Scientific Reports Biology Table of Contents e-alert: 25 November 2014

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25 November 2014      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               Biological Sciences               Low Piconewton Towing of CNS Axons against Diffusing and Surface-Bound Repellents Requires the Inhibition of Motor Protein-Associated Pathways ▶     Devrim Kilinc, Agata Blasiak, James J. O'Mahony et al.     Growth cones, dynamic structures at axon tips, integrate chemical and physical stimuli and translate them into coordinated axon behaviour, e.g., elongation or turning. External …             Systematic prediction of drug combinations based on clinical side-effects ▶     Hui Huang, Ping Zhang, Xiaoyan A. Qu et al.     Drug co-prescription (or drug combination) is a therapeutic strategy widely used as it may improve efficacy and reduce side-effect (SE). Since it is impractical to screen all …             Glucocorticosteroids enhance replication of respiratory viruses: effect of adjuvant interferon ▶     Belinda J. Thomas, Rebecca A. Porritt, Paul J. Hertzog et al.     Glucocorticosteroids (GCS) are used on a daily basis to reduce airway inflammation in asthma and chronic obstructive pulmonary disease (COPD). This treatment is usually escalated …             System-level Study on Synergism and Antagonism of Active Ingredients in Traditional Chinese Medicine by Using Molecular Imprinting Technology ▶     Tengfei Chen, Jiangyong Gu, Xinzhuang Zhang et al.     In this work, synergism and antagonism among active ingredients of traditional Chinese medicine (TCM) were studied at system-level by using molecular imprinting technology. …             Gorilla gorilla gorilla gut: a potential reservoir of pathogenic bacteria as revealed using culturomics and molecular tools ▶     Fadi Bittar, Mamadou B. Keita, Jean-Christophe Lagier et al.     Wild apes are considered to be the most serious reservoir and source of zoonoses. However, little data are available about the gut microbiota and pathogenic bacteria in gorillas. …             Ablation of Tak1 in osteoclast progenitor leads to defects in skeletal growth and bone remodeling in mice ▶     Bing Qi, Qian Cong, Ping Li et al.     Tak1 is a MAPKKK that can be activated by growth factors and cytokines such as RANKL and BMPs and its downstream pathways include NF-κB and JNK/p38 MAPKs. Tak1 is essential for …             Modulation of specificity protein 1 by mithramycin A as a novel therapeutic strategy for cervical cancer ▶     Eun-Sun Choi, Jeong-Seok Nam, Ji-Youn Jung et al.     Cervical cancer is the third most common cancer and the third leading cause of death among women. However, the standard treatment for cervical cancer includes cisplatin, which …             Late-onset spastic ataxia phenotype in a patient with a homozygous DDHD2 mutation ▶     Hiroshi Doi, Masao Ushiyama, Takashi Baba et al.     Autosomal recessive cerebellar ataxias and autosomal recessive hereditary spastic paraplegias (ARHSPs) are clinically and genetically heterogeneous neurological disorders. Herein …             Coordinating Expression of RNA Binding Proteins with Their mRNA Targets ▶     Huifeng Jiang, Lin Xu, Zhe Wang et al.     Post-transcriptional regulation by RNA binding proteins (RBPs) plays prominent roles in a variety of biological processes. In this study, by analyzing the global regulatory …             Comparative genomic analysis of Mycobacterium iranicum UM_TJL against representative mycobacterial species suggests its environmental origin ▶     Joon Liang Tan, Yun Fong Ngeow, Wei Yee Wee et al.     Mycobacterium iranicum is a newly reported mycobacterial species. We present the first comparative study of M. iranicum UM_TJL and other mycobacteria. We found M. iranicum to …             Effects of Rhodiola on production, health and gut development of broilers reared at high altitude in Tibet ▶     Long Li, Honghui Wang, Xin Zhao     Rhodiola has long been used as a traditional medicine to increase resistance to physical stress in humans in Tibet. The current study was designed to investigate whether Rhodiola …             Oldest Directly Dated Remains of Sheep in China ▶     John Dodson, Eoin Dodson, Richard Banati et al.     