Nature Reviews Molecular Cell Biology contents March 2015 Volume 16 Number 3 pp 125-202

If you are unable to see the message below, click here to view.

TABLE OF CONTENTS
March 2015 Volume 16 Number 3
Impact Factor 36.458 *	In this issue Research Highlights Focus on: Transcription Also this month  Featured article: Getting up to speed with transcription elongation by RNA polymerase II Iris Jonkers & John T. Lis  Focus: Transcription
Subscribe   Facebook   RSS   Recommend to library   Twitter
Advertisement
1st Nature Immunology – Cellular & Molecular Immunology Joint Conference:  Inflammation, Stress and Immune Homeostasis  June 17-19, 2015 | The Swan Lake Hotel, Hefei, China Register Now!
RESEARCH HIGHLIGHTS Top Metabolism: Transcriptionally activating brown fat p125 | doi:10.1038/nrm3957 PRDM16 activates brown adipose-selective genes through direct interaction with the Mediator complex subunit MED1 at enhancer regions and the regulation of chromatin architecture. PDF Organelle dynamics: Organelles under the spotlight p126 | doi:10.1038/nrm3944 Kapitein and colleagues have used an optically controlled system that couples organelles and motor proteins to study the dynamics and roles of organelle transport. PDF Transcription: Relax, it's just a small cut p126 | doi:10.1038/nrm3954 DNA topoisomerase 1 mediates single-strand nicks to relieve the inhibitory effect of DNA supercoiling on enhancer-dependent transcription. PDF Transcription: A mitochondrial switch between transcription and replication p128 | doi:10.1038/nrm3955 A new study shows that the mitochondrial transcription elongation factor TEFM serves as a molecular switch between replication and transcription. PDF JOURNAL CLUB Orchestrating transcription with the pol II CTD p128 | doi:10.1038/nrm3956 Ronald and Joan Conaway highlight studies that established the role of phosphorylation of the RNA polymerase II carboxy-terminal domain (CTD) in the transition from transcription initiation to elongation, which paved the ground for following work on the CTD in regulating co-transcriptional processes. PDF IN BRIEF Chromatin: HP1 locked up | Cell signalling: Orphan receptor finds ligand | Extracellular matrix: Collagen directs invadopodia | Transcription: Unidirectional human promoters | Chromatin: ZNF143 in the loop | Gene expression: DYRK1A targets Pol II PDF Molecular Cell Biology JOBS of the week Research Scientist in Texture / Touch Biophysics Nestlé Research Center (NRC) Research Assistant University of Kansas Medical Center (KUMC) PhD position - Proteogenomics Universities of Rio de Janeiro and Groningen Postdoc in Developmental Biology / Angiogenesis / Hypertenstion Cincinnati Children's Hospital Medical Center Postdoctoral Research Fellow University of Edinburgh More Science jobs from Molecular Cell Biology EVENT More science events from
Focus on: Transcription REVIEWS Top Structural basis of transcription initiation by RNA polymerase II Sarah Sainsbury, Carrie Bernecky & Patrick Cramer p129 | doi:10.1038/nrm3952 Transcription of eukaryotic protein-coding genes requires the assembly of a conserved initiation complex at promoter DNA. Structural information on this complex, which comprises RNA polymerase II and the general transcription factors, is beginning to reveal the mechanisms underlying the initial steps of transcription, such as the recognition and opening of promoter DNA. Abstract | Full Text | PDF | Supplementary information The selection and function of cell type-specific enhancers Sven Heinz, Casey E. Romanoski, Christopher Benner & Christopher K. Glass p144 | doi:10.1038/nrm3949 Many gene expression patterns are dictated by enhancers. Mammalian genomes contain millions of potential enhancers, but only a small subset of them is active in any cell type. Emerging data uncover how cell type-specific enhancer function is established, including the involvement of higher-order genomic organization in the process. Abstract | Full Text | PDF The Mediator complex: a central integrator of transcription Benjamin L. Allen & Dylan J. Taatjes p155 | doi:10.1038/nrm3951 RNA polymerase II (Pol II) is globally regulated by Mediator, a large, conformationally flexible protein complex with a variable subunit composition. These biochemical characteristics are fundamental for the ability of Mediator to control processes involved in transcription, including the organization of chromatin architecture and the regulation of Pol II pre-initiation, initiation, re-initiation, pausing and elongation. Abstract | Full Text | PDF | Supplementary information Getting up to speed with transcription elongation by RNA polymerase II Iris Jonkers & John T. Lis p167 | doi:10.1038/nrm3953 Pausing of RNA polymerase II (Pol II) in promoter-proximal regions and its release to initiate productive elongation are key steps in the regulation of transcription, and involve many factors. Evidence is now emerging that transcriptional elongation is highly dynamic. Elongation rates vary between genes and across the length of a gene, affecting splicing, termination and genome stability. Abstract | Full Text | PDF Histone exchange, chromatin structure and the regulation of transcription Swaminathan Venkatesh & Jerry L. Workman p178 | doi:10.1038/nrm3941 Access of RNA polymerase II to DNA is regulated by the ordered disassembly of nucleosomes and by histone exchange. Chromatin modifications, chromatin remodellers, histone chaperones and histone variants control nucleosomal dynamics, and dysregulation of these components results in aberrant transcription. Abstract | Full Text | PDF Transcription termination and the control of the transcriptome: why, where and how to stop Odil Porrua & Domenico Libri p190 | doi:10.1038/nrm3943 Transcription termination has a central role in regulating gene expression, maintaining the stability of the transcriptome and controlling pervasive transcription. New insights have recently been gained into the molecular basis of termination and the timely and efficient dismantling of elongation complexes at mRNA-coding and non-coding RNA loci. Abstract | Full Text | PDF | Supplementary information
Advertisement
Epstein-Barr Virus and Human Cancer This special feature of Experimental & Molecular Medicine contains six review articles that provide an overview of our current understanding of Epstein-Barr virology and oncogenesis and of EBV-associated neoplasm. Access the Special Feature on EBV and Human Cancer today!
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2013 Journal Citation Report (Thomson Reuters, 2013)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.