Nature Medicine Contents: January 2015 Volume 21 Number 1 pp 1-98

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TABLE OF CONTENTS January 2015 Volume 21, Issue 1 Editorial News News and Views Articles Letters Technical Reports Subscribe   Facebook   RSS   Recommend to library   Twitter   Podcast Editorial Top Re-defining Technical Reports   p1 doi:10.1038/nm.3785 A refocused scope will infuse new technology into the regular research section of Nature Medicine and strengthen the synergy between regular research articles and Technical Reports. News Top Startups tout commercially 3D-printed tissue for drug screening   p2 Manasi Vaidya doi:10.1038/nm0115-2 News Feature A sense of immunity: Scientists are detailing the immune system as never before   pp3 - 5 Amanda B. Keener doi:10.1038/nm0115-3 News in Brief Biomedical briefing   pp6 - 7 doi:10.1038/nm0115-6 News Feature Biting back: Vaccine efforts redoubled as rabies deadline looms   pp8 - 10 Shraddha Chakradhar doi:10.1038/nm0115-8 News and Views Top Aging platelets stimulate TPO production   pp11 - 12 Benjamin T Kile doi:10.1038/nm.3780 The growth factor thrombopoietin (TPO) drives platelet biogenesis by inducing megakaryocyte production. A new study in mice identifies a feedback mechanism by which clearance of aged, desialylated platelets stimulates TPO synthesis by hepatocytes. See also: Article by Grozovsky et al. Human CD4+ T cells spontaneously detect somatic mutations in cancer cells   pp12 - 14 Willem W Overwijk doi:10.1038/nm.3783 CD4+ helper T cells are immune cells that can specifically target cancer cells, but the antigens they recognize on tumor cells are mostly unknown. A new study shows that CD4+ T cells recognize peptides encoded by mutated genes in human melanoma, opening the way for new approaches to cancer immunotherapy. See also: Letter by Linnemann et al. Regulation of glucose homeostasis using radiogenetics and magnetogenetics in mice   pp14 - 16 Ingo B Leibiger and Per-Olof Berggren doi:10.1038/nm.3782 Endogenous expression of tailored nanoparticles in cells followed by application of low-frequency radio waves or a magnetic field can be used to noninvasively modulate gene expression. This approach successfully induces insulin transgene expression in diabetic mice. See also: Technical Report by Stanley et al. Notch signaling maintains T cell memories   pp16 - 18 Aaron M Miller and Stephen P Schoenberger doi:10.1038/nm.3784 Notch signaling regulates developmental processes. A new study in mice shows that Notch signaling regulates the maintenance and survival of memory CD4+ T lymphocytes through a mechanism involving glucose uptake, and it suggests that Notch signaling can be modulated to treat autoimmune conditions. See also: Article by Maekawa et al. Nature Medicine JOBS of the week Postdoctoral Research Fellow University of Lleida (UDL-IRBLLEIDA) 3 PhD studentships University College London (UCL) Postdoctoral Fellow Stony Brook University Postdoctoral Researcher University of Kaiserslautern, Germany More Science jobs from Nature Medicine EVENT Nutritional Immunology: Role in Health and Disease 31.07.15 Lisbon, Portugal More science events from Articles Top Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy   pp19 - 26 Norihiko Yokoi, Yuko Fukata, Daisuke Kase, Taisuke Miyazaki, Martine Jaegle et al. doi:10.1038/nm.3759 New mouse models help unravel the mechanisms through which LGI1 missense mutations cause epilepsy. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents   pp27 - 36 Brian Finan, Bin Yang, Nickki Ottaway, David L Smiley, Tao Ma et al. doi:10.1038/nm.3761 A rationally designed peptide agonist that targets three key hormone receptors reduces obesity and its complications in a manner superior to other agonists. Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development   pp37 - 46 Hyun Mi Kang, Seon Ho Ahn, Peter Choi, Yi-An Ko, Seung Hyeok Han et al. doi:10.1038/nm.3762 A new study shows that reduced fat metabolism in renal tubule cells contributes to kidney fibrosis. The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling   pp47 - 54 Renata Grozovsky, Antonija Jurak Begonja, Kaifeng Liu, Gary Visner, John H Hartwig et al. doi:10.1038/nm.3770 Binding of aged, desialylated platelets to the Ashwell-Morell receptor induces hepatic expression of the cytokine thrombopoietin via JAK2-STAT3 signaling, providing a feedback mechanism to control platelet production. See also: News and Views by Kile Notch controls the survival of memory CD4+ T cells by regulating glucose uptake   pp55 - 61 Yoichi Maekawa, Chieko Ishifune, Shin-ichi Tsukumo, Katsuto Hozumi, Hideo Yagita et al. doi:10.1038/nm.3758 See also: News and Views by Miller & Schoenberger Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche   pp62 - 70 Hayley Davis, Shazia Irshad, Mukesh Bansal, Hannah Rafferty, Tatjana Boitsova et al. doi:10.1038/nm.3750 The authors report a mechanistic basis for intestinal polyp formation in patients with hereditary mixed polyposis syndrome that involves the aberrant epithelial expression of morphogens and leads to the formation of ectopic intestinal crypts by progenitor cells outside the stem cell niche, a mechanism that seems to also be involved in human ectopic serrated polyps. Letters Top Mutations in G protein [beta] subunits promote transformation and kinase inhibitor resistance   pp71 - 75 Akinori Yoda, Guillaume Adelmant, Jerome Tamburini, Bjoern Chapuy, Nobuaki Shindoh et al. doi:10.1038/nm.3751 The authors identify mutations in [beta] subunits of G proteins that promote transformation and therapy resistance. Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia   pp76 - 80 Christopher S Fry, Jonah D Lee, Jyothi Mula, Tyler J Kirby, Janna R Jackson et al. doi:10.1038/nm.3710 Loss of muscle satellite cells during aging has been thought to contribute to sarcopenia, but experimentally induced depletion of these cells in adult mice does not result in this condition. High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma   pp81 - 85 Carsten Linnemann, Marit M van Buuren, Laura Bies, Els M E Verdegaal, Remko Schotte et al. doi:10.1038/nm.3773 Ton Schumacher and colleagues show that melanoma patients have CD4+ T cells reactive to mutated tumor antigens. See also: News and Views by Overwijk Technical Reports Top In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire   pp86 - 91 Brandon J DeKosky, Takaaki Kojima, Alexa Rodin, Wissam Charab, Gregory C Ippolito et al. doi:10.1038/nm.3743 Georgiou and colleagues describe a single-cell, emulsion-based approach for the high-throughput determination of the paired antibody variable heavy and light chain (VH-VL) repertoire encoded by the more than 2 [times] 106 B cells in human peripheral blood samples. Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles   pp92 - 98 Sarah A Stanley, Jeremy Sauer, Ravi S Kane, Jonathan S Dordick and Jeffrey M Friedman doi:10.1038/nm.3730 Development and validation of a genetically encoded system in which gene expression is regulated remotely and noninvasively by either low-frequency radio waves or a static magnetic field. See also: News and Views by Leibiger & Berggren Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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