SciBX: Science-Business eXchange Contents: December 11 2014, Volume 7 / Issue 47

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Advertisement Biopharma Dealmakers A supplement to Nature Biotechnology and Nature Reviews Drug Discovery The November 2014 issue of Biopharma Dealmakers showcases companies with partnering opportunities. This week, find out about how you can collaborate with Oryzon Genomics TABLE OF CONTENTS December 11 2014, Volume 7 / Issue 47 Analysis Cover Story Targets and Mechanisms The Distillery: Therapeutics Cancer Cardiovascular disease Endocrine/metabolic disease Hepatic disease Infectious disease Inflammation Musculoskeletal disease Neurology Pulmonary disease Various The Distillery: Techniques Assays and screens Disease models Markers Advertisement Biopharma Dealmakers A supplement to Nature Biotechnology and Nature Reviews Drug Discovery   The November 2014 issue of Biopharma Dealmakers showcases companies with partnering opportunities. This week, find out about how you can collaborate with Boehringer Ingelheim      Analysis Cover Story Top Universal reversal for heparin Kai-Jye Lou doi:10.1038/scibx.2014.1366 A synthetic, universal heparin reversal agent could provide a lower-risk option for preventing bleeding during surgery than protamine, the standard of care, but finding industry partners could be the challenge. Full Text | PDF Targets and Mechanisms Top Terazosin reborn Lauren Martz doi:10.1038/scibx.2014.1367 Chinese researchers have found that the generic α-blocker terazosin prevents apoptosis and want to pursue it for stroke, but they will need to navigate a landscape of difficult preclinical models. Full Text | PDF PIEZO de resistance Benjamin Boettner doi:10.1038/scibx.2014.1368 A Duke team has found a new role for PIEZO calcium channels in cartilage damage, suggesting channel inhibitors could be developed for joint injury or osteoarthritis. Full Text | PDF Lysin in wait Stephen Parmley doi:10.1038/scibx.2014.1369 Micreos and ContraFect are separately developing phage lysins, which are not prone to bacterial resistance, as complements to antibiotics. Full Text | PDF Distillery: Therapeutics Cancer Top Breast cancer anti-estrogen resistance 4 (BCAR4) doi:10.1038/scibx.2014.1370 In vitro and mouse studies suggest inhibiting BCAR4 could help treat metastatic breast cancer. Full Text | PDF Nicotinamide adenine dinucleotide (NAD+); unconventional prefoldin RPB5 interactor (URI1; URI) doi:10.1038/scibx.2014.1371 Studies in mice and human samples suggest increasing NAD+ could help treat or prevent hepatocellular carcinoma (HCC). Full Text | PDF AXL receptor tyrosine kinase (AXL; UFO); discoidin domain receptor tyrosine kinase 2 (DDR2); c-Met proto-oncogene (MET; HGFR); insulin-like growth factor-1 receptor (IGF1R; CD221) doi:10.1038/scibx.2014.1372 Mouse studies suggest inhibitors of IGF1R, MET and AXL could synergize with Sprycel dasatinib to help treat lung squamous cell cancers (SCCs) with activating DDR2 mutations. Full Text | PDF BRAF; checkpoint kinase 1 (Chk1; CHEK1); Chk2 (CHEK2); ataxia telangiectasia mutated (ATM); VEGF doi:10.1038/scibx.2014.1373 In vitro and mouse studies suggest inhibiting the DNA damage repair pathway could help treat melanoma. Full Text | PDF Mesothelin doi:10.1038/scibx.2014.1374 Mouse studies suggest intrapleural delivery of chimeric antigen receptor (CAR) T cells could help treat malignant pleural mesothelioma (MPM) and other pleural malignancies. Full Text | PDF Epidermal growth factor receptor 1 (EGFR1; HER1; ErbB1) doi:10.1038/scibx.2014.1375 In vitro studies suggest diaminopyrimidine inhibitors of mutant EGFR1 could help treat NSCLC. Full Text | PDF Cardiovascular disease Top MicroRNA-24 (miR-24) doi:10.1038/scibx.2014.1376 Studies in patient samples and mice suggest miR-24 could help prevent abdominal aortic aneurysms (AAAs). Full Text | PDF Endocrine/metabolic disease Top IL-22; IL-23; IL-24 (MDA7) doi:10.1038/scibx.2014.1377 Mouse studies suggest IL-22 or inhibition of IL-23 and IL-24 could help treat diabetes. Full Text | PDF Hepatic disease Top Cytochrome P450 family 2 subfamily E polypeptide 1 (CYP2E1) doi:10.1038/scibx.2014.1378 Mouse studies suggest the plant-derived natural compound demethyleneberberine could help treat alcoholic liver disease. Full Text | PDF Infectious disease Top IL-18; IL-22; toll-like receptor 5 (TLR5); NRL family CARD domain containing 4 (NLRC4) doi:10.1038/scibx.2014.1379 Mouse studies suggest the bacterial protein flagellin or IL-18 plus IL-22 could help treat rotaviral infection. Full Text | PDF Inflammation Top Coiled-coil domain containing 88B (CCDC88B; CCDC88) doi:10.1038/scibx.2014.1380 In vitro and mouse studies suggest inhibiting CCDC88B could help treat inflammatory conditions such as cerebral malaria infection. Full Text | PDF Musculoskeletal disease Top N-terminal acetyltransferase complex ARD1 subunit homolog A (NAA10; ARD1A; ARD1); runt-related transcription factor 2 (RUNX2) doi:10.1038/scibx.2014.1381 In vitro and rodent studies suggest inhibiting NAA10 could promote bone fracture healing. Full Text | PDF Piezo-type mechanosensitive ion channel component 1 (PIEZO1); PIEZO2 doi:10.1038/scibx.2014.1382 Cell and tissue culture studies suggest inhibiting PIEZO1 and PIEZO2 could prevent load-induced articular cartilage damage. Full Text | PDF Neurology Top Phosphoglycerate kinase 1 (PGK1); heat shock protein 90 (Hsp90) doi:10.1038/scibx.2014.1383 In vitro and rodent models suggest the generic hypertension drug terazosin could help treat stroke or sepsis. Full Text | PDF Pulmonary disease Top Tumor protein 63 (TP63; p63); keratin 5 (KRT5) doi:10.1038/scibx.2014.1384 Mouse studies suggest distal airway stem cell transplants could help regenerate lung tissue following injury. Full Text | PDF Transient receptor potential vanilloid 4 (TRPV4; VRL2); transforming growth factor β1 (TGFB1) doi:10.1038/scibx.2014.1385 In vivo and in vitro studies suggest inhibiting TRPV4 could help treat idiopathic pulmonary fibrosis (IPF). Full Text | PDF Various Top Glioma-associated oncogene homolog 1 zinc finger protein (GLI1) doi:10.1038/scibx.2014.1386 Mouse studies suggest depleting GLI1-expressing mesenchymal stem cells could decrease fibrotic organ damage. Full Text | PDF Receptor-interacting serine-threonine kinase 1 (RIPK1; RIP1); cyclophilin A (CYPA; PPIA) doi:10.1038/scibx.2014.1387 Mouse studies suggest the ferrostatin 16-86 could help protect against ischemia/reperfusion injury and kidney damage. Full Text | PDF E3 ubiquitin ligase; SMAD specific E3 ubiquitin protein ligase 2 (SMURF2); NEDD4 family E3 ubiquitin-protein ligase (RSP5) doi:10.1038/scibx.2014.1388 In vitro studies identified compounds that could help develop inhibitors of E3 ubiquitin ligases to treat various diseases. Full Text | PDF Distillery: Techniques Assays and screens Top Chromatin immunoprecipitation with reference exogenous genome (ChIP-Rx) doi:10.1038/scibx.2014.1389 ChIP-Rx could be useful for epigenome profiling to enable quantitative comparison between samples. Full Text | PDF Inducible Tet repressor protein (TetR)-RNA interaction system for control of Plasmodium falciparum gene expression doi:10.1038/scibx.2014.1390 A system for controlling P. falciparum gene expression could be useful for identifying new targets and treatments for malaria. Full Text | PDF Rapid diagnostic system to detect low levels of bacteria in blood doi:10.1038/scibx.2014.1391 The Integrated Comprehensive Droplet Digital Detection System could help rapidly detect bacteria in blood samples. Full Text | PDF Disease models Top Mouse multiple myeloma (MM) model with constitutive IL-6 signal transducer (IL-6ST; gp130; CD130) expression doi:10.1038/scibx.2014.1392 Mice that express constitutively active gp130 in bone marrow could be useful as models for studying MM and evaluating therapeutic candidates. Full Text | PDF Markers Top Mutant NRL family CARD domain containing 4 (NLRC4) as a marker of familial cold autoinflammatory syndrome (FCAS) doi:10.1038/scibx.2014.1393 Studies in patients and mice suggest a mutation in NLRC4 could be a diagnostic marker for FCAS, which involves episodes of rash, arthralgia and fever after exposure to cold stimuli. Full Text | PDF Top

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