The EDGE

CDDis celebrates 1000 publications of essential research

E H Baehrecke

Cell Death Dis 2014 5: e1042; 10.1038/cddis.2014.19

1000 successes as CDDIS reaches 1000 published papers!

G Melino

Cell Death Dis 2014 5: e1041; 10.1038/cddis.2014.15

Reviews

Modulation of apoptosis sensitivity through the interplay with autophagic and proteasomal degradation pathways

M E Delgado, L Dyck, M A Laussmann and M Rehm

Cell Death Dis 2014 5: e1011; 10.1038/cddis.2013.520

Clinical update on cancer: molecular oncology of head and neck cancer

Y Suh, I Amelio, T Guerrero Urbano and M Tavassoli

Cell Death Dis 2014 5: e1018; 10.1038/cddis.2013.548

Molecular mechanisms of hepatic apoptosis

K Wang

Cell Death Dis 2014 5: e996; 10.1038/cddis.2013.499

Original Articles

Cytolethal distending toxin B as a cell-killing component of tumor-targeted anthrax toxin fusion proteins

C Bachran, R Hasikova, C E Leysath, I Sastalla, Y Zhang, R J Fattah, S Liu and S H Leppla

Cell Death Dis 2014 5: e1003; 10.1038/cddis.2013.540

Ankrd2 is a modulator of NF-κB-mediated inflammatory responses during muscle differentiation

C Bean, N K Verma, D L Yamamoto, F Chemello, V Cenni, M C Filomena, J Chen, M L Bang and G Lanfranchi

Cell Death Dis 2014 5: e1002; 10.1038/cddis.2013.525

The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression

M S Becker, P Schmezer, R Breuer, S F Haas, M A Essers, P H Krammer and M Li-Weber

Cell Death Dis 2014 5: e1000; 10.1038/cddis.2013.528

Pretubulysin: a new option for the treatment of metastatic cancer

S Braig, R M Wiedmann, J Liebl, M Singer, R Kubisch, L Schreiner, B A Abhari, E Wagner, U Kazmaier, S Fulda and A M Vollmar

Cell Death Dis 2014 5: e1001; 10.1038/cddis.2013.510

The interaction between mesenchymal stem cells and steroids during inflammation

X Chen, Y Gan, W Li, J Su, Y Zhang, Y Huang, A I Roberts, Y Han, J Li, Y Wang and Y Shi

Cell Death Dis 2014 5: e1009; 10.1038/cddis.2013.537

miR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting telomerase reverse transcriptase

L Chen, M-H Lü, D Zhang, N-B Hao, Y-H Fan, Y-Y Wu, S-M Wang, R Xie, D-C Fang, H Zhang, C-J Hu and S-M Yang

Cell Death Dis 2014 5: e1034; 10.1038/cddis.2013.553

The fine-tuning of TRAF2–GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex

A De Luca, G Mei, N Rosato, E Nicolai, L Federici, C Palumbo, A Pastore, M Serra and A M Caccuri

Cell Death Dis 2014 5: e1015; 10.1038/cddis.2013.529

Discrepant NOXA (PMAIP1) transcript and NOXA protein levels: a potential Achilles’ heel in mantle cell lymphoma

M A Dengler, A Weilbacher, M Gutekunst, A M Staiger, M C Vöhringer, H Horn, G Ott, W E Aulitzky and H van der Kuip

Cell Death Dis 2014 5: e1013; 10.1038/cddis.2013.552

Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons

A M Dolga, A de Andrade, L Meissner, H-G Knaus, M Höllerhage, P Christophersen, H Zischka, N Plesnila, G U Höglinger and C Culmsee

Cell Death Dis 2014 5: e999; 10.1038/cddis.2013.530

Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress

N Doti, C Reuther, P L Scognamiglio, A M Dolga, N Plesnila, M Ruvo and C Culmsee

Cell Death Dis 2014 5: e993; 10.1038/cddis.2013.518

Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70

H Endo, M Yano, Y Okumura and H Kido

Cell Death Dis 2014 5: e1027; 10.1038/cddis.2013.550

Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulating Src-dependent caspase-7 phosphorylation

Y Fu, G Yang, F Zhu, C Peng, W Li, H Li, H-G Kim, A M Bode, Z Dong and Z Dong

Cell Death Dis 2014 5: e983; 10.1038/cddis.2013.509

A cell-penetrating peptide based on the interaction between c-Src and connexin43 reverses glioma stem cell phenotype

E Gangoso, C Thirant, H Chneiweiss, J M Medina and A Tabernero

Cell Death Dis 2014 5: e1023; 10.1038/cddis.2013.560

Calcineurin suppresses AMPK-dependent cytoprotective autophagy in cardiomyocytes under oxidative stress

