Nature Cell Biology contents: January 2015 Volume 17 Number 1, pp 1 - 105

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TABLE OF CONTENTS January 2015 Volume 17, Issue 1 News and Views Articles Letter Corrigenda Retraction Subscribe   Facebook   RSS   Recommend to library   Twitter   News and Views Top Ironing out VPS34 inhibition   pp1 - 3 Timothy Marsh and Jayanta Debnath doi:10.1038/ncb3089 The class III phosphoinositide 3-kinase VPS34 regulates autophagosome formation. Three groups have developed VPS34 inhibitors and shown their utility in investigating and defining autophagic processes. Solving the centriole disengagement puzzle   pp3 - 5 Andrew M. Fry doi:10.1038/ncb3087 The microcephaly protein, Cep215, contributes to the engagement of duplicated centrioles in interphase. Now two distinct pools of Cep215 at centrosomes are identified, one bound to Cep68 and the other to pericentrin. Plk1-mediated degradation of Cep68 and separase-mediated cleavage of pericentrin release both pools of Cep215, thereby promoting centriole disengagement. See also: Article by Pagan et al. Hippo signalling directs intestinal fate   pp5 - 6 Marie Le Bouteiller and Kim B. Jensen doi:10.1038/ncb3086 Hippo signalling has been associated with many important tissue functions including the regulation of organ size. In the intestinal epithelium differing functions have been proposed for the effectors of Hippo signalling, YAP and TAZ1. These are now shown to have a dual role in the intestinal epithelium, regulating both stem cell proliferation and differentiation along a specific secretory lineage. See also: Article by Imajo et al. Cell Biology JOBS of the week Post-Doctoral Position in cell biology / neuronal morphogenesis CRBM-CNRS PostDoctoral Positions in Skeletal Cell Biology UConn Health Center Graduate student in Stem Cell Biology Technion - Israel Institute of Technology Postdoctoral Position - Department of Cell & Molecular Biology St. Jude Children's Research Hospital (SJCRH) Post Doctoral Associate University of Massachusetts More Science jobs from Cell Biology EVENT Cell Biology of the Heart: Beyond the Myocyte-Centric View 01.03.15 Copper Mountain, USA More science events from Articles Top Dual role of YAP and TAZ in renewal of the intestinal epithelium   pp7 - 19 Masamichi Imajo, Miki Ebisuya and Eisuke Nishida doi:10.1038/ncb3084 Imajo and colleagues report that the Hippo signalling pathway components YAP and TAZ act via TEAD to promote intestinal stem/progenitor cell proliferation and via Klf4 to trigger their differentiation. AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation   pp20 - 30 Valentina Cianfanelli, Claudia Fuoco, Mar Lorente, Maria Salazar, Fabio Quondamatteo et al. doi:10.1038/ncb3072 mTOR signalling both inhibits autophagy and promotes cell proliferation. Cecconi and colleagues report that AMBRA1 links these two processes by facilitating dephosphorylation and degradation of the proto-oncogene c-Myc. Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing   pp31 - 43 Julia K. Pagan, Antonio Marzio, Mathew J. K. Jones, Anita Saraf, Prasad V. Jallepalli et al. doi:10.1038/ncb3076 Pagano and colleagues find that Plk1 and the E3 ubiquitin ligase SCFβTrCP mediate degradation of the centrosome cohesion protein Cep68 and show this mediates removal of Cep215 from the PCM and subsequent centriole separation in late mitosis. Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis   pp44 - 56 Sona Kang, Linus T. Tsai, Yiming Zhou, Adam Evertts, Su Xu et al. doi:10.1038/ncb3080 Rosen and colleagues perform epigenomic and transcriptomic analyses of insulin-resistant cells, and report that the vitamin D receptor and glucocorticoid receptor mediate transcriptional responses that promote insulin resistance. White-to-brown metabolic conversion of human adipocytes by JAK inhibition   pp57 - 67 Annie Moisan, Youn-Kyoung Lee, Jitao David Zhang, Carolyn S. Hudak, Claas A. Meyer et al. doi:10.1038/ncb3075 Moisan, Cowan and colleagues perform a small-molecule screen to identify compounds that promote white-to-brown adipocyte conversion in vitro. They report that two inhibitors of the JAK–STAT signalling pathway stimulate browning of human adipocytes. STRIPAK components determine mode of cancer cell migration and metastasis   pp68 - 80 Chris D. Madsen, Steven Hooper, Melda Tozluoglu, Andreas Bruckbauer, Georgina Fletcher et al. doi:10.1038/ncb3083 Sahai and colleagues delineate a pathway through which components of the STRIPAK complex promote amoeboid cancer cell migration by regulating the linkage of the actomyosin network to the plasma membrane. The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling   pp81 - 94 Tomoyo Okada, Surajit Sinha, Ilaria Esposito, Gaia Schiavon, Miguel A. López-Lago et al. doi:10.1038/ncb3082 Giancotti and colleagues report that the Rnd1 Rho GTPase suppresses the epithelial–mesenchymal transition and mammary tumorigenesis by inhibiting Ras-MAPK signalling through a Plexin B1–Rap1–p120 Ras-GAP signalling axis. Letter Top Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase   pp95 - 103 Biao Ma, Yan Chen, Ling Chen, Hongcheng Cheng, Chenglong Mu et al. doi:10.1038/ncb3073 Wu and colleagues report that under hypoxic conditions the LATS2 kinase is targeted for degradation by the SIAH2 ubiquitin ligase, leading to inhibition of the Hippo kinase cascade and activation of YAP, which promotes tumour growth. Corrigenda Top Corrigendum: MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins   p104 Kasey C. Vickers, Brian T. Palmisano, Bassem M. Shoucri, Robert D. Shamburek and Alan T. Remaley doi:10.1038/ncb3074 Corrigendum: MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability   p104 Eyleen J. O'Rourke and Gary Ruvkun doi:10.1038/ncb3085 Retraction Top Retraction: Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion   p105 Sonya G. Fonseca, Fumihiko Urano, Gordon C. Weir, Jesper Gromada and Mark Burcin doi:10.1038/ncb3088 Editorial note Top Editorial note: Integrating insulin secretion and ER stress in pancreatic β-cells   p105 Katleen Lemaire and Frans Schuit doi:10.1038/ncb3093 Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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