TABLE OF CONTENTS
|  |  |  | Volume 135, Issue 3 (March 2015) |  | In this issue Editorial Research Techniques Made Simple JID VisualDx Quiz Cells to Surgery Quiz Commentaries Reviews Original Articles Letters to the Editor Erratum Corrigenda
Also new    AOP | |  |  |  | Advertisement |  | The International Societies of Investigative Dermatology Announce an Informational Open Discussion on Goals, Approach and Membership Opportunities Designated representatives of cutaneous biology research societies worldwide are invited to attend. The meeting will be held on Saturday, May 9, 2015 at 2:00 pm in the Hilton Atlanta Hotel. Details can be found here. | | | |  |  | Editorial | Top |  | From the Bench to the Bedside and Back: An Essential JourneyEugene A Bauer J Invest Dermatol 2015 135: 643-645; 10.1038/jid.2014.513 Full Text | PDF |  |  |  | Clinical SnippetsJ Invest Dermatol 2014 135: 646; 10.1038/jid.2014.538 Full Text | PDF |  |  |  | BJD Editor's ChoiceJ Invest Dermatol 2014 135: 647; 10.1038/jid.2014.539 Full Text | PDF |  |  |  | Editors' PicksJ Invest Dermatol 2015 135: 648; 10.1038/jid.2014.540 Full Text | PDF |  | Research Techniques Made Simple
| Top |  | Basics of ImmunohistochemistryVivien Schacht and Johannes S Kern J Invest Dermatol 2014 135: e30; 10.1038/jid.2014.541 Full Text | PDF |  | JID VisualDx Quiz
| Top |  | JID VisualDx Quiz: March 2015Andrew Ross and Robert S Kirsner J Invest Dermatol 2015 135: e26; 10.1038/jid.2014.542 Full Text | PDF |  | Cells to Surgery Quiz
| Top |  | Cells to Surgery Quiz: March 2015Fleta N Bray, Brian J Simmons, Robert D Griffith, Leyre Falto-Aizpurua, Mohammad-Ali Yazdani Abyaneh and Keyvan Nouri J Invest Dermatol 2015 135: e11; 10.1038/jid.2014.543 Full Text | PDF |  | Commentaries | Top |  | Cohort Studies (and Skin Cancer) Never Come AloneJoris A C Verkouteren, Robert J T van der Leest and Tamar Nijsten J Invest Dermatol 2015 135: 649-651; 10.1038/jid.2014.482 Abstract | Full Text | PDF |  |  |  | Clonal Analysis of B-Cell Response in Pemphigus Course: Toward More Effective TherapiesGiovanni Di Zenzo and Giovanna Zambruno J Invest Dermatol 2015 135: 651-654; 10.1038/jid.2014.499 Abstract | Full Text | PDF |  |  |  | New Insights into Genes, Immunity, and the Occurrence of DermatophytosisMaria T García-Romero and Roberto Arenas J Invest Dermatol 2015 135: 655-657; 10.1038/jid.2014.498 Abstract | Full Text | PDF |  |  |  | Metabolic Vulnerability in Melanoma: A ME2 (Me Too) StoryBin Zheng and David E Fisher J Invest Dermatol 2015 135: 657-659; 10.1038/jid.2014.449 Abstract | Full Text | PDF |  |  |  | Unfolding the Mutational Landscape of Human MelanomaDiwakar Davar, Yan Lin and John M Kirkwood J Invest Dermatol 2015 135: 659-662; 10.1038/jid.2014.467 Abstract | Full Text | PDF |  |  |  | Silencing Autocrine Death: A Ubiquitin Ligase that Blocks Activation-Induced Cell Death in Cutaneous T-Cell LymphomaClaus-Detlev Klemke, Maria Feoktistova and Martin Leverkus J Invest Dermatol 2015 135: 662-665; 10.1038/jid.2014.468 Abstract | Full Text | PDF |  | Reviews | Top |  | Genetics of Aplasia Cutis Reveal Novel Regulators of Skin MorphogenesisAlexander G Marneros J Invest Dermatol 2015 