Nature Immunology Contents: February 2015 Volume 16 pp 129 - 214

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Advertisement A*STAR Research - Highlighting the best of research at the Agency for Science, Technology and Research (A*STAR), Singapore's premier research organization   Recent Highlights Immunology: Immune cells' repertoire revealed | Immunology: A signal to kill | Cancer biology: Tumor-causing crosstalk Download the A*STAR Research app now! TABLE OF CONTENTS February 2015 Volume 16, Issue 2 Commentary News and Views Research Highlights Review Articles Errata Corrigenda Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Innate Immune Memory (18-20 March 2015)  Wellcome Trust Genome Campus, Hinxton, Cambridge, UK This new meeting will discuss how the innate immune system is activated and regulated and how it can be harnessed to develop new therapies to treat inflammatory diseases, infection and cancer. Abstract/Bursary Deadline: 30 Jan. Registration Deadline: 18 Feb.   Commentary Top Immunology careers at the NIH, FDA and CDC: different paths that focus on advancing public health   pp129 - 132 Marta Catalfamo, Alison Mawle and Daniela Verthelyi doi:10.1038/ni.3061 The NIH, FDA and CDC offer a wide spectrum of job opportunities focused on improving public health through the discovery and translation of research, the regulation of safe and effective medicines, and the protection of health security. News and Views Top Inflammatory ILC2 cells: disguising themselves as progenitors?   pp133 - 134 Shigeo Koyasu doi:10.1038/ni.3080 Type 2 cytokine-producing innate lymphoid cells (ILC2 cells) can respond to interleukins IL-25 and IL-33. Distinct subsets are now recognized as inflammatory ILC2 cells and natural ILC2 cells that differ in their responses to these cytokines. See also: Article by Huang et al. Broad and strong: the ultimate antibody to dengue virus   pp135 - 137 Josefina Coloma and Eva Harris doi:10.1038/ni.3081 The identification of a new class of cross-reactive monoclonal antibodies that strongly neutralize all four serotypes of dengue virus has important implications for vaccine design as well as for the evaluation of vaccines and of natural infection with dengue virus. See also: Article by Dejnirattisai et al. GPR15: a tale of two species   pp137 - 139 Janine Bilsborough and Joanne L Viney doi:10.1038/ni.3084 The chemoattractant receptor GPR15 directs the homing of T cells to the colon; however, GRP15 expression differs in the effector and regulatory T cell subsets of humans versus those of mice. These findings have profound implications for the potential targeting of GRP15 for therapeutic intervention. See also: Article by Nguyen et al. PTENtiating autoimmunity through Treg cell deregulation   pp139 - 140 John P Ray and Joe Craft doi:10.1038/ni.3082 Regulatory T cells require the phosphatase PTEN to maintain suppressive function in homeostatic conditions through preserved expression of CD25 and the transcription factor Foxp3. See also: Article by Shrestha et al. | Article by Huynh et al. Immunology JOBS of the week Postdoctoral Fellow in Cellular Immunology University of Crete, Medical School Postdoctoral Researcher in Immunology United Arab Emiraes University Postdoctoral Position in Cancer Immunology Universität Basel Open Rank Faculty Position University of North Carolina at Chapel Hill More Science jobs from Research Highlights Top Microbial allies against malaria | Fueling T cells | The fetal imprint of tissues | Unfold and destroy | Platelet checkpoint | Balancing protein degradation Review Top Pathophysiology of T follicular helper cells in humans and mice   pp142 - 152 Hideki Ueno, Jacques Banchereau and Carola G Vinuesa doi:10.1038/ni.3054 In this Review, Ueno, Vinuesa and Banchereau discuss the similarities and differences between mouse and human follicular helper T cells (TFH cells) and discuss their role in response to vaccines and in disease pathogenesis. Articles Top Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine   pp153 - 160 Jennifer K Bando, Hong-Erh Liang and Richard M Locksley doi:10.1038/ni.3057 