Cell Death and Differentiation - Table of Contents alert Volume 22 Issue 1

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Special Issue on microRNAs – the smallest RNA regulators of gene expression It is now well recognised that the majority of non-protein-coding genomic DNA is not “junk” but specifies a range of regulatory RNA molecules which finely tune protein expression. This issue of CDD contains an editorial and 5 reviews on a particular class of these regulatory RNAs, the microRNAs (miRs) of around 22 nucleotides, and which exert their effects by binding to consensus sites in the 3'UTRs of mRNAs. The reviews cover the role of miRs from their early association with CLL to other forms of cancer, their importance in the development of the epidermis and their potential as disease biomarkers as secreted in exosomes. In addition, we publish a News and Commentary on CRISPR, a technology which is not only revolutionising genetic manipulation in the lab, but which has the potential to treat genetic disease in vivo. TABLE OF CONTENTS Volume 22, Issue 1 (January 2015) In this issue Editorial News And Commentary Reviews Original Papers Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Editorial Top MicroRNAs—getting the hang of it A H Lund Cell Death Differ 2014 22: 1-2; 10.1038/cdd.2014.114 Full Text | PDF News And Commentary Top CRISPR: a new method for genetic engineering – A prokaryotic immune component may potentially open a new era of gene silencing OPEN I Amelio and G Melino Cell Death Differ 2014 22: 3-5; advance online publication, April 4, 2014; 10.1038/cdd.2014.39 Full Text | PDF Reviews Top Role of miR-15/16 in CLL Y Pekarsky and C M Croce Cell Death Differ 2014 22: 6-11; advance online publication, June 27, 2014; 10.1038/cdd.2014.87 Abstract | Full Text MicroRNAs and p63 in epithelial stemness OPEN E Candi, I Amelio, M Agostini and G Melino Cell Death Differ 2014 22: 12-21; advance online publication, August 29, 2014; 10.1038/cdd.2014.113 Abstract | Full Text The complexity of miRNA-mediated repression A Wilczynska and M Bushell Cell Death Differ 2014 22: 22-33; advance online publication, September 5, 2014; 10.1038/cdd.2014.112 Abstract | Full Text Exosomes as divine messengers: are they the Hermes of modern molecular oncology? C Braicu, C Tomuleasa, P Monroig, A Cucuianu, I Berindan-Neagoe and G A Calin Cell Death Differ 2014 22: 34-45; advance online publication, September 19, 2014; 10.1038/cdd.2014.130 Abstract | Full Text MicroRNAs in liver cancer: a model for investigating pathogenesis and novel therapeutic approaches E Callegari, L Gramantieri, M Domenicali, L D'Abundo, S Sabbioni and M Negrini Cell Death Differ 2014 22: 46-57; advance online publication, September 5, 2014; 10.1038/cdd.2014.136 Abstract | Full Text Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 OPEN L Galluzzi, J M Bravo-San Pedro, I Vitale, S A Aaronson, J M Abrams, D Adam, E S Alnemri, L Altucci, D Andrews, M Annicchiarico-Petruzzelli, E H Baehrecke, N G Bazan, M J Bertrand, K Bianchi, M V Blagosklonny, K Blomgren, C Borner, D E Bredesen, C Brenner, M Campanella, E Candi, F Cecconi, F K Chan, N S Chandel, E H Cheng, J E Chipuk, J A Cidlowski, A Ciechanover, T M Dawson, V L Dawson, V De Laurenzi, R De Maria, K-M Debatin, N Di Daniele, V M Dixit, B D Dynlacht, W S El-Deiry, G M Fimia, R A Flavell, S Fulda, C Garrido, M-L Gougeon, D R Green, H Gronemeyer, G Hajnoczky, J M Hardwick, M O Hengartner, H Ichijo, B Joseph, P J Jost, T Kaufmann, O Kepp, D J Klionsky, R A Knight, S Kumar, J J Lemasters, B Levine, A Linkermann, S A Lipton, R A Lockshin, C López-Otín, E Lugli, F Madeo, W Malorni, J-C Marine, S J Martin, J-C Martinou, J P Medema, P Meier, S Melino, N Mizushima, U Moll, C Muñoz-Pinedo, G Nuñez, A Oberst, T Panaretakis, J M Penninger, M E Peter, M Piacentini, P Pinton, J H Prehn, H Puthalakath, G A Rabinovich, K S Ravichandran, R Rizzuto, C M Rodrigues, D C Rubinsztein, T Rudel, Y Shi, H-U