The EMBO Journal Table of Contents for 12 February 2015; Vol. 34, No. 4

12 February 2015 | Volume 34, Number 4 Submit Table of Contents Have you seen? Articles Volume 34, Number 4 Have you seen? Emergence of cancer stem cells in hepatocellular carcinoma Hepatocyte‐specific ablation of PR‐SET7 in mice results in hepatocellular carcinomas with features of the human disease. This new model offers access to relevant tumor‐propagating cells for future studies. Sahra Pilz and Gunnar Schotta Published online 08.01.2015 KSHV‐TK: thymidine kinase or tyrosine kinase? The Kaposi's sarcoma‐associated herpesvirus encodes a putative thymidine kinase that shows tyrosine kinase activity instead. KSHV‐TK regulates focal adhesions and, as a consequence, the actin cytoskeleton through RhoA signaling. Michael Lagunoff Published online 08.01.2015 Articles Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR‐SET7‐deficient livers DNA damage, necrosis and inflammation caused by loss of the histone methyltransferase PR‐SET7 in adult mouse hepatocytes triggers compensatory activation of resident ductal progenitor cells, culminating in hepatocellular carcinoma. Kostas C Nikolaou, Panagiotis Moulos, George Chalepakis, Pantelis Hatzis, Hisanobu Oda, Danny Reinberg, and Iannis Talianidis Published online 16.12.2014 KSHV‐TK is a tyrosine kinase that disrupts focal adhesions and induces Rho‐mediated cell contraction Gammaherpesviruses are known to encode very inefficient thymidine kinases. KSHV thymidine kinase is actually a tyrosine kinase that induces focal adhesion disassembly via its interaction with known regulators including members of the Crk‐related family of adaptor proteins. Michael B Gill, Rachel Turner, Philip G Stevenson, and Michael Way Published online 03.12.2014 Commensal microbiota influence systemic autoimmune responses Neonatal colonization of the intestine by segmented filamentous bacteria affects systemic autoimmune responses against nuclear antigens in adult life. Jens T Van Praet, Erin Donovan, Inge Vanassche, Michael B Drennan, Fien Windels, Amélie Dendooven, Liesbeth Allais, Claude A Cuvelier, Fons van de Loo, Paula S Norris, Andrey A Kruglov, Sergei A Nedospasov, Sylvie Rabot, Raul Tito, Jeroen Raes, Valerie Gaboriau‐Routhiau, Nadine Cerf‐Bensussan, Tom Van de Wiele, Gérard Eberl, Carl F Ware, and Dirk Elewaut Published online 19.01.2015 LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation The oncogene LAPTM4B prolongs EGFR signalling. LAPTM4B promotes ubiquitination of ESCRT component Hrs, preventing endosomal EGFR sorting, which is counteracted by phosphoinositide PtdIns(4,5)P2. Xiaojun Tan, Yue Sun, Narendra Thapa, Yihan Liao, Andrew C Hedman, and Richard A Anderson Published online 14.01.2015 Nucleoid occlusion protein Noc recruits DNA to the bacterial cell membrane Nucleoid occlusion (Noc) protects the bacterial chromosome from the division machinery. In B. subtilis, Noc protein binding to DNA enables subsequent binding of Noc to the membrane, recruiting the chromosome and physically preventing cell division. David William Adams, Ling Juan Wu, and Jeff Errington Published online 07.01.2015 Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer Antagonist‐bound androgen receptor significantly shifts its genomic binding gene expression profiles. These data inform novel targets for therapeutic interventions. Zhong Chen, Xun Lan, Jennifer M Thomas‐Ahner, Dayong Wu, Xiangtao Liu, Zhenqing Ye, Liguo Wang, Benjamin Sunkel, Cassandra Grenade, Junsheng Chen, Debra L Zynger, Pearlly S Yan, Jiaoti Huang, Kenneth P Nephew, Tim H‐M Huang, Shili Lin, Steven K Clinton, Wei Li, Victor X Jin, and Qianben Wang Published online 22.12.2014 Antithetical NFATc1–Sox2 and p53–miR200 signaling networks govern pancreatic cancer cell plasticity Cancer “stemness” and metastasis have been associated with EMT features, while defined molecular mechanisms remain scarce. This new study establishes an NFATc1–Sox2‐driven EMT program as crucial determinant for pancreatic cancer progression. Shiv K Singh, Nai‐Ming Chen, Elisabeth Hessmann, Jens Siveke, Marlen Lahmann, Garima Singh, Nadine Voelker, Sophia Vogt, Irene Esposito, Ansgar Schmidt, Cornelia Brendel, Thorsten Stiewe, Jochen Gaedcke, Marco Mernberger, Howard C Crawford, William R Bamlet, Jin‐San Zhang, Xiao‐Kun Li, Thomas C Smyrk, Daniel D Billadeau, Matthias Hebrok, Albrecht Neesse, Alexander Koenig, and Volker Ellenrieder Published online 13.01.2015 Dynamic loading and redistribution of the Mcm2‐7 helicase complex through the cell cycle Pre‐replicative chromatin loading of the full Mcm2‐7 complement depends on cyclin E/Cdk2 activity and involves transcription‐dependent redistribution beyond ORC binding sites. Sara K Powell, Heather K MacAlpine, Joseph A Prinz, Yulong Li, Jason A Belsky, and David M MacAlpine Published online 02.01.2015 NTR1 is required for transcription elongation checkpoints at alternative exons in Arabidopsis AtNTR1, the Arabidopsis homologue of spliceosome disassembly factor NTR1, is required for pausing of RNA polymerase II at strong alternative splicing sites. Jakub Dolata, Yanwu Guo, Agnieszka Kołowerzo, Dariusz Smoliński, Grzegorz Brzyżek, Artur Jarmołowski, and Szymon Świeżewski Published online 07.01.2015 A Tetrahymena Hsp90 co‐chaperone promotes siRNA loading by ATP‐dependent and ATP‐independent mechanisms Characterization of the conjugation‐induced Coi12p co‐chaperone shows that it counteracts the Argonaute‐binding negative siRNA loading regulator Giw1p via dual mechanisms. Sophie L Woehrer, Lucia Aronica, Jan H Suhren, Clara Jana‐Lui Busch, Tomoko Noto, and Kazufumi Mochizuki Published online 14.01.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.