Scientific Reports Biology Table of Contents e-alert: 12 May 2015

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12 May 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports       Nature Genetics in association with the Wellcome Trust present: The Genomics of Common Diseases 2015 September 2-5, 2015 | Cambridge, UK Register now!         Biological Sciences               Larynx carcinoma regulates tumor-associated macrophages through PLGF signaling ▶     Xu Zhou, Ying Qi     Cancer neovascularization plays an essential role in the metastasis of larynx carcinoma (LC). However, the underlying molecular mechanisms are not completely understood. …             Targeting blood thrombogenicity precipitates atherothrombotic events in a mouse model of plaque destabilization ▶     Xiaoling Liu, Mei Ni, Lianyue Ma et al.     Although some features of plaque instability can be observed in genetically modified mouse models, atherothrombosis induction in mice has been attested to be difficult. We sought …             K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy ▶     Joao Vasco Ferreira, Ana Rosa Soares, Jose Silva Ramalho et al.     Chaperone-Mediated Autophagy is a selective form of autophagy. Recently, the degradation of a newly identified CMA substrate, the HIF1A transcription factor, was found to be …             Identification of enzymes involved in SUMOylation in Trypanosoma brucei ▶     Kaiqin Ye, Xuecheng Zhang, Jun Ni et al.     Small ubiquitin-like modifier (SUMO), a reversible post-translational protein modifier, plays important roles in diverse cellular mechanisms. Three enzymes, E1 (activating …             Four-pole galvanic vestibular stimulation causes body sway about three axes ▶     Kazuma Aoyama, Hiroyuki Iizuka, Hideyuki Ando et al.     Galvanic vestibular stimulation (GVS) can be applied to induce the feeling of directional virtual head motion by stimulating the vestibular organs electrically. Conventional …             Capturing the embryonic stages of self-assembly - design rules for molecular computation ▶     Peter N. Nirmalraj, Damien Thompson, Heike E. Riel     The drive towards organic computing is gaining momentum. Interestingly, the building blocks for such architectures is based on molecular ensembles extending from nucleic acids to …             lncRNA GAS5 enhances G1 cell cycle arrest via binding to YBX1 to regulate p21 expression in stomach cancer ▶     Yongchao Liu, Jing Zhao, Wenhong Zhang et al.     Long non-coding RNAs (lncRNAs), which have evolved as important gene expression modulators, are involved in human malignancies. The down-regulation of lncRNA growth arrest …             Hypermethylated Epidermal growth factor receptor (EGFR) promoter is associated with gastric cancer ▶     Xiaoling Weng, Hong Zhang, Junyi Ye et al.     Epidermal growth factor receptor (EGFR) is a member of the receptor tyrosine kinases ErbB family and it is found to be overexpressed in gastric cancer. However, the mechanism of …             A Controllable Aptamer-Based Self-Assembled DNA Dendrimer for High Affinity Targeting, Bioimaging and Drug Delivery ▶     Huimin Zhang, Yanli Ma, Yi Xie et al.     Targeted drug delivery is important in cancer therapy to decrease the systemic toxicity resulting from nonspecific drug distribution and to enhance drug delivery efficiency. We …             Velvet-mediated repression of β-glucan synthesis in Aspergillus nidulans spores ▶     Hee-Soo Park, Yeong Man Yu, Mi-Kyung Lee et al.     Beta-glucans are a heterologous group of fibrous glucose polymers that are a major constituent of cell walls in Ascomycetes and Basidiomycetes fungi. Synthesis of β (1,3)- and …             The transgenic cloned pig population with integrated and controllable GH expression that has higher feed efficiency and meat production ▶     Huiming Ju, Jiaqing Zhang, Lijing Bai et al.     Sustained expression of the GH gene has been shown to have detrimental effects on the health of animals. In the current study, transgenic founder pigs, with controllable pig …             Three-Dimensional Image of Cleavage Bodies in Nuclei Is Configured Using Gas Cluster Ion Beam with Time-of-Flight Secondary Ion Mass Spectrometry ▶     Noritaka Masaki, Itsuko Ishizaki, Takahiro Hayasaka et al.     Structural variations of DNA in nuclei are deeply related with development, aging, and diseases through transcriptional regulation. In order to bare cross sections of samples …             Variation in koala microbiomes within and between individuals: effect of body region and captivity status ▶     Niccoló Alfano, Alexandre Courtiol, Hanna Vielgrader et al.     