135: 666-672; advance online publication, October 30, 2014; 10.1038/jid.2014.413 Abstract | Full Text | PDF |  |  |  | Innate Lymphoid Cells in the SkinBrian S Kim J Invest Dermatol 2015 135: 673-678; advance online publication, October 23, 2014; 10.1038/jid.2014.401 Abstract | Full Text | PDF |  | Original Articles | Top |  | APPENDAGES | Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial–Mesenchymal InteractionsJennifer E Kloepper, Olivier R Baris, Karen Reuter, Ken Kobayashi, Daniela Weiland, Silvia Vidali, Desmond J Tobin, Catherin Niemann, Rudolf J Wiesner and Ralf Paus J Invest Dermatol 2015 135: 679-689; advance online publication, November 5, 2014; 10.1038/jid.2014.475 Abstract | Full Text | PDF |  |  |  | Testing Chemotherapeutic Agents in the Feather Follicle Identifies a Selective Blockade of Cell Proliferation and a Key Role for Sonic Hedgehog Signaling in Chemotherapy-Induced Tissue DamageGuojiang Xie, Hangwei Wang, Zhipeng Yan, Linyan Cai, Guixuan Zhou, Wanzhong He, Ralf Paus and Zhicao Yue J Invest Dermatol 2015 135: 690-700; advance online publication, September 18, 2014; 10.1038/jid.2014.409 Abstract | Full Text | PDF |  |  |  | The Ciliopathy Gene Rpgrip1l Is Essential for Hair Follicle DevelopmentJiang Chen, Christine Laclef, Alejandra Moncayo, Elizabeth R Snedecor, Ning Yang, Li Li, Ken-Ichi Takemaru, Ralf Paus, Sylvie Schneider-Maunoury and Richard A Clark J Invest Dermatol 2015 135: 701-709; advance online publication, November 14, 2014; 10.1038/jid.2014.483 Abstract | Full Text | PDF |  |  |  | CLINICAL RESEARCH | Automated Delineation of Dermal–Epidermal Junction in Reflectance Confocal Microscopy Image Stacks of Human SkinSila Kurugol, Kivanc Kose, Brian Park, Jennifer G Dy, Dana H Brooks and Milind Rajadhyaksha J Invest Dermatol 2015 135: 710-717; advance online publication, September 3, 2014; 10.1038/jid.2014.379 Abstract | Full Text | PDF |  |  |  | CONNECTIVE TISSUE | The Tsk2/+ Mouse Fibrotic Phenotype Is Due to a Gain-of-Function Mutation in the PIIINP Segment of the Col3a1 GeneKristen B Long, Zhenghui Li, Chelsea M Burgwin, Susanna G Choe, Viktor Martyanov, Sihem Sassi-Gaha, Josh P Earl, Rory A Eutsey, Azad Ahmed, Garth D Ehrlich, Carol M Artlett, Michael L Whitfield and Elizabeth P Blankenhorn J Invest Dermatol 2015 135: 718-727; advance online publication, October 20, 2014; 10.1038/jid.2014.455 Abstract | Full Text | PDF |  |  |  | EPIDEMIOLOGY | Exclusive Development of a Single Type of Keratinocyte Skin Cancer: Evidence from an Australian Population–Based Cohort StudyUlrike Keim, Jolieke C van der Pols, Gail M Williams and Adèle C Green J Invest Dermatol 2015 135: 728-733; advance online publication, September 18, 2014; 10.1038/jid.2014.410 Abstract | Full Text | PDF |  |  |  | GENETICS | Mutations in the TTDN1 Gene Are Associated with a Distinct Trichothiodystrophy PhenotypeElizabeth R Heller, Sikandar G Khan, Christiane Kuschal, Deborah Tamura, John J DiGiovanna and Kenneth H Kraemer J Invest Dermatol 2015 135: 734-741; advance online publication, October 7, 2014; 10.1038/jid.2014.440 Abstract | Full Text | PDF |  |  |  | IMMUNOLOGY/INFECTION | Persistence of Anti-Desmoglein 3 IgG+ B-Cell Clones in Pemphigus Patients over YearsChristoph M Hammers, Jing Chen, Chenyan Lin, Stephen Kacir, Don L Siegel, Aimee S Payne and John R Stanley J Invest Dermatol 2015 135: 742-749; advance online publication, July 14, 2014; 10.1038/jid.2014.291 Abstract | Full Text | PDF |  |  |  | Low DEFB4 Copy Number and High Systemic hBD-2 and IL-22 Levels Are Associated with DermatophytosisSameh W Jaradat, Susana Cubillos, Nadine Krieg, Katja Lehmann, Bassam Issa, Susann Piehler, Sylvi Wehner-Diab, Uta-Christina Hipler and Johannes Norgauer J Invest Dermatol 2015 135: 750-758; advance online publication, September 1, 2014; 10.1038/jid.2014.369 Abstract | Full Text | PDF |  |  |  | Quantitative Proteomics of the Human Skin Secretome Reveal a Reduction in Immune Defense Mediators in Ectodermal Dysplasia PatientsMarc Burian, Ana Velic, Katarina Matic, Stephanie Günther, Beatrice Kraft, Lena Gonser, Stephan Forchhammer, Yvonne Tiffert, Christian Naumer, Michael Krohn, Mark Berneburg, Amir S Yazdi, Boris Maček and Birgit Schittek J Invest Dermatol 2015 135: 759-767; advance online publication, October 27, 2014; 10.1038/jid.2014.462 Abstract | Full Text | PDF |  |  |  | Effects of Intravenous Immunoglobulins on Mice with Experimental Epidermolysis Bullosa AcquisitaMisa Hirose, Benjamin Tiburzy, Norito Ishii, Elena Pipi, Sabina Wende, Ellen Rentz, Falk Nimmerjahn, Detlef Zillikens, Rudolf A Manz, Ralf J Ludwig and Michael Kasperkiewicz J Invest Dermatol 2015 135: 768-775; advance online publication, October 20, 2014; 10.1038/jid.2014.453 Abstract | Full Text | PDF |  |  |  | KERATINOCYTES/EPIDERMIS | Effect of Prolactin-Induced Protein on Human Skin: New Insight into the Digestive Action of This Aspartic Peptidase on the Stratum Corneum and Its Induction of Keratinocyte ProliferationShuji Sugiura, Misao Tazuke, Shoichi Ueno, Yasuo Sugiura, Ikuo Kato, Yoshimitsu Miyahira, Yutaka Yamamoto, Hiroshi Sato, Jun Udagawa, Masami Uehara and Hisashi Sugiura J Invest Dermatol 2015 135: 776-785; advance online publication, October 14, 2014; 10.1038/jid.2014.448 Abstract | Full Text | PDF |  |  |  | CD271 Mediates Stem Cells to Early Progeny Transition in Human EpidermisFrancesca Truzzi, Annalisa Saltari, Elisabetta Palazzo, Roberta Lotti, Tiziana Petrachi, Katiuscia Dallaglio, Claudia Gemelli, Giulia Grisendi, Massimo Dominici, Carlo Pincelli and Alessandra Marconi J Invest Dermatol 2015 135: 786-795; advance online publication, October 20, 2014; 10.1038/jid.2014.454 Abstract | Full Text | PDF |  |  |  | Hydration Status Regulates Sodium Flux and Inflammatory Pathways through Epithelial Sodium Channel (ENaC) in the SkinWei Xu, Seok Jong Hong, Michael Zeitchek, Garry Cooper, Shengxian Jia, Ping Xie, Hannan A Qureshi, Aimei Zhong, Marshall D Porterfield, Robert D Galiano, D James Surmeier and Thomas A Mustoe J Invest Dermatol 2015 135: 796-806; advance online publication, November 5, 2014; 10.1038/jid.2014.477 Abstract | Full Text | PDF |  |  |  | MELANOCYTES/MELANOMA | Human Mitochondrial NAD(P)+–Dependent Malic Enzyme Participates in Cutaneous Melanoma Progression and InvasionYung-Lung Chang, Hong-Wei Gao, Chien-Ping Chiang, Wei-Ming Wang, Shih-Ming