Nature Communications - 13 May 2015

Advertisement Help PNAS celebrate its 100th anniversary! Visit the PNAS 100th Anniversary Portal for commentaries, perspectives, special features, and more celebrating 100 years of service to science and society.  http://pnas100th.org     Weekly Content Alert Nature Communications is now fully open access. Read more. 13 May 2015  Featured image: Shao et al. present a microfluidic device for isolation of glioblastoma-specific exosomes from patient blood for prediction of therapy effectiveness. Latest content: Articles Corrigendum Errata Journal homepage Recommend to library Web feed   Advertisement Celebrating the 25th Anniversary of SELEX: An Aptamer Symposium Supported by the American Society of Gene & Cell Therapy, the Aptamers Workshop will provide a unique opportunity to celebrate the 25th anniversary of aptamers and to meet researchers around the world developing nucleic acid aptamers as high affinity targeting reagents for both diagnosis and therapy. Find out more: www.asgct.org/am15/     Nature Communications - now fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Articles View all Articles     Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier OPEN Kristina E. Froud, Ann Chi Yan Wong, Jennie M. E. Cederholm, Matthias Klugmann, Shaun L. Sandow, Jean-Pierre Julien, Allen F. Ryan and Gary D. Housley The medial olivocochlear efferent reflex regulates cochlear outer hair cell-based amplification of sound energy. Here the authors show this dynamic control of hearing sensitivity is driven by sensory input from the outer hair cells and their type II spiral ganglion neuron innervation. 12 May 2015 | doi: 10.1038/ncomms8115 Biological Sciences  Neuroscience  Widespread seasonal gene expression reveals annual differences in human immunity and physiology OPEN Xaquin Castro Dopico, Marina Evangelou, Ricardo C. Ferreira, Hui Guo, Marcin L. Pekalski, Deborah J. Smyth, Nicholas Cooper, Oliver S. Burren, Anthony J. Fulford, Branwen J. Hennig, Andrew M. Prentice, Anette-G. Ziegler, Ezio Bonifacio, Chris Wallace and John A. Todd Infectious and chronic diseases display seasonal patterns, yet seasonal changes in physiology are rarely thought to affect human health. Here the authors show seasonal variation in all major blood cells and in gene and protein expression in diverse tissues, suggesting a mechanism for seasonal disease proneness and physiology. 12 May 2015 | doi: 10.1038/ncomms8000 Biological Sciences  Genetics  Medical research  Interplay between enterobactin, myeloperoxidase and lipocalin 2 regulates E. coli survival in the inflamed gut Vishal Singh, Beng San Yeoh, Xia Xiao, Manish Kumar, Michael Bachman, Niels Borregaard, Bina Joe and Matam Vijay-Kumar Gut inflammation triggers a bloom of certain resident bacteria such as E. coli that can contribute to disease. Here, Singh et al. show that a siderophore produced by E. coli inhibits the antibacterial activity of host myeloperoxidase and enhances bacterial survival in the gut of lab mice. 12 May 2015 | doi: 10.1038/ncomms8113 Biological Sciences  Biochemistry  Immunology  Microbiology  Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2 Hyun-Jung Choi, Haiying Zhang, Hongryeol Park, Kyu-Sung Choi, Heon-Woo Lee, Vijayendra Agrawal, Young-Myeong Kim and Young-Guen Kwon Angiogenesis is regulated by dynamic changes in endothelial cell contact. Here, the authors show that signals from endothelial cell junctions affect the subcellular localization and function of Yes-associated protein, ultimately modifying angiopoietin-2 expression and angiogenic activity of endothelial cells. 12 May 2015 | doi: 10.1038/ncomms7943 Biological Sciences  Cell biology  Developmental biology  Anammox Planctomycetes have a peptidoglycan cell wall OPEN Muriel C.F. van Teeseling, Rob J. Mesman, Erkin Kuru, Akbar Espaillat, Felipe Cava, Yves V. Brun, Michael S. VanNieuwenhze, Boran Kartal and Laura van Niftrik Planctomycetes are unusual bacteria with complex intracellular compartments and an apparent lack of peptidoglycan in their cell walls. Here, van Teeseling et al. show that the cell wall of an anammox planctomycete does contain peptidoglycan, and propose to redefine planctomycetes as Gram-negative bacteria. 12 May 2015 | doi: 10.1038/ncomms7878 Biological Sciences  Cell biology  Microbiology  Climate variability modulates western US ozone air quality in spring via deep stratospheric intrusions OPEN Meiyun Lin, Arlene M. Fiore, Larry W. Horowitz, Andrew O. Langford, Samuel J. Oltmans, David Tarasick and Harald E. Rieder Deep stratospheric ozone intrusions can elevate western US ground-level ozone to unhealthy concentrations, but the factors driving interannual variability are poorly understood. Here, the authors combine observations and numerical simulations showing a link between intrusion events and strong La Niña winters. 12 May 2015 | doi: 10.1038/ncomms8105 Earth Sciences  Atmospheric science  Climate science  Conformational rearrangements in the transmembrane domain of CNGA1 channels revealed by single-molecule force spectroscopy OPEN Sourav Maity, Monica Mazzolini, Manuel Arcangeletti, Alejandro Valbuena, Paolo Fabris, Marco Lazzarino and Vincent Torre Cyclic nucleotide gated channels are activated after binding cyclic nucleotides. Here, using single molecule force spectroscopy, the authors reveal that cyclic nucleotide binding causes conformational changes and tighter coupling of the S4 helix to the pore forming domain. 12 May 2015 | doi: 10.1038/ncomms8093 Biological Sciences  Biophysics  MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis Wen Pan, Shu Zhu, Dai Dai, Zheng Liu, Dan Li, Bin Li, Nicola Gagliani, Yunjiang Zheng, Yuanjia Tang, Matthew T. Weirauch, Xiaoting Chen, Wei Zhu, Yue Wang, Bo Chen, Youcun Qian, Yingxuan Chen, Jingyuan Fang, Ronald Herbst, Laura Richman, Bahija Jallal et al. Compromised function of regulatory T cells can lead to autoimmunity. Here the authors show that miR-125a stabilizes regulatory T-cell function and is downregulated in lupus and Crohn’s disease, as well as autoimmune mouse models, and that a chemical miR-125a analogue reverts established disease in a mouse model of multiple sclerosis. 