Metagenomic analysis of 16S ribosomal RNA has been used to profile microbial communities at high resolution, and to examine their association with host diet or diseases. We …             Generic amyloidogenicity of mammalian prion proteins from species susceptible and resistant to prions ▶     Sofie Nyström, Per Hammarström     Prion diseases are lethal, infectious diseases associated with prion protein (PrP) misfolding. A large number of mammals are susceptible to both sporadic and acquired prion …             A small, microRNA-size, ribonucleic acid regulating gene expression and development of Shiga toxin-converting bacteriophage Φ24Β ▶     Bożena Nejman-Faleńczyk, Sylwia Bloch, Katarzyna Licznerska et al.     A microRNA-size (20-nt long) molecule has been identified in Escherichia coli after induction of Shiga toxin-converting bacteriophage Φ24B. This small RNA, named 24B_1, is …             Biodegradable CSMA/PECA/Graphene Porous Hybrid Scaffold for Cartilage Tissue Engineering ▶     JinFeng Liao, Ying Qu, BingYang Chu et al.     Owing to the limited repair capacity of articular cartilage, it is essential to develop tissue-engineered cartilage for patients suffering from joint disease and trauma. Herein, …             Osteogenic Embryoid Body-Derived Material Induces Bone Formation In Vivo ▶     Ken Sutha, Zvi Schwartz, Yun Wang et al.     The progressive loss of endogenous regenerative capacity that accompanies mammalian aging has been attributed at least in part to alterations in the extracellular matrix (ECM) …             Comprehensive analysis of the T-cell receptor beta chain gene in rhesus monkey by high throughput sequencing ▶     Zhoufang Li, Guangjie Liu, Yin Tong et al.     Profiling immune repertoires by high throughput sequencing enhances our understanding of immune system complexity and immune-related diseases in humans. Previously, cloning and …             Identification of differentially expressed genes related to aphid resistance in cucumber (Cucumis sativus L.) ▶     Danna Liang, Min Liu, Qijing Hu et al.     Cucumber, a very important vegetable crop worldwide, is easily damaged by pests. Aphids (Aphis gossypii Glover) are among the most serious pests in cucumber production and often …             Tubulin structure-based drug design for the development of novel 4β-sulfur-substituted podophyllum tubulin inhibitors with anti-tumor activity ▶     Wei Zhao, Jia-Ke Bai, Hong-Mei Li et al.     The well-characterized anti-tubulin agent, podophyllotoxin (PTOX), with the 4′-position methoxyl group, targets the colchicines domain located between α- and β-tubulin. Two …             A novel caspase 8 selective small molecule potentiates TRAIL-induced cell death ▶     Octavian Bucur, Gabriel Gaidos, Achani Yatawara et al.     Recombinant soluble TRAIL and agonistic antibodies against TRAIL receptors (DR4 and DR5) are currently being created for clinical cancer therapy, due to their selective killing …             Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases ▶     Lun Zhang, Jian-Chuan Wang, Li Hou et al.     The His-x-Asp (HxD) motif is one of the most conserved structural components of the catalytic core of protein kinases; however, the functional role of the conserved histidine is …             A peptide N-terminal protection strategy for comprehensive glycoproteome analysis using hydrazide chemistry based method ▶     Junfeng Huang, Hongqiang Qin, Zhen Sun et al.     Enrichment of glycopeptides by hydrazide chemistry (HC) is a popular method for glycoproteomics analysis. However, possible side reactions of peptide backbones during the glycan …             Evaluation and integration of cancer gene classifiers: identification and ranking of plausible drivers ▶     Yang Liu, Feng Tian, Zhenjun Hu et al.     The number of mutated genes in cancer cells is far larger than the number of mutations that drive cancer. The difficulty this creates for identifying relevant alterations has …             Structure and mechanism of an antibiotics-synthesizing 3-hydroxykynurenine C-methyltransferase ▶     Sheng-Chia Chen, Chi-Hung Huang, Shu-Jung Lai et al.     Streptosporangium sibiricum SibL catalyzes the methyl transfer from S-adenosylmethionine (SAM) to 3-hydroxykynurenine (3-HK) to produce S-adenosylhomocysteine (SAH) and …             Tissue spray ionization mass spectrometry for rapid recognition of human lung squamous cell carcinoma ▶     Yiping Wei, Liru Chen, Wei Zhou et al.     Tissue spray ionization mass spectrometry (TSI-MS) directly on small tissue samples has been shown to provide highly specific molecular information. In this study, we apply this …             Targets of drugs are generally, and targets of drugs having side effects are specifically good spreaders of human interactome perturbations ▶     Áron R. Perez-Lopez, Kristóf Z. Szalay, Dénes Türei et al.     