Scientific Reports Biology Table of Contents e-alert: 20 January 2015

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20 January 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports         Nature Index 2014 China   The Nature Index 2014 China supplement examines a snapshot of results from the Nature Index, comparing the cities and institutions within the country that contributed to some of the highest quality research during the previous calendar year. Access the Index free online.           Biological Sciences               Systems pharmacology of mifepristone (RU486) reveals its 47 hub targets and network: Comprehensive analysis and pharmacological focus on FAK-Src-Paxillin complex ▶     Suhong Yu, Xingtian Yang, Yewei Zhu et al.     Mifepristone (RU486), a synthetic steroid compound used as an abortifacient drug, has received considerable attention to its anticancer activity recently. To explore the …             A wireless neural recording system with a precision motorized microdrive for freely behaving animals ▶     Taku Hasegawa, Hisataka Fujimoto, Koichiro Tashiro et al.     The brain is composed of many different types of neurons. Therefore, analysis of brain activity with single-cell resolution could provide fundamental insights into brain …             CW-EPR studies revealed different motional properties and oligomeric states of the integrin β1a transmembrane domain in detergent micelles or liposomes ▶     Lu Yu, Wei Wang, Shenglong Ling et al.     Integrins are heterodimeric membrane proteins that regulate essential processes: cell migration, cell growth, extracellular matrix assembly and tumor metastasis. Each integrin α …             Prenatal regression of the trophotaenial placenta in a viviparous fish, Xenotoca eiseni ▶     Atsuo Iida, Toshiyuki Nishimaki, Atsuko Sehara-Fujisawa     The trophotaenial placenta is a branching, ribbon-like structure that extends from the perianal region of the embryo in viviparous teleost fishes belonging to the family …             Ion Selectivity in the Selectivity Filters of Acid-Sensing Ion Channels ▶     Todor Dudev, Carmay Lim     Sodium-selective acid sensing ion channels (ASICs), which belong to the epithelial sodium channel (ENaC) superfamily, are key players in many physiological processes (e.g. …             Introducing stage-specific spatial distribution into the Levins metapopulation model ▶     Takefumi Nakazawa     The Levins model is a classical but still widely used metapopulation model that describes temporal changes in the regional abundance of a species by extinction and colonization …             Astrocytes Increase ATP Exocytosis Mediated Calcium Signaling in Response to Microgroove Structures ▶     Ajay V. Singh, Michael Raymond, Fabiano Pace et al.     Following central nervous system (CNS) injury, activated astrocytes form glial scars, which inhibit axonal regeneration, leading to long-term functional deficits. Engineered …             The role of myosin-II in force generation of DRG filopodia and lamellipodia ▶     Wasim A. Sayyad, Ladan Amin, Paolo Fabris et al.     Differentiating neurons process the mechanical stimulus by exerting the protrusive forces through lamellipodia and filopodia. We used optical tweezers, video imaging and …             Probing time-dependent mechanical behaviors of catch bonds based on two-state models ▶     Xiaofeng Chen, Zhixiu Mao, Bin Chen     With lifetime counter-intuitively being prolonged under forces, catch bonds can play critical roles in various sub-cellular processes. By adopting different “catching” strategies …             Effect of Knocking Down the Insulin Receptor on Mouse Rod Responses ▶     Michael L. Woodruff, Ammaji Rajala, Gordon L. Fain et al.     Previous experiments have shown that the insulin receptor (IR) is expressed in mammalian rods and contributes to the protection of photoreceptors during bright-light exposure. …             Cell-free expression, purification, and ligand-binding analysis of Drosophila melanogaster olfactory receptors DmOR67a, DmOR85b and DmORCO ▶     Lotta Tollstoy Tegler, Karolina Corin, Julia Hillger et al.     Insects transmit numerous devastating diseases, including malaria, dengue fever, and sleeping sickness. Olfactory cues guide insects to their hosts, and are thus responsible for …             Tuning LeSPL-CNR expression by SlymiR157 affects tomato fruit ripening ▶     Weiwei Chen, Junhua Kong, Tongfei Lai et al.     