12 May 2015 | doi: 10.1038/ncomms8096 Biological Sciences  Immunology  The structure of FMNL2–Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation OPEN Sonja Kühn, Constanze Erdmann, Frieda Kage, Jennifer Block, Lisa Schwenkmezger, Anika Steffen, Klemens Rottner and Matthias Geyer FMNL formins polymerize actin filaments to generate cellular protrusions such as lamellipodia and filopodia at the leading edge of a cell. Here the authors provide detailed mechanistic insights into the formation of actin-based protrusions through GTPase dependent activation and membrane localization of FMNL1 and FMNL2. 12 May 2015 | doi: 10.1038/ncomms8088 Biological Sciences  Biophysics  Cell biology  CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis OPEN Qi-Quan Huang, Harris Perlman, Robert Birkett, Renee Doyle, Deyu Fang, G. Kenneth Haines, William Robinson, Syamal Datta, Zan Huang, Quan-Zhen Li, Hyewon Phee and Richard M. Pope Dendritic cells are critical for initiation of immune responses and for induction of tolerance. Here the authors show that deletion of survival factor c-flip in CD11c-expressing cells subset perturbs CD8a+ dendritic cell, NK and macrophage pools, and leads to development of autoimmune arthritis. 12 May 2015 | doi: 10.1038/ncomms8086 Biological Sciences  Immunology  FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization InSug O-Sullivan, Wenwei Zhang, David H. Wasserman, Chong Wee Liew, Jonathan Liu, Jihye Paik, Ronald A. DePinho, Donna Beer Stolz, C. Ronald Kahn, Michael W. Schwartz and Terry G. Unterman Insulin and the transcription factor FoxO1 are key regulators of glucose metabolism. Using mice that lack insulin receptor and FoxO1 in the liver, O-Sullivan et al. show that extrahepatic effects of insulin are sufficient to maintain glucose homeostasis when hepatic FoxO1 is disrupted. 12 May 2015 | doi: 10.1038/ncomms8079 Biological Sciences  Medical research  External stimulation-controllable heat-storage ceramics OPEN Hiroko Tokoro, Marie Yoshikiyo, Kenta Imoto, Asuka Namai, Tomomichi Nasu, Kosuke Nakagawa, Noriaki Ozaki, Fumiyoshi Hakoe, Kenji Tanaka, Kouji Chiba, Rie Makiura, Kosmas Prassides and Shin-ichi Ohkoshi Materials that can store and release heat on demand are of use for energy storage applications. Here, the authors discover a ceramic material that can reversibly store energy from heat, light or electricity and release this energy as heat through the application of pressure. 12 May 2015 | doi: 10.1038/ncomms8037 Physical Sciences  Materials science  Physical chemistry  High-speed multiple-mode mass-sensing resolves dynamic nanoscale mass distributions OPEN Selim Olcum, Nathan Cermak, Steven C. Wasserman and Scott R. Manalis Nanomechanical resonators are sensitive to tiny changes in their mass. Here, the authors demonstrate a method for quickly measuring many resonator modes and use it to analyse the mass and position of multiple nanoparticles flowing in a fluid channel with a precision of 40 attograms and 150 nm, respectively. 12 May 2015 | doi: 10.1038/ncomms8070 Physical Sciences  Applied physics  Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo Paul M. Titchenell, Qingwei Chu, Bobby R. Monks and Morris J. Birnbaum Insulin and the transcription factor FoxO1 are key regulators of hepatic glucose metabolism. Here, Titchenell et al. provide evidence for the existence of an insulin-dependent extrahepatic pathway that is fully capable of regulating hepatic glucose production in the absence of hepatic FoxO1. 12 May 2015 | doi: 10.1038/ncomms8078 Biological Sciences  Medical research  Analysis of opo cis-regulatory landscape uncovers Vsx2 requirement in early eye morphogenesis Ines Gago-Rodrigues, Ana Fernández-Miñán, Joaquin Letelier, Silvia Naranjo, Juan J. Tena, José L. Gómez-Skarmeta and Juan R. Martinez-Morales The transcriptional regulation of morphogenetic effectors during eye development is poorly understood. Here, the authors show that transcription of an endocytosis regulator Opo is crucial for the neural retina development in zebrafish and activated by the interaction of the transcription factor Vsx2 and retinal enhancer H6_10137. 12 May 2015 | doi: 10.1038/ncomms8054 Biological Sciences  Cell biology  Developmental biology  Single-molecule super-resolution imaging of chromosomes and in situ haplotype visualization using Oligopaint FISH probes OPEN Brian J. Beliveau, Alistair N. Boettiger, Maier S. Avendaño, Ralf Jungmann, Ruth B. McCole, Eric F. Joyce, Caroline Kim-Kiselak, Frédéric Bantignies, Chamith Y. Fonseka, Jelena Erceg, Mohammed A. Hannan, Hien G. Hoang, David Colognori, Jeannie T. Lee, William M. Shih, Peng Yin, Xiaowei Zhuang and Chao-ting Wu The spatial organization of the genome within the nucleus impacts many processes. Here the authors combine oligo-based DNA FISH with single-molecule super-resolution microscopy to image single-copy genomic regions and, taking advantage of SNPs, distinguish allelic regions of homologous chromosomes. 12 May 2015 | doi: 10.1038/ncomms8147 Biological Sciences  Cell biology  Genetics  Planctomycetes do possess a peptidoglycan cell wall OPEN Olga Jeske, Margarete Schüler, Peter Schumann, Alexander Schneider, Christian Boedeker, Mareike Jogler, Daniel Bollschweiler, Manfred Rohde, Christoph Mayer, Harald Engelhardt, Stefan Spring and Christian Jogler Planctomycetes appear to differ from all other bacteria in their cellular organization and their apparent lack of a peptidoglycan (PG) cell wall. Here Jeske et al. show that Planctomycetes do possess a typical PG cell wall and that their cellular architecture resembles that of Gram-negative bacteria. 12 May 2015 | doi: 10.1038/ncomms8116 Biological Sciences  Cell biology  Microbiology  Quantification of thickness and wrinkling of exfoliated two-dimensional zeolite nanosheets OPEN Prashant Kumar, Kumar Varoon Agrawal, Michael Tsapatsis and K. Andre Mkhoyan Two-dimensional sheets of zeolites can function as molecular sieves for applications such as membranes or as catalysts. Here, the authors demonstrate a method using electron diffraction patterns to accurately measure the thickness and wrinkles of thin zeolite nanosheets. 