H He, X Liu, L Lv, H Liang, B Leng, D Zhao, Y Zhang, Z Du, X Chen, S Li, Y Lu and H Shan

Cell Death Dis 2014 5: e997; 10.1038/cddis.2013.533

Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1)

J Huang, N Zhou, K Watabe, Z Lu, F Wu, M Xu and Y-Y Mo

Cell Death Dis 2014 5: e1008; 10.1038/cddis.2013.541

Weakened rate-dependent depression of Hoffmann’s reflex and increased motoneuron hyperactivity after motor cortical infarction in mice

S Lee, T Toda, H Kiyama and T Yamashita

Cell Death Dis 2014 5: e1007; 10.1038/cddis.2013.544

RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo

G Li, L Liu, C Shan, Q Cheng, A Budhraja, T Zhou, H Cui and N Gao

Cell Death Dis 2014 5: ; 10.1038/cddis.2013.519

Role of IGF2BP3 in trophoblast cell invasion and migration

W Li, D Liu, W Chang, X Lu, Y-L Wang, H Wang, C Zhu, H-Y Lin, Y Zhang, J Zhou and H Wang

Cell Death Dis 2014 5: e1025; 10.1038/cddis.2013.545

A positive feedback loop between EBP2 and c-Myc regulates rDNA transcription, cell proliferation, and tumorigenesis

P Liao, W Wang, M Shen, W Pan, K Zhang, R Wang, T Chen, Y Chen, H Chen and P Wang

Cell Death Dis 2014 5: e1032; 10.1038/cddis.2013.536

Association of p21 with NF-YA suppresses the expression of Polo-like kinase 1 and prevents mitotic death in response to DNA damage

Y-C Lin, Y-N Chen, K-F Lin, F-F Wang, T-Y Chou and M-Y Chen

Cell Death Dis 2014 5: e987; 10.1038/cddis.2013.527

PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN

L Liu, Q Wen, R Gong, L Gilles, M J Stankiewicz, W Li, M Guo, L Li, X Sun, W Li, J D Crispino and Z Huang

Cell Death Dis 2014 5: e988; 10.1038/cddis.2013.512

Roles of Wnt/β-catenin signaling in the gastric cancer stem cells proliferation and salinomycin treatment

J Mao, S Fan, W Ma, P Fan, B Wang, J Zhang, H Wang, B Tang, Q Zhang, X Yu, L Wang, B Song and L Li

Cell Death Dis 2014 5: e1039; 10.1038/cddis.2013.515

Osteolytic bone metastasis is hampered by impinging on the interplay among autophagy, anoikis and ossification

P Maroni, P Bendinelli, E Matteucci, A Locatelli, T Nakamura, G Scita and M A Desiderio

Cell Death Dis 2014 5: e1005; 10.1038/cddis.2013.465

MiR-216a: a link between endothelial dysfunction and autophagy

R Menghini, V Casagrande, A Marino, V Marchetti, M Cardellini, R Stoehr, S Rizza, E Martelli, S Greco, A Mauriello, A Ippoliti, F Martelli, R Lauro and M Federici

Cell Death Dis 2014 5: e1029; 10.1038/cddis.2013.556

ROS-PIASγ cross talk channelizes ATM signaling from resistance to apoptosis during chemosensitization of resistant tumors

S Mohanty, S Saha, D Md S Hossain, A Adhikary, S Mukherjee, A Manna, S Chakraborty, M Mazumdar, P Ray, K Das, J Chakraborty, G Sa and T Das

Cell Death Dis 2014 5: e1021; 10.1038/cddis.2013.534

Control of glioma cell death and differentiation by PKM2–Oct4 interaction

M Morfouace, L Lalier, L Oliver, M Cheray, C Pecqueur, P-F Cartron and F M Vallette

Cell Death Dis 2014 5: e1036; 10.1038/cddis.2013.561

Antitumor activity of [Pt(O,O’-acac)(γ-acac)(DMS)] in mouse xenograft model of breast cancer

A Muscella, C Vetrugno, D Migoni, F Biagioni, F P Fanizzi, F Fornai, S A De Pascali and S Marsigliante

Cell Death Dis 2014 5: e1014; 10.1038/cddis.2013.554

OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation

W L Ng, G Chen, M Wang, H Wang, M Story, J W Shay, X Zhang, J Wang, A R M R Amin, B Hu, F A Cucinotta and Y Wang

Cell Death Dis 2014 5: e1024; 10.1038/cddis.2013.563

The aryl hydrocarbon receptor mediates raloxifene-induced apoptosis in estrogen receptor-negative hepatoma and breast cancer cells

