Nature Cell Biology contents: March 2015 Volume 17 Number 3, pp 195-350

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View the RFA: www.nyscf.org/neuro Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BEATSON INTERNATIONAL CANCER CONFERENCE Control of Cell Polarity & Movement in Cancer 5-8 July 2015, Glasgow, Scotland Highlighting recent exciting research into molecular & cellular events contributing to loss of epithelial polarity during carcinogenesis, and how cancer cells acquire different types of polarity enabling them to migrate & invade. Registration details here   Advertisement Epigenome Roadmap Nature Publishing Group presents an online portal - the Epigenome Roadmap - which collects key research papers from The NIH Roadmap Epigenomics Program, complemented by thematical 'threads' to help the readers mine the wealth of available information. Access the Epigenome Roadmap for FREE at: nature.com/epigenomeroadmap Produced with exclusive support from  Illumina   Editorials Top Spotlight on Metabolism   p195 doi:10.1038/ncb3127 In this issue, we present the first of a series of Reviews discussing different aspects of cell metabolism. Introducing double-blind peer review   p195 doi:10.1038/ncb3140 Nature and its sister journals start offering anonymity to authors during the peer-review process. Reviews Top Tipping the metabolic scales towards increased longevity in mammals   pp196 - 203 Celine E. Riera and Andrew Dillin doi:10.1038/ncb3107 Riera and Dillin review how longevity is affected by metabolic changes and mitochondrial function. In vivo reprogramming for tissue repair   pp204 - 211 Christophe Heinrich, Francesca M. Spagnoli and Benedikt Berninger doi:10.1038/ncb3108 Berninger and colleagues define milestones for in vivo reprogramming and discuss recent developments in reprogramming into pancreatic b-cells and neurons News and Views Top Merlin's wizardry guides cohesive migration   pp212 - 213 Ansgar Zoch and Helen Morrison doi:10.1038/ncb3126 Cells often migrate in tightly connected groups with coordinated movement and polarity. The collective migration of epithelial cell sheets is now shown to be mediated by a signalling axis that involves the merlin tumour-suppressor protein, the tight-junction-associated angiomotin–Rich1 complex and the Rac1 small GTPase. See also: Article by Das et al. Huntingtin facilitates selective autophagy   pp214 - 215 Amir Gelman, Moran Rawet-Slobodkin and Zvulun Elazar doi:10.1038/ncb3125 Selective autophagy is essential for maintaining cellular homeostasis under different growth conditions. Huntingtin, mutated versions of which have been implicated in Huntington disease, is now shown to act as a scaffold protein that couples the induction of autophagy and the selective recruitment of cargo into autophagosomes. See also: Article by Rui et al. Cell Biology JOBS of the week Doctoral (PhD) student position with doctoral grant (KID funding) in cell biology Karolinska Institutet (KI) Principal Investigators (in Cell & Developmental Biology) University of Dundee Head of Microscopy Facility / Group Leader in Plant Cell Biology Max Planck Institute of Molecular Physiology Postdoctoral Fellowship - Cancer Stem Cell Biology Cleveland Clinic Lerner Research Institute 3 year Post-doctoral position in Cell and Developmental Biology Inserm More Science jobs from Cell Biology EVENT Cellular Biology of Addiction 04.08.15 Cold Spring Barbour, USA More science events from Articles Top Expansion of stem cells counteracts age-related mammary regression in compound Timp1/Timp3 null mice   pp217 - 227 Hartland W. Jackson, Paul Waterhouse, Ankit Sinha, Thomas Kislinger, Hal K. Berman et al. doi:10.1038/ncb3118 Khokha and colleagues report that lack of the metalloproteinase inhibitors TIMP1 and TIMP3 in female mice increases the size of the mammary basal stem cell pool and that this is maintained in ageing mice. Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation   pp228 - 240 Quanlong Lu, Christine Insinna, Carolyn Ott, Jimmy Stauffer, Petra A. Pintado et al. doi:10.1038/ncb3109 Westlake and colleagues discover that membrane shaping EHD proteins participate in ciliogenesis by taking part in ciliary vesicle formation and transition zone protein recruitment. Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs   pp241 - 250 Alejo E. Rodríguez-Fraticelli, Jennifer Bagwell, Minerva Bosch-Fortea, Gaelle Boncompain, Natalia Reglero-Real et al. doi:10.1038/ncb3106 Bagnat, Martín-Belmonte and colleagues reveal that plasmolipin (PLLP) is upregulated in the zebrafish midgut during development and controls epithelial patterning by promoting polarized endocytosis. FEAR-mediated activation of Cdc14 is the limiting step for spindle elongation and anaphase progression   pp251 - 261 Michela Roccuzzo, Clara Visintin, Federico Tili and Rosella Visintin doi:10.1038/ncb3105 Visentin and colleagues find a role for the FEAR network and Cdc5 in anaphase spindle elongation involving Cdc14-mediated dephosphorylation of the kinesin Cin8. Huntingtin functions as a scaffold for selective macroautophagy   pp262 - 275 Yan-Ning Rui, Zhen Xu, Bindi Patel, Zhihua Chen, Dongsheng Chen et al. doi:10.1038/ncb3101 Zhang, Cuervo and colleagues find that Huntingtin (Htt), which is commonly mutated in Huntington disease, regulates selective autophagy. Htt enhances interactions between p62, LC3 and ubiquitylated cargo and derepresses ULK1 kinase activity. See also: News and Views by Gelman et al. A molecular mechanotransduction pathway regulates collective migration of epithelial cells   pp276 - 287 Tamal Das, Kai Safferling, Sebastian Rausch, Niels Grabe, Heike Boehm et al. doi:10.1038/ncb3115 Spatz and colleagues report that intercellular pulling forces between leader and follower cells in migrating epithelial sheets regulate merlin subcellular localization and the crosstalk between merlin and Rac1 to promote collective cell migration. See also: News and Views by Zoch & Morrison Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB   pp288 - 299 Diego L. Medina, Simone Di Paola, Ivana Peluso, Andrea Armani, Diego De Stefani et al. doi:10.1038/ncb3114 Medina, Ballabio and colleagues report that calcium release from the lysosome stimulates calcineurin, which dephosphorylates and activates TFEB. These findings reveal a central role for calcium signalling in autophagy and lysosome homeostasis. ATG12–ATG3 interacts with Alix to promote basal autophagic flux and late endosome function   pp300 - 310 Lyndsay Murrow, Ritu Malhotra and Jayanta Debnath doi:10.1038/ncb3112 Debnath and colleagues report that the E2-like enzyme ATG3 is a target for ATG12 conjugation. ATG12–ATG3 conjugates interact with the ESCRT-associated protein Alix and regulate late endosome localization and exosome biogenesis. Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis   pp311 - 321 Einav Shoshan, Aaron K. Mobley, Russell R. Braeuer, Takafumi Kamiya, Li Huang et al. doi:10.1038/ncb3110 Bar-Eli and colleagues report that CREB-mediated downregulation of the RNA-editing enzyme ADAR1 results in decreased adenosine-to-inosine editing of miR-455-5p, which enhances melanoma growth and metastasis. FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification   pp322 - 332 Nikos Kourtis, Rana S. Moubarak, Beatriz Aranda-Orgilles, Kevin Lui, Iraz T. Aydin et al. doi:10.1038/ncb3121 Aifantis and colleagues report that FBXW7α controls the heat-shock response pathway by targeting HSF1 for degradation. In melanoma FBXW7α deficiency leads to increased nuclear HSF1, and induction of a pro-invasive gene expression program. Letter Top Directional Notch trafficking in Sara endosomes during asymmetric cell division in the spinal cord   pp333 - 339 Sabine Kressmann, Claudia Campos, Irinka Castanon, Maximilian Fürthauer and Marcos González-Gaitán doi:10.1038/ncb3119 Castanon, González-Gaitán and colleagues report that Sara endosomes can regulate asymmetric cell division by unequally positioning endocytosed Notch ligand in one daughter cell. Technical Report Top A high-throughput platform for stem cell niche co-cultures and downstream gene expression analysis   pp340 - 349 Adam D. Gracz, Ian A. Williamson, Kyle C. Roche, Michael J. Johnston, Fengchao Wang et al. doi:10.1038/ncb3104 Magness and colleagues present a microwell-based culture system to analyse interactions between intestinal stem cells (ISCs) and Paneth cells, and show that their direct contact enhances formation of ISC-derived organoids. Corrigendum Top A Trio–Rac1–Pak1 signalling axis drives invadopodia disassembly   p350 Yasmin Moshfegh, Jose Javier Bravo-Cordero, Veronika Miskolci, John Condeelis and Louis Hodgson doi:10.1038/ncb3123 Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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