Nature Communications - 25 February 2015

Weekly Content Alert 25 February 2015  Featured image: Li et al. show that the hierarchical helical microstructure of the shell of pteropod sea snails prevents crack formation and increases the shell’s fracture resistance. Latest content: Articles Corrigendum Erratum Journal homepage Recommend to library Web feed   Advertisement Nature Communications is now fully open access All new submissions to Nature Communications, if accepted, will be published open access and an article processing charge will apply. For more information visit the website. Many research funders and institutions make funds available to pay open access APCs: please consult our open access funding page to check if your funder or institution has funding available. For advice on whether you are eligible for APC funding and help in approaching funders and institutions please contact us at openaccess@nature.com.        Latest Articles View all Articles     An extreme event of sea-level rise along the Northeast coast of North America in 2009–2010 Paul B. Goddard, Jianjun Yin, Stephen M. Griffies and Shaoqing Zhang Extreme sea level rises are a threat to coastal communities, but their cause, in terms of seasonal or interannual time scales, has received little attention. Here, the authors combine observational and model data to show that one such rise in 2009–10 was caused by a 30% downturn in the Atlantic overturning circulation. 24 February 2015 | doi: 10.1038/ncomms7346 Earth Sciences  Climate science  Oceanography  Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children Xiumei Hong, Ke Hao, Christine Ladd-Acosta, Kasper D. Hansen, Hui-Ju Tsai, Xin Liu, Xin Xu, Timothy A. Thornton, Deanna Caruso, Corinne A. Keet, Yifei Sun, Guoying Wang, Wei Luo, Rajesh Kumar, Ramsay Fuleihan, Anne Marie Singh, Jennifer S. Kim, Rachel E. Story, Ruchi S. Gupta, Peisong Gao et al. Food allergy is a growing clinical and public health burden. Here, the authors carry out a genome-wide association study in samples with well-defined allergies to a variety of foods, and identify the 6p21.32 region that significantly increases risk of developing peanut allergy. 24 February 2015 | doi: 10.1038/ncomms7304 Biological Sciences  Genetics  Hippos stem from the longest sequence of terrestrial cetartiodactyl evolution in Africa Fabrice Lihoreau, Jean-Renaud Boisserie, Fredrick Kyalo Manthi and Stéphane Ducrocq The evolutionary origin of Hippopotamidae, the family of hippos, is poorly understood. Here, the authors describe a new fossil from Kenya that unambiguously roots Hippopotamidae into the group that includes the first large terrestrial mammals to invade Africa, more than 30 million years ago. 24 February 2015 | doi: 10.1038/ncomms7264 Biological Sciences  Evolution  Palaeontology  Formation of titanium monoxide (001) single-crystalline thin film induced by ion bombardment of titanium dioxide (110) B.M. Pabón, J.I. Beltrán, G. Sánchez-Santolino, I. Palacio, J. López-Sánchez, J. Rubio-Zuazo, J.M. Rojo, P. Ferrer, A. Mascaraque, M.C. Muñoz, M. Varela, G.R. Castro and O. Rodríguez de la Fuente Precise surface modification of titanium dioxide is useful for numerous applications. Here, the authors report that high ion dose bombardment transforms the surface of titanium dioxide (110) into single-crystalline titanium oxide (001) thin film, unlike previous lower energy ion bombardment studies. 24 February 2015 | doi: 10.1038/ncomms7147 Physical Sciences  Condensed matter  Materials science  Engineered pairs of distinct photoswitches for optogenetic control of cellular proteins Fuun Kawano, Hideyuki Suzuki, Akihiro Furuya and Moritoshi Sato Photoreceptor-based photoswitches have proved to be powerful tools for the specific control of protein activity in live cells. Here the authors describe Magnets, a new set of photoswitches based on the Vivid photoreceptor with enhanced hetero-dimerization specificity and variable activation kinetics. 24 February 2015 | doi: 10.1038/ncomms7256 Biological Sciences  Biochemistry  Bioengineering  Cell biology  Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions Jeremy Bonzi, Olivier Bornet, Stephane Betzi, Brian T. Kasper, Lara K. Mahal, Stephane J. Mancini, Claudine Schiff, Corinne Sebban-Kreuzer, Francoise Guerlesquin and Latifa Elantak Galectin-1 (GAL1) is a secreted protein that binds to glycans and to the pre-B-cell receptor (pre-BCR). Here Bonzi et al. show that pre-BCR binding to GAL1 causes a conformational change in the GAL1 carbohydrate-binding site to inhibit binding to selected glycans. 24 February 2015 | doi: 10.1038/ncomms7194 Biological Sciences  Biochemistry  Real-time tracking of cell cycle progression during CD8+ effector and memory T-cell differentiation OPEN Ichiko Kinjyo, Jim Qin, Sioh-Yang Tan, Cameron J. Wellard, Paulus Mrass, William Ritchie, Atsushi Doi, Lois L. Cavanagh, Michio Tomura, Asako Sakaue-Sawano, Osami Kanagawa, Atsushi Miyawaki, Philip D. Hodgkin and Wolfgang Weninger CD8+ memory T cells appear during infection via a process of selection and differentiation that remains poorly understood. Using a fluorescent indicator of cell cycle progression, Kinjyo et al. show that slow-cycling memory precursors are derived from fast-cycling-activated T cells in influenza-infected mice. 24 February 2015 | doi: 10.1038/ncomms7301 Biological Sciences  Immunology  Multimode optomechanical dynamics in a cavity with avoided crossings D. Lee, M. Underwood, D. Mason, A.B. Shkarin, S.W. Hoch and J.G.E. Harris Optomechanical systems are typically modelled as a single cavity mode coupled to a mechanical oscillator. Here, the authors report on the realization of a multimode optomechanical setup whose distinct features arise from the mechanically induced coupling between the cavity modes. 