The EMBO Journal Table of Contents for 12 May 2015; Vol. 34, No. 10

12 May 2015 | Volume 34, Number 10 Submit Table of Contents Have you seen? Reviews Articles Volume 34, Number 10 Have you seen? Gut stem cells, a story of snails, flies and mice Functional work in various animal models establishes the Snail‐family transcription factor Escargot/Snai1 at the crossroad of intestinal stem cell self‐renewal and differentiation. Marc Amoyel Published online 11.04.2015 Tregs strip dendritic cells of CD70 to regulate Th1 differentiation A recent study reveals a new mechanism by which regulatory T cells suppress excessive inflammatory responses. Lukasz Wojciech and Leszek Ignatowicz Published online 13.04.2015 Blocking integrin inactivation as an anti‐angiogenic therapy A recent study in Nature reports on the discovery of a MAP4K4‐dependent mechanism for integrin inactivation and endothelial cell migration. This leads the authors to pharmacological exploration for anti‐angiogenic therapies. Pipsa Saharinen and Johanna Ivaska Published online 31.03.2015 Reviews Focus: Induced Pluripotency & Cellular Reprogramming: Reprogramming of cell fate: epigenetic memory and the erasure of memories past Petra Hajkova & colleagues feature the interplay of chromatin structure with cell fate determining transcription factors as therapeutic opportunity in the context of cellular reprogramming. Buhe Nashun, Peter WS Hill, and Petra Hajkova Published online 27.03.2015 Chemokine‐guided cell migration and motility in zebrafish development Chemokines are vertebrate‐specific molecules with a wide range of activities in different aspects of animal physiology. Bussmann and Raz review here their involvement in single and collective cell migration in zebrafish. Jeroen Bussmann and Erez Raz Published online 11.03.2015 Articles Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium Conditional deletion of Snai1 in the mouse intestine establishes its role in determining lineage choice versus stem cell self‐renewal in a mammalian epithelium. Katja Horvay, Thierry Jardé, Franca Casagranda, Victoria M Perreau, Katharina Haigh, Christian M Nefzger, Reyhan Akhtar, Thomas Gridley, Geert Berx, Jody J Haigh, Nick Barker, Jose M Polo, Gary R Hime, and Helen E Abud Published online 10.03.2015 Thymus‐derived regulatory T cells restrain pro‐inflammatory Th1 responses by downregulating CD70 on dendritic cells Inhibition of the CD70/CD27 costimulatory pathway for Th1‐helper T‐cell priming exemplifies a new way for Treg‐cell suppression of excessive inflammatory responses. Maxime Dhainaut, Caroline Coquerelle, Sophie Uzureau, Julie Denoeud, Valérie Acolty, Guillaume Oldenhove, Adrien Galuppo, Tim Sparwasser, Kris Thielemans, Etienne Pays, Hideo Yagita, Jannie Borst, and Muriel Moser Published online 18.03.2015 Aerobic glycolysis tunes YAP/TAZ transcriptional activity The direct binding of Phosphofructokinase‐1 with TEAD transcription factors in breast cancer cells unravels a new molecular link between cancer cell metabolism and YAP/TAZ‐mediated gene regulation. Elena Enzo, Giulia Santinon, Arianna Pocaterra, Mariaceleste Aragona, Silvia Bresolin, Mattia Forcato, Daniela Grifoni, Annalisa Pession, Francesca Zanconato, Giulia Guzzo, Silvio Bicciato, and Sirio Dupont Published online 21.03.2015 Telomerase abrogates aneuploidy‐induced telomere replication stress, senescence and cell depletion This study reports on new regulators of aneuploidy‐induced replication stress and characterizes telomerase activity as sufficient to bypass aneuploidy‐induced replication stress at telomeres. Jitendra K Meena, Aurora Cerutti, Christine Beichler, Yohei Morita, Christopher Bruhn, Mukesh Kumar, Johann M Kraus, Michael R Speicher, Zhao‐Qi Wang, Hans A Kestler, Fabrizio d'Adda di Fagagna, Cagatay Günes, and Karl Lenhard Rudolph Published online 27.03.2015 Ubiquitin‐like protein UBL5 promotes the functional integrity of the Fanconi anemia pathway An atypical ubiquitin‐like protein functions in DNA interstrand crosslink repair by impinging on FANCI–FANCD2 complex formation independent of its spliceosome‐modulating role. Yasuyoshi Oka, Simon Bekker‐Jensen, and Niels Mailand Published online 09.04.2015 Cockayne syndrome group B protein regulates DNA double‐strand break repair and checkpoint activation Generation of human cells lacking the transcription‐coupled repair protein CSB reveals unexpected roles in DNA double‐strand break repair pathway choice and activation of ATM‐mediated DNA damage responses. Nicole L Batenburg, Elizabeth L Thompson, Eric A Hendrickson, and Xu‐Dong Zhu Published online 27.03.2015 Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β‐cell function The functional and molecular characterization of Insm1 reveals its crucial role in the maintenance of adult pancreatic β‐cell identity. Shiqi Jia, Andranik Ivanov, Dinko Blasevic, Thomas Müller, Bettina Purfürst, Wei Sun, Wei Chen, Matthew N Poy, Nikolaus Rajewsky, and Carmen Birchmeier Published online 31.03.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.