The EMBO Journal Table of Contents for 14 January 2015; Vol. 34, No. 2

14 January 2015 | Volume 34, Number 2 Submit Table of Contents Have you seen? Review Articles Resource Volume 34, Number 2 Have you seen? Autophagy mediates nonselective RNA degradation in starving yeast Nitrogen starvation in yeast triggers bulk RNA import into the vacuole for degradation, thereby extending nonselective autophagy to cellular RNA homeostasis. Evelyn Welter and Zvulun Elazar Published online 09.12.2014 Bacteriophage exclusion, a new defense system Bacteriophage exclusion, a novel DNA methylation‐based virus resistance mechanism widely conserved in bacteria, provides innate immunity against both lytic and lysogenic phages. Rodolphe Barrangou and John van der Oost Published online 12.12.2014 An ER clamp for endosome fission The formation of endosome–ER contact sites triggers endosome fission and mediates cargo sorting. Camilla Raiborg and Harald Stenmark Published online 12.12.2014 Review Pluripotent stem cell energy metabolism: an update The metabolic capacity, mitochondrial activity, and the potential of cells to self‐renew/to be reprogrammed are intimately connected. This timely review features most recent advances in pluripotent stem cell energetics. Tara Teslaa and Michael A Teitell Published online 04.12.2014 Articles Bulk RNA degradation by nitrogen starvation‐induced autophagy in yeast Vacuolar RNA decay upon non‐selective autophagy is followed by nucleobase excretion from the cell, which may prevent toxic build‐up of degradation products. Hanghang Huang, Tomoko Kawamata, Tetsuro Horie, Hiroshi Tsugawa, Yasumune Nakayama, Yoshinori Ohsumi, and Eiichiro Fukusaki Published online 02.12.2014 BREX is a novel phage resistance system widespread in microbial genomes BREX is a novel host DNA methylation‐based defense system that protects B. cereus against a broad variety of phages. BREX‐like systems can be found in 10% of sequenced bacterial genomes. Tamara Goldfarb, Hila Sberro, Eyal Weinstock, Ofir Cohen, Shany Doron, Yoav Charpak‐Amikam, Shaked Afik, Gal Ofir, and Rotem Sorek Published online 01.12.2014 A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity Elevated acetylation of the mouse nuclear Farnesoid X receptor (FXR) in obesity inhibits its SUMOylation, which promotes hepatic inflammation and metabolic dysfunction in vivo. Dong‐Hyun Kim, Zhen Xiao, Sanghoon Kwon, Xiaoxiao Sun, Daniel Ryerson, David Tkac, Ping Ma, Shwu‐Yuan Wu, Cheng‐Ming Chiang, Edward Zhou, H Eric Xu, Jorma J Palvimo, Lin‐Feng Chen, Byron Kemper, and Jongsook Kim Kemper Published online 25.11.2014 Gli1/DNA interaction is a druggable target for Hedgehog‐dependent tumors Structural features of the Gli1 zinc finger binding to DNA are explored to characterise Glabrescione B as novel and effective Hh‐inhibitor in Gli1‐dependent tumors. Paola Infante, Mattia Mori, Romina Alfonsi, Francesca Ghirga, Federica Aiello, Sara Toscano, Cinzia Ingallina, Mariangela Siler, Danilo Cucchi, Agnese Po, Evelina Miele, Davide D'Amico, Gianluca Canettieri, Enrico De Smaele, Elisabetta Ferretti, Isabella Screpanti, Gloria Uccello Barretta, Maurizio Botta, Bruno Botta, Alberto Gulino, and Lucia Di Marcotullio Published online 04.12.2014 Dusp5 negatively regulates IL‐33‐mediated eosinophil survival and function DUSP5 modulates IL‐33‐mediated survival signals in eosinophils by regulating the activation of ERK1/2 and controlling BCL‐XL expression and function. Derek A Holmes, Jung‐Hua Yeh, Donghong Yan, Min Xu, and Andrew C Chan Published online 14.11.2014 RNA polymerase II contributes to preventing transcription‐mediated replication fork stalls Identification of specific yeast RNA polymerase II mutations that cause genomic instability by enhancing collisions with the DNA replication machinery suggests that eukaryotic RNAP II is more than a passive entity in the management of transcription–replication encounters. Irene Felipe‐Abrio, Juan Lafuente‐Barquero, María L García‐Rubio, and Andrés Aguilera Published online 01.12.2014 Resource Quantitative comparison of a human cancer cell surface proteome between interphase and mitosis Proteomic analysis of cell surface changes during cell division provides insight into molecular correlates of mitotic cell rounding and detachment and identifies mitosis‐selective surface markers with resource potential for anticancer therapy. Nurhan Özlü, Mohammad H Qureshi, Yusuke Toyoda, Bernhard Y Renard, Gürkan Mollaoglu, Nazlı E Özkan, Selda Bulbul, Ina Poser, Wiebke Timm, Anthony A Hyman, Timothy J Mitchison, and Judith A Steen Published online 04.12.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.