24 February 2015 | doi: 10.1038/ncomms7232 Physical Sciences  Applied physics  Observation of long-lived interlayer excitons in monolayer MoSe2–WSe2 heterostructures Pasqual Rivera, John R. Schaibley, Aaron M. Jones, Jason S. Ross, Sanfeng Wu, Grant Aivazian, Philip Klement, Kyle Seyler, Genevieve Clark, Nirmal J. Ghimire, Jiaqiang Yan, D. G. Mandrus, Wang Yao and Xiaodong Xu Monolayer transition metal dichalcogenide heterostructures with type II band alignment have generated wide interest in device physics at the two-dimensional limit. Here, Rivera et al. observe interlayer excitons in vertically stacked MoSe2–WSe2 heterostructures and demonstrate tunability of the energy and luminescence. 24 February 2015 | doi: 10.1038/ncomms7242 Physical Sciences  Condensed matter  Materials science  Nanotechnology  Weak linkage between the heaviest rainfall and tallest storms OPEN Atsushi Hamada, Yukari N. Takayabu, Chuntao Liu and Edward J. Zipser Conventionally, the heaviest rainfall is associated with the most intense storms, yet this relationship remains untested. Here, Hamada et al. analyse 11 years of radar observations from the topics and subtropics, and conclude that the heaviest rainfall is most commonly associated with less intense convection. 24 February 2015 | doi: 10.1038/ncomms7213 Earth Sciences  Atmospheric science  Ambipolar zinc-polyiodide electrolyte for a high-energy density aqueous redox flow battery OPEN Bin Li, Zimin Nie, M. Vijayakumar, Guosheng Li, Jun Liu, Vincent Sprenkle and Wei Wang Conventional redox flow batteries have low energy densities. Here the authors present an aqueous redox flow battery with an ambipolar and bifunctional zinc-polyiodide electrolyte, which exhibits an energy density approaching to that of lithium ion batteries. 24 February 2015 | doi: 10.1038/ncomms7303 Chemical Sciences  Materials science  Physical chemistry  Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking Andreas Papadopulos, Guillermo A. Gomez, Sally Martin, Jade Jackson, Rachel S. Gormal, Damien J. Keating, Alpha S. Yap and Frederic A. Meunier Secretory vesicles must cross a dense cortical actin network to dock and fuse with the plasma membrane. Papadopulos et al. reveal that, in neurosecretory cells, relaxation of this network acts as a 'casting net', driving tethered vesicles towards the plasma membrane. 24 February 2015 | doi: 10.1038/ncomms7297 Biological Sciences  Cell biology  Neuroscience  Silicon-chip mid-infrared frequency comb generation Austin G. Griffith, Ryan K.W. Lau, Jaime Cardenas, Yoshitomo Okawachi, Aseema Mohanty, Romy Fain, Yoon Ho Daniel Lee, Mengjie Yu, Christopher T. Phare, Carl B. Poitras, Alexander L. Gaeta and Michal Lipson Optical frequency combs in the mid-infrared are required for molecular gas detection applications but their realization in compact microresonator-based platforms is challenging. Here, Griffith et al. demonstrate on-chip broadband comb generation on a silicon microresonator spanning from 2.1 to 3.5 μm. 24 February 2015 | doi: 10.1038/ncomms7299 Physical Sciences  Applied physics  Nanotechnology  Optical physics  Visualization and thermodynamic encoding of single-molecule partition function projections Carlos-Andres Palma, Jonas Björk, Florian Klappenberger, Emmanuel Arras, Dirk Kühne, Sven Stafström and Johannes V. Barth It is challenging to determine thermodynamic quantities for single molecules. Here, the authors access single-molecule thermodynamic information via a microscopic and computational study of a confined molecule, for which the resulting patterns represent a real-space equilibrium probability distribution. 23 February 2015 | doi: 10.1038/ncomms7210 Chemical Sciences  Physical chemistry  Cyclic stretching of soft substrates induces spreading and growth OPEN Yidan Cui, Feroz M. Hameed, Bo Yang, Kyunghee Lee, Catherine Qiurong Pan, Sungsu Park and Michael Sheetz Cells grown on a stiff substrate are stimulated through physical cues to spread, create actin stress fibres and proliferate. Here Cui et al. show that cyclic stretching cells on a soft pillar substrate has the same effect as growth on a stiff substrate, and results in nuclear translocation of YAP and MRTF-A. 23 February 2015 | doi: 10.1038/ncomms7333 Biological Sciences  Biophysics  Cell biology  Metabolic cross-feeding via intercellular nanotubes among bacteria Samay Pande, Shraddha Shitut, Lisa Freund, Martin Westermann, Felix Bertels, Claudia Colesie, Ilka B. Bischofs and Christian Kost Some bacteria can form nanotubes to transfer proteins and plasmids between neighbouring cells. Here, the authors show that nanotubes can also mediate the exchange of cytoplasmic amino acids between cells of the same or different bacterial species. 23 February 2015 | doi: 10.1038/ncomms7238 Biological Sciences  Cell biology  Microbiology  A multicentre-bonded [ZnI]8 cluster with cubic aromaticity Ping Cui, Han-Shi Hu, Bin Zhao, Jeffery T. Miller, Peng Cheng and Jun Li Zinc(I) bimetallic clusters have previously been reported, but they are not stable in air. Here, the authors synthesize octametallic Zinc(I) clusters with multi-centred zinc–zinc bonds and extensive electron delocalization over the cluster, resulting in cubic aromaticity and enhanced stability. 23 February 2015 | doi: 10.1038/ncomms7331 Chemical Sciences  Inorganic chemistry  Suppression of nuclear spin bath fluctuations in self-assembled quantum dots induced by inhomogeneous strain OPEN E.A. Chekhovich, M. Hopkinson, M.S. Skolnick and A.I. Tartakovskii Decoherence of the nuclear spin bath causes decoherence of electron spin qubits in the solid state. Here, Chekhovich et al. use spin-echo measurements to demonstrate the suppression of nuclear spin fluctuations in semiconductor quantum dots via strain-induced quadrupolar interactions. 23 February 2015 | doi: 10.1038/ncomms7348 Physical Sciences  Condensed matter  Materials science  Nanotechnology  Self-catalysed aerobic oxidization of organic linker in porous crystal for on-demand regulation of sorption behaviours Pei-Qin Liao, Ai-Xin Zhu, Wei-Xiong Zhang, Jie-Peng Zhang and Xiao-Ming Chen Controlling and selectively altering the structure of materials opens up the possibility of modulating their physical properties. Here, the authors report a method for altering the properties of a coordination polymer, where the metal centres active molecular oxygen to oxidize the organic ligand. 