Laboratory Investigation - Table of Contents alert Volume 94 Issue 12

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TABLE OF CONTENTS Volume 94, Issue 12 (December 2014) In this issue Inside the USCAP Journals Research Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Inside the USCAP Journals Top Inside the USCAP Journals 2014 94: 1310-1311; 10.1038/labinvest.2014.137 Full Text Research Articles Top ANGIOGENESIS, CARDIOVASCULAR AND PULMONARY SYSTEMS Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness In this paper the authors demonstrate that cigarette smoke influences functional plasticity of myeloid-derived regulatory cells that are critical regulators of asthma. Increased production of reactive oxygen species regulates activation of the NFκβ- pathway and production of pro-inflammatory cytokine IL-33. These factors induce phenotypic changes in these regulatory myeloid cells that then cause exacerbation of airway responses. These observations delineate mechanisms of their differentiation and function in asthmatic smokers and identify these regulatory cells as novel targets for anti-asthma therapy. Yong Wang, Tong Huan Jin, Aisha Farhana, Jason Freeman, Kim Estell, Jaroslaw W Zmijewski, Amit Gaggar, Victor J Thannickal, Lisa M Schwiebert, Adrie JC Steyn and Jessy S Deshane 2014 94: 1312-1325; advance online publication, November 3, 2014; 10.1038/labinvest.2014.126 Abstract | Full Text Characterization of a novel model incorporating airway epithelial damage and related fibrosis to the pathogenesis of asthma Airway epithelial damage in the etiology of asthma has not been targeted by current treatments or significantly addressed in animal models of allergic airway disease. This study therefore incorporated epithelial damage into a well-established model of chronic allergic airway disease, and demonstrated that epithelial damage is a key contributor to airway fibrosis and related airway hyperresponsiveness. Simon G Royce, Krupesh P Patel and Chrishan S Samuel 2014 94: 1326-1339; advance online publication, September 29, 2014; 10.1038/labinvest.2014.119 Abstract | Full Text BLOOD, LYMPHATICS, IMMUNE SYSTEM AND STEM CELLS Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration Because microvascular pericytes possess mesenchymal plasticity, the authors established immortalized capillary cells from the vasa vasorum of peripheral arteries of SV40T-transgenic mice. The cloned cell lines maintained the proper phenotype during long-term culture and should provide a reproducible cellular tool for high-throughput studies on angiogenesis, vascular remodeling and regeneration. Maki Kabara, Jun-ichi Kawabe, Motoki Matsuki, Yoshiki Hira, Akiho Minoshima, Kohei Shimamura, Atsushi Yamauchi, Tatsuya Aonuma, Masato Nishimura, Yukihiro Saito, Naofumi Takehara and Naoyuki Hasebe 2014 94: 1340-1354; advance online publication, October 20, 2014; 10.1038/labinvest.2014.121 Abstract | Full Text Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity In this report, the authors investigated the effects of stromal fibroblasts on the tumor-initiating capacity and stem-like properties of ovarian cancer stem-like cells. Their results indicate that fibroblasts and ovarian CSCs mutually cooperate to enhance their growth and tumorigenic capacity through autocrine and paracrine fibroblast growth factor 4 and -2 signaling. Kazuyo Yasuda, Toshihiko Torigoe, Tasuku Mariya, Takuya Asano, Takafumi Kuroda, Junichi Matsuzaki, Kanae Ikeda, Makoto Yamauchi, Makoto Emori, Hiroko Asanuma, Tadashi Hasegawa, Tsuyoshi Saito, Yoshihiko Hirohashi and Noriyuki Sato 2014 94: 1355-1369; advance online publication, October 20, 2014; 10.1038/labinvest.2014.122 Abstract | Full Text miR-106b modulates cancer stem cell characteristics through TGF-β/Smad signaling in CD44-positive gastric cancer cells This study shows that the microRNA miR-106b expression is increased in CD44+ gastric cancer stem cells and regulates gastric cancer stem-like properties including epithelial-mesenchymal transition phenotypes through TGF-β/Smad signaling. These results suggest that gastric cancer treatment can be devised by modulating stem cell activity. Dayeon Yu, Hyun-Soo Shin, Yeo Song Lee and Yong Chan Lee 