11 May 2015 | doi: 10.1038/ncomms8128 Chemical Sciences  Inorganic chemistry  Nanotechnology  Atomistic mechanisms of nonstoichiometry-induced twin boundary structural transformation in titanium dioxide OPEN Rong Sun, Zhongchang Wang, Mitsuhiro Saito, Naoya Shibata and Yuichi Ikuhara Grain boundaries in polycrystalline materials strongly influence their mechanical properties. Here, the authors investigate polycrystalline TiO2 by high-resolution electron microscopy and observe that structural defects form ordered structures at grain boundaries influencing their properties. 11 May 2015 | doi: 10.1038/ncomms8120 Physical Sciences  Materials science  Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain OPEN Vegard Eldholm, Johana Monteserin, Adrien Rieux, Beatriz Lopez, Benjamin Sobkowiak, Viviana Ritacco and Francois Balloux The early origin and evolution of multidrug resistant strains of Mycobacterium tuberculosis are poorly understood. Here, the authors perform genomic and phylogenetic analyses of 252 clinical isolates from a tuberculosis outbreak in Argentina and reconstruct the timeline of the acquisition of antibiotic resistance. 11 May 2015 | doi: 10.1038/ncomms8119 Biological Sciences  Evolution  Genetics  Microbiology  Chirality transfer from gold nanocluster to adsorbate evidenced by vibrational circular dichroism OPEN Igor Dolamic, Birte Varnholt and Thomas Bürgi The transfer of chirality from surfaces to molecular species may have implications in areas from the origin of homochirality to heterogeneous catalysis. Here, the authors show that a chiral gold cluster can transfer its inherent chirality to adsorbed, achiral molecules, causing them to adopt chiral conformations. 11 May 2015 | doi: 10.1038/ncomms8117 Chemical Sciences  Nanotechnology  Physical chemistry  Non-autonomous DAF-16/FOXO activity antagonizes age-related loss of C. elegans germline stem/progenitor cells OPEN Zhao Qin and E. Jane Albert Hubbard The number of germline stem/progenitor cells in C. elegans declines with age. Here the authors show this cell loss is mediated by the transcription factor DAF-16/FOXO acting in specific somatic gonad cells, demonstrating that stem cell aging can be anatomically uncoupled from organismal aging. 11 May 2015 | doi: 10.1038/ncomms8107 Biological Sciences  Medical research  Characterization of genome-wide ordered sequence-tagged Mycobacterium mutant libraries by Cartesian Pooling-Coordinate Sequencing OPEN Kristof Vandewalle, Nele Festjens, Evelyn Plets, Marnik Vuylsteke, Yvan Saeys and Nico Callewaert The generation of characterized panels of specific mutants is an essential but time-consuming step of reverse genetic studies. Here Vandewalle et al. describe CP-CSeq, an easy to implement parallel sequencing method for rapid library construction. 11 May 2015 | doi: 10.1038/ncomms8106 Biological Sciences  Genetics  Microbiology  Evidence for photochemical production of reactive oxygen species in desert soils Christos D. Georgiou, Henry J. Sun, Christopher P. McKay, Konstantinos Grintzalis, Ioannis Papapostolou, Dimitrios Zisimopoulos, Konstantinos Panagiotidis, Gaosen Zhang, Eleni Koutsopoulou, George E. Christidis and Irene Margiolaki Intense solar radiation on desiccated desert soils can cause a short circuit in biogeochemical cycles leading to the release of CO2 and nitrogen oxides. Here, the authors show that this can be linked to the production of soil superoxide radicals, which then produce peroxides and hydroxyl radicals. 11 May 2015 | doi: 10.1038/ncomms8100 Earth Sciences  Biogeochemistry  Structural basis for dynamic mechanism of nitrate/nitrite antiport by NarK OPEN Masahiro Fukuda, Hironori Takeda, Hideaki E. Kato, Shintaro Doki, Koichi Ito, Andrés D. Maturana, Ryuichiro Ishitani and Osamu Nureki Nitrate/nitrite porters (NNP) play a central role in nitrate uptake in archaea, bacteria, fungi and plants. Here, Fukuda et al. use a liposome-based transport assay, X-ray crystallography and molecular dynamics simulation to reveal the dynamic nitrate/nitrite antiport mechanism of a bacterial NNP, NarK. 11 May 2015 | doi: 10.1038/ncomms8097 Biological Sciences  Biochemistry  Biophysics  Oncogenes create a unique landscape of fragile sites Karin Miron, Tamar Golan-Lev, Raz Dvir, Eyal Ben-David and Batsheva Kerem Aberrant oncogene expression can cause replication stress leading to chromosomal breaks. Here the authors map the chromosomal break loci induced by two different oncogenes and by a replication inhibitor, and show that each treatment induces a unique pattern of breaks in the same cell type. 11 May 2015 | doi: 10.1038/ncomms8094 Biological Sciences  Cancer  Genetics  Elucidation of IgH 3′ region regulatory role during class switch recombination via germline deletion Alexis Saintamand, Pauline Rouaud, Faten Saad, Géraldine Rios, Michel Cogné and Yves Denizot The molecular mechanisms of antibody class switching are incompletely understood. Here the authors show by using mice specifically lacking the IgH 3′ regulatory region enhancers that they prime the first steps of the class switch recombination. 11 May 2015 | doi: 10.1038/ncomms8084 Biological Sciences  Immunology  Molecular biology  Active graphene–silicon hybrid diode for terahertz waves OPEN Quan Li, Zhen Tian, Xueqian Zhang, Ranjan Singh, Liangliang Du, Jianqiang Gu, Jiaguang Han and Weili Zhang Graphene has demonstrated the ability to modulate terahertz (THz) waves by optical or electrical excitation, but modulation depths have been low. Here, Li et al. demonstrate enhanced modulation and polarity-dependent THz attenuation using external voltage bias and photoexcitation on a graphene–silicon film. 11 May 2015 | doi: 10.1038/ncomms8082 Physical Sciences  Optical physics  Absence of surrogate light chain results in spontaneous autoreactive germinal centres expanding VH81X-expressing B cells Ola Grimsholm, Weicheng Ren, Angelina I. Bernardi, Haixia Chen, Giljun Park, Alessandro Camponeschi, Dongfeng Chen, Berglind Bergmann, Nina Höök, Sofia Andersson, Anneli Strömberg, Inger Gjertsson, Susanna Cardell, Ulf Yrlid, Alessandra De Riva and Inga-Lill Mårtensson Self-reactive B cells producing autoantibodies are associated with autoimmune conditions. Here, the authors show that in mice lacking the surrogate light chain, which normally assembles with antibody heavy chain to form a pre-B-cell receptor, the autoantibody-producing cells derive from germinal centres. 