23 February 2015 | doi: 10.1038/ncomms7350 Chemical Sciences  Inorganic chemistry  Materials science  Organic chemistry  A mechanically sensitive cell layer regulates the physical properties of the Arabidopsis seed coat Audrey Creff, Lysiane Brocard and Gwyneth Ingram Mechanical signalling is an important regulator of plant development. Here, Creff et al. propose that the perception of mechanical signals in growing seeds by a specific cell layer in the seed coat controls the accumulation of gibberellic acid and links mechanical signals to the regulation of seed size. 23 February 2015 | doi: 10.1038/ncomms7382 Biological Sciences  Plant sciences  Volatile signalling by sesquiterpenes from ectomycorrhizal fungi reprogrammes root architecture OPEN Franck A. Ditengou, Anna Müller, Maaria Rosenkranz, Judith Felten, Hanna Lasok, Maja Miloradovic van Doorn, Valerie Legué, Klaus Palme, Jörg-Peter Schnitzler and Andrea Polle Soil-dwelling ectomycorrhizal fungi trigger remodelling of root architecture as part of a mutualistic symbiotic relationship with host plants. Here, Ditengou et al. identify fungal-derived sesquiterpenes as volatile signals capable of stimulating lateral root production in Arabidopsis and Populus. 23 February 2015 | doi: 10.1038/ncomms7279 Biological Sciences  Plant sciences  Nutritional stress induces exchange of cell material and energetic coupling between bacterial species Saida Benomar, David Ranava, María Luz Cárdenas, Eric Trably, Yan Rafrafi, Adrien Ducret, Jérôme Hamelin, Elisabeth Lojou, Jean-Philippe Steyer and Marie-Thérèse Giudici-Orticoni Bacterial communities adapt to changing environments by modulating patterns of nutrient flow between species. Benomar et al. show that under nutrient stress, the sulfate-reducing bacterium Desulfovibrio vulgaris can exchange cytoplasmic material with Clostridium acetobutylicum, altering metabolic flux. 23 February 2015 | doi: 10.1038/ncomms7283 Biological Sciences  Cell biology  Microbiology  Direct and selective hydrogenolysis of arenols and aryl methyl ethers Shuhei Kusumoto and Kyoko Nozaki Deoxygenating phenols is a difficult task, made more complex by the tendency of hydrogenation techniques to also reduce the aromatic ring. Here, the authors show an iridium catalyst that can selectively cleave the C–O bond in phenols and related compounds, as well as cleaving aryl methyl ethers. 23 February 2015 | doi: 10.1038/ncomms7296 Chemical Sciences  Catalysis  Organic chemistry  Refractory dissolved organic nitrogen accumulation in high-elevation lakes S.J. Goldberg, G.I. Ball, B.C. Allen, S.G. Schladow, A.J. Simpson, H. Masoom, R. Soong, H.D. Graven and L.I. Aluwihare Some nutrient budgets and fluxes in aquatic environments are poorly constrained. Here, the authors identify a novel pathway of reactive nitrogen sequestration in lakes of the Sierra Nevada, and investigate the relative reactivity of dissolved organic carbon. 23 February 2015 | doi: 10.1038/ncomms7347 Earth Sciences  Biogeochemistry  Towards graphyne molecular electronics Zhihai Li, Manuel Smeu, Arnaud Rives, Valérie Maraval, Remi Chauvin, Mark A. Ratner and Eric Borguet α-Graphyne, a carbon-expanded version of graphene, is predicted to exhibit high conductivity due to its Dirac cone electronic structure. Here, Li et al. design and synthesize a series of molecular fragments of α-graphyne, on the basis of which single molecular junctions are realized. 20 February 2015 | doi: 10.1038/ncomms7321 Physical Sciences  Applied physics  Materials science  Physical chemistry  Electroneutrality breakdown and specific ion effects in nanoconfined aqueous electrolytes observed by NMR Zhi-Xiang Luo, Yun-Zhao Xing, Yan-Chun Ling, Alfred Kleinhammes and Yue Wu It is generally believed that charge neutrality is maintained in electrolytes nanoconfined by uncharged surfaces. Here, the authors show that electroneutrality breakdown is substantial in nanoconfined aqueous electrolytes, and it depends on ion-specific interfacial interactions and ion–ion correlations. 20 February 2015 | doi: 10.1038/ncomms7358 Chemical Sciences  Condensed matter  Physical chemistry  Consequences of chirality on the dynamics of a water-soluble supramolecular polymer OPEN Matthew B. Baker, Lorenzo Albertazzi, Ilja K. Voets, Christianus M.A. Leenders, Anja R.A. Palmans, Giovanni M. Pavan and E.W. Meijer Water-soluble supramolecular polymers assemble from individual building blocks, but there is a lack of understanding as to how the properties depend on the components. Here the authors show how the introduction of chiral groups can affect the structural features and dynamic behaviour of the polymer. 20 February 2015 | doi: 10.1038/ncomms7234 Chemical Sciences  Materials science  Organic chemistry  Almost quantum correlations Miguel Navascués, Yelena Guryanova, Matty J. Hoban and Antonio Acín Physical theories can be classified by the strength of the correlations that they allow to be generated between systems. Here, the authors introduce the set of almost quantum correlations that, despite being larger than strict quantum correlations, do not lead to operational contradictions. 20 February 2015 | doi: 10.1038/ncomms7288 Physical Sciences  Theoretical physics  Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis OPEN Monika Srivastava, Guowen Duan, Nadia J. Kershaw, Vicki Athanasopoulos, Janet H. C. Yeo, Toyoyuki Ose, Desheng Hu, Simon H. J. Brown, Slobodan Jergic, Hardip R. Patel, Alvin Pratama, Sashika Richards, Anil Verma, E. Yvonne Jones, Vigo Heissmeyer, Thomas Preiss, Nicholas E. Dixon, Mark M. W. Chong, Jeffrey J. Babon and Carola G. Vinuesa et al. Roquin is an RNA-binding protein that promotes the degradation of specific mRNAs and is crucial for the maintenance of peripheral immune tolerance. Here the authors show that, in addition to its target mRNAs, Roquin can bind miR-146a and the RISC component Ago2 to control homeostasis of both RNA species. 