Nature Reviews Immunology Contents December 2014 Volume 14 Number 12 pp 775-835

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TABLE OF CONTENTS
December 2014 Volume 14 Number 12
Impact Factor 33.836 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: The IL-20 subfamily of cytokines — from host defence to tissue homeostasis Sascha Rutz, Xiaoting Wang & Wenjun Ouyang
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RESEARCH HIGHLIGHTS Top Parasite immunity: Chitinase-like proteins smoke out worms p775 | doi:10.1038/nri3770 Chitinase-like proteins promote innate interleukin-17 production and neutrophilia. PDF Autoimmunity: Troublemaker T cells target ribosomal protein p776 | doi:10.1038/nri3772 A new study identifies a ubiquitously expressed ribosomal protein that is recognized by arthritogenic T cells. PDF Tumour immunology: Anticancer drugs copy bugs p776 | doi:10.1038/nri3775 The induction of a type I interferon response in cancer cells is linked to the efficacy of certain chemotherapies. PDF Infectious disease: The tolerance of superspreaders p776 | doi:10.1038/nri3776 Superspreaders of Salmonella infection are uniquely able to tolerate antibiotic treatment. PDF Cell death: Breaking down memory p778 | doi:10.1038/nri3774 Autophagy is important for the transition of effector CD8+ T cells into memory T cells. PDF Tumour immunology: The new midfielders in the tumour microenvironment p778 | doi:10.1038/nri3781 Broz et al. identify a rare intratumoral CD103+ dendritic cell population that stimulates cytotoxic T cells. PDF Cytokines: ISG15 — human deficiency reveals new proficiency p780 | doi:10.1038/nri3767 A new study of individuals deficient for the ubiquitin-like protein ISG15 demonstrates a role for this molecule in regulating the type I IFN response. PDF Infectious disease: IL-22 complements protection p780 | doi:10.1038/nri3768 Clostridium difficile infection induces the expression of interleukin-22, which regulates the complement system to eliminate systemically translocated pathobionts. PDF Mucosal immunology: Sick of the flu p781 | doi:10.1038/nri3773 Respiratory infection with influenza virus causes intestinal symptoms through the specific recruitment of lung-induced CD4+ T cells to the intestinal mucosa. PDF IN BRIEF Immune tolerance: Regulatory T cells require constant reassurance | Reproductive immunology: Hyaluronan protects the cervix from infection | Antiviral immunity: Whipping up a remedy for rotavirus infection | Infectious disease: Fungal restriction of renal T cell migration | Innate immunity: IFNs lead TLR4 responses down the TRIF path | Antiviral immunity: Linking lncRNA to IFN regulation PDF Immunology JOBS of the week Master of Medical Sciences Degree in Immunology Harvard Medical School Multiple Postdoc Openings in Particle Tracking, Immunology, Microbiome, Vaccines University of North Carolina at Chapel Hill Postdoctoral Scientist in Immuno-metabolism University of North Carolina at Chapel Hill Graduate Student Sanquin Research Postdoctoral Fellow University of Cincinnati More Science jobs from Immunology EVENT Immunology of Diabetes Society 14th International Congress 12.04.15 Munich, Germany More science events from
REVIEWS		Top
The IL-20 subfamily of cytokines — from host defence to tissue homeostasis Sascha Rutz, Xiaoting Wang & Wenjun Ouyang p783 | doi:10.1038/nri3766 This Review describes the biology of the interleukin-20 (IL-20) subfamily of cytokines. The authors detail the cellular sources and targets of these cytokines, and explain their key roles in promoting immunity to infections and driving tissue repair. They also discuss the emerging roles for IL-20 subfamily cytokines in metabolism and tumour immunology. Abstract | Full Text | PDF
Immunity in Drosophila melanogaster — from microbial recognition to whole-organism physiology Nicolas Buchon, Neal Silverman & Sara Cherry p796 | doi:10.1038/nri3763 Being able to use Drosophila melanogaster to study immunity on a whole-organism level is proving to be highly valuable in deciphering the links between systemic metabolic and hormonal changes and the immune response. Here, the authors describe the insights gained so far into organism-wide immune regulation and the future directions for research in D. melanogaster. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Complement — tapping into new sites and effector systems Martin Kolev, Gaelle Le Friec & Claudia Kemper p811 | doi:10.1038/nri3761 Recent studies have shown that complement activation is not confined to the serum but also occurs within cellular compartments. This has led to an emerging understanding that complement components can intersect diverse cellular metabolic and effector pathways. Here, the authors propose that the different locations of complement activation dictate its diverse functions. Abstract | Full Text | PDF
OPINION SMOCs: supramolecular organizing centres that control innate immunity Jonathan C. Kagan, Venkat Giri Magupalli & Hao Wu p821 | doi:10.1038/nri3757 This Opinion article proposes that higher-order protein complexes — referred to as supramolecular organizing centres (SMOCs) — form on specific organelles by nucleated polymerization downstream of innate immune receptors to amplify the signal and reach a response threshold. Abstract | Full Text | PDF
OPINION Host–microorganism interactions in lung diseases Benjamin J. Marsland & Eva S. Gollwitzer p827 | doi:10.1038/nri3769 The recent realization that the airways harbour a steady-state microbiota necessitates a shift in our understanding of respiratory health and disease, drawing from similarities with host-microorganism relationships in the intestines. Abstract | Full Text | PDF | Supplementary information
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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