11 May 2015 | doi: 10.1038/ncomms8077 Biological Sciences  Immunology  Degradation of Ndd1 by APC/CCdh1 generates a feed forward loop that times mitotic protein accumulation Julia Sajman, Drora Zenvirth, Mor Nitzan, Hanah Margalit, Kobi J. Simpson-Lavy, Yuval Reiss, Itamar Cohen, Tommer Ravid and Michael Brandeis Ndd1 activates the transcription of mitotic regulators. Here the authors show that the ubiquitin ligase complex APC/CCdh1 ubiquitinates Ndd1 as well as Ndd1 target genes, creating a feedforward loop that generates an early class of substrates that accumulate at S phase and a late class that accumulate at G2. 11 May 2015 | doi: 10.1038/ncomms8075 Biological Sciences  Cell biology  Tie-mediated signal from apoptotic cells protects stem cells in Drosophila melanogaster Yalan Xing, Tin Tin Su and Hannele Ruohola-Baker Some normal and cancer stem cells are resistant to killing by genotoxins, but the mechanism for this resistance is poorly understood. Here the authors show that adult stem cells in Drosophila melanogaster germline and midgut are resistant to genotoxic stimuli and find that this is mediated by signalling via the receptor tyrosine kinase Tie released from apoptotic cells. 11 May 2015 | doi: 10.1038/ncomms8058 Biological Sciences  Cancer  Cell biology  IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis Petra Krause, Venetia Morris, Jason A. Greenbaum, Yoon Park, Unni Bjoerheden, Zbigniew Mikulski, Tracy Muffley, Jr-Wen Shui, Gisen Kim, Hilde Cheroutre, Yun-Cai Liu, Bjoern Peters, Mitchell Kronenberg and Masako Murai Innate immune responses are regulated in the intestine to prevent excessive inflammation. Here the authors demonstrate a pivotal role for intestinal macrophages that constitutively produce IL-10 in controlling excessive innate immune activation and preventing tissue damage after an acute bacterial infection. 11 May 2015 | doi: 10.1038/ncomms8055 Biological Sciences  Immunology  Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation W. K. Eddie Ip and Ruslan Medzhitov The inflammasomes are multiprotein structures that trigger inflammation in response to diverse stress conditions. Here, Ip and Medzhitov show that the NLRP3 and NLRC4 inflammasomes in macrophages act as sensors of hyperosmotic stress and participate in salt-induced inflammatory responses. 11 May 2015 | doi: 10.1038/ncomms7931 Biological Sciences  Cell biology  Immunology  Theory of Floquet band formation and local pseudospin textures in pump-probe photoemission of graphene M.A. Sentef, M. Claassen, A.F. Kemper, B. Moritz, T. Oka, J.K. Freericks and T.P. Devereaux Condensed matter research has seen prominent recent advances in ultrafast optical manipulation and topological materials. Here, Sentef et al. simulate the development of the photoemission-measured band structure of Floquet states in graphene excited by low-frequency circularly-polarized laser pulses. 11 May 2015 | doi: 10.1038/ncomms8047 Physical Sciences  Condensed matter  Theoretical physics  Cells change their sensitivity to an EGF morphogen gradient to control EGF-induced gene expression OPEN Jeroen Sebastiaan van Zon, Simone Kienle, Guizela Huelsz-Prince, Michalis Barkoulas and Alexander van Oudenaarden How morphogen gradients induce complex gene expression programmes in the receiving cells is poorly understood. Here the authors use a quantitative approach to show that in C. elegans vulva induction cells control morphogen-induced gene expression by changing their sensitivity to the morphogen. 11 May 2015 | doi: 10.1038/ncomms8053 Biological Sciences  Cell biology  Developmental biology  Commissural axonal corridors instruct neuronal migration in the mouse spinal cord Christophe Laumonnerie, Yong Guang Tong, Helena Alstermark and Sara I. Wilson During vertebrate embryogenesis, migration of neuronal cell bodies and axons occurs simultaneously, but to what degree they influence each other’s development remains unclear. Here the authors find that in the mouse spinal cord commissural axons influence neuronal migration in two different ways. 11 May 2015 | doi: 10.1038/ncomms8028 Biological Sciences  Developmental biology  Neuroscience  High-density waveguide superlattices with low crosstalk Weiwei Song, Robert Gatdula, Siamak Abbaslou, Ming Lu, Aaron Stein, Warren Y-C Lai, J. Provine, R. Fabian W. Pease, Demetrios N. Christodoulides and Wei Jiang High-density integration will be vital for silicon photonics, but as we approach sub-wavelength distances between components, the crosstalk becomes intolerable. Here, Song et al. demonstrate waveguide integration at a half-wavelength pitch with low crosstalk using advanced superlattice design concepts. 11 May 2015 | doi: 10.1038/ncomms8027 Physical Sciences  Applied physics  Condensed matter  Optical physics  Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation OPEN Jingdong Cheng, Huirong Yang, Jian Fang, Lixiang Ma, Rui Gong, Ping Wang, Ze Li and Yanhui Xu DNMT1 is a methyl-transferase involved in maintaining tissue-specific patterns of DNA methylation. Here the authors solve the structure of a DNMT1-USP7 complex and demonstrate the mechanism by which DNMT1 stability is regulated through acetylation by preventing association with the deubiquitinase USP7. 11 May 2015 | doi: 10.1038/ncomms8023 Biological Sciences  Biophysics  Molecular biology  RNA structure determination by solid-state NMR spectroscopy OPEN Alexander Marchanka, Bernd Simon, Gerhard Althoff-Ospelt and Teresa Carlomagno The determination of RNA structures within high-molecular weight protein-RNA complexes in non-crystalline state is technically challenging. Here, the authors describe a solid-state NMR protocol for the determination of RNA structures at high resolution. 