20 February 2015 | doi: 10.1038/ncomms7253 Biological Sciences  Biochemistry  Immunology  Molecular biology  A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins OPEN Guntur Fibriansah, Joanne L. Tan, Scott A. Smith, Ruklanthi de Alwis, Thiam-Seng Ng, Victor A. Kostyuchenko, Ramesh S. Jadi, Petra Kukkaro, Aravinda M. de Silva, James E. Crowe and Shee-Mei Lok There is no licensed vaccine or therapeutic for dengue virus (DENV) infection. Here, the authors show that a highly potent human monoclonal antibody binds to DENV particles in an unusual and very effective way by interacting with three viral envelope proteins. 20 February 2015 | doi: 10.1038/ncomms7341 Biological Sciences  Immunology  Microbiology  Virology  High rate and stable cycling of lithium metal anode OPEN Jiangfeng Qian, Wesley A. Henderson, Wu Xu, Priyanka Bhattacharya, Mark Engelhard, Oleg Borodin and Ji-Guang Zhang Lithium metal is an ideal anode material for rechargeable batteries, but lithium dendritic growth and limited Columbic efficiency prevent its applications. Here, the authors report the use of highly concentrated electrolytes composed of ether solvents and the salt lithium bis(fluorosulfonyl)imide to enable high-rate cycling of lithium anode. 20 February 2015 | doi: 10.1038/ncomms7362 Chemical Sciences  Materials science  Physical chemistry  Enhanced magnetic Purcell effect in room-temperature masers OPEN Jonathan Breeze, Ke-Jie Tan, Benjamin Richards, Juna Sathian, Mark Oxborrow and Neil McN Alford Masers are promising for applications that use microwave radiation. Here, the authors present a compact room-temperature maser design using a high permittivity dielectric material for the resonator to achieve low optical pumping powers. This design pushes masers closer towards their promised applications. 20 February 2015 | doi: 10.1038/ncomms7215 Physical Sciences  Optical physics  An octave-spanning mid-infrared frequency comb generated in a silicon nanophotonic wire waveguide OPEN Bart Kuyken, Takuro Ideguchi, Simon Holzner, Ming Yan, Theodor W. Hänsch, Joris Van Campenhout, Peter Verheyen, Stéphane Coen, Francois Leo, Roel Baets, Gunther Roelkens and Nathalie Picqué Phase-coherent frequency combs in the mid-infrared have important potential applications but their fabrication remains challenging. Here, Kuyken et al. demonstrate an octave-spanning frequency comb in the mid-infrared using a highly nonlinear dispersion-engineered silicon waveguide on a silicon-on-insulator chip. 20 February 2015 | doi: 10.1038/ncomms7310 Physical Sciences  Applied physics  Nanotechnology  Optical physics  Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia Geou-Yarh Liou, Heike Döppler, Ursula B. Braun, Richard Panayiotou, Michele Scotti Buzhardt, Derek C. Radisky, Howard C. Crawford, Alan P. Fields, Nicole R. Murray, Q. Jane Wang, Michael Leitges and Peter Storz Acinar-to-ductal metaplasia (ADM) is a potential early step in the development of pancreatic cancer. Here, using an in vitro model of ADM, the authors show that protein kinase D1 (PKD1) is required for TGFα- or KRAS-induced ADM through Notch activation. 20 February 2015 | doi: 10.1038/ncomms7200 Biological Sciences  Cancer  Molecular biology  Developmental enhancers revealed by extensive DNA methylome maps of zebrafish early embryos Hyung Joo Lee, Rebecca F. Lowdon, Brett Maricque, Bo Zhang, Michael Stevens, Daofeng Li, Stephen L. Johnson and Ting Wang DNA methylation undergoes dynamic changes during development and cell differentiation. Here, by comparing DNA methylomes from different stages of embryonic development of the zebrafish, the authors suggest that developmental enhancers are a major target of DNA methylation changes during embryogenesis. 20 February 2015 | doi: 10.1038/ncomms7315 Biological Sciences  Genetics  Molecular biology  Crystalline silicon core fibres from aluminium core preforms Chong Hou, Xiaoting Jia, Lei Wei, Swee-Ching Tan, Xin Zhao, John D. Joannopoulos and Yoel Fink The integration of silicon optoelectronic devices in a fibre platform has great potential, but drawing such fibres is difficult. Using a simple, low cost and scalable method, Hou et al. fabricate a metre-long crystalline silicon-core, silica-clad fibre from a preform not containing elemental silicon. 20 February 2015 | doi: 10.1038/ncomms7248 Chemical Sciences  Materials science  Nanotechnology  Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis Hongtan Wu, Luyao Wei, Fuqin Fan, Suyuan Ji, Shihao Zhang, Jing Geng, Lixin Hong, Xin Fan, Qinghua Chen, Jing Tian, Mingting Jiang, Xiufeng Sun, Changnan Jin, Zhen-Yu Yin, Qingxu Liu, Jinjia Zhang, Funiu Qin, Kwang-Huei Lin, Jau-Song Yu, Xianming Deng et al. The Hippo pathway is a major regulator of organ size and growth control. Here Wu et al. provide evidence for a novel link between the Hippo signalling pathway and the unfolded protein response (UPR) in regulating organ growth and tumorigenesis. 19 February 2015 | doi: 10.1038/ncomms7239 Biological Sciences  Cancer  Molecular biology  Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue Atsushi Kuwahara, Chikafumi Ozone, Tokushige Nakano, Koichi Saito, Mototsugu Eiraku and Yoshiki Sasai The ciliary margin of the eye functions as a source of multipotent progenitor cells in certain organisms but whether it plays this role in humans has not been easy to study. Here the authors culture human embryonic stem cells that self-organize into retinal tissue, and show that ciliary margin-like growth zones emerge from the developing human retinal tissue and contain stem cell niches. 19 February 2015 | doi: 10.1038/ncomms7286 Biological Sciences  Cell biology  Developmental biology  Origin of band gaps in graphene on hexagonal boron nitride OPEN Jeil Jung, Ashley M. DaSilva, Allan H. MacDonald and Shaffique Adam Graphene doesn’t usually have a bandgap but one can appear when the two-dimensional material is placed on a hexagonal boron nitride substrate. Jung et al. now develop a theory that indicates that this occurs because the graphene’s carbon atoms structurally relax when placed on boron nitride. 