The EMBO Journal Table of Contents for 5 May 2015; Vol. 34, No. 9

5 May 2015 | Volume 34, Number 9 Submit Table of Contents Have you seen? Reviews Articles Volume 34, Number 9 Have you seen? Astro‐logics with microRNAs Differentiation of astrocytes requires the joint action of two miRNAs that repress a shared set of target genes whose expression would be disruptive for cell fate transitioning. Chen Eitan and Eran Hornstein Published online 03.03.2015 Regulatory T cell differentiation: cooperation saves the day An inducible microRNA cooperates with a constitutive one to fine‐tune regulatory T cell induction. Adrian Liston and Susan M Schlenner Published online 24.02.2015 Plasmolipin—a new player in endocytosis and epithelial development Plasmolipin is a novel component of the apical endocytosis machinery that not only controls proper epithelial polarization, but is also involved in intestinal cell fate specification in zebrafish through the control of Notch signaling. Armelle Le Guelte and Ian G Macara Published online 30.03.2015 Reviews Focus: Induced Pluripotency & Cellular Reprogramming: Generating human intestinal tissues from pluripotent stem cells to study development and disease James Wells and Katie Sinagoga summarize efforts on directed differentiation of pluripotent stem cells into human intestinal organoids. The ex vivo reconstruction of this complex organ enables future studies on development and many diseases influenced by intestinal functions. Katie L Sinagoga and James M Wells Published online 19.03.2015 Switching roles: the functional plasticity of adult tissue stem cells This review compares the structural make‐up of distinct adult stem cell niches, describes their plasticity upon damage/during regeneration and alludes to modes of their physiological regulation. Agnieszka Wabik and Philip H Jones Published online 26.03.2015 Articles Let‐7 and miR‐125 cooperate to prime progenitors for astrogliogenesis The coordinate action of multiple miRNAs is required to shape cellular gene expression profiles and facilitate transition from glial progenitor cells to astrocytes. Archana Shenoy, Muhammad Danial, and Robert H Blelloch Published online 23.02.2015 Induced miR‐99a expression represses Mtor cooperatively with miR‐150 to promote regulatory T‐cell differentiation miRNAs identified in an overexpression screen reveal the importance of coordinated suppression of mTOR expression for promoting Treg induction. Sebastian C Warth, Kai P Hoefig, Anian Hiekel, Sonja Schallenberg, Ksenija Jovanovic, Ludger Klein, Karsten Kretschmer, K Mark Ansel, and Vigo Heissmeyer Published online 23.02.2015 Che‐1‐induced inhibition of mTOR pathway enables stress‐induced autophagy The RNA polymerase‐binding protein Che‐1 inhibits the mTOR pathway in response to stress, thereby sustaining autophagy and multiple myeloma cell growth. Agata Desantis, Tiziana Bruno, Valeria Catena, Francesca De Nicola, Frauke Goeman, Simona Iezzi, Cristina Sorino, Maurilio Ponzoni, Gianluca Bossi, Vincenzo Federico, Francesca La Rosa, Maria Rosaria Ricciardi, Elena Lesma, Paolo D'Onorio De Meo, Tiziana Castrignanò, Maria Teresa Petrucci, Francesco Pisani, Marta Chesi, P Leif Bergsagel, Aristide Floridi, Giovanni Tonon, Claudio Passananti, Giovanni Blandino, and Maurizio Fanciulli Published online 14.03.2015 FGF22 signaling regulates synapse formation during post‐injury remodeling of the spinal cord FGF22 is a synaptogenic mediator in the adult nervous system and promotes synaptic plasticity and circuit remodeling in a mouse model of spinal cord injury. Anne Jacobi, Kristina Loy, Anja M Schmalz, Mikael Hellsten, Hisashi Umemori, Martin Kerschensteiner, and Florence M Bareyre Published online 12.03.2015 An LXR–NCOA5 gene regulatory complex directs inflammatory crosstalk‐dependent repression of macrophage cholesterol efflux Inflammatory signaling impinges on LXR–NCOA5 dependent mechanisms controlling lipid transporter expression and macrophage cholesterol efflux. Mark A Gillespie, Elizabeth S Gold, Stephen A Ramsey, Irina Podolsky, Alan Aderem, and Jeffrey A Ranish Published online 09.03.2015 Error‐free and mutagenic processing of topoisomerase 1‐provoked damage at genomic ribonucleotides In vitro reconstitution reveals how covalent Top1–DNA complexes formed during removal of misincorporated ribonucleotides can be repaired in either an error‐free or error‐prone manner. Justin L Sparks and Peter M Burgers Published online 16.03.2015 X‐ray and Cryo‐EM structures reveal mutual conformational changes of Kinesin and GTP‐state microtubules upon binding Cryo‐EM and crystal structures of nucleotide‐free KIF5C with and without microtubules reveal their mutual conformational changes, providing insight into the preferential binding of KIF5C to GTP‐state microtubules that is crucial for polarized axonal transport in neurons. Manatsu Morikawa, Hiroaki Yajima, Ryo Nitta, Shigeyuki Inoue, Toshihiko Ogura, Chikara Sato, and Nobutaka Hirokawa Published online 16.03.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.