11 May 2015 | doi: 10.1038/ncomms8024 Biological Sciences  Biophysics  Ubiquity of Kelvin–Helmholtz waves at Earth’s magnetopause OPEN Shiva Kavosi and Joachim Raeder Although magnetic reconnection is recognized as the dominant mode for solar wind plasma to enter the magnetosphere, Kelvin–Helmholtz waves (KHW) have been suggested to also be involved. Here, the authors use 7 years of THEMIS data to show that KHW occur 19% of the time, and may be important for plasma transport. 11 May 2015 | doi: 10.1038/ncomms8019 Earth Sciences  Geology and geophysics  Planetary sciences  Infrared identification of the Criegee intermediates syn- and anti-CH3CHOO, and their distinct conformation-dependent reactivity OPEN Hui-Yu Lin, Yu-Hsuan Huang, Xiaohong Wang, Joel M. Bowman, Yoshifumi Nishimura, Henryk A. Witek and Yuan-Pern Lee Criegee intermediates—formed by the breakdown of alkanes in the atmosphere—are difficult to identify in the gas phase. Here, the authors report the infrared spectrum of the Criegee intermediate CH3CHOO and identify both the syn- and anti-conformers. 11 May 2015 | doi: 10.1038/ncomms8012 Chemical Sciences  Atmospheric science  Atomic and molecular physics  Physical chemistry  Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification OPEN Caroline Mauvezin, Péter Nagy, Gábor Juhász and Thomas P. Neufeld BafilomycinA1 is an autophagy inhibitor, presumably owing to its blocking effect on the lysosomal proton pump V-ATPase. Here the authors show that V-ATPase-deficient lysosomes can still fuse with autophagosomes, showing that lysosomal acidification and fusion are two separable, independent events. 11 May 2015 | doi: 10.1038/ncomms8007 Biological Sciences  Cell biology  TCR ITAM multiplicity is required for the generation of follicular helper T-cells OPEN SuJin Hwang, Amy C. Palin, LiQi Li, Ki-Duk Song, Jan Lee, Jasmin Herz, Noah Tubo, Hamlet Chu, Marion Pepper, Renaud Lesourne, Ekaterina Zvezdova, Julia Pinkhasov, Marc K. Jenkins, Dorian McGavern and Paul E. Love The strength of TCR activation shapes T cell selection and differentiation. Here the authors show by modulating the number of activatory motifs in TCR complex that the strength of TCR signal is critical for the development of some T cell subsets but not for T cell effector functions or repertoire. 11 May 2015 | doi: 10.1038/ncomms7982 Biological Sciences  Immunology  Supramolecular block copolymers by kinetically controlled co-self-assembly of planar and core-twisted perylene bisimides OPEN Daniel Görl, Xin Zhang, Vladimir Stepanenko and Frank Würthner Block co-polymers are becoming of ever-increasing importance in polymer science. Here, the authors show that the co-assembly of two perylene bisimide dyes leads to supramolecular block copolymer structures with a regular alternating sequence of short blocks of respective homoaggregates. 11 May 2015 | doi: 10.1038/ncomms8009 Chemical Sciences  Materials science  Nanotechnology  Organic chemistry  Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma OPEN Huilin Shao, Jaehoon Chung, Kyungheon Lee, Leonora Balaj, Changwook Min, Bob S. Carter, Fred H. Hochberg, Xandra O. Breakefield, Hakho Lee and Ralph Weissleder Predicting and monitoring chemotherapy response remains a challenge for glioma treatment. Here the authors show that a microfluidic device can isolate glioma-derived exosomes from patient blood and accurately determine the levels of mRNA of key enzymes important for chemoresponsiveness. 11 May 2015 | doi: 10.1038/ncomms7999 Biological Sciences  Biotechnology  Cancer  Medical research  Investigation of exotic stable calcium carbides using theory and experiment OPEN Yan-Ling Li, Sheng-Nan Wang, Artem R. Oganov, Huiyang Gou, Jesse S. Smith and Timothy A. Strobel Pressure causes profound changes in the properties of atoms and chemical bonding leading to unusual materials. Here, the authors investigate the Ca-C system and find that it becomes increasingly complex and develops a multitude of phases with various compositions and new structures at higher pressures. 11 May 2015 | doi: 10.1038/ncomms7974 Physical Sciences  Condensed matter  Materials science  Pigment cell movement is not required for generation of Turing patterns in zebrafish skin OPEN D. Bullara and Y. De Decker Pigment pattern formation in zebrafish depends on the interactions between the pigment cells. Here the authors present a mathematical model based on mutual interaction of pigment cells in the absence of cell motion, revising the current model of the pattern formation that relies on reaction–diffusion Turing patterns. 11 May 2015 | doi: 10.1038/ncomms7971 Biological Sciences  Biophysics  Developmental biology  Spatially and temporally resolved gas distributions around heterogeneous catalysts using infrared planar laser-induced fluorescence OPEN Johan Zetterberg, Sara Blomberg, Johan Gustafson, Jonas Evertsson, Jianfeng Zhou, Emma C. Adams, Per-Anders Carlsson, Marcus Aldén and Edvin Lundgren Visualization of the gas distribution around working catalyst is crucial for understanding structure–activity relationships. Here, the authors show that gas distribution can be imaged in situ with high spatial and temporal resolution using infrared planar laser-induced fluorescence. 08 May 2015 | doi: 10.1038/ncomms8076 Chemical Sciences  Catalysis  Physical chemistry  Coupled reversion and stream-hyporheic exchange processes increase environmental persistence of trenbolone metabolites Adam S. Ward, David M. Cwiertny, Edward P. Kolodziej and Colleen C. Brehm Cattle growth hormone metabolites found in agricultural runoff are primarily removed from surface waters by photodegradation. Here, Ward et al. develop a model of stream transport, finding reversion in perpetually dark hyporheic zones increases environmental persistence of these endocrine disruptors. 