19 February 2015 | doi: 10.1038/ncomms7308 Physical Sciences  Materials science  Biophysical mechanisms that maintain biodiversity through trade-offs Justin R. Meyer, Ivana Gudelj and Robert Beardmore Trade-offs between life history traits are key to understanding biodiversity. Here, the authors use population genetics models and experimental microbial evolution to show that trade-off geometry can be deduced from fundamental biological principles, and used to predict biodiversity stability. 19 February 2015 | doi: 10.1038/ncomms7278 Biological Sciences  Ecology  Evolution  Microbiology  Unfolding a molecular trefoil derived from a zwitterionic metallopeptide to form self-assembled nanostructures Ye Zhang, Ning Zhou, Junfeng Shi, Susan Sondej Pochapsky, Thomas C. Pochapsky, Bei Zhang, Xixiang Zhang and Bing Xu Molecular self-assembly can be influenced by a number of external factors, though solvent effects are less commonly explored. Here, the authors present a three-armed metallopeptide complex that has a folded monomeric conformation in organic solvent, but can self-assemble in water into a supramolecular gel. 19 February 2015 | doi: 10.1038/ncomms7165 Chemical Sciences  Materials science  Physical chemistry  A balance between membrane elasticity and polymerization energy sets the shape of spherical clathrin coats OPEN Mohammed Saleem, Sandrine Morlot, Annika Hohendahl, John Manzi, Martin Lenz and Aurélien Roux A relationship between membrane tension and clathrin polymerization during endocytosis has not been experimentally established. Here, the authors show using an in vitro reconstituted system and theoretical modelling that membrane tension regulates clathrin polymerization into spherical cages by varying the membrane budding energy. 19 February 2015 | doi: 10.1038/ncomms7249 Biological Sciences  Biophysics  Self-assembled hydrogels utilizing polymer–nanoparticle interactions Eric A. Appel, Mark W. Tibbitt, Matthew J. Webber, Bradley A. Mattix, Omid Veiseh and Robert Langer Mouldable hydrogels find a variety of applications in the biomedical industry. Here, Appel et al. show a method to fabricate hydrogels through a self-assembly process based on the interaction between biopolymers and functional nanoparticles for multistage drug delivery in vivo. 19 February 2015 | doi: 10.1038/ncomms7295 Chemical Sciences  Materials science  AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control Malte Gersch, Kirsten Famulla, Maria Dahmen, Christoph Göbl, Imran Malik, Klaus Richter, Vadim S. Korotkov, Peter Sass, Helga Rübsamen-Schaeff, Tobias Madl, Heike Brötz-Oesterhelt and Stephan A. Sieber Acyldepsipeptides are natural antibiotics that function by activating the ClpP protease and deregulating proteolysis. Here, Gersch et al. show that acyldepsipeptides not only increase access to the active sites but also exert conformational control, thereby allosterically stimulating ClpP catalysis. 19 February 2015 | doi: 10.1038/ncomms7320 Biological Sciences  Biochemistry  Chemical biology  TGF-β3-expressing CD4+CD25−LAG3+ regulatory T cells control humoral immune responses OPEN Tomohisa Okamura, Shuji Sumitomo, Kaoru Morita, Yukiko Iwasaki, Mariko Inoue, Shinichiro Nakachi, Toshihiko Komai, Hirofumi Shoda, Jun-ichi Miyazaki, Keishi Fujio and Kazuhiko Yamamoto B cells reactive against self antigens can cause autoimmune disease, but are normally suppressed by regulatory T cells (Tregs). Here the authors show that a subset of Tregs can suppress lupus in a mouse model by making TGF-β3 cytokine and by engaging an inhibitory PD-1 receptor on B cells. 19 February 2015 | doi: 10.1038/ncomms7329 Biological Sciences  Immunology  Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses OPEN Patricia Bonnavion, Alexander C. Jackson, Matthew E. Carter and Luis de Lecea The hypothalamic-pituitary-adrenal axis coordinates behavioral and physiological responses to stress but the mechanisms are poorly understood. Here, the authors show that neurons that produce hypocretin/orexin in the lateral hypothalamic area regulate corticosterone release and a variety of behaviors related to the stress response. 19 February 2015 | doi: 10.1038/ncomms7266 Biological Sciences  Neuroscience  Escape from crossover interference increases with maternal age OPEN Christopher L. Campbell, Nicholas A. Furlotte, Nick Eriksson, David Hinds and Adam Auton Recombination is a meiotic process that ensures accurate chromosome segregation. Here, the authors characterize recombination patterns in over 4,200 families. Their results show that recombination rate increases with maternal age, and highlight sex differences in the distribution of these events. 19 February 2015 | doi: 10.1038/ncomms7260 Biological Sciences  Genetics  Molecular biology  Substrate stress relaxation regulates cell spreading Ovijit Chaudhuri, Luo Gu, Max Darnell, Darinka Klumpers, Sidi A. Bencherif, James C. Weaver, Nathaniel Huebsch and David J. Mooney Studies of cellular mechanotransduction commonly use elastic substrates, whereas biological substrates are viscoelastic, exhibiting stress relaxation. Here, the authors show through computational modelling and experiments that viscoelastic substrates can stimulate cell spreading to a greater extent than purely elastic substrates with the same initial stiffness. 19 February 2015 | doi: 10.1038/ncomms7365 Biological Sciences  Biophysics  Cell biology  In vivo odourant response properties of migrating adult-born neurons in the mouse olfactory bulb Yury Kovalchuk, Ryota Homma, Yajie Liang, Anatoliy Maslyukov, Marina Hermes, Thomas Thestrup, Oliver Griesbeck, Jovica Ninkovic, Lawrence B. Cohen and Olga Garaschuk Juxtaglomerular neurons (JGNs) of the mammalian olfactory bulb are generated throughout life, but when and how these adult-born cells acquire responsiveness to sensory stimuli remains unknown. Here, the authors use in vivo two-photon imaging to monitor the migration and integration of adult-born JGNs and their sensory response properties. 