10.1038/ncomms8339 Biological Sciences  Biotechnology  Medical research  Tandem C–H oxidation/cyclization/rearrangement and its application to asymmetric syntheses of (−)-brussonol and (−)-przewalskine E OPEN Zhi-Wei Jiao, Yong-Qiang Tu, Qing Zhang, Wen-Xing Liu, Shu-Yu Zhang, Shao-Hua Wang, Fu-Min Zhang and Sen Jiang The ability to form complex molecular architectures from simpler precursors is important for drug discovery and medicinal chemistry. Here, the authors report a cascade reaction giving access to tricyclic products and apply it in the total synthesis of two natural products. 17 June 2015 | doi: 10.1038/ncomms8332 Chemical Sciences  Catalysis  Organic chemistry  Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch OPEN Irene Maria Aspalter, Emma Gordon, Alexandre Dubrac, Anan Ragab, Jarek Narloch, Pedro Vizán, Ilse Geudens, Russell Thomas Collins, Claudio Areias Franco, Cristina Luna Abrahams, Gavin Thurston, Marcus Fruttiger, Ian Rosewell, Anne Eichmann and Holger Gerhardt Notch signals are crucial for organization of angiogenic sprouting cells into the leading ‘tip’ and trailing ‘stalk’ cells. Here the authors show that endothelial neuropilin-1 quantitatively inhibits TGF-β/BMP signalling, explaining how Notch-mediated regulation of neuropilin-1 specifies endothelial tip and stalk cells. 17 June 2015 | doi: 10.1038/ncomms8264 Biological Sciences  Cell biology  Developmental biology  Monozygotic twins discordant for common variable immunodeficiency reveal impaired DNA demethylation during naïve-to-memory B-cell transition OPEN Virginia C. Rodríguez-Cortez, Lucia del Pino-Molina, Javier Rodríguez-Ubreva, Laura Ciudad, David Gómez-Cabrero, Carlos Company, José M. Urquiza, Jesper Tegnér, Carlos Rodríguez-Gallego, Eduardo López-Granados and Esteban Ballestar Epigenetic changes are thought to contribute to the aetiology of common variable immunodeficiency (CVID), a disease characterized by loss of B-cell function. Here, by comparing DNA methylation profile in B cells from monozygotic twins discordant for CVID, the authors show a gain of DNA methylation in CVID B cells. 17 June 2015 | doi: 10.1038/ncomms8335 Biological Sciences  Immunology  A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs OPEN Tudor A. Fulga, Elizabeth M. McNeill, Richard Binari, Julia Yelick, Alexandra Blanche, Matthew Booker, Bruno R. Steinkraus, Michael Schnall-Levin, Yong Zhao, Todd DeLuca, Fernando Bejarano, Zhe Han, Eric C. Lai, Dennis P. Wall, Norbert Perrimon and David Van Vactor Transgenic RNA ‘sponges’ that inhibit specific microRNAs are valuable tools for functional studies. Fulga et al. present a library of conditional microRNA sponges in Drosophila, and reveal widespread involvement of microRNAs in the maintenance of adult muscle structure and function. 17 June 2015 | doi: 10.1038/ncomms8279 Biological Sciences  Developmental biology  Genetics    Nature communications JOBS of the week PhD Student Universität Basel Postdoctoral Fellow University of Maryland School of Medicine Postdoctoral Research Fellow University of Leeds PhD student KU Leuven, Laboratory of Clinical and Experimental Endocrinology Bioinformatician University of Glasgow Postdoctoral Researchers John Innes Centre (JIC) Postdoctoral position Lund University Research Associate The University of Sheffield Research Assistant Professor University of Pennsylvania Postdoctoral Scholar The University of Iowa More Science jobs from Nature communications EVENT 6th World ADC Summit San Diego 2015 19.10.15 San Diego, USA More science events from       Latest Corrigenda     Corrigendum: Landscape of the mitochondrial Hsp90 metabolome in tumours Young Chan Chae, Alessia Angelin, Sofia Lisanti, Andrew V. Kossenkov, Kaye D. Speicher, Huan Wang, James F. Powers, Arthur S. Tischler, Karel Pacak, Stephanie Fliedner, Ryan D. Michalek, Edward D. Karoly, Douglas C. Wallace, Lucia R. Languino, David W. Speicher and Dario C. Altieri 18 June 2015 | doi: 10.1038/ncomms8605 Biological Sciences  Cancer  Cell biology      Corrigendum: Ultrasensitive and label-free molecular-level detection enabled by light phase control in magnetoplasmonic nanoantennas Nicolò Maccaferri, Keith E Gregorczyk, Thales V.A.G. de Oliveira, Mikko Kataja, Sebastiaan van Dijken, Zhaleh Pirzadeh, Alexandre Dmitriev, Johan Åkerman, Mato Knez and Paolo Vavassori 18 June 2015 | doi: 10.1038/ncomms8431 Physical Sciences  Analytical chemistry  Applied physics  Nanotechnology      Corrigendum: Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression Rosemary C. Bagot, Eric M. Parise, Catherine J. Peña, Hong-Xing Zhang, Ian Maze, Dipesh Chaudhury, Brianna Persaud, Roger Cachope, Carlos A. Bolaños-Guzmán, Joseph F. Cheer, Karl Deisseroth, Ming-Hu Han and Eric J. Nestler 17 June 2015 | doi: 10.1038/ncomms8626     Corrigendum: Abiotic ligation of DNA oligomers templated by their liquid crystal ordering Tommaso P. Fraccia, Gregory P. Smith, Giuliano Zanchetta, Elvezia Paraboschi, Youngwoo Yi, David M. Walba, Giorgio Dieci, Noel A. Clark and Tommaso Bellini 17 June 2015 | doi: 10.1038/ncomms8463       Latest Erratum     Erratum: G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy Nozomi Hayashiji, Shinsuke Yuasa, Yuko Miyagoe-Suzuki, Mie Hara, Naoki Ito, Hisayuki Hashimoto, Dai Kusumoto, Tomohisa Seki, Shugo Tohyama, Masaki Kodaira, Akira Kunitomi, Shin Kashimura, Makoto Takei, Yuki Saito, Shinichiro Okata, Toru Egashira, Jin Endo, Toshikuni Sasaoka, Shin’ichi Takeda and Keiichi Fukuda et al. 18 June 2015 | doi: 10.1038/ncomms8295 Biological Sciences  Medical research      Advertisement Noncoding RNAs in Endocrinology  Noncoding RNAs have important roles in the development and regulation of the endocrine system. This web collection on noncoding RNAs in endocrinology highlights current and future applications of noncoding RNAs as diagnostic and prognostic biomarkers and as therapeutic targets for personalized management of patients with a wide range of endocrine diseases. 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