08 May 2015 | doi: 10.1038/ncomms8067 Earth Sciences  Biogeochemistry  Ecology  Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression OPEN Rosemary C. Bagot, Eric M. Parise, Catherine J. Peña, Hong-Xing Zhang, Ian Maze, Dipesh Chaudhury, Brianna Persaud, Roger Cachope, Carlos A. Bolaños-Guzmán, Joseph Cheer, Karl Deisseroth, Ming-Hu Han and Eric J. Nestler Enhanced glutamatergic transmission in the nucleus accumbens (NAc) has been implicated in the pathophysiology of depression, yet the underlying source is not known. Here, the authors demonstrate a unique role for ventral hippocampal-NAc glutamatergic projections in regulating depression-like behaviour. 08 May 2015 | doi: 10.1038/ncomms8062 Biological Sciences  Neuroscience  Direct observation of finite size effects in chains of antiferromagnetically coupled spins OPEN T. Guidi, B. Gillon, S. A. Mason, E. Garlatti, S. Carretta, P. Santini, A. Stunault, R. Caciuffo, J. van Slageren, B. Klemke, A. Cousson, G. A. Timco and R. E. P. Winpenny Molecular magnets are among the smallest structures that may be exploited for quantum information processing. Here, Guidi et al. use polarized neutron scattering to observe finite size effects and a noncollinear spin arrangement in a Cr8Cd ring molecule, an even-numbered open antiferromagnetic spin-3/2 chain. 08 May 2015 | doi: 10.1038/ncomms8061 Physical Sciences  Applied physics  Condensed matter  Perovskite–fullerene hybrid materials suppress hysteresis in planar diodes OPEN Jixian Xu, Andrei Buin, Alexander H. Ip, Wei Li, Oleksandr Voznyy, Riccardo Comin, Mingjian Yuan, Seokmin Jeon, Zhijun Ning, Jeffrey J. McDowell, Pongsakorn Kanjanaboos, Jon-Paul Sun, Xinzheng Lan, Li Na Quan, Dong Ha Kim, Ian G. Hill, Peter Maksymovych and Edward H. Sargent Metal halide perovskites are promising for solar energy harvesting, but currently prone to a large hysteresis and current instability. Here, Xu et al. show improvements in a hybrid material in which the fullerene is distributed at perovskite grain boundaries and thus passivates defects effectively. 08 May 2015 | doi: 10.1038/ncomms8081 Physical Sciences  Condensed matter  Materials science  Nanotechnology  Clk post-transcriptional control denoises circadian transcription both temporally and spatially Immanuel Lerner, Osnat Bartok, Victoria Wolfson, Jerome S. Menet, Uri Weissbein, Shaked Afik, Daniel Haimovich, Chen Gafni, Nir Friedman, Michael Rosbash and Sebastian Kadener CLOCK (CLK) is essential for the development and maintenance of circadian rhythms in Drosophila. Here, the authors show that Clk mRNA is regulated by miRNA bantam, and deletion of bantam binding site leads to stochastic CLK-driven transcription and development of the circadian neurons. 08 May 2015 | doi: 10.1038/ncomms8056 Biological Sciences  Cell biology  Molecular biology  eQTL mapping identifies insertion- and deletion-specific eQTLs in multiple tissues Jinyan Huang, Jun Chen, Jorge Esparza, Jun Ding, James T. Elder, Goncalo R. Abecasis, Young-Ae Lee, G. Mark Lathrop, Miriam F. Moffatt, William O. C. Cookson and Liming Liang Expression quantitative trait loci (eQTLs) may provide insight into the functional mechanisms underlying disease risk variants. Here the authors characterize INDEL-specific eQTLs in several tissues and show that these can have both tissue-specific and tissue-consistent effects. 08 May 2015 | doi: 10.1038/ncomms7821 Biological Sciences  Genetics  IM30 triggers membrane fusion in cyanobacteria and chloroplasts Raoul Hennig, Jennifer Heidrich, Michael Saur, Lars Schmüser, Steven J. Roeters, Nadja Hellmann, Sander Woutersen, Mischa Bonn, Tobias Weidner, Jürgen Markl and Dirk Schneider Thylakoid membranes are critical components of chloroplasts and cyanobacteria. Here, Hennig et al. demonstrate that IM30, a conserved chloroplast and cyanobacterial protein, binds to thylakoid membranes and can trigger membrane destabilization and fusion in a Mg2+ dependent manner. 08 May 2015 | doi: 10.1038/ncomms8018 Biological Sciences  Cell biology  Plant sciences  Topological control of the Caulobacter cell cycle circuitry by a polarized single-domain PAS protein OPEN Stefano Sanselicio, Matthieu Bergé, Laurence Théraulaz, Sunish Kumar Radhakrishnan and Patrick H. Viollier The bacterium Caulobacter crescentus is a model organism for research on the bacterial cell cycle and cell division processes. Here, Sanselicio et al. show that the MopJ protein contributes to the control of cell cycle and growth in C. crescentus. 08 May 2015 | doi: 10.1038/ncomms8005 Biological Sciences  Cell biology  Microbiology  Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8+ T cells OPEN Valérie Martinet, Sandrine Tonon, David Torres, Abdulkader Azouz, Muriel Nguyen, Arnaud Kohler, Véronique Flamand, Chai-An Mao, William H. Klein, Oberdan Leo and Stanislas Goriely Eomesodermin is the key transcription factor for the development of ‘virtual memory’ T cells that develop in the absence of antigen-driven activation. Here the authors show that type I interferons directly activate eomesodermin and contribute to the homeostasis of virtual memory CD8+ T cells. 08 May 2015 | doi: 10.1038/ncomms8089 Biological Sciences  Immunology  Expression of the vault RNA protects cells from undergoing apoptosis OPEN Melanie Amort, Birgit Nachbauer, Selma Tuzlak, Arnd Kieser, Aloys Schepers, Andreas Villunger and Norbert Polacek Cellular functions of the vault complex, a large ribonucleoprotein assembly remain elusive. Here, the authors show that Epstein–Barr virus infection enhances the expression of the vault complex-associated RNAs, which leads to improved survival of infected cells due to the inhibition of cell apoptosis. 08 May 2015 | doi: 10.1038/ncomms8030 Biological Sciences  Cell biology  Virology  JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis OPEN Yohei Abe, Royhan Rozqie, Yoshihiro Matsumura, Takeshi Kawamura, Ryo Nakaki, Yuya Tsurutani, Kyoko Tanimura-Inagaki, Akira Shiono, Kenta Magoori, Kanako Nakamura, Shotaro Ogi, Shingo Kajimura, Hiroshi Kimura, Toshiya Tanaka, Kiyoko Fukami, Timothy F. Osborne, Tatsuhiko Kodama, Hiroyuki Aburatani, Takeshi Inagaki and Juro Sakai et al. Demethylase JMJD1A activates thermogenesis-related target genes in response to β-adrenergic hormones. Here, the authors show that phosphorylation of JMJD1A at S265 increases its interaction with the SWI/SNF chromatin remodeler, leading to long-range chromatin interactions and target gene activation. 