19 February 2015 | doi: 10.1038/ncomms7349 Biological Sciences  Neuroscience  Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo OPEN Huey-Wen Hsiao, Tzu-Sheng Hsu, Wen-Hsien Liu, Wan-Chen Hsieh, Ting-Fang Chou, Yu-Jung Wu, Si-Tse Jiang and Ming-Zong Lai Foxp3, a key transcription factor of regulatory T cells, is targeted to degradation by HIF-1α. Here the authors show that Deltex1 promotes degradation of HIF-1α, thus stabilizing Foxp3 levels and function of regulatory T cells in vivo. 19 February 2015 | doi: 10.1038/ncomms7353 Biological Sciences  Immunology  TMC-1 attenuates C. elegans development and sexual behaviour in a chemically defined food environment Liusuo Zhang, Daisy G. Gualberto, Xiaoyan Guo, Paola Correa, Changhoon Jee and L. Rene Garcia The tmc-1 gene encodes for a sodium channel that has been linked to chemosensation in C. elegans. Here the authors show that in a non-optimal nutrient environment, tmc-1 mediates physiological worm responses such as developmental retardation and inhibited sexual behaviour. 19 February 2015 | doi: 10.1038/ncomms7345 Biological Sciences  Medical research  Origin and consequences of silicate glass passivation by surface layers OPEN Stéphane Gin, Patrick Jollivet, Maxime Fournier, Frédéric Angeli, Pierre Frugier and Thibault Charpentier The long term durability of silicate glasses is of significant importance, not least due to applications in nuclear waste repositories. Here, the authors study glass corrosion and show that its rate drops as a passivating layer forms via a self-healing mechanism. 19 February 2015 | doi: 10.1038/ncomms7360 Chemical Sciences  Materials science  Physical chemistry  Exploring atomic defects in molybdenum disulphide monolayers OPEN Jinhua Hong, Zhixin Hu, Matt Probert, Kun Li, Danhui Lv, Xinan Yang, Lin Gu, Nannan Mao, Qingliang Feng, Liming Xie, Jin Zhang, Dianzhong Wu, Zhiyong Zhang, Chuanhong Jin, Wei Ji, Xixiang Zhang, Jun Yuan and Ze Zhang Imperfections can greatly alter a material’s properties. Here, the authors investigate the influence of point defects on the electronic structure, charge-carrier mobility and optical absorption of molybdenum disulphide prepared by mechanical exfoliation, physical and chemical vapour deposition. 19 February 2015 | doi: 10.1038/ncomms7293 Physical Sciences  Materials science  Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci OPEN Roland Jäger, Gabriele Migliorini, Marc Henrion, Radhika Kandaswamy, Helen E. Speedy, Andreas Heindl, Nicola Whiffin, Maria J. Carnicer, Laura Broome, Nicola Dryden, Takashi Nagano, Stefan Schoenfelder, Martin Enge, Yinyin Yuan, Jussi Taipale, Peter Fraser, Olivia Fletcher and Richard S. Houlston Multiple regulatory elements distant from their targets on the linear genome can influence gene expression through chromatin looping. Here, the authors report an improved chromosome conformation capture approach that can be used to identify long-range chromatin interactions in cancer risk loci. 19 February 2015 | doi: 10.1038/ncomms7178 Biological Sciences  Genetics  Molecular biology  RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL OPEN Kate E. Lawlor, Nufail Khan, Alison Mildenhall, Motti Gerlic, Ben A. Croker, Akshay A. D’Cruz, Cathrine Hall, Sukhdeep Kaur Spall, Holly Anderton, Seth L. Masters, Maryam Rashidi, Ian P. Wicks, Warren S. Alexander, Yasuhiro Mitsuuchi, Christopher A. Benetatos, Stephen M. Condon, W. Wei-Lynn Wong, John Silke, David L. Vaux and James E. Vince et al. RIPK3 can cause necroptotic cell death via MLKL phosphorylation, and activate NLRP3 inflammasome. Here the authors show that MLKL is dispensable for NLRP3 activation by RIPK3, and highlight how different IAP proteins limit RIPK3 induced apoptosis, necroptosis and IL-1 secretion. 18 February 2015 | doi: 10.1038/ncomms7282 Biological Sciences  Immunology  Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase Amarjit Mishra, Alexandra L. Brown, Xianglan Yao, Shutong Yang, Sung-Jun Park, Chengyu Liu, Pradeep K. Dagur, J. Philip McCoy, Karen J. Keeran, Gayle Z. Nugent, Kenneth R. Jeffries, Xuan Qu, Zu-Xi Yu, Stewart J. Levine and Jay H. Chung House dust mites are a common cause of allergic asthma. Here, the authors show that the Th2-mediated inflammatory responses triggered by mites in mouse airways are mediated by the activation of DNA-dependent protein kinase (DNA-PK) in dendritic cells. 18 February 2015 | doi: 10.1038/ncomms7224 Biological Sciences  Immunology  Hierarchical structural design for fracture resistance in the shell of the pteropod Clio pyramidata Ling Li, James C. Weaver and Christine Ortiz The hierarchical structural motifs of biomaterials can lead to advantageous mechanical properties. Here, the authors reveal that a fibre-like helical structure across the shell of a planktonic pteropod suppresses crack propagation and is responsible for a high fracture resistance. 18 February 2015 | doi: 10.1038/ncomms7216 Biological Sciences  Bioengineering  Materials science  Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy David G. Ousterout, Ami M. Kabadi, Pratiksha I. Thakore, William H. Majoros, Timothy E. Reddy and Charles A. Gersbach Duchenne muscular dystrophy is caused by mutations in the dystrophin gene. Here, Ousterout et al. use multiplexed CRISPR/Cas9 genome editing to excise a large portion of the gene that carries over 60% of known dystrophin mutations. They show that this excision restores dystrophin expression in patient-derived cells. 18 February 2015 | doi: 10.1038/ncomms7244 Biological Sciences  Medical research  Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo Misako Matsumoto, Megumi Tatematsu, Fumiko Nishikawa, Masahiro Azuma, Noriko Ishii, Akiko Morii-Sakai, Hiroaki Shime and Tsukasa Seya Activation of TLRs by microbial ligands induces complex innate immune responses to activate host defence. Here the authors show that a synthetic TLR3 ligand can boost protective immunity without robust inflammatory cytokine production, minimizing toxic effects of immunization. 