In plants, microRNAs (miRNAs) play essential roles in growth, development, yield, stress response and interactions with pathogens. However no miRNA has been experimentally …             Progressive glucose stimulation of islet beta cells reveals a transition from segregated to integrated modular functional connectivity patterns ▶     Rene Markovič, Andraž Stožer, Marko Gosak et al.     Collective beta cell activity in islets of Langerhans is critical for the supply of insulin within an organism. Even though individual beta cells are intrinsically heterogeneous, …             A model of face selection in viewing video stories ▶     Yuki Suda, Shigeru Kitazawa     When typical adults watch TV programs, they show surprisingly stereo-typed gaze behaviours, as indicated by the almost simultaneous shifts of their gazes from one face to …             Novel recombinant chimeric virus-like particle is immunogenic and protective against both enterovirus 71 and coxsackievirus A16 in mice ▶     Hui Zhao, Hao-Yang Li, Jian-Feng Han et al.     Hand-foot-and-mouth disease (HFMD) has been recognized as an important global public health issue, which is predominantly caused by enterovirus 71 (EV-A71) and coxsackievirus A16 …             Species survival emerge from rare events of individual migration ▶     Yuval R. Zelnik, Sorin Solomon, Gur Yaari     Ecosystems greatly vary in their species composition and interactions, yet they all show remarkable resilience to external influences. Recent experiments have highlighted the …             A closer look at the apparent correlation of structural and functional connectivity in excitable neural networks ▶     Arnaud Messé, Marc-Thorsten Hütt, Peter König et al.     The relationship between the structural connectivity (SC) and functional connectivity (FC) of neural systems is a central focus in brain network science. It is an open question, …             Reputation drives cooperative behaviour and network formation in human groups ▶     Jose A. Cuesta, Carlos Gracia-Lázaro, Alfredo Ferrer et al.     Cooperativeness is a defining feature of human nature. Theoreticians have suggested several mechanisms to explain this ubiquitous phenomenon, including reciprocity, reputation, …             Electrical Detection of Dengue Biomarker Using Egg Yolk Immunoglobulin as the Biological Recognition Element ▶     Alessandra Figueiredo, Nirton C. S. Vieira, Juliana F. dos Santos et al.     Nonstructural protein 1 (NS1) is secreted by dengue virus in the first days of infection and acts as an excellent dengue biomarker. Here, the direct electrical detection of NS1 …             An ignored variable: solution preparation temperature in protein crystallization ▶     Rui-Qing Chen, Qin-Qin Lu, Qing-Di Cheng et al.     Protein crystallization is affected by many parameters, among which certain parameters have not been well controlled. The temperature at which the protein and precipitant …             Selection of Nanobodies that Block the Enzymatic and Cytotoxic Activities of the Binary Clostridium Difficile Toxin CDT ▶     Mandy Unger, Anna Marei Eichhoff, Lucas Schumacher et al.     The spore-forming gut bacterium Clostridium difficile is the leading cause of antibiotic-associated diarrhea in hospitalized patients. The major virulence factors are two large …             Enriched Environment Inhibits Mouse Pancreatic Cancer Growth and Down-regulates the Expression of Mitochondria-related Genes in Cancer Cells ▶     Guohua Li, Yu Gan, Yingchao Fan et al.     Psycho-social stress has been suggested to influence the development of cancer, but it remains poorly defined with regard to pancreatic cancer, a lethal malignancy with few …             Implication of high risk Human papillomavirus HR-HPV infection in prostate cancer in Indian population- A pioneering case-control analysis ▶     Neha Singh, Showket Hussain, Nandita Kakkar et al.     Prostate cancer is the second most common cancer with sexual history as a consistent risk factor. This is the pioneering study that evaluates the frequency of HPV infection in …             Somatic chromosomal translocation between Ewsr1 and Fli1 loci leads to dilated cardiomyopathy in a mouse model ▶     Miwa Tanaka, Shuichi Yamaguchi, Yukari Yamazaki et al.     