Huang, Chien-Fen Ku, Guang-Yaw Liu and Hui-Chih Hung J Invest Dermatol 2015 135: 807-815; advance online publication, September 9, 2014; 10.1038/jid.2014.385 Abstract | Full Text | PDF |  |  |  | The Genomic Landscape of Childhood and Adolescent MelanomaJIDOPENCharles Lu, Jinghui Zhang, Panduka Nagahawatte, John Easton, Seungjae Lee, Zhifa Liu, Li Ding, Matthew A Wyczalkowski, Marcus Valentine, Fariba Navid, Heather Mulder, Ruth G Tatevossian, James Dalton, James Davenport, Zhirong Yin, Michael Edmonson, Michael Rusch, Gang Wu, Yongjin Li, Matthew Parker, Erin Hedlund, Sheila Shurtleff, Susana Raimondi, Vadodaria Bhavin, Yergeau Donald, Elaine R Mardis, Richard K Wilson, William E Evans, David W Ellison, Stanley Pounds, Michael Dyer, James R Downing, Alberto Pappo and Armita Bahrami for the St Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project J Invest Dermatol 2015 135: 816-823; advance online publication, September 30, 2014; 10.1038/jid.2014.425 Abstract | Full Text | PDF |  |  |  | Clonogenic Cell Subpopulations Maintain Congenital Melanocytic NeviChristelle Charbel, Romain H Fontaine, Natacha Kadlub, Aurore Coulomb-L’Hermine, Thomas Rouillé, Alexandre How-Kit, Philippe Moguelet, Jorg Tost, Arnaud Picard, Selim Aractingi and Sarah Guégan J Invest Dermatol 2015 135: 824-833; advance online publication, October 13, 2014; 10.1038/jid.2014.437 Abstract | Full Text | PDF |  |  |  | Omeprazole, a Gastric Proton Pump Inhibitor, Inhibits Melanogenesis by Blocking ATP7A TraffickingMary S Matsui, Michael J Petris, Yoko Niki, Nevena Karaman-Jurukovska, Neelam Muizzuddin, Masamitsu Ichihashi and Daniel B Yarosh J Invest Dermatol 2015 135: 834-841; advance online publication, October 22, 2014; 10.1038/jid.2014.461 Abstract | Full Text | PDF |  |  |  | Combining a BCL2 Inhibitor with the Retinoid Derivative Fenretinide Targets Melanoma Cells Including Melanoma Initiating CellsNabanita Mukherjee, Steven N Reuland, Yan Lu, Yuchun Luo, Karoline Lambert, Mayumi Fujita, William A Robinson, Steven E Robinson, David A Norris and Yiqun G Shellman J Invest Dermatol 2015 135: 842-850; advance online publication, October 28, 2014; 10.1038/jid.2014.464 Abstract | Full Text | PDF |  |  |  | PHOTOBIOLOGY | Anti-Apoptotic NF-κB and “Gain of Function” mutp53 in Concert Act Pro-Apoptotic in Response to UVB+IL-1 via Enhanced TNF ProductionJIDOPENInes Müller, Stefan Beissert and Dagmar Kulms J Invest Dermatol 2015 135: 851-860; advance online publication, November 7, 2014; 10.1038/jid.2014.481 Abstract | Full Text | PDF |  |  |  | TUMOR BIOLOGY | c-CBL E3 Ubiquitin Ligase Is Overexpressed in Cutaneous T-Cell Lymphoma: Its Inhibition Promotes Activation-Induced Cell DeathJianqiang Wu, Katrin A Salva and Gary S Wood J Invest Dermatol 2015 135: 861-868; advance online publication, August 14, 2014; 10.1038/jid.2014.364 Abstract | Full Text | PDF |  |  |  | PKK Suppresses Tumor Growth and Is Decreased in Squamous Cell Carcinoma of the SkinBrian Poligone, Elaine S Gilmore, Carolina V Alexander, David Oleksyn, Kathleen Gillespie, Jiyong Zhao, Sherrif F Ibrahim, Alice P Pentland, Marc D Brown and Luojing Chen J Invest Dermatol 2015 135: 869-876; advance