18 February 2015 | doi: 10.1038/ncomms7280 Biological Sciences  Biotechnology  Immunology  Hydrodynamic phonon transport in suspended graphene Sangyeop Lee, David Broido, Keivan Esfarjani and Gang Chen Hydrodynamic phonon transport occurs when phonons are able to drift over macroscopic distances, leading to the breakdown of Fourier’s law of heat conduction. Here, the authors predict that this regime occurs in suspended graphene at higher temperatures than bulk materials. 18 February 2015 | doi: 10.1038/ncomms7290 Physical Sciences  Materials science  Dendritic geometry shapes neuronal cAMP signalling to the nucleus OPEN Lu Li, Nicolas Gervasi and Jean-Antoine Girault Neurons have complex dendritic trees but the rules governing the propagation of signals from dendrites to nuclei remain unclear. Here the authors combine diffusion-reaction modelling and live imaging to investigate the mechanisms regulating cAMP signalling in neurons and find that dendritic tree geometry shapes synapse-to-nucleus signalling. 18 February 2015 | doi: 10.1038/ncomms7319 Biological Sciences  Neuroscience  Small-molecule inhibitors targeting INK4 protein p18INK4C enhance ex vivo expansion of haematopoietic stem cells Yingdai Gao, Peng Yang, Hongmei Shen, Hui Yu, Xianmin Song, Liyan Zhang, Peng Zhang, Haizi Cheng, Zhaojun Xie, Sha Hao, Fang Dong, Shihui Ma, Qing Ji, Patrick Bartlow, Yahui Ding, Lirong Wang, Haibin Liu, Yanxin Li, Hui Cheng, Weimin Miao et al. The cyclin-dependent kinase inhibitors p18 and p27 confer advantage to the propagation of haematopoietic stem cells (HSCs). In this manuscript, the authors demonstrate that p18 is a potent negative regulator of HSC self-renewal, and identify novel small molecules putatively inhibiting p18 that promote HSC growth in culture and mouse transplant assays. 18 February 2015 | doi: 10.1038/ncomms7328 Biological Sciences  Cell biology  Developmental biology  Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster Adam J. Dobson, John M. Chaston, Peter D. Newell, Leanne Donahue, Sara L. Hermann, David R. Sannino, Stephanie Westmiller, Adam C.-N. Wong, Andrew G. Clark, Brian P. Lazzaro and Angela E. Douglas The gut microbiota affects animal nutrition, but it is unclear whether this effect depends on host genetic makeup. This study shows that host genotype modifies the gut microbiota’s impact on host nutrition, and identifies genetic determinants of this variation in the fruit fly. 18 February 2015 | doi: 10.1038/ncomms7312 Biological Sciences  Genetics  Microbiology  Unique features of mutations revealed by sequentially reprogrammed induced pluripotent stem cells Shuai Gao, Caihong Zheng, Gang Chang, Wenqiang Liu, Xiaochen Kou, Kun Tan, Li Tao, Kai Xu, Hong Wang, Jun Cai, Jianhui Tian and Shaorong Gao Mice can be generated from induced pluripotent stem cells (iPSCs) but the impact of accumulated mutations on the developmental potential of the cells remains to be determined. Here the authors show that mice generated from iPSCs tolerate the accumulation of somatic mutations for up to six generations, but their viability decreased with increasing generations. 18 February 2015 | doi: 10.1038/ncomms7318 Biological Sciences  Cell biology  Developmental biology  Experimental diagenesis of organo-mineral structures formed by microaerophilic Fe(II)-oxidizing bacteria Aude Picard, Andreas Kappler, Gregor Schmid, Luca Quaroni and Martin Obst Twisted iron-rich stalks provide evidence for iron-oxidizing bacteria in sedimentary deposits. Picard et al. show experimentally the persistence of such structures exposed to temperatures and pressures typical of diagenetic conditions, providing spectroscopic signatures to aid their reliable identification. 18 February 2015 | doi: 10.1038/ncomms7277 Biological Sciences  Biogeochemistry  Microbiology  Tetrahedrally coordinated carbonates in Earth’s lower mantle Eglantine Boulard, Ding Pan, Giulia Galli, Zhenxian Liu and Wendy L. Mao The behaviour of subducted carbonates at high pressures within the Earth is still poorly understood. Here, the authors present experimental and theoretical evidence of a new carbon–oxygen bond in a high-pressure mineral phase, which has implications for the viscosity and mobility of carbonate melts. 18 February 2015 | doi: 10.1038/ncomms7311 Earth Sciences  Geology and geophysics  Considerably improved photovoltaic performance of carbon nanotube-based solar cells using metal oxide layers Feijiu Wang, Daichi Kozawa, Yuhei Miyauchi, Kazushi Hiraoka, Shinichiro Mouri, Yutaka Ohno and Kazunari Matsuda The interface between electrodes and active layers of electronic devices such as solar cells is crucial for the device performance. Here, the authors show that metal oxides MoOx and ZnO play an important role in reducing the electronic barrier at the interface in photovoltaic devices based on carbon nanotubes. 18 February 2015 | doi: 10.1038/ncomms7305 Physical Sciences  Applied physics  Optical physics  CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production OPEN Vishal Khairnar, Vikas Duhan, Sathish Kumar Maney, Nadine Honke, Namir Shaabani, Aleksandra A. Pandyra, Marc Seifert, Vitaly Pozdeev, Haifeng C. Xu, Piyush Sharma, Fabian Baldin, Florian Marquardsen, Katja Merches, Elisabeth Lang, Carsten Kirschning, Astrid M. Westendorf, Dieter Häussinger, Florian Lang, Ulf Dittmer, Ralf Küppers et al. Antibody responses are regulated by selective survival of B cells with proper antigen specificity. Here the authors show that CEACAM1 is critical for B-cell survival during homeostasis and antiviral responses. 18 February 2015 | doi: 10.1038/ncomms7217 Biological Sciences  Immunology  A cnidarian homologue of an insect gustatory receptor functions in developmental body patterning Michael Saina, Henriette Busengdal, Chiara Sinigaglia, Libero Petrone, Paola Oliveri, Fabian Rentzsch and Richard Benton Insect gustatory and olfactory receptor genes encode transmembrane proteins that detect diverse chemicals, but their evolutionary origins are unclear. This study identifies homologues of these genes in non-Bilateria and reveals an unexpected role for one in sea anemone embryonic development. 