07 May 2015 | doi: 10.1038/ncomms8052 Biological Sciences  Cell biology  Molecular biology  Charge order from orbital-dependent coupling evidenced by NbSe2 Felix Flicker and Jasper van Wezel Two-dimensional charge ordering cannot be fully described by Peierls-like weak coupling mechanisms appropriate for one-dimensional materials. Here, the authors show how strong orbital-dependent electron–phonon coupling drives two-dimensional charge ordering in archetypal niobium diselenide. 07 May 2015 | doi: 10.1038/ncomms8034 Physical Sciences  Condensed matter  Theoretical physics  Electronic modulation of infrared radiation in graphene plasmonic resonators Victor W. Brar, Michelle C. Sherrott, Min Seok Jang, Seyoon Kim, Laura Kim, Mansoo Choi, Luke A. Sweatlock and Harry A. Atwater Graphene’s exotic properties make it suitable for many different optoelectronic devices. Brar et al. show that graphene plasmonic resonators can be exploited to produce narrow spectral emission in the mid-infrared, whose frequency and intensity can be modulated by electrostatic gating. 07 May 2015 | doi: 10.1038/ncomms8032 Physical Sciences  Condensed matter  Nanotechnology  Optical physics  IκBβ enhances the generation of the low-affinity NFκB/RelA homodimer Rachel Tsui, Jeffrey D. Kearns, Candace Lynch, Don Vu, Kim A. Ngo, Soumen Basak, Gourisankar Ghosh and Alexander Hoffmann The NFκB signalling pathway is regulated through the formation of transcription factor dimers but mechanisms controlling their formation are poorly understood. Here, Tsui et al. report that IκBb is a positive regulator of Rel-NFκB dimer formation, using in vitro and in vivo experiments and mathematical modelling. 07 May 2015 | doi: 10.1038/ncomms8068 Biological Sciences  Cell biology  Subwavelength-thick lenses with high numerical apertures and large efficiency based on high-contrast transmitarrays Amir Arbabi, Yu Horie, Alexander J. Ball, Mahmood Bagheri and Andrei Faraon Replacing conventional components with flat optic devices such as flat lenses is desirable for imaging and on-chip integration, but performance has hindered their use. Here, Arbabi et al. report a wavelength-thin, high-contrast transmitarray micro-lens with a 0.57 λ focal spot and 82% focusing efficiency. 07 May 2015 | doi: 10.1038/ncomms8069 Physical Sciences  Materials science  Nanotechnology  Optical physics  Extreme 13C depletion of carbonates formed during oxidation of biogenic methane in fractured granite OPEN Henrik Drake, Mats E. Åström, Christine Heim, Curt Broman, Jan Åström, Martin Whitehouse, Magnus Ivarsson, Sandra Siljeström and Peter Sjövall Precipitation of 13C-depleted authigenic carbonate is a tracer of sulphate-dependent anaerobic methane oxidation, particularly in marine sediments. Here, the authors present extremely 13C-depleted carbonates from deep granitoid rocks suggesting the presence of microbial sulphate reducers and methane oxidisers. 07 May 2015 | doi: 10.1038/ncomms8020 Earth Sciences  Biogeochemistry  Geology and geophysics  Stochasticity, periodicity and localized light structures in partially mode-locked fibre lasers OPEN D. V. Churkin, S. Sugavanam, N. Tarasov, S. Khorev, S. V. Smirnov, S. M. Kobtsev and S. K. Turitsyn The interplay of processes with different spatio-temporal scales is present in many physical systems but its study is challenging. Here, Churkin et al. study the dynamics of a partially mode-locked laser where stochastic and periodic processes interplay by mapping the evolution of the intensity autocorrelation function. 07 May 2015 | doi: 10.1038/ncomms8004 Physical Sciences  Applied physics  Optical physics  Microwave spectroscopy of the low-filling-factor bilayer electron solid in a wide quantum well OPEN A. T. Hatke, Y. Liu, L. W. Engel, M. Shayegan, L. N. Pfeiffer, K. W. West and K. W. Baldwin In 2D electron gases, insulating behaviour at low fractional quantum Hall filling factors is understood by the formation of an electronic Wigner solid. Here, the authors use microwave spectroscopy to evidence an electron liquid–solid mixed phase in bilayer states of GaAs/AlGaAs wide quantum wells. 07 May 2015 | doi: 10.1038/ncomms8071 Physical Sciences  Applied physics  Condensed matter  Surface lattice resonances and magneto-optical response in magnetic nanoparticle arrays OPEN M. Kataja, T. K. Hakala, A. Julku, M. J. Huttunen, S. van Dijken and P. Törmä By incorporating magnetic materials into periodic nanostructures, additional control over the magneto-optical response of the system can be introduced. Kataja et al. show that arrays of magnetic nanoparticles exhibit Fano-type surface plasmon resonances with cross-coupling tuned by the lattice symmetry. 07 May 2015 | doi: 10.1038/ncomms8072 Physical Sciences  Condensed matter  Nanotechnology  Optical physics  Integrated digital inverters based on two-dimensional anisotropic ReS2 field-effect transistors OPEN Erfu Liu, Yajun Fu, Yaojia Wang, Yanqing Feng, Huimei Liu, Xiangang Wan, Wei Zhou, Baigeng Wang, Lubin Shao, Ching-Hwa Ho, Ying-Sheng Huang, Zhengyi Cao, Laiguo Wang, Aidong Li, Junwen Zeng, Fengqi Song, Xinran Wang, Yi Shi, Hongtao Yuan, Harold Y. Hwang et al. Many two-dimensional materials exhibit isotropic properties, but anisotropy can extend the functionality of future devices. Here, the authors fabricate field-effect transistors from single and few-layer rhenium disulfide and observe an anisotropic ratio of three to one along the two principle axes 07 May 2015 | doi: 10.1038/ncomms7991 Physical Sciences  Applied physics  Materials science  Competition between recombination and extraction of free charges determines the fill factor of organic solar cells OPEN Davide Bartesaghi, Irene del Carmen Pérez, Juliane Kniepert, Steffen Roland, Mathieu Turbiez, Dieter Neher and L. Jan Anton Koster The open circuit voltage, short circuit current and fill factor determine the conversion efficiency of organic solar cells, yet the fill factor is not well understood. Here, Bartesaghi et al. demonstrate the fill-factor dependence on the ratio of the recombination and extraction rates of free charges. 