Nature Reviews Molecular Cell Biology contents January 2015 Volume 16 Number 1 pp 1-64

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TABLE OF CONTENTS
January 2015 Volume 16 Number 1
Impact Factor 36.458 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Post-translational modifications  Featured article: Intrinsically disordered proteins in cellular signalling and regulation Peter E. Wright & H. Jane Dyson
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RESEARCH HIGHLIGHTS Top Stem cells: Multiple routes to pluripotency p1 | doi:10.1038/nrm3927 Five papers report extensive transcriptomic, epigenomic and proteomic analyses of reprogramming, revealing the existence of several reprogramming routes and multiple unique pluripotent cell states. PDF Protein translocation: Slowly (translate) but surely (translocate) p2 | doi:10.1038/nrm3921 The signal recognition particle (SRP) interacts with nascent polypeptides and assists protein translocation across membranes. Pechmann et al. identified that downstream non-optimal codons in the mRNA attenuate translation and promote SRP binding. PDF Chromosome segregation: An exit for sister chromatids p2 | doi:10.1038/nrm3926 Two papers in Science now provide insights into the highly regulated interface of the cohesin complex and a potential DNA exit gate. PDF JOURNAL CLUB Accidentally enucleating autophagy p4 | doi:10.1038/nrm3917 Bertrand Joseph describes the conversation that led him to research the nuclear regulation of autophagy. PDF Telomeres: Chaperonin' telomerase p4 | doi:10.1038/nrm3925 A new study shows that the chaperonin TRiC is required for TCAB1 folding in the telomerase biogenesis pathway. PDF IN BRIEF Circadian rhythms: NuRD sets the CLOCK | Non-coding RNA: Parasite exosomes deliver RNA to hosts | Morphogenesis: Getting cells moving | Technique: Capturing translation initiation | Cytoskeleton: How big cells are organized | Cell migration: Making contacts while on the move PDF Molecular Cell Biology JOBS of the week PhD Studentship in Molecular Cell Biology University of St Andrews Postdoctoral Position - Department of Cell & Molecular Biology St. Jude Children's Research Hospital (SJCRH) Post Doctoral Associate University of Massachusetts Post doctoral fellow University of Pittsburgh Cellular and / or Molecular Biologist University of Birmingham- Alabama More Science jobs from Molecular Cell Biology EVENT 36th New Phytologist Symposium: Cell biology at the plant�microbe interface 29.11.15 Munich, Germany More science events from
REVIEWS		Top
Article series: Post-translational modifications Non-histone protein methylation as a regulator of cellular signalling and function Kyle K. Biggar & Shawn S.-C. Li p5 | doi:10.1038/nrm3915 Lys and Arg methylation on non-histone proteins regulates various signalling pathways, and its crosstalk with other post-translational modifications and with histone methylation affects cellular processes such as transcription and DNA damage repair. Advances in proteomics now allow us to decode the methylproteome and elucidate its functions. Abstract | Full Text | PDF | Supplementary information
Intrinsically disordered proteins in cellular signalling and regulation Peter E. Wright & H. Jane Dyson p18 | doi:10.1038/nrm3920 Intrinsically disordered proteins (IDPs) are key components of the cellular signalling machinery. Their flexible conformation enables them to interact with different partners and to participate in the assembly of signalling complexes and membrane-less organelles; this leads to different cellular outcomes. Post-translational modification of IDPs and alternative splicing add complexity to regulatory networks. Abstract | Full Text | PDF
Article series: Post-translational modifications Protein neddylation: beyond cullin-RING ligases Radoslav I. Enchev, Brenda A. Schulman & Matthias Peter p30 | doi:10.1038/nrm3919 Post-translational modification of proteins by NEDD8 has been mainly characterized in terms of the cullin-RING E3 ligase family. However, recent studies have indicated that there might be non-cullin neddylation targets that require further verification. Abstract | Full Text | PDF | Supplementary information
Mammalian iron-sulphur proteins: novel insights into biogenesis and function Tracey A. Rouault p45 | doi:10.1038/nrm3909 New insights into how iron-sulphur (Fe-S) clusters are incorporated into proteins, particularly the discovery of a role for Leu-Tyr-Arg motifs in Fe-S recipient proteins, are shedding light on the fundamental roles of Fe-S proteins in mammalian cells. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Regulation of kinetochore-microtubule attachments through homeostatic control during mitosis Kristina M. Godek, Lilian Kabeche & Duane A. Compton p57 | doi:10.1038/nrm3916 Faithful chromosome segregation during mitosis depends on the bi-oriented attachment of chromosomes to spindle microtubules through their kinetochores. The precise regulation of kinetochore-microtubule attachment that ensures error-free mitosis may be explained by homeostatic principles involving receptors, a core control network, effectors and feedback control. Abstract | Full Text | PDF
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