EMBO reports Table of Contents for January 2015; Vol. 16, No. 1

January 2015 | Volume 16, Number 1 Submit Table of Contents Editorial Science & Society Reviews Scientific Reports Volume 16, Number 1 Editorial To absent friends EMBO Reports starts the new year reminiscing about Howy Jacobs' tenure as Chief Editor and the legacy he leaves behind. The Editors Published online 05.01.2015 Science & Society Research ethics and stem cells: Is it time to re‐think current approaches to oversight? Given a decade of regulatory experience and the changing nature of research using human embryonic stem cells, it is time to reconsider whether the current practice of dual ethics reviews for stem cell research is still appropriate. Timothy Caulfield, Kalina Kamenova, Ubaka Ogbogu, Amy Zarzeczny, Jay Baltz, Shelly Benjaminy, Paul A Cassar, Marianne Clark, Rosario Isasi, Bartha Knoppers, Lori Knowles, Gregory Korbutt, James V Lavery, Geoffrey P Lomax, Zubin Master, Michael McDonald, Nina Preto, and Maeghan Toews Published online 04.12.2014 Lessons in learning: An effective process for engaging 12‐ to 14‐year‐olds in stem cell biology Engaging school children with cutting‐edge science remains challenging. Here, the authors reflect on their experience of developing lessons for high school children about the scientific, medical and ethical implications of stem cell research. Emma Kemp and Ian Chambers Published online 17.12.2014 The outsourcing and commercialization of science: Is the lab CEO the future of academic research? Commercial research services – genome sequencing and analysis, culture collection – make research in the life sciences easier, but carry the risk of fundamentally altering the role of researchers in research and potentially stifling creativity. David R Smith Published online 26.11.2014 Omics and the bioeconomy: Applications of genomics hold great potential for a future bio‐based economy and sustainable development Omics technologies hold great potential for a future “bioeconomy” that could meet the grand challenges of the 21st century to reconcile sustainable economic development and environmental protection. Gerardo Jiménez‐Sánchez and Jim Philp Published online 04.12.2014 More transparency for clinical trial data: The decision by the European Medicines Agency to make clinical trial reports publicly available could provide a boon for biomedical research The recent decision by the European Medicines Agency to proactively publish clinical trial reports is a great step towards more transparency in clinical research, but also creates new challenges for the rights and privacy of patients. Philip Hunter Published online 04.12.2014 Reviews Exosomes and other extracellular vesicles in host–pathogen interactions Exosomes and other extracellular vesicles mediate intercellular communication. Pathogen‐induced vesicles are key to pathogen dissemination and modulate immune responses in their favor, but also to help the host combat infectious disease. Jeffrey S Schorey, Yong Cheng, Prachi P Singh, and Victoria L Smith Published online 08.12.2014 Stem and progenitor cell dysfunction in human trisomies This review analyzes the impact of human trisomies on stem and progenitor cell functions with a special focus on trisomy 21 and hematopoiesis. Binbin Liu, Sarah Filippi, Anindita Roy, and Irene Roberts Published online 17.12.2014 Scientific Reports Direct interaction between Id1 and Zrf1 controls neural differentiation of embryonic stem cells This study shows that the direct interaction between Id1 and Zrf1 blocks Zrf1 recruitment to chromatin thus impairing neural commitment of embryonic stem cells. During differentiation, Id1 levels decrease allowing Zrf1 to activate neural genes. Luigi Aloia, Arantxa Gutierrez, Juan Martin Caballero, and Luciano Di Croce Published online 31.10.2014 Identification and characterization of novel factors that act in the nonsense‐mediated mRNA decay pathway in nematodes, flies and mammals A genome‐wide RNAi screen in C. elegans identifies five novel NMD genes that are required for development and conserved throughout evolution, suggesting that the regulation of the NMD pathway is more complex than previously thought. Angela Casadio, Dasa Longman, Nele Hug, Laurent Delavaine, Raúl Vallejos Baier, Claudio R Alonso, and Javier F Cáceres Published online 01.12.2014 LRRK2 localizes to endosomes and interacts with clathrin‐light chains to limit Rac1 activation Both LRRK2 and the clathrin machinery are found mutated in inherited Parkinson's disease. This study provides the first link between both, by showing that LRRK2 binds clathrin‐light chains to control Rac1 activation in mammalian cells and flies. Andrea MA Schreij, Mathilde Chaineau, Wenjing Ruan, Susan Lin, Philip A Barker, Edward A Fon, and Peter S McPherson Published online 26.11.2014 SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1 SOS1 and Ras promote the assembly of tight junctions in human bronchial epithelial cells by signaling through MEK and ERK. This controls the expression of EMP1, which is essential for tight junction formation and function in human airway epithelia. Joanne Durgan, Guangbo Tao, Matthew S Walters, Oliver Florey, Anja Schmidt, Vanessa Arbelaez, Neal Rosen, Ronald G Crystal, and Alan Hall Published online 13.11.2014 YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress The mitochondrial protease YME1L is selectively degraded during stress that depletes ATP and depolarizes mitochondria. Loss of YME1L compromises the regulation of mitochondrial inner membrane proteostasis and sensitizes cells to death. T Kelly Rainbolt, Jaclyn M Saunders, and R Luke Wiseman Published online 27.11.2014 Functional analysis of related CrRLK1L receptor‐like kinases in pollen tube reception Plant CrRLK1L receptor‐like kinases are involved in various signaling processes. Domain swapping shows that, for pollen tube reception, the extracellular domains of three members (FER, ANX1, HERK1) are not interchangeable, whereas their intercellular domains are functionally equivalent. Sharon A Kessler, Heike Lindner, Daniel S Jones, and Ueli Grossniklaus Published online 09.12.2014 Conserved abundance and topological features in chromatin‐remodeling protein interaction networks Quantitative proteomic analysis of a yeast and human chromatin remodeling protein interaction network demonstrates the conservation of protein content, abundance, and topology in this network. This allowed cross‐species prediction of missing values and led to the discovery of a conserved low‐abundance subnetwork. Mihaela E Sardiu, Joshua M Gilmore, Brad D Groppe, Damir Herman, Sreenivasa R Ramisetty, Yong Cai, Jingji Jin, Ronald C Conaway, Joan W Conaway, Laurence Florens, and Michael P Washburn Published online 26.11.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.