Network-based methods are playing an increasingly important role in drug design. Our main question in this paper was whether the efficiency of drug target proteins to spread …             Interactional synchrony in chimpanzees: Examination through a finger-tapping experiment ▶     Lira Yu, Masaki Tomonaga     Humans often unconsciously coordinate behaviour with that of others in daily life. This interpersonal coordination, including mimicry and interactional synchrony, has been …             CART treatment improves memory and synaptic structure in APP/PS1 mice ▶     Jia-li Jin, Anthony K.F. Liou, Yejie Shi et al.     Major characteristics of Alzheimer’s disease (AD) include deposits of β-amyloid (Aβ) peptide in the brain, loss of synapses, and cognitive dysfunction. Cocaine- and …             The T cell receptor resides in ordered plasma membrane nanodomains that aggregate upon patching of the receptor ▶     Jelena Dinic, Astrid Riehl, Jeremy Adler et al.     Two related models for T cell signalling initiation suggest either that T cell receptor (TCR) engagement leads to its recruitment to ordered membrane domains, often referred to …             Toxin acidic residue evolutionary function-guided design of de novo peptide drugs for the immunotherapeutic target, the Kv1.3 channel ▶     Zongyun Chen, Youtian Hu, Jing Hong et al.     During the long-term evolution of animal toxins acting on potassium channels, the acidic residues can orientate the toxin binding interfaces by adjusting the molecular polarity. …             Maternal salt and fat intake causes hypertension and sustained endothelial dysfunction in fetal, weanling and adult male resistance vessels ▶     Clint Gray, Claudia J. Harrison, Stephanie A. Segovia et al.     Maternal salt and fat intake can independently programme adult cardiovascular status, increasing risk of cardiovascular disease in offspring. Despite its relevance to modern …             BRET evidence that β2 adrenergic receptors do not oligomerize in cells ▶     Tien-Hung Lan, Qiuju Liu, Chunman Li et al.     Bioluminescence resonance energy transfer (BRET) is often used to study association of membrane proteins, and in particular oligomerization of G protein-coupled receptors …             BMP7 and EREG Contribute to the Inductive Potential of Dental Mesenchyme ▶     Bo Gao, Xin Zhou, Xuedong Zhou et al.     Odontogenesis is accomplished by reciprocal signaling between the epithelial and mesenchymal compartments. It is generally accepted that the inductive mesenchyme is capable of …             Transcriptional control of fungal cell cycle and cellular events by Fkh2, a forkhead transcription factor in an insect pathogen ▶     Juan-Juan Wang, Lei Qiu, Qing Cai et al.     Transcriptional control of the cell cycle by forkhead (Fkh) transcription factors is likely associated with fungal adaptation to host and environment. Here we show that Fkh2, an …             Deletion of the Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity ▶     Hiroya Ohta, Morichika Konishi, Yusuke Kobayashi et al.     Some neurotrophic factors, which are potent regulators of neuronal development and function, have recently been implicated in the control of energy balance by increasing energy …             Selectivity Mechanism of the Voltage-gated Proton Channel, HV1 ▶     Todor Dudev, Boris Musset, Deri Morgan et al.     Voltage-gated proton channels, HV1, trigger bioluminescence in dinoflagellates, enable calcification in coccolithophores, and play multifarious roles in human health. Because the …             The Relationship Between Altered Mitochondrial DNA Copy Number And Cancer Risk: A Meta-Analysis ▶     Jia Mi, Geng Tian, Shuang Liu et al.     Currently, a comprehensive assessment between mitochondrial DNA (mtDNA) content and cancer risk is lacking. We designed this meta-analysis to test the hypothesis that altered …             Characterization and Modeling of Nonfilamentary Ta/TaOx/TiO2/Ti Analog Synaptic Device ▶     Yu-Fen Wang, Yen-Chuan Lin, I-Ting Wang et al.     A two-terminal analog synaptic device that precisely emulates biological synaptic features is expected to be a critical component for future hardware-based neuromorphic …             Post-transcriptional inactivation of matrix metalloproteinase-12 after focal cerebral ischemia attenuates brain damage ▶     Bharath Chelluboina, Aditi Warhekar, Matt Dillard et al.     