A mouse model that recapitulates the human Ewing's sarcoma-specific chromosomal translocation was generated utilizing the Cre/loxP-mediated recombination technique. A cross …             Essential roles of leucine-rich glioma inactivated 1 in the development of embryonic and postnatal cerebellum ▶     Ya-Jun Xie, Liang Zhou, Nanwei Jiang et al.     Leucine-rich glioma inactivated 1 (LGI1) is a secreted protein that interacts with ADAM transmembrane proteins, and its mutations are linked to human epilepsy. The function of …             Multielement stoichiometry in Quercus variabilis under natural phosphorus variation in subtropical China ▶     Xuan Zhou, Xiao Sun, Baoming Du et al.     Plant stoichiometry in relation to environmental factors has recently received increasing attention. However, regulations and variations of plant elements in different …             Extreme convergence in egg-laying strategy across insect orders ▶     Julia Goldberg, Joachim Bresseel, Jerome Constant et al.     The eggs of stick and leaf insects (Phasmatodea) bear strong resemblance to plant seeds and are commonly dispersed by females dropping them to the litter. Here we report a novel …             Cigarette smoking hinders human periodontal ligament-derived stem cell proliferation, migration and differentiation potentials ▶     Tsz Kin Ng, Li Huang, Di Cao et al.     Cigarette smoking contributes to the development of destructive periodontal diseases and delays its healing process. Our previous study demonstrated that nicotine, a major …             Mesenchymal stem cells detect and defend against gammaherpesvirus infection via the cGAS-STING pathway ▶     Kun Yang, Jinli Wang, Minhao Wu et al.     Mesenchymal stem cells (MSCs) are widely used in clinical settings to treat tissue injuries and autoimmune disorders due to their multipotentiality and immunomodulation. …             Integrin alpha L controls the homing of regulatory T cells during CNS autoimmunity in the absence of integrin alpha 4 ▶     Simon Glatigny, Rebekka Duhen, Carlos Arbelaez et al.     Experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS), results from an autoimmune attack of the central nervous system (CNS) by effector T …             A novel IgM–H-Ficolin complement pathway to attack allogenic cancer cells in vitro ▶     Xiaoying Lei, Chaoxu Liu, Kazem Azadzoi et al.     The pentameric serum IgMs are critical to immune defense and surveillance through cytotoxicity against microbes and nascent cancer cells. Ficolins, a group of oligomeric lectins …             Systematical analyses of variants in CTCF-binding sites identified a novel lung cancer susceptibility locus among Chinese population ▶     Juncheng Dai, Meng Zhu, Cheng Wang et al.     Genome-wide association studies identified genetic susceptibility variants mostly lie outside of protein-coding regions. It suggested variants located at transcriptional …             Functional characterization of aquaporins and aquaglyceroporins of the yellow fever mosquito, Aedes aegypti ▶     Lisa L. Drake, Stacy D. Rodriguez, Immo A. Hansen     After taking vertebrate blood, female mosquitoes quickly shed excess water and ions while retaining and concentrating the mostly proteinaceous nutrients. Aquaporins (AQPs) are an …             Insulin-like growth factor-1 endues monocytes with immune suppressive ability to inhibit inflammation in the intestine ▶     Rong-Ti Ge, Li-Hua Mo, Ruijin Wu et al.     The pathogenesis of some chronic inflammation such as inflammatory bowel disease is unclear. Insulin-like growth factor-1 (IGF1) has active immune regulatory capability. This …             ERRATUM: A reduction in reactive oxygen species contributes to dihydromyricetin-induced apoptosis in human hepatocellular carcinoma cells ▶     Bin Liu, Xiaoyu Tan, Jian Liang et al.                 The CarO rhodopsin of the fungus Fusarium fujikuroi is a light-driven proton pump that retards spore germination ▶     Jorge García-Martínez, Michael Brunk, Javier Avalos et al.     Rhodopsins are membrane-embedded photoreceptors found in all major taxonomic kingdoms using retinal as their chromophore. They play well-known functions in different biological …             Attention Modulates Cortical Processing of Pitch Feedback Errors in Voice Control ▶     Huijing Hu, Ying Liu, Zhiqiang Guo et al.     