Innate lymphoid cells (ILCs) contribute to lymphoid tissue development and influence immune responses. Locksley and colleagues identify arginase 1-expressing fetal ILC precursors that give rise to multiple ILC subsets and lymphoid tissue-inducer cells. IL-25-responsive, lineage-negative KLRG1hi cells are multipotential 'inflammatory' type 2 innate lymphoid cells   pp161 - 169 Yuefeng Huang, Liying Guo, Jin Qiu, Xi Chen, Jane Hu-Li et al. doi:10.1038/ni.3078 Type 2 innate lymphoid cells (ILC2 cells) contribute to early immune responses directed against helminths and fungi. Paul and colleagues identify distinct inflammatory IL-25-responsive and natural IL-33-responsive ILC2 cells in lung tissues. See also: News and Views by Koyasu A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus   pp170 - 177 Wanwisa Dejnirattisai, Wiyada Wongwiwat, Sunpetchuda Supasa, Xiaokang Zhang, Xinghong Dai et al. doi:10.1038/ni.3058 Dengue virus is an important emerging pathogen, but so far there is no vaccine effective for all serotypes. Screaton and colleagues identify a class of broadly reactive human antibodies focused on an epitope that bridges two virion subunits. See also: News and Views by Coloma & Harris Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses   pp178 - 187 Sharad Shrestha, Kai Yang, Cliff Guy, Peter Vogel, Geoffrey Neale et al. doi:10.1038/ni.3076 Treg cells control effector cells such as TH1 and TFH cells. Chi and colleagues demonstrate that PTEN is cell-intrinsically required for Treg cell lineage stability and regulation of effector T cell responses. See also: News and Views by Ray & Craft Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability   pp188 - 196 Alexandria Huynh, Michel DuPage, Bhavana Priyadharshini, Peter T Sage, Jason Quiros et al. doi:10.1038/ni.3077 Regulatory T cells normally maintain high expression of the phosphatase PTEN. Turka and colleagues use conditional deletion of PTEN in regulatory T cells to show that it is critical for their function and stability. See also: News and Views by Ray & Craft Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance   pp197 - 206 Fang Yu, Suveena Sharma, Julie Edwards, Lionel Feigenbaum and Jinfang Zhu doi:10.1038/ni.3053 Regulatory T cells can express the classic effector T cell transcription factors T-bet and GATA-3. Zhu and colleagues demonstrate that T-bet and GATA-3 are dynamically expressed in regulatory T cells and are redundantly essential for stabilizing the identity and function of these cells. Role and species-specific expression of colon T cell homing receptor GPR15 in colitis   pp207 - 213 Linh P Nguyen, Junliang Pan, Thanh Theresa Dinh, Husein Hadeiba, Edward O'Hara III et al. doi:10.1038/ni.3079 The chemoattractant receptor GPR15 can direct CD4+ T cells to the colon. Habtezion and colleagues show that GATA-3 and Foxp3 exhibit species-specific differences in promoting GPR15 expression and thereby influences homing of CD4+ effector and regulatory T cells. See also: News and Views by Bilsborough & Viney Corrigenda Top Corrigendum: TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells   p214 Katharina Gerlach, YouYi Hwang, Alexej Nikolaev, Raja Atreya, Heike Dornhoff et al. doi:10.1038/ni0215-214c Corrigendum: Inducible nitric oxide synthase is a major intermediate in signaling pathways for the survival of plasma cells   p214 Ankur S Saini, Gautam N Shenoy, Satyajit Rath, Vineeta Bal and Anna George doi:10.1038/ni0215-214d Corrigendum: Transcriptional programs of the lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing   p214 doi:10.1038/ni0215-214e Errata Top Erratum: Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, ROR[gamma]t and dectin-2   p214 Patricia R Taylor, Sanhita Roy, Sixto M Leal Jr, Yan Sun, Scott J Howell et al. doi:10.1038/ni0215-214a Erratum: Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development   p214 Byron B Au-Yeung, Heather J Melichar, Jenny O Ross, Debra A Cheng, Julie Zikherman et al. doi:10.1038/ni0215-214b Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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