The EMBO Journal Table of Contents for 03 February 2015; Vol. 34, No. 3

03 February 2015 | Volume 34, Number 3 Submit Table of Contents Have you seen? Articles Volume 34, Number 3 Have you seen? Cellular stress response cross talk maintains protein and energy homeostasis New work reveals interplay between heat shock factor 1 (HSF1), the key regulator of the proteotoxic stress response, and AMP‐activated protein kinase (AMPK), the primary sensor in the metabolic stress response. Cynthia L Swan and Lea Sistonen Published online 02.01.2015 It's cold, mom! It's cyclic GMP The guanylyl cyclase GC‐G/cGMP pathway functions as a cold‐induced thermosensor that triggers protective maternal care. Michaela Kuhn Published online 02.01.2015 Microexons—Tiny but mighty Extremely short, multiples of three nucleotides encoding ‘microexons’ have been previously noticed, though mostly missed by traditional transcriptomics. Two novel studies establish the global presence and evolutionary conservation of microexons, while offering first glimpses into their regulation and functional significance in neurogenesis and autism. Claudia Scheckel and Robert B Darnell Published online 22.12.2014 Articles Suppression of the HSF1‐mediated proteotoxic stress response by the metabolic stress sensor AMPK Identification of AMPK‐mediated HSF1 suppression by metabolic stress not only showcases a complex interplay of cellular stress responses, but also suggests a novel strategy to target HSF1 and proteostasis in malignancy. Siyuan Dai, Zijian Tang, Junyue Cao, Wei Zhou, Huawen Li, Stephen Sampson, and Chengkai Dai Published online 25.11.2014 Receptor guanylyl cyclase‐G is a novel thermosensory protein activated by cool temperatures The membrane‐spanning receptor guanylyl cyclase subtype GC‐G, specifically expressed in the Grueneberg ganglion neurons in the nose, is a novel thermosensor for cool ambient temperatures in mammals in vivo. Ying‐Chi Chao, Chih‐Cheng Chen, Yuh‐Charn Lin, Heinz Breer, Joerg Fleischer, and Ruey‐Bing Yang Published online 01.12.2014 Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis PINK1‐mediated ubiquitin phosphorylation is not only involved in Parkin activation, but has the potential to affect ubiquitin conjugation and signaling at various levels. Tobias Wauer, Kirby N Swatek, Jane L Wagstaff, Christina Gladkova, Jonathan N Pruneda, Martin A Michel, Malte Gersch, Christopher M Johnson, Stefan MV Freund, and David Komander Published online 19.12.2014 USP45 deubiquitylase controls ERCC1–XPF endonuclease‐mediated DNA damage responses A key endonuclease of DNA nucleotide excision repair and interstrand cross‐link repair is regulated by reversible ubiquitylation. Ana B Perez‐Oliva, Christophe Lachaud, Piotr Szyniarowski, Ivan Muñoz, Thomas Macartney, Ian Hickson, John Rouse, and Dario R Alessi Published online 23.12.2014 microRNA‐379 couples glucocorticoid hormones to dysfunctional lipid homeostasis The discovery of miR‐379 as a direct glucocorticoid receptor target in the liver integrates miRNAs in the physiological control of lipid homeostasis. Roldan M de Guia, Adam J Rose, Anke Sommerfeld, Oksana Seibert, Daniela Strzoda, Annika Zota, Yvonne Feuchter, Anja Krones‐Herzig, Tjeerd Sijmonsma, Milen Kirilov, Carsten Sticht, Norbert Gretz, Geesje Dallinga‐Thie, Sven Diederichs, Nora Klöting, Matthias Blüher, Mauricio Berriel Diaz, and Stephan Herzig Published online 15.12.2014 Functional screen reveals essential roles of miR‐27a/24 in differentiation of embryonic stem cells A focused screen, followed by CRISPR/Cas9 functional genome editing establishes the miR‐23~27~24 cluster as essential regulator of self‐renewal and ESC‐differentiation. Yanni Ma, Nan Yao, Guang Liu, Lei Dong, Yufang Liu, Meili Zhang, Fang Wang, Bin Wang, Xueju Wei, He Dong, Lanlan Wang, Shaowei Ji, Junwu Zhang, Yangming Wang, Yue Huang, and Jia Yu Published online 17.12.2014 The CatSper channel controls chemosensation in sea urchin sperm The identification of CatSper as the long‐sought Ca2+ channel driving chemotaxis in sea urchin sperm reveals similarities and variations in the molecular makeup of chemosensory signaling pathways in mammals and marine invertebrates. Reinhard Seifert, Melanie Flick, Wolfgang Bönigk, Luis Alvarez, Christian Trötschel, Ansgar Poetsch, Astrid Müller, Normann Goodwin, Patric Pelzer, Nachiket D Kashikar, Elisabeth Kremmer, Jan Jikeli, Bernd Timmermann, Heiner Kuhl, Dmitry Fridman, Florian Windler, U Benjamin Kaupp, and Timo Strünker Published online 22.12.2014 A THEMIS:SHP1 complex promotes T‐cell survival The THEMIS:GRB2:SHP complex dampens TCR signalling and favours T‐cell survival by modulating signalling thresholds and ligand discrimination. Wolfgang Paster, Annika M Bruger, Kristin Katsch, Claude Grégoire, Romain Roncagalli, Guo Fu, Nicholas RJ Gascoigne, Konstantina Nika, Andre Cohnen, Stephan M Feller, Philip C Simister, Kelly C Molder, Shaun‐Paul Cordoba, Omer Dushek, Bernard Malissen, and Oreste Acuto Published online 22.12.2014 BRCA1 and CtIP promote alternative non‐homologous end‐joining at uncapped telomeres Telomere uncapping by TRF2 inactivation reveals new roles for DNA double‐strand break end‐processing enzymes in removing single‐stranded telomere overhangs and mediating end‐to‐end fusions. Sophie Badie, Ana Rita Carlos, Cecilia Folio, Keiji Okamoto, Peter Bouwman, Jos Jonkers, and Madalena Tarsounas Published online 12.01.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.