Considerable evidence has shown that unexpected alterations in auditory feedback elicit fast compensatory adjustments in vocal production. Although generally thought to be …             Development of a High Affinity, Non-covalent Biologic to Add Functionality to Fabs ▶     Kendra N. Avery, Cindy Zer, Krzysztof P. Bzymek et al.     Functionalization of monoclonal antibodies (mAbs) requires chemical derivatization and/or genetic manipulation. Inherent in these methods are challenges with protein …             The Electrical Network of Maize Root Apex is Gravity Dependent ▶     Elisa Masi, Marzena Ciszak, Diego Comparini et al.     Investigations carried out on maize roots under microgravity and hypergravity revealed that gravity conditions have strong effects on the network of plant electrical activity. …             Poultry farms as a source of avian influenza A (H7N9) virus reassortment and human infection ▶     Donglin Wu, Shumei Zou, Tian Bai et al.     Live poultry markets are a source of human infection with avian influenza A (H7N9) virus. On February 21, 2014, a poultry farmer infected with H7N9 virus was identified in Jilin, …             Genetic Diversity of Avian Influenza A (H10N8) Virus in Live Poultry Markets and Its Association with Human Infections in China ▶     Mingbin Liu, Xiaodan Li, Hui Yuan et al.     Following the first human infection with the influenza A (H10N8) virus in Nanchang, China in December 2013, we identified two additional patients on January 19 and February 9, …             Glial β-Oxidation regulates Drosophila Energy Metabolism ▶     Joachim G. Schulz, Antonio Laranjeira, Leen Van Huffel et al.     The brain's impotence to utilize long-chain fatty acids as fuel, one of the dogmas in neuroscience, is surprising, since the nervous system is the tissue most energy consuming …             qPMS9: An Efficient Algorithm for Quorum Planted Motif Search ▶     Marius Nicolae, Sanguthevar Rajasekaran     Discovering patterns in biological sequences is a crucial problem. For example, the identification of patterns in DNA sequences has resulted in the determination of open reading …             Semi-automatic organelle detection on transmission electron microscopic images ▶     Takumi Higaki, Natsumaro Kutsuna, Kae Akita et al.     Recent advances in the acquisition of large-scale datasets of transmission electron microscope images have allowed researchers to determine the number and the distribution of …             Rapid, Sensitive, and Reusable Detection of Glucose by a Robust Radiofrequency Integrated Passive Device Biosensor Chip ▶     Nam-Young Kim, Kishor Kumar Adhikari, Rajendra Dhakal et al.     Tremendous demands for sensitive and reliable label-free biosensors have stimulated intensive research into developing miniaturized radiofrequency resonators for a wide range of …             Biological interaction of living cells with COSAN-based synthetic vesicles ▶     Màrius Tarrés, Elisabetta Canetta, Eleanor Paul et al.     Cobaltabisdicarbollide (COSAN) [3,3′-Co(1,2-C2B9H11)2]−, is a complex boron-based anion that has the unusual property of self-assembly into membranes and vesicles. These …             Identification of molecular signature of head and neck cancer stem-like cells ▶     Shubham Shrivastava, Robert Steele, Melanie Sowadski et al.     Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer in the world. HNSCC remains difficult to treat, and despite advances in treatment, overall …             Gene pyramiding enhances durable blast disease resistance in rice ▶     Shuichi Fukuoka, Norikuni Saka, Yuko Mizukami et al.     Effective control of blast, a devastating fungal disease of rice, would increase and stabilize worldwide food production. Resistance mediated by quantitative trait loci (QTLs), …             Extracellular vesicle-mediated export of fungal RNA ▶     Roberta Peres da Silva, Rosana Puccia, Marcio L. Rodrigues et al.     Extracellular vesicles (EVs) play an important role in the biology of various organisms, including fungi, in which they are required for the trafficking of molecules across the …             Cross-resistance and interactions between Bt toxins Cry1Ac and Cry2Ab against the cotton bollworm ▶     Jizhen Wei, Yuyuan Guo, Gemei Liang et al.     