Nature Cell Biology contents: July 2015 Volume 17 Number 7, pp 829 - 953

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TABLE OF CONTENTS July 2015 Volume 17, Issue 7 Review Obituary News and Views Articles Corrigenda Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Helmholtz Zentrum München and Nature Medicine are pleased to announce: THE 3RD ANNUAL HELMHOLTZ-NATURE MEDICINE DIABETES CONFERENCE September 19-21, 2015 | Munich, Germany  REGISTER NOW!    Review Top Proteostasis control by the unfolded protein response   pp829 - 838 Claudio Hetz, Eric Chevet and Scott A. Oakes doi:10.1038/ncb3184 Obituary Top Alan Hall 1952-2015   pp839 - 840 Filippo G. Giancotti, Cole M. Haynes, Laura M. Machesky, Michael F. Olson and Michael Overholtzer doi:10.1038/ncb3190 News and Views Top How cells coordinate waste removal through their major proteolytic pathways   pp841 - 842 Sascha Martens and Andreas Bachmair doi:10.1038/ncb3198 The eukaryotic cell uses two complex machineries to degrade unwanted proteins. The first is the ubiquitin–proteasome system and the second is autophagy. A new study contributes to our understanding of how the two systems interconnect to coordinate protein degradation. See also: Article by Cha-Molstad et al. Rubicon swaps autophagy for LAP   pp843 - 845 Keith B. Boyle and Felix Randow doi:10.1038/ncb3197 Phagocytic cells engulf their prey into vesicular structures called phagosomes, of which a certain proportion becomes demarcated for enhanced maturation by a process called LC3-associated phagocytosis (LAP). Light has now been shed on the molecular requirements of LAP, establishing a central role for the protein Rubicon in the immune response to Aspergillus fumigatus. See also: Article by Martinez et al. Super-resolution links vinculin localization to function in focal adhesions   pp845 - 847 Grégory Giannone doi:10.1038/ncb3196 Integrin-based focal adhesions integrate biochemical and biomechanical signals from the extracellular matrix and the actin cytoskeleton. The combination of three-dimensional super-resolution imaging and loss- or gain-of-function protein mutants now links the nanoscale dynamic localization of proteins to their activation and function within focal adhesions. See also: Article by Case et al. Cell Biology JOBS of the week Stem Cell Biology Research Scientist ODU Research Foundation Postdoctoral Fellow in Computational Biology Queen's University at Kingston Postdoctoral Research Fellow Mayo Clinic - Rochester ERC funded Postdoc on epigenomics in normal and malignant T-cell development Ghent University Postodctoral Fellow Murdoch Childrens Research Institute More Science jobs from Cell Biology EVENT 36th New Phytologist Symposium: Cell biology at the plant?microbe interface 29.12.15 Munich, Germany More science events from Advertisement Fluorescence is at your fingertips with ZOE™, a benchtop cell imager you control by touch screen. Features brightfield illumination and three fluorescent channels. Step out of the darkroom, see the light!   Articles Top Pulsatile cell-autonomous contractility drives compaction in the mouse embryo   pp849 - 855 Jean-Léon Maître, Ritsuya Niwayama, Hervé Turlier, François Nédélec and Takashi Hiiragi doi:10.1038/ncb3185 By measuring surface tensions in developing mouse embryos, Maître and colleagues show that compaction of the blastomere stage embryo is driven by downregulation of actomyosin at cell–cell contacts. The oncogene c-Jun impedes somatic cell reprogramming   pp856 - 867 Jing Liu, Qingkai Han, Tianran Peng, Meixiu Peng, Bei Wei et al. doi:10.1038/ncb3193 Pei and colleagues report that the oncogene c-Jun acts as a somatic cell reprogramming barrier, and that its truncated dominant-negative form can substitute for Oct4 in reprogramming. The kinetochore encodes a mechanical switch to disrupt spindle assembly checkpoint signalling   pp868 - 879 Pavithra Aravamudhan, Alan A. Goldfarb and Ajit P. Joglekar doi:10.1038/ncb3179 Joglekar and colleagues show that in budding yeast, kinetochore–microtubule attachment mediates silencing of the spindle assembly checkpoint through physical separation of Mps1 kinase from its substrate Spc105. Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions   pp880 - 892 Lindsay B. Case, Michelle A. Baird, Gleb Shtengel, Sharon L. Campbell, Harald F. Hess et al. doi:10.1038/ncb3180 Waterman and colleagues use super-resolution microscopy and biosensor technology to characterize the spatiotemporal regulation of the protein interactions within focal adhesions that control vinculin activation and function during focal adhesion maturation. See also: News and Views by Giannone Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins   pp893 - 906 Jennifer Martinez, R. K. Subbarao Malireddi, Qun Lu, Larissa Dias Cunha, Stephane Pelletier et al. doi:10.1038/ncb3192 Green and colleagues characterize LC3-associated phagocytosis as a process that depends on Rubicon, Beclin-1, UVRAG and VPS34 but not on canonical autophagy proteins. See also: News and Views by Boyle & Randow Microtubule-associated proteins control the kinetics of microtubule nucleation   pp907 - 916 Michal Wieczorek, Susanne Bechstedt, Sami Chaaban and Gary J. Brouhard doi:10.1038/ncb3188 Through single-molecule analyses, Brouhard and colleagues find a kinetic barrier to microtubule nucleation, which can be overcome by the action of the microtubule-associated proteins XMAP215 and TPX2. Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding   pp917 - 929 Hyunjoo Cha-Molstad, Ki Sa Sung, Joonsung Hwang, Kyoung A. Kim, Ji Eun Yu et al. doi:10.1038/ncb3177 Kim and colleagues and Kwon and colleagues reveal that amino-terminal arginylation of BiP promotes its targeting to autophagy adaptor p62 and subsequent lysosomal degradation of BiP, p62 and associated cargo. See also: News and Views by Martens & Bachmair A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy   pp930 - 942 Guowu Hu, Travis McQuiston, Amélie Bernard, Yoon-Dong Park, Jin Qiu et al. doi:10.1038/ncb3189 Williamson and colleagues demonstrate that mRNA-decapping enzyme Dcp2 is phosphorylated by mTORC1, leading to degradation of Atg mRNA and suppression of autophagy, influencing immunity and inflammation. Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival   pp943 - 952 Paul W. Furlow, Steven Zhang, T. David Soong, Nils Halberg, Hani Goodarzi et al. doi:10.1038/ncb3194 Tavazoie and colleagues report that activation of pannexin-1 channels and the subsequent stimulation of autocrine purinergic signalling promotes the survival of disseminated cancer cells in the microvasculature of metastasis target organs. Corrigenda Top Corrigenda: Kinetochore components are required for central spindle assembly   p953 Gilliane Maton, Frances Edwards, Benjamin Lacroix, Marine Stefanutti, Kimberley Laband et al. doi:10.1038/ncb3199 Corrigenda: MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism   p953 Karthik Mallilankaraman, César Cárdenas, Patrick J. Doonan, Harish C. Chandramoorthy, Krishna M. Irrinki et al. doi:10.1038/ncb3202 Top Advertisement Nature Immunology Focus on The immunology of HIV Nature Immunology presents a series of specially commissioned articles that discuss the most recent progress in understanding the immune response to HIV and how this new insight can be harnessed for prophylactic vaccines and immunotherapies.  Click here for more information.     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. 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