This study highlights the possible pathological role of MMP-12 in the context of ischemic stroke. Male rats were subjected to a two-hour middle cerebral artery occlusion (MCAO) …             Female rule in lemurs is ancestral and hormonally mediated ▶     Joseph M. A. Petty, Christine M. Drea     Female social dominance (FSD) over males is unusual in mammals, yet characterizes most Malagasy lemurs, which represent almost 30% of all primates. Despite its prevalence in this …             The Function of the Alula in Avian Flight ▶     Sang-im Lee, Jooha Kim, Hyungmin Park et al.     The alula is a small structure located at the joint between the hand-wing and arm-wing of birds and is known to be used in slow flight with high angles of attack such as landing. …             A seed mixture increases dominance of resistance to Bt cotton in Helicoverpa zea ▶     Thierry Brévault, Bruce E. Tabashnik, Yves Carrière     Widely grown transgenic crops producing insecticidal proteins from Bacillus thuringiensis (Bt) can benefit agriculture, but adaptation by pests threatens their continued success. …             Role of RNase H1 in DNA repair: removal of single ribonucleotide misincorporated into DNA in collaboration with RNase H2 ▶     Elias Tannous, Eiko Kanaya, Shigenori Kanaya     Several RNases H1 cleave the RNA-DNA junction of Okazaki fragment-like RNA-DNA/DNA substrate. This activity, termed 3’-junction ribonuclease (3’-JRNase) activity, is different …             Different strategies, but indifferent strategy adaptation during action cascading ▶     Moritz Mückschel, Ann-Kathrin Stock, Christian Beste     Every day, we need to apply different action control strategies to successfully interact with ever-changing environments. In situations requiring several responses, we often have …             Metastatic breast cancer cells in lymph nodes increase nodal collagen density ▶     Asif Rizwan, Camille Bulte, Anusha Kalaichelvan et al.     The most life-threatening aspect of breast cancer is the occurrence of metastatic disease. The tumor draining lymph nodes typically are the first sites of metastasis in breast …             Niche divergence accelerates evolution in Asian endemic Procapra gazelles ▶     Junhua Hu, Zhigang Jiang, Jing Chen et al.     Ecological niche divergence and adaptation to new environments are thought to play important roles in driving speciation. Whether recently evolved species show evidence for niche …             Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking ▶     Margherita Brindisi, Simone Brogi, Nicola Relitti et al.     Leishmaniasis is a neglected vector-born disease caused by a protozoan of the genus Leishmania and affecting more than 1.300.000 people worldwide. The couple …             A novel and rapid method for obtaining high titre intact prion strains from mammalian brain ▶     Adam Wenborn, Cassandra Terry, Nathalie Gros et al.     Mammalian prions exist as multiple strains which produce characteristic and highly reproducible phenotypes in defined hosts. How this strain diversity is encoded by a …             An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging ▶     Matteo Cornaglia, Laurent Mouchiroud, Alexis Marette et al.     Studies of the real-time dynamics of embryonic development require a gentle embryo handling method, the possibility of long-term live imaging during the complete embryogenesis, …             Derivation and characterization of human embryonic stem cells on human amnion epithelial cells ▶     Dongmei Lai, Yongwei Wang, Jian Sun et al.     Culture conditions that support the growth of undifferentiated human embryonic stem cells (hESCs) have already been established using primary human amnion epithelial cells …             Dual-color dual-focus line-scanning FCS for quantitative analysis of receptor-ligand interactions in living specimens ▶     René M. Dörlich, Qing Chen, Per Niklas Hedde et al.     Cellular communication in multi-cellular organisms is mediated to a large extent by a multitude of cell-surface receptors that bind specific ligands. An in-depth understanding of …             Ca-Mediated Electroformation of Cell-Sized Lipid Vesicles ▶     Fei Tao, Peng Yang     Cell-sized lipid giant unilamellar vesicles (GUVs) are formed when lipid molecules self-assemble to construct a single bilayer compartment with similar morphology to living cells. …             The spinning apparatus of webspinners – functional-morphology, morphometrics and spinning behaviour ▶     Sebastian Büsse, Thomas Hörnschemeyer, Kyle Hohu et al.     