To delay evolution of pest resistance to transgenic crops producing insecticidal proteins from Bacillus thuringiensis (Bt), the "pyramid" strategy uses plants that produce two or …             Co-immunization with DNA and protein mixture: A safe and efficacious immunotherapeutic strategy for Alzheimer's disease in PDAPP mice ▶     Si Liu, DanYang Shi, Hai-Chao Wang et al.     Active immunotherapy targeting β-amyloid (Aβ) is the most promising strategy to prevent or treat Alzheimer's disease (AD). Based on pre-clinical studies and clinical trials, a …             A potent tumoricidal co-drug ‘Bet-CA’ - an ester derivative of betulinic acid and dichloroacetate selectively and synergistically kills cancer cells ▶     Suchandrima Saha, Monisankar Ghosh, Samir Kumar Dutta     Selective targeting of cancer cells employing multiple combinations as co-drug holds promise for new generation therapeutics. Betulinic acid (BA), a plant secondary metabolite …             NQO1-induced activation of AMPK contributes to cancer cell death by oxygen-glucose deprivation ▶     Hyemi Lee, Eun-Taex Oh, Bo-Hwa Choi et al.     Oxygen and glucose deprivation (OGD) due to insufficient blood circulation can decrease cancer cell survival and proliferation in solid tumors. OGD increases the intracellular …             Gr33a Modulates Drosophila Male Courtship Preference ▶     Yujia Hu, Yi Han, Yingyao Shao et al.     In any gamogenetic species, attraction between individuals of the opposite sex promotes reproductive success that guarantees their thriving. Consequently, mate determination …             Profiling of cis-Diol-containing Nucleosides and Ribosylated Metabolites by Boronate-affinity Organic-silica Hybrid Monolithic Capillary Liquid Chromatography/Mass Spectrometry ▶     Han-Peng Jiang, Chu-Bo Qi, Jie-Mei Chu et al.     RNA contains a large number of modified nucleosides. In the metabolic re-exchange of RNA, modified nucleosides cannot be recycled and are thus excreted from cells into biological …             Mitochondrial aquaporin-8-mediated hydrogen peroxide transport is essential for teleost spermatozoon motility ▶     François Chauvigné, Mónica Boj, Roderick Nigel Finn et al.     Reactive oxygen species (ROS), particularly hydrogen peroxide (H2O2), cause oxidative cell damage and inhibit sperm function. In most oviparous fishes that spawn in seawater …             Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naïve mice ▶     Kailash Singh, Marcus Hjort, Lina Thorvaldson et al.     Regulatory T (Treg) cells are characterized by the expression of CD4, CD25 and the intracellular Foxp3. However, these markers do not indicate whether Treg cells are thymic …             Scrutinizing calcium flux oscillations in T lymphocytes to deduce the strength of stimulus ▶     Susan N. Christo, Kerrilyn R. Diener, Robert E. Nordon et al.     The capture and activation of individual T cells on functionalised surfaces enables real-time analyses of the magnitude and rhythm of intracellular calcium release. Application …             Low toxicity and long circulation time of Polyampholyte-coated magnetic nanoparticles for blood pool contrast agents ▶     Qi Wang, Ming Shen, Tao Zhao et al.     Polyampholyte-coated (poly(acrylic acid) (PAA)-co-3-(diethylamino)-propylamine (DEAPA)) magnetite nanoparticles (PAMNPs) have been prepared as contrasting agent used in magnetic …             Utilization of different waste proteins to create a novel PGPR-containing bio-organic fertilizer ▶     Yan Huang, Li Sun, Jianshu Zhao et al.     High-quality bio-organic fertilizers (BIOs) cannot be produced without the addition of some proteins, while many waste proteins are haphazardly disposed, causing serious …             Asymmetric interaction paired with a super-rational strategy might resolve the tragedy of the commons without requiring recognition or negotiation ▶     Jun-Zhou He, Rui-Wu Wang, Christopher X. J. Jensen et al.     Avoiding the tragedy of the commons requires that one or more individuals in a group or partnership “volunteer”, benefiting the group at a cost to themselves. Recognition and …             No DNA damage response and negligible genome-wide transcriptional changes in human embryonic stem cells exposed to terahertz radiation ▶     A. N. Bogomazova, E. M. Vassina, T. N. Goryachkovskaya et al.     