18 February 2015 | doi: 10.1038/ncomms7243 Biological Sciences  Developmental biology  Evolution  NEDD4 controls intestinal stem cell homeostasis by regulating the Hippo signalling pathway Sung Jun Bae, Myungjin Kim, Sung-Hee Kim, Young Eun Kwon, Ji-Hoon Lee, Jaesang Kim, Chin Ha Chung, Won-Jae Lee and Jae Hong Seol The Hippo pathway plays a role in regulating organ size and stem cell renewal but the regulatory mechanisms that fine-tune this pathway are not well understood. Here the authors report on the role of NEDD4 as a negative regulator of the Hippo signalling components, WW45 and LATS kinase, and in controlling cell proliferation and intestinal stem cell homeostasis. 18 February 2015 | doi: 10.1038/ncomms7314 Biological Sciences  Cell biology  Developmental biology  Cracking-assisted photolithography for mixed-scale patterning and nanofluidic applications Minseok Kim, Dogyeong Ha and Taesung Kim Cracks in material are not always unwanted; sometimes, they can be manipulated to produce micro and nanoscale patterns. Here, Kim et al. report a cracking-assisted nanofabrication technique based on conventional photolithography process, which allows accurate control over the geometry of the nanopatterns in arbitrary shape. 18 February 2015 | doi: 10.1038/ncomms7247 Physical Sciences  Applied physics  Materials science  Nanotechnology  Epigenomic footprints across 111 reference epigenomes reveal tissue-specific epigenetic regulation of lincRNAs OPEN Viren Amin, R. Alan Harris, Vitor Onuchic, Andrew R. Jackson, Tim Charnecki, Sameer Paithankar, Sai Lakshmi Subramanian, Kevin Riehle, Cristian Coarfa and Aleksandar Milosavljevic Tissue-specific functions have been established for some lincRNAs. Here, by analysing 111 reference epigenomes from the NIH Roadmap Epigenomics project, the authors report tissue-specific epigenomic regulation of 3,753 lincRNAs and their strong connection with tissue-specific pathways. 18 February 2015 | doi: 10.1038/ncomms7370 Biological Sciences  Genetics  Molecular biology  Epigenetic and transcriptional determinants of the human breast OPEN Philippe Gascard, Misha Bilenky, Mahvash Sigaroudinia, Jianxin Zhao, Luolan Li, Annaick Carles, Allen Delaney, Angela Tam, Baljit Kamoh, Stephanie Cho, Malachi Griffith, Andy Chu, Gordon Robertson, Dorothy Cheung, Irene Li, Alireza Heravi-Moussavi, Michelle Moksa, Matthew Mingay, Angela Hussainkhel, Brad Davis et al. Epigenetic changes associated with post-natal differentiation have been characterized. Here the authors generate epigenomic and transcriptional profiles from primary human breast cells, providing insights into the transcriptional and epigenetic events that define post-natal cell differentiation in vivo. 18 February 2015 | doi: 10.1038/ncomms7351 Biological Sciences  Developmental biology  Molecular biology  Intermediate DNA methylation is a conserved signature of genome regulation OPEN GiNell Elliott, Chibo Hong, Xiaoyun Xing, Xin Zhou, Daofeng Li, Cristian Coarfa, Robert J.A. Bell, Cecile L. Maire, Keith L. Ligon, Mahvash Sigaroudinia, Philippe Gascard, Thea D. Tlsty, R. Alan Harris, Leonard C. Schalkwyk, Misha Bilenky, Jonathan Mill, Peggy J. Farnham, Manolis Kellis, Marco A. Marra, Aleksandar Milosavljevic et al. Many loci in the mammalian genome are intermediately methylated. Here, by comprehensively identifying these loci and quantifying their relationship with gene activity, the authors show that intermediate methylation is an evolutionarily conserved epigenomic signature of gene regulation. 18 February 2015 | doi: 10.1038/ncomms7363 Biological Sciences  Genetics  Molecular biology    Nature Communications JOBS of the week Postdoctoral Fellow University of Kentucky Postdoctoral Researcher The Genome Analysis Centre (TGAC) PhD Studentship in Immunology The Babraham Institute Postdoctoral Fellow Lurie Children's Hospital Research Center Research Assistant University of Bristol PhD position Institut für Ostseeforschung Postdoctoral Fellow Harvard Medical School Prostate Cancer UK PhD Studentship University of Hull Postdoctoral Researcher University of Idaho Senior Research Associate University of East Anglia (UEA) More Science jobs from Nature Communications EVENT Mind & Brain Prize 2015 25.09.15 Torino, Italy More science events from       Latest Corrigendum     Corrigendum: Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleases Daniel Sommer, Annika E. Peters, Tristan Wirtz, Maren Mai, Justus Ackermann, Yasser Thabet, Jürgen Schmidt, Heike Weighardt, F. Thomas Wunderlich, Joachim Degen, Joachim L. Schultze and Marc Beyer 20 February 2015 | doi: 10.1038/ncomms6927 Biological Sciences  Biotechnology  Developmental biology        Latest Erratum     Erratum: Interstitial modification of palladium nanoparticles with boron atoms as a green catalyst for selective hydrogenation Chun Wong Aaron Chan, Abdul Hanif Mahadi, Molly Meng-Jung Li, Elena Cristina Corbos, Chiu Tang, Glenn Jones, Winson Chun Hsin Kuo, James Cookson, Christopher Michael Brown, Peter Trenton Bishop and Shik Chi Edman Tsang 23 February 2015 | doi: 10.1038/ncomms7487 Chemical Sciences  Catalysis  Inorganic chemistry  Materials science      Advertisement Nature Collections  Nobel Prize in Chemistry 2014  The 2014 Nobel Prize in Chemistry was awarded for the development of super-resolution fluorescence microscopy. This collection of news pieces and articles by the Nobel laureates and their collaborators celebrates this achievement. Produced with support from  ZEISS Microscopy      Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com  More Nature Events You have been sent this Table of Contents Alert because you have opted in to receive it. 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