The origins of domesticated sheep (Ovis sp.) in China remain unknown. Previous workers have speculated that sheep may have been present in China up to 7000 years ago, however …             Heterogeneous Red Blood Cell Adhesion and Deformability in Sickle Cell Disease ▶     Yunus Alapan, Jane A. Little, Umut A. Gurkan     We present a microfluidic approach that allows simultaneous interrogation of RBC properties in physiological flow conditions at a single cell level. With this method, we studied …             Cloning and characterization of wnt4a gene and evidence for positive selection in half-smooth tongue sole (Cynoglossus semilaevis) ▶     Qiaomu Hu, Ying Zhu, Yang Liu et al.     Wnt4 gene plays a role in developmental processes in mammals. However, little is known regarding its function in teleosts. We cloned and characterized the full-length half-smooth …             Dissecting the Human Protein-Protein Interaction Network via Phylogenetic Decomposition ▶     Cho-Yi Chen, Andy Ho, Hsin-Yuan Huang et al.     The protein-protein interaction (PPI) network offers a conceptual framework for better understanding the functional organization of the proteome. However, the intricacy of …             Global human frequencies of predicted nuclear pathogenic variants and the role played by protein hydrophobicity in pathogenicity potential ▶     Luísa Pereira, Pedro Soares, Petr Triska et al.     Mitochondrial proteins are coded by nuclear (nDNA) and mitochondrial (mtDNA) genes, implying a complex cross-talk between the two genomes. Here we investigated the diversity …             Aging disrupts cell subpopulation dynamics and diminishes the function of mesenchymal stem cells ▶     Dominik Duscher, Robert C. Rennert, Michael Januszyk et al.     Advanced age is associated with an increased risk of vascular morbidity, attributable in part to impairments in new blood vessel formation. Mesenchymal stem cells (MSCs) have …             ERRATUM: Methylation Patterns of the IFN-γ Gene in Cervical Cancer Tissues ▶     Dong Ma, Chunyang Jiang, Xiaoli Hu et al.                 Tree shrew database (TreeshrewDB): a genomic knowledge base for the Chinese tree shrew ▶     Yu Fan, Dandan Yu, Yong-Gang Yao     The tree shrew (Tupaia belangeri) is a small mammal with a close relationship to primates and it has been proposed as an alternative experimental animal to primates in biomedical …             Characteristics of Long Non-coding RNAs in the Brown Norway Rat and Alterations in the Dahl Salt-Sensitive Rat ▶     Feng Wang, Liping Li, Haiming Xu et al.     Long non-coding RNAs (lncRNAs) are potentially important mediators of genomic regulation. lncRNAs, however, remain poorly characterized in the rat model organism widely used in …             Increased radiation from Chernobyl decreases the expression of red colouration in natural populations of bank voles (Myodes glareolus) ▶     Zbyszek Boratyński, Philipp Lehmann, Tapio Mappes et al.     Pheomelanin is a pink to red version of melanin pigment deposited in skin and hair. Due to its bright colour, pheomelanin plays a crucial function in signalling, in particular …             Quantitative Proteomic Analysis of Meningiomas for the Identification of Surrogate Protein Markers ▶     Samridhi Sharma, Sandipan Ray, Aliasgar Moiyadi et al.     Meningiomas are the most common non-glial tumors of the brain and spine. Pathophysiology and definite histological grading of meningiomas are frequently found to be deceptive due …             Transcriptome-wide Variability in Single Embryonic Development Cells ▶     Vincent Piras, Masaru Tomita, Kumar Selvarajoo     Molecular heterogeneity of individual molecules within single cells has been recently shown to be crucial for cell fate diversifications. However, on a global scale, the effect …             Stochastic promoter activation affects Nanog expression variability in mouse embryonic stem cells ▶     Hiroshi Ochiai, Takeshi Sugawara, Tetsushi Sakuma et al.     Mouse embryonic stem cells (mESCs) are self-renewing and capable of differentiating into any of the three germ layers. An interesting feature of mESCs is the presence of …             gp78 elongates of polyubiquitin chains from the distal end through the cooperation of its G2BR and CUE domains ▶     Weixiao Liu, Yongliang Shang, Wei Li     The modification of proteins with polyubiquitin chains alters their stability, localization and activity, thus regulating various aspects of cellular functions in eukaryotic …             Inhibition of breast cancer growth and metastasis by a biomimetic peptide ▶     Esak Lee, Seung Jae Lee, Jacob E. Koskimaki et al.     