online publication, October 6, 2014; 10.1038/jid.2014.428 Abstract | Full Text | PDF |  |  |  | Gallium Maltolate Inhibits Human Cutaneous T-Cell Lymphoma Tumor Development in MiceXuesong Wu, Timothy W Wang, George M Lessmann, Jamal Saleh, Xiping Liu, Christopher R Chitambar and Sam T Hwang J Invest Dermatol 2015 135: 877-884; advance online publication, November 5, 2014; 10.1038/jid.2014.476 Abstract | Full Text | PDF |  |  |  | WOUND HEALING | Modulation of Type II TGF-β Receptor Degradation by Integrin-Linked KinaseLinda Vi, Stellar Boo, Samar Sayedyahossein, Randeep K Singh, Sarah McLean, Gianni M Di Guglielmo and Lina Dagnino J Invest Dermatol 2015 135: 885-894; advance online publication, September 30, 2014; 10.1038/jid.2014.427 Abstract | Full Text | PDF |  |  |  | Expert Advice Provided through Telemedicine Improves Healing of Chronic Wounds: Prospective Cluster Controlled StudyKian Zarchi, Vibeke B Haugaard, Deirdre N Dufour and Gregor B E Jemec J Invest Dermatol 2015 135: 895-900; advance online publication, October 7, 2014; 10.1038/jid.2014.441 Abstract | Full Text | PDF |  | Letters to the Editor | Top |  | Obesity and Risks for Malignant Melanoma and Non-Melanoma Skin Cancer: Results from a Large Danish Prospective Cohort StudyCamilla Præstegaard, Susanne K Kjær, Jane Christensen, Anne Tjønneland, Jytte Halkjær and Allan Jensen J Invest Dermatol 2015 135: 901-904; advance online publication, October 7, 2014; 10.1038/jid.2014.438 Full Text | PDF |  |  |  | Incidence and Mortality of Neurofibromatosis: A Total Population Study in FinlandElina Uusitalo, Jussi Leppävirta, Anna Koffert, Sakari Suominen, Jussi Vahtera, Tero Vahlberg, Minna Pöyhönen, Juha Peltonen and Sirkku Peltonen J Invest Dermatol 2015 135: 904-906; advance online publication, October 29, 2014; 10.1038/jid.2014.465 Full Text | PDF |  |  |  | A Gain-of-Function Mutation in TRPV3 Causes Focal Palmoplantar Keratoderma in a Chinese FamilyYuqing He, Kang Zeng, Xibao Zhang, Qiaolin Chen, Jiang Wu, Hong Li, Yong Zhou, Gustavo Glusman, Jared Roach, Alton Etheridge, Shizhen Qing, Qiang Tian, Inyoul Lee, Xin Tian, Xiaoning Wang, Zhihua Wu, Leroy Hood, Yuanlin Ding and Kai Wang J Invest Dermatol 2015 135: 907-909; advance online publication, October 6, 2014; 10.1038/jid.2014.429 Full Text | PDF |  |  |  | Erlotinib-Induced Skin Inflammation Is IL-1 Mediated in KC-Tie2 Mice and Human Skin Organ CultureNicole L Ward, Narasimharao Bhagathavula, Andrew Johnston, Sean M Dawes, Wen Fu, Sylviane Lambert, Michael K Dame, Roscoe L Warner, Johann E Gudjonsson, James Varani and James T Elder J Invest Dermatol 2015 135: 910-913; advance online publication, October 13, 2014; 10.1038/jid.2014.445 Full Text | PDF |  |  |  | IgE Anti-LJM11 Sand Fly Salivary Antigen May Herald the Onset of Fogo Selvagem in Endemic Brazilian RegionsYe Qian, Joseph S Jeong, Maha Abdeladhim, Jesus G Valenzuela, Valeria Aoki, Gunter Hans-Filhio, Evandro A Rivitti and Luis A Diaz for the Cooperative Group on Fogo Selvagem Research J Invest Dermatol 2015 135: 913-915; advance online publication, October 6, 2014; 10.1038/jid.2014.430 Full Text | PDF |  |  |  | Recombinant Soluble CD32 Suppresses Disease