Simon, B R Stockwell, G Szabadkai, S W Tait, H L Tang, N Tavernarakis, Y Tsujimoto, T Vanden Berghe, P Vandenabeele, A Villunger, E F Wagner, H Walczak, E White, W G Wood, J Yuan, Z Zakeri, B Zhivotovsky, G Melino and G Kroemer Cell Death Differ 2014 22: 58-73; advance online publication, September 19, 2014; 10.1038/cdd.2014.137 Abstract | Full Text Original Papers Top Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes S S Metkar, M Marchioretto, V Antonini, L Lunelli, B Wang, R JC Gilbert, G Anderluh, R Roth, M Pooga, J Pardo, J E Heuser, M D Serra and C J Froelich Cell Death Differ 2014 22: 74-85; advance online publication, August 22, 2014; 10.1038/cdd.2014.110 Abstract | Full Text Genotoxic stress/p53-induced DNAJB9 inhibits the pro-apoptotic function of p53 H J Lee, J M Kim, K H Kim, J I Heo, S J Kwak and J A Han Cell Death Differ 2014 22: 86-95; advance online publication, August 22, 2014; 10.1038/cdd.2014.116 Abstract | Full Text Transmissible cytotoxicity of multiple myeloma cells by cord blood-derived NK cells is mediated by vesicle trafficking B Martin-Antonio, A Najjar, S N Robinson, C Chew, S Li, E Yvon, M W Thomas, I Mc Niece, R Orlowski, C Muñoz-Pinedo, C Bueno, P Menendez, C Fernández de Larrea, A Urbano-Ispizua, E J Shpall and N Shah Cell Death Differ 2014 22: 96-107; advance online publication, August 29, 2014; 10.1038/cdd.2014.120 Abstract | Full Text Oocyte-specific inactivation of Omcg1 leads to DNA damage and c-Abl/TAp63-dependent oocyte death associated with dramatic remodeling of ovarian somatic cells S Vandormael-Pournin, C J Guigon, M Ishaq, N Coudouel, P Avé, M Huerre, S Magre, J Cohen-Tannoudji and M Cohen-Tannoudji Cell Death Differ 2014 22: 108-117; advance online publication, August 29, 2014; 10.1038/cdd.2014.122 Abstract | Full Text L-GILZ binds p53 and MDM2 and suppresses tumor growth through p53 activation in human cancer cells E Ayroldi, M G Petrillo, A Bastianelli, M C Marchetti, S Ronchetti, G Nocentini, L Ricciotti, L Cannarile and C Riccardi Cell Death Differ 2014 22: 118-130; advance online publication, August 29, 2014; 10.1038/cdd.2014.129 Abstract | Full Text Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation M Salazar, M Lorente, E García-Taboada, E Pérez Gómez, D Dávila, P Zúñiga-García, J María Flores, A Rodríguez, Z Hegedus, D Mosén-Ansorena, A M Aransay, S Hernández-Tiedra, I López-Valero, M Quintanilla, C Sánchez, J L Iovanna, N Dusetti, M Guzmán, S E Francis, A Carracedo, E Kiss-Toth and G Velasco Cell Death Differ 2014 22: 131-144; advance online publication, August 29, 2014; 10.1038/cdd.2014.133 Abstract | Full Text Induction of tissue-specific stem cells by reprogramming factors, and tissue-specific selection H Noguchi, I Saitoh, T Tsugata, H Kataoka, M Watanabe and Y Noguchi Cell Death Differ 2014 22: 145-155; advance online publication, September 5, 2014; 10.1038/cdd.2014.132 Abstract | Full Text Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase S Maniam, A S Coutts, M R Stratford, J McGouran, B Kessler and N B La Thangue Cell Death Differ 2014 22: 156-163; advance online publication, August 29, 2014; 10.1038/cdd.2014.135 Abstract | Full Text Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection P A Lang, A Meryk, A A Pandyra, D Brenner, A Brüstle, H C Xu, K Merches, F Lang, V Khairnar, P Sharma, P Funkner, M Recher, N Shaabani, G S Duncan, V Duhan, B Homey, P S Ohashi, D Häussinger, P A Knolle, N Honke, T W Mak and K S Lang Cell Death Differ 2014 22: 164-173; advance online publication, September 26, 2014; 10.1038/cdd.2014.138 Abstract | Full Text Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins S Kurtulus, A Sholl, J Toe, P Tripathi, J Raynor, K-P Li, M Pellegrini and D A Hildeman Cell Death Differ 2014 22: 174-184; advance online publication, August 15, 2014; 10.1038/cdd.2014.118 Abstract | Full Text Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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