Webspinners (Insecta: Embioptera) have a distinctly unique behaviour with related morphological characteristics. Producing silk with the basitarsomeres of their forelegs plays a …             Single-cell evaluation of red blood cell bio-mechanical and nano-structural alterations upon chemically induced oxidative stress ▶     Ameya Sinha, Trang T. T. Chu, Ming Dao et al.     Erythroid cells, specifically red blood cells (RBCs), are constantly exposed to highly reactive radicals during cellular gaseous exchange. Such exposure often exceeds the cells' …             Thermally induced collision of droplets in an immiscible outer fluid ▶     Ashkan Davanlou, Ranganathan Kumar     Micro-total analysis systems (μTAS) have attracted wide attention and are identified as a promising solution for sample transport, filtration, chemical reactions, separation and …             Circadian variations of clock gene Per2 and cell cycle genes in different stages of carcinogenesis in golden hamster buccal mucosa ▶     Xue-Mei Tan, Hua Ye, Kai Yang et al.     Previous studies have suggested that the expression of clock genes have circadian rhythms, and many cell cycle genes are regulated by clock genes. The disruption of circadian …             Blind Depth-variant Deconvolution of 3D Data in Wide-field Fluorescence Microscopy ▶     Boyoung Kim, Takeshi Naemura     This paper proposes a new deconvolution method for 3D fluorescence wide-field microscopy. Most previous methods are insufficient in terms of restoring a 3D cell structure, since a …             A versatile clearing agent for multi-modal brain imaging ▶     Irene Costantini, Jean-Pierre Ghobril, Antonino Paolo Di Giovanna et al.     Extensive mapping of neuronal connections in the central nervous system requires high-throughput µm-scale imaging of large volumes. In recent years, different approaches have been …             Antimicrobial nano-silver non-woven polyethylene terephthalate fabric via an atmospheric pressure plasma deposition process ▶     Xiaolong Deng, Anton Yu Nikiforov, Tom Coenye et al.     An antimicrobial nano-silver non-woven polyethylene terephthalate (PET) fabric has been prepared in a three step process. The fabrics were first pretreated by depositing a layer …             Vascular plant abundance and diversity in an alpine heath under observed and simulated global change ▶     Juha M. Alatalo, Chelsea J. Little, Annika K. Jägerbrand et al.     Global change is predicted to cause shifts in species distributions and biodiversity in arctic tundra. We applied factorial warming and nutrient manipulation to a nutrient and …             A Tale of Two Hyper-diversities: Diversification dynamics of the two largest families of lichenized fungi ▶     Ekaphan Kraichak, Pradeep K. Divakar, Ana Crespo et al.     Renewed interests in macroevolutionary dynamics have led to the proliferation of studies on diversification processes in large taxonomic groups, such as angiosperms, mammals, and …             Journey of water in pine cones ▶     Kahye Song, Eunseop Yeom, Seung-Jun Seo et al.     Pine cones fold their scales when it rains to prevent seeds from short-distance dispersal. Given that the scales of pine cones consist of nothing but dead cells, this folding …             The proportion of genes in a functional category is linked to mass-specific metabolic rate and lifespan ▶     Kazuhiro Takemoto, Yuko Kawakami     Metabolic rate and lifespan are important biological parameters that are studied in a wide range of research fields. They are known to correlate with body mass, but their …             Local adaptation of Gymnocypris przewalskii (Cyprinidae) on the Tibetan Plateau ▶     Renyi Zhang, Arne Ludwig, Cunfang Zhang et al.     Divergent selection among environments affects species distributions and can lead to speciation. In this article, we investigated the transcriptomes of two ecotypes of scaleless …             Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein ▶     Nobumi Suzuki, Naoko Murata-Kamiya, Kohei Yanagiya et al.     Helicobacter pylori cagA-positive strain delivers the CagA oncoprotein into gastric epithelial cells and at the same time elicits stomach inflammation. To experimentally …             Genetic Architecture of Micro-Environmental Plasticity in Drosophila melanogaster ▶     Fabio Morgante, Peter Sørensen, Daniel A. Sorensen et al.     Individuals of the same genotype do not have the same phenotype for quantitative traits when reared under common macro-environmental conditions, a phenomenon called …             Clathrin inhibitor Pitstop-2 disrupts the nuclear pore complex permeability barrier ▶     Ivan Liashkovich, Dzmitry Pasrednik, Valeria Prystopiuk et al.     