Progression in Experimental Epidermolysis Bullosa AcquisitaHiroaki Iwata, Elena Pipi, Nicole Möckel, Peter Sondermann, Artem Vorobyev, Nina van Beek, Detlef Zillikens and Ralf J Ludwig J Invest Dermatol 2015 135: 916-919; advance online publication, October 20, 2014; 10.1038/jid.2014.451 Full Text | PDF |  |  |  | Immunochip-Based Analysis: High-Density Genotyping of Immune-Related Loci Sheds Further Light on the Autoimmune Genetic Architecture of Alopecia AreataSilke Redler, Marina Angisch, Stefanie Heilmann, Sabrina Wolf, Sandra Barth, Buket F Basmanav, Kathrin A Giehl, Sandra Hanneken, Sibylle Eigelshoven, Elisabeth Mangold, Roland Kruse, Bettina Blaumeiser, Markus Böhm, Michael Knapp, Natalie Garcia Bartels, Gerhard Lutz, Hans Wolff, Ulrike Blume-Peytavi, Markus M Nöthen, Tim Becker and Regina C Betz J Invest Dermatol 2015 135: 919-921; advance online publication, October 22, 2014; 10.1038/jid.2014.459 Full Text | PDF |  |  |  | A New Mouse Model of Junctional Epidermolysis Bullosa: The LAMB3 628G>A Knockin MouseJohanna Hammersen, Jin Hou, Stephanie Wünsche, Sven Brenner, Thomas Winkler and Holm Schneider J Invest Dermatol 2015 135: 921-924; advance online publication, October 28, 2014; 10.1038/jid.2014.466 Full Text | PDF |  | Erratum | Top |  | Editors’ PicksJ Invest Dermatol 2015 135: 925; advance online publication, August 21, 2014; 10.1038/jid.2014.331 Full Text | PDF |  | Corrigenda | Top |  | Mast Cells Are Required for Full Expression of Allergen/SEB-Induced Skin InflammationTomoaki Ando, Kenji Matsumoto, Siavash Namiranian, Hirotaka Yamashita, Haley Glatthorn, Miho Kimura, Brandon R Dolan, James J Lee, Stephen J Galli, Yuko Kawakami, Colin Jamora and Toshiaki Kawakami J Invest Dermatol 2015 135: 925; advance online publication, September 11, 2014; 10.1038/jid.2014.359 Full Text | PDF |  |  |  | Efficacy and Safety of Omalizumab in Patients with Chronic Idiopathic/Spontaneous Urticaria who Remain Symptomatic on H1 Antihistamines: A Randomized, Placebo-Controlled StudySarbjit S Saini, Carsten Bindslev-Jensen, Marcus Maurer, Jean-Jacques Grob, Emel Bülbül Baskan, Mary S Bradley, Janice Canvin, Abdelkader Rahmaoui, Panayiotis Georgiou, Oral Alpan, Sheldon Spector and Karin Rosén J Invest Dermatol 2015 135: 925; advance online publication, December 11, 2014; 10.1038/jid.2014.512 Full Text | PDF |  |  |  |  | Advertisement |  | Milestones in Cutaneous Malignancy Much of the current cancer lexicon is derived from studies of human or rodent skin. Furthermore, the three major cancer-causing environmental agents, UV light, fossil fuel combustion products, and papilloma viruses, were recognized by astute clinicians and experimental biologists because they produced skin tumors. In fact, clinical observations and experimental studies of skin significantly advanced our understanding of cancer development and progression. Read more in the Milestones in Cutaneous Malignancy | | | |  |  | Please note that you need to be a subscriber or site-license holder to enjoy full-text access to The Journal of Investigative Dermatology. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). 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