Terahertz (THz) radiation was proposed recently for use in various applications, including medical imaging and security scanners. However, there are concerns regarding the …             A novel function for Egr4 in posterior hindbrain development ▶     Chang-Joon Bae, Juhee Jeong, Jean-Pierre Saint-Jeannet     Segmentation of the vertebrate hindbrain is an evolutionarily conserved process. Here, we identify the transcription factor early growth response 4 (egr4) as a novel regulator of …             Genomic and metabolic analysis of fluoranthene degradation pathway in Celeribacter indicus P73T ▶     Junwei Cao, Qiliang Lai, Jun Yuan et al.     Celeribacter indicus P73T, isolated from deep-sea sediment from the Indian Ocean, is capable of degrading a wide range of polycyclic aromatic hydrocarbons (PAHs) and is the first …             Psychophysiological mechanisms underlying response selection in multidimensional space ▶     Moritz Mückschel, Christian Beste     In the outside world, response selection often requires the processing of information from different spatial dimensions. Yet, most neuroscientific approaches to the topic only …             The Topographical Arrangement of Cutoff Spatial Frequencies across Lower and Upper Visual Fields in Mouse V1 ▶     Xian Zhang, Xu An, Hanxiao Liu et al.     The visual response to spatial frequency (SF), a characteristic of spatial structure across position in space, is of particular importance for animal survival. A natural …             A glucose carbonate apatite complex exhibits in vitro and in vivo anti-tumour effects ▶     Hirofumi Yamamoto, Xin Wu, Hiroyuki Nakanishi et al.     Tumour targeting nanotechnology has recently made therapeutic progress and several therapeutic nanoparticles have been approved for clinical application. However, an ideal …             Restriction Cascade Exponential Amplification (RCEA) assay with an attomolar detection limit: a novel, highly specific, isothermal alternative to qPCR ▶     Andrey L. Ghindilis, Maria W. Smith, Holly M. Simon et al.     An alternative to qPCR was developed for nucleic acid assays, involving signal rather than target amplification. The new technology, Restriction Cascade Exponential Amplification …             Landscape cultivation alters δ30Si signature in terrestrial ecosystems ▶     Floor I. Vandevenne, Claire Delvaux, Harold J. Hughes et al.     Despite increasing recognition of the relevance of biological cycling for Si cycling in ecosystems and for Si export from soils to fluvial systems, effects of human cultivation …             Gene introduction into the mitochondria of Arabidopsis thaliana via peptide-based carriers ▶     Jo-Ann Chuah, Takeshi Yoshizumi, Yutaka Kodama et al.     Available methods in plant genetic transformation are nuclear and plastid transformations because similar procedures have not yet been established for the mitochondria. The …             The community distribution of bacteria and fungi on ancient wall paintings of the Mogao Grottoes ▶     Yantian Ma, He Zhang, Ye Du et al.     In this study, we compared the microbial communities colonising ancient cave wall paintings of the Mogao Grottoes exhibiting signs of biodeterioration. Ten samples were collected …             Conventional US, elastography, and contrast enhanced US features of papillary thyroid microcarcinoma predict central compartment lymph node metastases ▶     Yu-Rong Hong, Cao-Xin Yan, Guo-Qaing Mo et al.     Lymph node metastases at the time of diagnosis have a major impact on both therapeutic strategy and tumor recurrence for patients with papillary thyroid microcarcinoma (PTMC). …             Flagellar filament bio-templated inorganic oxide materials – towards an efficient lithium battery anode ▶     Sergei N. Beznosov, Pavan S. Veluri, Mikhail G. Pyatibratov et al.     Designing a new generation of energy-intensive and sustainable electrode materials for batteries to power a variety of applications is an imperative task. The use of biomaterials …             Effect of carbonic anhydrase on silicate weathering and carbonate formation at present day CO2 concentrations compared to primordial values ▶     Leilei Xiao, Bin Lian, Jianchao Hao et al.     It is widely recognized that carbonic anhydrase (CA) participates in silicate weathering and carbonate formation. 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