2014 94: 1370-1381; advance online publication, October 6, 2014; 10.1038/labinvest.2014.125 Abstract | Full Text BREAST, SKIN, SOFT TISSUE AND BONE Nestin depletion induces melanoma matrix metalloproteinases and invasion In melanoma cells, knock-down of the intermediate filament protein nestin inhibits spherogenic growth while enhancing invasion both in vitro and in vivo. These observations are associated with upregulation of matrix metaloproteinases that facilitate the invasive phenotype, thus establishing a nestin-matrix metalloproteinase switch as one determinant of tumorigenic vs invasive melanoma growth. Chung-Wei Lee, Qian Zhan, Cecilia Lezcano, Markus H Frank, John Huang, Allison R Larson, Jennifer Y Lin, Marilyn T Wan, Ping-I Lin, Jie Ma, Sonja Kleffel, Tobias Schatton, Christine G Lian and George F Murphy 2014 94: 1382-1395; advance online publication, November 3, 2014; 10.1038/labinvest.2014.130 Abstract | Full Text HEPATIC AND PANCREATIC SYSTEMS Downregulation of spleen tyrosine kinase in hepatocellular carcinoma by promoter CpG island hypermethylation and its potential role in carcinogenesis Because spleen tyrosine kinase (SYK) gene methylation identifies a subset of hepatocellular carcinoma (HCC) cases with poor prognosis, the authors established stable HCC cell lines with inducible SYK expression vectors. SYK expression increases adhesion of HCC cells to fibronectin and decreases migration and invasion. These findings suggest that that modulating SYK activity may be of therapeutic value in HCC. So-Hyun Shin, Kwang Ho Lee, Baek-Hee Kim, Sun Lee, Hwan Seok Lee, Ja-June Jang and Gyeong Hoon Kang 2014 94: 1396-1405; advance online publication, October 13, 2014; 10.1038/labinvest.2014.118 Abstract | Full Text Inhibition of mast cell-derived histamine secretion by cromolyn sodium treatment decreases biliary hyperplasia in cholestatic rodents This paper demonstrates that during biliary hyperplasia mast cells are recruited to the liver and histamine levels are significantly increased. Stabilization of mast cells with cromolyn reduces mast cell number and proliferation. Manipulation of mast cell-derived histamine may be a therapeutic target for the treatment of cholangiopathies. Lindsey L Kennedy, Laura A Hargrove, Allyson B Graf, Taylor C Francis, Kyle M Hodges, Quy P Nguyen, Yoshi Ueno, John F Greene, Fanyin Meng, Victoria D Huynh and Heather L Francis 2014 94: 1406-1418; advance online publication, November 3, 2014; 10.1038/labinvest.2014.129 Abstract | Full Text ORAL AND GASTROINTESTINAL SYSTEMS Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death Tauroursodeoxycholic acid is a hydrophilic bile salt that inhibits the development of colitis in mice. One of the mechanisms involved is protection of epithelial cells from cell death, therefore maintaining epithelial barrier function. These data demonstrate that tauroursodeoxycholic acid could be an add-on strategy to current immunosuppressive treatment of patients with ulcerative colitis. Debby Laukens, Lindsey Devisscher, Lien Van den Bossche, Pieter Hindryckx, Roosmarijn E Vandenbroucke, Yves-Paul Vandewynckel, Claude Cuvelier, Brigitta M Brinkman, Claude Libert, Peter Vandenabeele and Martine De Vos 2014 94: 1419-1430; advance online publication, October 13, 2014; 10.1038/labinvest.2014.117 Abstract | Full Text Oncogenic roles of Bmi1 and its therapeutic inhibition by histone deacetylase inhibitor in tongue cancer In this paper, the authors show that B lymphoma Mo-MLV insertion region 1 homolog (Bmi1) is aberrantly overexpressed in a significant fraction of tongue cancers and is associated with cervical node metastasis and reduced overall survival. Functional assays reveal that Bmi1 plays a key role in tongue tumorigenesis, and pharmacologic inhibition of Bmi1 by sodium butyrate significantly inhibits tumor growth in vivo. Zhongwu Li, Yanling Wang, Chunping Yuan, Yumin Zhu, Jing Qiu, Wei Zhang, Bing Qi, Heming Wu, Jinhai Ye, Hongbing Jiang, Jianrong Yang and Jie Cheng 2014 94: 1431-1445; advance online publication, October 6, 2014; 10.1038/labinvest.2014.123 Abstract | Full Text Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. 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