Metastasis is the main cause of mortality in cancer patients. Though there are many anti-cancer drugs targeting primary tumor growth, anti-metastatic agents are rarely developed. …             The visual magnocellular-dorsal dysfunction in Chinese children with developmental dyslexia impedes Chinese character recognition ▶     Jing Zhao, Yi Qian, Hong-Yan Bi et al.     The visual magnocellular-dorsal (M-D) deficit theory of developmental dyslexia (DD) is still highly debated. Many researchers have made great efforts to investigate the …             DHA-PC and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's disease ▶     Dai Yuki, Yuki Sugiura, Nobuhiro Zaima et al.     Alzheimer's disease (AD) is a progressive neurodegenerative disease that is characterized by senile plaques, neurofibrillary tangles, synaptic disruption, and neuronal loss. …             The association between romantic relationship status and 5-HT1A gene in young adults ▶     Jinting Liu, Pingyuan Gong, Xiaolin Zhou     What factors determine whether or not a young adult will fall in love? Sociological surveys and psychological studies have shown that non-genetic factors, such as socioeconomic …             Ontogenetic phase shifts in metabolism in a flounder Paralichthys olivaceus ▶     Mitsuharu Yagi, Shin Oikawa     Size-scaling metabolism is widely considered to be of significant importance in biology and ecology. Thus, allometric relationships between metabolic rate () and body mass (M), , …             Cicada-inspired cell-instructive nanopatterned arrays ▶     Ting Diu, Nilofar Faruqui, Terje Sjöström et al.     Biocompatible surfaces hold key to a variety of biomedical problems that are directly related to the competition between host-tissue cell integration and bacterial colonisation. …             Different Inhibitory Effect and Mechanism of Hydroxyapatite Nanoparticles on Normal Cells and Cancer Cells In Vitro and In Vivo ▶     Yingchao Han, Shipu Li, Xianying Cao et al.     Hydroxyapatite (HAP), similar to inorganic phase in bones, shows good biocompatibility and bioactivity as bone defect repairing material. Recently, nanoscaled HAP shows the …             Cell death induced by ozone and various non-thermal plasmas: therapeutic perspectives and limitations ▶     Oleg Lunov, Vitalii Zablotskii, Olexander Churpita et al.     Non-thermal plasma has been recognized as a promising tool across a vast variety of biomedical applications, with the potential to create novel therapeutic methods. However, the …             CORRIGENDUM: Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization ▶     Huile Gao, Zhi Yang, Shuang Zhang et al.                 ERRATUM: Sponge larval settlement cues: the role of microbial biofilms in a warming ocean ▶     S. Whalan, N. S. Webster                 Esterase in Imported Fire Ants, Solenopsis invicta and S. richteri (Hymenoptera: Formicidae): Activity, Kinetics and Variation ▶     J. Chen, T. Rashid, G. Feng     Solenopsis invicta and Solenopsis richteri are two closely related invasive ants native to South America. Despite their similarity in biology and behavior, S. invicta is a more …             Love makes smell blind: mating suppresses pheromone attraction in Drosophila females via Or65a olfactory neurons ▶     Sébastien Lebreton, Veit Grabe, Aman B. Omondi et al.     In Drosophila, the male sex pheromone cis-vaccenyl acetate (cVA) elicits aggregation and courtship, through the odorant receptor Or67d. Long-lasting exposure to cVA suppresses …             Assessing trade-offs to inform ecosystem-based fisheries management of forage fish ▶     Andrew Olaf Shelton, Jameal F. Samhouri, Adrian C. Stier et al.     Twenty-first century conservation is centered on negotiating trade-offs between the diverse needs of people and the needs of the other species constituting coupled human-natural …             The Role of the Helper Lipid on the DNA Transfection Efficiency of Lipopolyplex Formulations ▶     Zixiu Du, Mustafa M. Munye, Aristides D. Tagalakis et al.     Multifunctional, lipopolyplex formulations comprising a mixture of cationic liposomes and cationic, receptor-targeting peptides have potential use in gene therapy applications. …             Distinct modes of perimembrane TRP channel turnover revealed by TIR-FRAP ▶     Debapriya Ghosh, Andrei Segal, Thomas Voets     Transient Receptor Potential (TRP) channels form a broadly expressed and functionally diverse family of cation channels involved in various (patho)physiological processes. …             Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3 ▶     Yasuhiro Arimura, Kazuyoshi Shirayama, Naoki Horikoshi et al.     