Nature Reviews Molecular Cell Biology contents December 2014 Volume 15 Number 12 pp 761-833

If you are unable to see the message below, click here to view.

TABLE OF CONTENTS
December 2014 Volume 15 Number 12
Impact Factor 36.458 *	In this issue Foreword Research Highlights Focus on: The Extracellular Matrix Perspectives Also this month  Focus: The Extracellular Matrix
Subscribe   Facebook   RSS   Recommend to library   Twitter
Advertisement
Poster & Webcast on CRISPR-Cas technology from Nature Publishing Group Nature Reviews Microbiology  FREE POSTER CRISPR-CAS: EXTRAORDINARY EDITING  Presented by Nature Biotechnology  WEBCAST AND LIVE Q&A: A PRACTICAL GUIDE TO CRISPR TECHNOLOGY  Date: November 25, 2014 Produced with support from OriGene, Your Gene Company
FOREWORD		Top
Stretching the boundaries of extracellular matrix research p761 | doi:10.1038/nrm3908 Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Technique: DNA hairpins track traction p765 | doi:10.1038/nrm3905 Two studies report the design of DNA hairpins that function as optical probes of cellular traction forces, offering high spatiotemporal resolution and signal-to-noise ratio. PDF Extracellular matrix: Preconditioning the ECM for fibrosis p766 | doi:10.1038/nrm3906 Increased organization of the ECM mediated by myofibroblast remodelling pre-conditions for TGFβ activation. PDF Chromosome biology: Short telomeres can't reach p766 | doi:10.1038/nrm3914 Robin et al. describe telomere position effect over long distances (TPE-OLD), a phenomenon in which long (but not short) telomeres control gene expression by forming chromatin loops with genes located several Mb away. PDF Stem cells: Insulin-producing β cells in a dish p768 | doi:10.1038/nrm3907 A protocol for the large-scale differentiation of human pluripotent stem cells into functional β cells has been developed. PDF JOURNAL CLUB The needle in the ECM haystack p769 | doi:10.1038/nrm3899 Karl E. Kadler describes why the mechanism of collagen fibril assembly in vivo remains elusive. PDF Microscopy: Advancing imaging p769 | doi:10.1038/nrm3910 Betzig and colleagues created ultrathin light sheets to visualize dynamic processes at high speed and high spatiotemporal resolution. PDF IN BRIEF Cell migration: Moving towards ECM with LKB1 | Cell adhesion: Basement membranes stick together | Protein degradation: Piecing together protein quality control PDF Molecular Cell Biology JOBS of the week PhD Programme in Molecular Cell Biology University College London (UCL) Postdoctoral fellow Yale University School of Medicine Post Doctoral Associate University of Massachusetts Research Assistant Grade 6 University of Oxford More Science jobs from Molecular Cell Biology EVENT Stem cells: from basic research to bioprocessing 09.06.15 London, UK More science events from
Focus on: The Extracellular Matrix REVIEWS Top Extracellular matrix assembly: a multiscale deconstruction Janna K. Mouw, Guanqing Ou & Valerie M. Weaver p771 | doi:10.1038/nrm3902 The molecules that are associated with the extracellular matrix (ECM) in different tissues, including collagens, proteoglycans, laminins and fibronectin, and the manner in which they are assembled, determine the structure and the organization of the ECM. The resultant biochemical and biophysical properties of the ECM dictate its tissue-specific functions. Abstract | Full Text | PDF Remodelling the extracellular matrix in development and disease Caroline Bonnans, Jonathan Chou & Zena Werb p786 | doi:10.1038/nrm3904 The extracellular matrix (ECM) regulates many cellular functions, and its remodelling by enzymes such as metalloproteinases has a crucial role during development, as exemplified by intestinal, lung, mammary gland and submandibular gland morphogenesis. ECM structure and composition are important therapeutic targets, as their dysregulation contributes to conditions such as fibrosis and invasive cancer. Abstract | Full Text | PDF Mechanotransduction and extracellular matrix homeostasis Jay D. Humphrey, Eric R. Dufresne & Martin A. Schwartz p802 | doi:10.1038/nrm3896 In soft connective tissues at the steady state, cells continually read environmental cues and respond to promote mechanical homeostasis of the extracellular matrix and ensure cellular and tissue health. Progress has been made into our understanding of the molecular, cellular and tissue scale responses to mechanical load that promote mechanical homeostasis. Abstract | Full Text | PDF Physical influences of the extracellular environment on cell migration Guillaume Charras & Erik Sahai p813 | doi:10.1038/nrm3897 The physical properties of the extracellular environment — in terms of confinement, rigidity, surface topology and adhesion-ligand density — can have profound effects on the migration strategy and migration velocity of cells in different in vivo contexts. Abstract | Full Text | PDF
Focus on: The Extracellular Matrix PERSPECTIVES Top TIMELINE Appreciating force and shape — the rise of mechanotransduction in cell biology Thomas Iskratsch, Haguy Wolfenson & Michael P. Sheetz p825 | doi:10.1038/nrm3903 The form of vertebrates is shaped by the sensing and relaying of mechanical forces that are applied between cells and their microenvironment. Mechanobiology has emerged as a field of research dedicated to studying these forces and their communication through signalling processes, which are collectively known as mechanotransduction. Abstract | Full Text | PDF
Advertisement
Nature Reviews Microbiology  CALENDAR 2015 One of the most exciting recent developments in microbiology has been the discovery and characterization of the CRISPR-Cas adaptive immune system in bacteria and archaea. This special Calendar brings together CRISPR related images from a range of Nature Publishing Group journals. Produced with support from  OriGene, Your Gene Company
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2013 Journal Citation Report (Thomson Reuters, 2013)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.