Existence of a selective nucleocytoplasmic permeability barrier is attributed to Phenylalanine-Glycine rich proteins (FG-nups) within the central channel of the nuclear pore …             Developmentally dynamic genome: Evidence of genetic influences on increases and decreases in conduct problems from early childhood to adolescence ▶     Jean-Baptiste Pingault, Frühling Rijsdijk, Yao Zheng et al.     The development of conduct problems in childhood and adolescence is associated with adverse long-term outcomes, including psychiatric morbidity. Although genes constitute a …             Spying on small wildlife sounds using affordable collar-mounted miniature microphones: an innovative method to record individual daylong vocalisations in chipmunks ▶     Charline Couchoux, Maxime Aubert, Dany Garant et al.     Technological advances can greatly benefit the scientific community by making new areas of research accessible. The study of animal vocal communication, in particular, can gain …             Dynamic evolution and biogenesis of small RNAs during sex reversal ▶     Jie Liu, Majing Luo, Yue Sheng et al.     Understanding origin, evolution and functions of small RNA (sRNA) genes has been a great challenge in the past decade. Molecular mechanisms underlying sexual reversal in …             Reduced erythrocyte susceptibility and increased host clearance of young parasites slows Plasmodium growth in a murine model of severe malaria ▶     David S. Khoury, Deborah Cromer, Shannon E. Best et al.     The best correlate of malaria severity in human Plasmodium falciparum (Pf) infection is the total parasite load. Pf-infected humans could control parasite loads by two mechanisms, …             A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice ▶     Wei Chen, Rong Gao, Xinni Xie et al.     Exercise can increase peroxisome proliferator-activated receptor-δ (PPARδ) expression in skeletal muscle. PPARδ regulates muscle metabolism and reprograms muscle fibre types to …             An odor detection system based on automatically trained mice by relative go no-go olfactory operant conditioning ▶     Jing He, JingKuan Wei, Joshua D. Rizak et al.     Odor detection applications are needed by human societies in various circumstances. Rodent offers unique advantages in developing biologic odor detection systems. This report …             BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells ▶     Emma K Baker, Scott Taylor, Ankita Gupte et al.     Osteosarcoma (OS) survival rates have plateaued in part due to a lack of new therapeutic options. Here we demonstrate that bromodomain inhibitors (BETi), JQ1, I-BET151, I-BET762, …             Ozone-induced stomatal sluggishness changes carbon and water balance of temperate deciduous forests ▶     Yasutomo Hoshika, Genki Katata, Makoto Deushi et al.     Tropospheric ozone concentrations have increased by 60–100% in the Northern Hemisphere since the 19th century. The phytotoxic nature of ozone can impair forest productivity. In …             Genome-wide characterization and expression profiling of immune genes in the diamondback moth, Plutella xylostella (L.) ▶     Xiaofeng Xia, Liying Yu, Minqian Xue et al.     The diamondback moth, Plutella xylostella (L.), is a destructive pest that attacks cruciferous crops worldwide. Immune responses are important for interactions between insects …             Design, Synthesis and Inhibitory Activity of Photoswitchable RET Kinase Inhibitors ▶     Rubén Ferreira, Jesper R. Nilsson, Carlos Solano et al.     REarranged during Transfection (RET) is a transmembrane receptor tyrosine kinase required for normal development and maintenance of neurons of the central and peripheral nervous …             Formation of Poly[d(A-T)2] Specific Z-DNA by a Cationic Porphyrin ▶     Yoon Jung Jang, Changyun Lee, Seog K. Kim     Typical CD spectrum of the right-handed poly[d(A-T)2] was reversed when trans-bis(N-methylpyrimidium-4-yl)diphenyl porphyrin (trans-BMPyP) was bound, suggesting that the helicity …             Homozygosity mapping reveals novel and known mutations in Pakistani families with inherited retinal dystrophies ▶     Muhammad Arif Nadeem Saqib, Konstantinos Nikopoulos, Ehsan Ullah et al.     Inherited retinal dystrophies are phenotypically and genetically heterogeneous. This extensive heterogeneity poses a challenge when performing molecular diagnosis of patients, …             1Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA ▶     Gopinath Krishnan, Nivedita Chatterjee     In the retina, Müller glia is a dominant player of immune response. The HIV-1 transactivator viral protein (Tat) induces production of several neurotoxic cytokines in retinal …             3D Structural Fluctuation of IgG1 Antibody Revealed by Individual Particle Electron Tomography ▶     Xing Zhang, Lei Zhang, Huimin Tong et al.     