The centromere-specific histone H3 variant, CENP-A, is overexpressed in particular aggressive cancer cells, where it can be mislocalized ectopically in the form of heterotypic …             A marine inducible prophage vB_CibM-P1 isolated from the aerobic anoxygenic phototrophic bacterium Citromicrobium bathyomarinum JL354 ▶     Qiang Zheng, Rui Zhang, Yongle Xu et al.     A prophage vB_CibM-P1 was induced by mitomycin C from the epipelagic strain Citromicrobium bathyomarinum JL354, a member of the alpha-IV subcluster of marine aerobic anoxygenic …             Synthesis and discovery of 18α-GAMG as anticancer agent in vitro and in vivo via down expression of protein p65 ▶     Wen-jian Tang, Yong-an Yang, He Xu et al.     Glycyrrhizic acid (GA) is a natural product with favorable antitumor activity. But, glycyrrhetinic acid monoglucuronide (GAMG) showed stronger antitumor activity than GA. It is …             Adults Can Be Trained to Acquire Synesthetic Experiences ▶     Daniel Bor, Nicolas Rothen, David J. Schwartzman et al.     Synesthesia is a condition where presentation of one perceptual class consistently evokes additional experiences in different perceptual categories. Synesthesia is widely …             Development and application of loop-mediated isothermal amplification for detection of the F167Y mutation of carbendazim-resistant isolates in Fusarium graminearum ▶     Yabing Duan, Xiaoke Zhang, Changyan Ge et al.     Resistance of Fusarium graminearum to carbendazim is caused by point mutations in the β2-tubulin gene. The point mutation at codon 167 (TTT → TAT, F167Y) occurs in more than 90% …             A cytosolic glucose-6-phosphate dehydrogenase gene, ScG6PDH, plays a positive role in response to various abiotic stresses in sugarcane ▶     Yuting Yang, Zhiwei Fu, Yachun Su et al.     As one of the key enzymes in the oxidative pentose phosphate pathway, glucose-6-phosphate dehydrogenase (G6PDH) plays a role in response to abiotic stresses and pathogenesis. …             Dynamic multidrug recognition by multidrug transcriptional repressor LmrR ▶     Koh Takeuchi, Yuji Tokunaga, Misaki Imai et al.     LmrR is a multidrug transcriptional repressor that controls the expression of a major multidrug transporter, LmrCD, in Lactococcus lactis. However, the molecular mechanism by …             Use of the Meganuclease I-SceI of Saccharomycescerevisiae to select for gene deletions in actinomycetes ▶     Lorena T. Fernández-Martínez, Mervyn J. Bibb     The search for new natural products is leading to the isolation of novel actinomycete species, many of which will ultimately require genetic analysis. Some of these isolates will …             Self-assembled monolayers improve protein distribution on holey carbon cryo-EM supports ▶     Joel R. Meyerson, Prashant Rao, Janesh Kumar et al.     Poor partitioning of macromolecules into the holes of holey carbon support grids frequently limits structural determination by single particle cryo-electron microscopy (cryo-EM). …             Potential microRNA-mediated oncogenic intercellular communication revealed by pan-cancer analysis ▶     Yue Li, Zhaolei Zhang     Carcinogenesis consists of oncogenesis and metastasis, and intriguingly microRNAs (miRNAs) are involved in both processes. Although aberrant miRNA activities are prevalent in …             2-(4-Hydroxy-3-methoxyphenyl)-benzothiazole suppresses tumor progression and metastatic potential of breast cancer cells by inducing ubiquitin ligase CHIP ▶     Hiromi Hiyoshi, Natsuka Goto, Mai Tsuchiya et al.     Breast cancer is the most common malignancy among women and has poor survival and high recurrence rates for aggressive metastatic disease. Notably, triple-negative breast cancer …             Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells ▶     Mina Thon, Toru Hosoi, Michiko Yoshii et al.     Leptin is a circulating hormone that plays a critical role in regulating energy expenditure and food intake. Evidence to suggest the involvement of endoplasmic reticulum (ER) …             Period doubling induced by thermal noise amplification in genetic circuits ▶     G. Ruocco, A. Fratalocchi     Rhythms of life are dictated by oscillations, which take place in a wide rage of biological scales. 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