Nature Cell Biology contents: February 2014 Volume 16 Number 2, pp 127 - 200

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See also: Article by Wu et al. Methyltransferases modulate RNA stability in embryonic stem cells   pp129 - 131 Shuibin Lin and Richard I. Gregory doi:10.1038/ncb2914 Emerging data support that RNA methylation plays important roles in RNA processing and metabolism. The methyltransferases Mettl3 and Mettl14 are shown to catalyse N6-methyladenosine (m6A) RNA modification in embryonic stem cells (ESCs). This m6A modification controls RNA metabolism and functions to destabilize mRNAs encoding developmental regulators to help sustain ESC self-renewal. See also: Letter by Wang et al. Articles Top A polarized Ca2+, diacylglycerol and STIM1 signalling system regulates directed cell migration   pp133 - 144 Feng-Chiao Tsai, Akiko Seki, Hee Won Yang, Arnold Hayer, Silvia Carrasco et al. doi:10.1038/ncb2906 Meyer and colleagues used live-cell imaging to study the spatial organization of Ca2+ signalling network components during cell migration. The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis   pp145 - 156 Hiroki Shibuya, Kei-ichiro Ishiguro and Yoshinori Watanabe doi:10.1038/ncb2896 Meiotic chromosome movement is needed for homologue pairing and synapsis. Watanabe and colleagues identify TERB1 as a protein needed for telomere mobility and attachment to the nuclear envelope, and for telomere enrichment of meiotic cohesin. Cell Biology JOBS of the week Epigenetics and Stem Cell Biology Max Planck Institute for Heart and Lung Research Research Fellow- T Cell Receptor Biology Dana-Farber Cancer Institute (DFCI) Researcher in Immunology and Cell Biology Virginia Commonwealth University Assistant or Associate Professor in Pluripotent Stem Cell Biology KU Leuven PhD in Fungal Cell Biology Centre National de la Recherche Scientifique (CNRS) More Science jobs from Cell Biology EVENT Computational Cell Biology: Mechanistic Modeling for Experimentalists 22nd July – 11th August 2014 Cold Spring Harbor, USA More science events from Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease   pp157 - 166 Roberta Tufi, Sonia Gandhi, Inês P. de Castro, Susann Lehmann, Plamena R. Angelova et al. doi:10.1038/ncb2901 Mutations in PINK1 cause early-onset Parkinson’s disease. Martins and colleagues find that the expression levels of genes involved in nucleotide metabolism are upregulated in a Drosophila pink1 mutant, and that this affects neuronal mitochondrial DNA synthesis. They find that enhancing nucleotide synthesis through genetics or pharmacological approaches rescues mitochondrial defects associated with PINK1 mutations. Cortical F-actin stabilization generates apical–lateral patterns of junctional contractility that integrate cells into epithelia   pp167 - 178 Selwin K. Wu, Guillermo A. Gomez, Magdalene Michael, Suzie Verma, Hayley L. Cox et al. doi:10.1038/ncb2900 Yap and colleagues demonstrate that E-cadherin-based cell–cell junctions exhibit distinct patterns of apical and lateral contractility. They show that N-WASP-dependent stabilization of F-actin mediates increased apical junctional tension, and that modulation of intra-junctional tension differences can promote extrusion of cells from monolayers. See also: News and Views by Behrndt & Heisenberg In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators   pp179 - 190 Wen-Hui Lien, Lisa Polak, Mingyan Lin, Kenneth Lay, Deyou Zheng et al. doi:10.1038/ncb2903 Hair follicle stem cells (HFSCs) regenerate hair in response to Wnt signalling. Fuchs and colleagues use a genome-wide survey to discover that Wnt effectors TCF3, TCF4 and Groucho (TLE) coordinately repress Wnt target genes. They find that although β-catenin is dispensable for HSFC viability and proliferation, it is essential to relieve this repression to initiate hair follicle fate during the hair regeneration cycle. Letter Top N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells   pp191 - 198 Yang Wang, Yue Li, Julia I. Toth, Matthew D. Petroski, Zhaolei Zhang et al. doi:10.1038/ncb2902 N6-methyladenosine (m6A) is an abundant internal modification of messenger RNA (mRNA) that has been reported recently in thousands of mammalian mRNAs and long non-coding RNAs (lncRNAs). Zhao and colleagues identify two methyltransferases responsible for this modification in mammalian cells, and demonstrate that they are required for embryonic stem cell self-renewal maintenance through an effect of the modification on the degradation of developmental regulator transcripts. See also: News and Views by Lin & Gregory Corrigendum Top Corrigendum: A genetic screen identies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway   p200 Morvarid Mohseni, Jianlong Sun, Allison Lau, Stephen Curtis, Jeffrey Goldsmith et al. doi:10.1038/ncb2912 Errata Top Erratum: Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis   p200 Zhenyu Cai, Siriporn Jitkaew, Jie Zhao, Hsueh-Cheng Chiang, Swati Choksi et al. doi:10.1038/ncb2908 Erratum: Kidney structures differentiated from stem cells   p200 Benjamin D. Humphreys doi:10.1038/ncb2911 Top Advertisement Nature Insight Frontiers in Biology Highlighting important advances in biology.  Access the Insight online    Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. 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