Commonly used methods for determining protein structure, including X-ray crystallography and single-particle reconstruction, often provide a single and unique three-dimensional …             Differential contribution of frugivorous birds to dispersal patterns of the endangered Chinese yew (Taxus chinensis) ▶     Ning Li, Shu-bo Fang, Xin-hai Li et al.     The contribution of forest generalists and specialists to the dispersal pattern of tree species is not well understood. Specialists are considered low-quality dispersers because …             Resveratrol antibacterial activity against Escherichia coli is mediated by Z-ring formation inhibition via suppression of FtsZ expression ▶     Dahyun Hwang, Young-Hee Lim     Resveratrol exhibits a potent antimicrobial activity. However, the mechanism underlying its antibacterial activity has not been shown. In this study, the antibacterial mechanism …             Repeatability of evolution on epistatic landscapes ▶     Benedikt Bauer, Chaitanya S. Gokhale     Evolution is a dynamic process. The two classical forces of evolution are mutation and selection. Assuming small mutation rates, evolution can be predicted based solely on the …             The Tomato yellow leaf curl virus V2 protein forms aggregates depending on the cytoskeleton integrity and binds viral genomic DNA ▶     Adi Moshe, Eduard Belausov, Annette Niehl et al.     The spread of Tomato yellow leaf curl virus (TYLCV) was accompanied by the formation of coat protein (CP) aggregates of increasing size in the cytoplasm and nucleus of infected …             Systematic optimization of human pluripotent stem cells media using Design of Experiments ▶     Paulo A. Marinho, Thanathom Chailangkarn, Alysson R. Muotri     Human pluripotent stem cells (hPSC) are used to study the early stages of human development in vitro and, increasingly due to somatic cell reprogramming, cellular and molecular …             Ultra-high density intra-specific genetic linkage maps accelerate identification of functionally relevant molecular tags governing important agronomic traits in chickpea ▶     Alice Kujur, Hari D. Upadhyaya, Tanima Shree et al.     We discovered 26785 and 16573 high-quality SNPs differentiating two parental genotypes of a RIL mapping population using reference desi and kabuli genome-based GBS assay. Of …             Tau co-organizes dynamic microtubule and actin networks ▶     Auréliane Elie, Elea Prezel, Christophe Guérin et al.     The crosstalk between microtubules and actin is essential for cellular functions. However, mechanisms underlying the microtubule-actin organization by cross-linkers remain …             Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3β dependent mechanism ▶     Elena Gavilán, Servando Giráldez, Inmaculada Sánchez-Aguayo et al.     Targeting the ubiquitin proteasome pathway has emerged as a rational approach in the treatment of human cancers. Autophagy has been described as a cytoprotective mechanism to …             A Four-Year Follow-up Study of Renal Epithelioid Angiomyolipoma: A Multi-Center Experience and Literature Review ▶     Jun H. Lei, Liang R. Liu, Qiang Wei et al.     In this study, we systematically explored the clinical manifestations, diagnosis, treatment, and prognosis of renal epithelioid angiomyolipoma (EAML) retrospectively by analyzing …             Rice (Oryza sativa L) plantation affects the stability of biochar in paddy soil ▶     Mengxiong Wu, Qibo Feng, Xue Sun et al.     Conversion of rice straw into biochar for soil amendment appears to be a promising method to increase long-term carbon sequestration and reduce greenhouse gas (GHG) emissions. …             Macro-to-micro cortical vascular imaging underlies regional differences in ischemic brain ▶     Suzan Dziennis, Jia Qin, Lei Shi et al.     The ability to non-invasively monitor and quantify hemodynamic responses down to the capillary level is important for improved diagnosis, treatment and management of …             Ecological impacts of large-scale disposal of mining waste in the deep sea ▶     David J. Hughes, Tracy M. Shimmield, Kenneth D. Black et al.     Deep-Sea Tailings Placement (DSTP) from terrestrial mines is one of several large-scale industrial activities now taking place in the deep sea. The scale and persistence of its …             Temporal perception deficits in schizophrenia: integration is the problem, not deployment of attentions ▶     Li Su, Brad Wyble, Lai-quan Zhou et al.     Patients with schizophrenia are known to have impairments in sensory processing. 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