Nature Reviews Microbiology contents April 2015 Volume 13 Number 4 pp 185-248

TABLE OF CONTENTS
April 2015 Volume 13 Number 4
Impact Factor 23.317 *	In this issue Research Highlights News and Analysis Reviews Perspectives Also this month Article series: Vector-borne diseases  Featured article: Salmonellae interactions with host processes Doris L. LaRock, Anu Chaudhary & Samuel I. Miller
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RESEARCH HIGHLIGHTS Top Bacterial genetics: What CRISPR memories are made of p185 | doi:10.1038/nrmicro3457 Two studies report mechanistic details of how bacteria select and integrate viral DNA fragments into CRISPR loci to create immunological memory of past invaders. PDF Structural biology: Hand in hand structure and function of T6SSs p186 | doi:10.1038/nrmicro3459 Two studies report the atomic structure of two bacterial type VI secretion systems and identify specific domains that are essential for their function. PDF Viral infection: Tracking down HIV's hiding place p186 | doi:10.1038/nrmicro3466 A new study finds that HIV-1 preferentially integrates into regions of chromatin that are proximal to nuclear pores. PDF Viral pathogenesis: HSV avoids the RIPper p188 | doi:10.1038/nrmicro3453 Two studies reveal that herpes simplex virus 1 can suppress necroptosis of human cells via binding of the viral protein ICP6 to RIP1 and RIP3 kinases. PDF Parasite biology: The antisense antigen switch p188 | doi:10.1038/nrmicro3455 A new study shows that antisense long noncoding RNAs contribute to var gene activation in Plasmodium falciparum. PDF Antimicrobials: Resistance is costly for Candida p189 | doi:10.1038/nrmicro3454 A new study shows that drug combination therapy results in fitness trade-offs in Candida albicans. PDF IN BRIEF Viral pathogenesis: Travelling in clusters | Bacterial evolution: Bugs-to-bunny in a single-hit tropism shift | Viral infection: Better protection against HIV | Bacterial evolution: Resurrecting motility | Fungal genomics: A personalized symbiosis toolkit | Bacterial toxins: A signal for toxin production PDF Microbiology JOBS of the week W2-Professor for Translational Microbiology Rheinische Friedrich-Wilhelms-Universitat More Science jobs from Microbiology EVENT EMBO | EMBL Symposium: New Approaches and Concepts in Microbiology 11.10.15 Heidelberg, Germany More science events from
NEWS AND ANALYSIS		Top
GENOME WATCH A switch in time Thomas Crellen & Stefano Iantorno p190 | doi:10.1038/nrmicro3458 This month's Genome Watch highlights how genome analysis can reveal insights into the adaptation of Plasmodium falciparum and Plasmodium vivax to human hosts. PDF
REVIEWS		Top
Salmonellae interactions with host processes Doris L. LaRock, Anu Chaudhary & Samuel I. Miller p191 | doi:10.1038/nrmicro3420 In this Review, Miller and colleagues discuss the arsenal of effector proteins that salmonellae use to manipulate their animal hosts, in addition to the host response to these infections. The authors also discuss the challenges ahead for unravelling the mechanistic details of effector function. Abstract | Full Text | PDF | Supplementary information
Now you see me, now you don't: the interaction of Salmonella with innate immune receptors A. Marijke Keestra-Gounder, Renée M. Tsolis & Andreas J. Bäumler p206 | doi:10.1038/nrmicro3428 Salmonella enterica serovars are human pathogens that are commonly used to study host-bacterium interaction mechanisms. In this Review, Baumler and colleagues discuss how the innate immune system recognizes non-typhoidal and typhoidal serovars, and how specific virulence factors and changes in virulence gene regulation alter innate immune responses. Abstract | Full Text | PDF
Ecology and exploration of the rare biosphere Michael D. J. Lynch & Josh D. Neufeld p217 | doi:10.1038/nrmicro3400 The detection and subsequent analysis of low-abundance microbial populations — the 'rare biosphere' — have demonstrated the persistence, population dynamics, dispersion and predation of these microbial species. Lynch and Neufeld discuss the ecology of rare microbial populations and highlight molecular and computational methods for targeting taxonomic 'blind spots' in the rare biosphere of complex microbial communities. Abstract | Full Text | PDF
Article series: Vector-borne diseases The many projected futures of dengue Jane P. Messina et al. p230 | doi:10.1038/nrmicro3430 Predicting the future global distribution of vector-borne diseases is a complex task that depends on the generation of accurate mathematical models. Here, Messina and colleagues compare and contrast the main approaches that have been used to predict the future distribution of dengue and propose a set of minimum criteria for future projections that, by analogy, are applicable to other vector-borne diseases. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Bacterial morphogenesis and the enigmatic MreB helix Jeff Errington p241 | doi:10.1038/nrmicro3398 In this Opinion article, Errington reviews the studies that describe the role of MreB in the determination and maintenance of rod cell shape in bacteria, and he presents a model to reconcile the conflicting data. Abstract | Full Text | PDF
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