07 May 2015 | doi: 10.1038/ncomms8083 Physical Sciences  Materials science  Physical chemistry  Triangular prism-shaped β-peptoid helices as unique biomimetic scaffolds OPEN Jonas S. Laursen, Pernille Harris, Peter Fristrup and Christian A. Olsen β-Peptoids are based on N-alkylated β-aminopropionic acid residues, which have been inspired by the more intensely studied peptoids and β-peptides. Here, the authors report X-ray crystal structures of oligomeric β-peptoids demonstrating secondary structures with this backbone. 06 May 2015 | doi: 10.1038/ncomms8013 Chemical Sciences  Chemical biology  Materials science  Expression of heterologous sigma factors enables functional screening of metagenomic and heterologous genomic libraries OPEN Stefan M. Gaida, Nicholas R. Sandoval, Sergios A. Nicolaou, Yili Chen, Keerthi P. Venkataramanan and Eleftherios T. Papoutsakis Screening genomic or metagenomic libraries for interesting products or activities is often hampered by poor gene expression in a heterologous host. Here the authors show that the expression of a Lactobacillus sigma factor greatly enhances transcription of heterologous and environmental DNA in E. coli. 06 May 2015 | doi: 10.1038/ncomms8045 Biological Sciences  Biotechnology  Microbiology  Electrochemical polymerization of pyrene derivatives on functionalized carbon nanotubes for pseudocapacitive electrodes OPEN John C. Bachman, Reza Kavian, Daniel J. Graham, Dong Young Kim, Suguru Noda, Daniel G. Nocera, Yang Shao-Horn and Seung Woo Lee Electrochemically active organic molecules are an important class of electrode materials for energy storage. Here, the authors report organic electrodes made of polycyclic aromatic hydrocarbons and functionalized few-walled carbon nanotubes, which show promising electrochemical performance. 06 May 2015 | doi: 10.1038/ncomms8040 Chemical Sciences  Materials science  Nanotechnology  Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2 OPEN Ye Yan, Cynthia Wladyka, Junichi Fujii and Shanthini Sockanathan Neuron differentiation is marked by changes in intracellular redox status. Here Yan et al. show that ER-resident peroxiredoxin 4 senses increased H2O2 and prevents the surface expression of differentiation-promoting GDE2 by modifying cysteine residues within GDE2. 06 May 2015 | doi: 10.1038/ncomms8006 Biological Sciences  Cell biology  Neuroscience  The low-affinity complex of cytochrome c and its peroxidase OPEN Karen Van de Water, Yann G. J. Sterckx and Alexander N. Volkov The redox activity of cytochrome c in complex with its peroxidase has been rationalized by two possible models; a readily observable high-affinity complex and a more elusive but potentially more active low-affinity complex. Here, the authors provide an NMR-based structural mapping of this low-affinity complex. 06 May 2015 | doi: 10.1038/ncomms8073 Biological Sciences  Biochemistry  Measuring the dynamic structure factor of a quantum gas undergoing a structural phase transition OPEN Renate Landig, Ferdinand Brennecke, Rafael Mottl, Tobias Donner and Tilman Esslinger The dynamic structure factor is measured in condensed matter systems via neutron scattering, but this is not applicable to ultracold atomic gases. Here, the authors show how it can be measured relying on the strongly enhanced inelastic scattering of photons off a quantum gas in an optical cavity. 06 May 2015 | doi: 10.1038/ncomms8046 Physical Sciences  Atomic and molecular physics    Nature communications JOBS of the week Postdoctoral Researcher University of Maryland Baltimore Postdoctoral Research Assistant University of Dundee Postdoctoral Scientist John Innes Centre (JIC) Research Fellow The University of Warwick Tenure-track Faculty Positions University of Kentucky Postdoctoral Scientist Medical Research Council Postdoctoral Research Scientists Cancer Research UK Beatson Institute in Glasgow PhD Scholarship in Organic Synthesis Technical University of Denmark (DTU) 5-Year Postdoctoral Research Fellow London School of Hygiene & Tropical Medicine Assistant Professor - Social and Behavioural Sciences (18 positions) Utrecht University More Science jobs from Nature communications EVENT EMBO Practical Course: Two-photon imaging of brain function: From spiny dendrites to circuits 05.09.15 Munich, Germany More science events from       Latest Corrigendum     Corrigendum: Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival Dennis S. Rice, Jorgelina M. Calandria, William C. Gordon, Bokkyoo Jun, Yongdong Zhou, Claire M. Gelfman, Songhua Li, Minghao Jin, Eric J. Knott, Bo Chang, Alex Abuin, Tawfik Issa, David Potter, Kenneth A. Platt and Nicolas G. Bazan 12 May 2015 | doi: 10.1038/ncomms8225 Biological Sciences  Medical research  Neuroscience        Latest Errata     Erratum: Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis Lucy A. Weinert, Roy R. Chaudhuri, Jinhong Wang, Sarah E. Peters, Jukka Corander, Thibaut Jombart, Abiyad Baig, Kate J. Howell, Minna Vehkala, Niko Välimäki, David Harris, Tran Thi Bich Chieu, Nguyen Van Vinh Chau, James Campbell, Constance Schultsz, Julian Parkhill, Stephen D. Bentley, Paul R. Langford, Andrew N. Rycroft, Brendan W. Wren et al. 12 May 2015 | doi: 10.1038/ncomms8272 Biological Sciences  Evolution  Genetics  Microbiology      Erratum: Different forms of effective connectivity in primate frontotemporal pathways Christopher I. 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Ring et al. 12 May 2015 | doi: 10.1038/ncomms8171 Biological Sciences  Genetics  Medical research      Advertisement 1st Nature Immunology - Cellular & Molecular Immunology Joint Conference: Inflammation, Stress and Immune Homeostasis June 17-19, 2015 | The Swan Lake Hotel, Hefei, China  Register Now!    Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com  More Nature Events You have been sent this Table of Contents Alert because you have opted in to receive it. 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