E F O'Donnell, D C Koch, W H Bisson, H S Jang and S K Kolluri

Cell Death Dis 2014 5: e1038; 10.1038/cddis.2013.549

Plasmodium falciparum signal recognition particle components and anti-parasitic effect of ivermectin in blocking nucleo-cytoplasmic shuttling of SRP

M Panchal, K Rawat, G Kumar, K M Kibria, S Singh, Md Kalamuddin, A Mohmmed, P Malhotra and R Tuteja

Cell Death Dis 2014 5: e994; 10.1038/cddis.2013.521

GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis

E Pantazi, E Gemenetzidis, G Trigiante, G Warnes, L Shan, X Mao, M Ikram, M-T Teh, Y-J Lu and M P Philpott

Cell Death Dis 2014 5: e1028; 10.1038/cddis.2013.535

Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells

V Pavet, Y Shlyakhtina, T He, D G Ceschin, P Kohonen, M Perälä, O Kallioniemi and H Gronemeyer

Cell Death Dis 2014 5: e1043; 10.1038/cddis.2014.5

Human recombinant glutamate oxaloacetate transaminase 1 (GOT1) supplemented with oxaloacetate induces a protective effect after cerebral ischemia

M Pérez-Mato, P Ramos-Cabrer, T Sobrino, M Blanco, A Ruban, D Mirelman, P Menendez, J Castillo and F Campos

Cell Death Dis 2014 5: e992; 10.1038/cddis.2013.507

CDK5-induced p-PPARγ(Ser 112) downregulates GFAP via PPREs in developing rat brain: effect of metal mixture and troglitazone in astrocytes

A Rai, S Tripathi, R Kushwaha, P Singh, P Srivastava, S Sanyal and S Bandyopadhyay

Cell Death Dis 2014 5: e1033; 10.1038/cddis.2013.514

Mitochondrial dysfunction, oxidative stress, and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson’s model

A Ray, B A Martinez, L A Berkowitz, G A Caldwell and K A Caldwell

Cell Death Dis 2014 5: e984; 10.1038/cddis.2013.513

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

Q Remijsen, V Goossens, S Grootjans, C Van den Haute, N Vanlangenakker, Y Dondelinger, R Roelandt, I Bruggeman, A Goncalves, M J M Bertrand, V Baekelandt, N Takahashi, T V Berghe and P Vandenabeele

Cell Death Dis 2014 5: e1004; 10.1038/cddis.2013.531

Cross-regulation of Connexin43 and β-catenin influences differentiation of human neural progenitor cells

F Rinaldi, E M Hartfield, L A Crompton, J L Badger, C P Glover, C M Kelly, A E Rosser, J B Uney and M A Caldwell

Cell Death Dis 2014 5: e1017; 10.1038/cddis.2013.546

HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer

R Schulz, F Streller, A H Scheel, J Rüschoff, M-C Reinert, M Dobbelstein, N D Marchenko and U M Moll

Cell Death Dis 2014 5: e980; 10.1038/cddis.2013.508

c-Jun N-terminal kinase has a key role in Alzheimer disease synaptic dysfunction in vivo

A Sclip, A Tozzi, A Abaza, D Cardinetti, I Colombo, P Calabresi, M Salmona, E Welker and T Borsello

Cell Death Dis 2014 5: e1019; 10.1038/cddis.2013.559

Novel osmotin attenuates glutamate-induced synaptic dysfunction and neurodegeneration via the JNK/PI3K/Akt pathway in postnatal rat brain

S A Shah, H Y Lee, R A Bressan, D J Yun and M O Kim

Cell Death Dis 2014 5: e1026; 10.1038/cddis.2013.538

STAT1-mediated Bim expression promotes the apoptosis of retinal pericytes under high glucose conditions

E S Shin, Q Huang, Z Gurel, T L Palenski, I Zaitoun, C M Sorenson and N Sheibani

Cell Death Dis 2014 5: e986; 10.1038/cddis.2013.517

Integrin inhibition promotes atypical anoikis in glioma cells

M Silginer, M Weller, U Ziegler and P Roth

Cell Death Dis 2014 5: e1012; 10.1038/cddis.2013.543

Pro-apoptotic Sorafenib signaling in murine hepatocytes depends on malignancy and is associated with PUMA expression in vitro and in vivo

R Sonntag, N Gassler, J-M Bangen, C Trautwein and C Liedtke

Cell Death Dis 2014 5: e1030; 10.1038/cddis.2013.557

The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function

L K J Stadler, D C Tomlinson, T Lee, M A Knowles and P Ko Ferrigno

Cell Death Dis 2014 5: e1037; 10.1038/cddis.2013.564

original article

Zinc depletion regulates the processing and secretion of IL-1β

H Summersgill, H England, G Lopez-Castejon, C B Lawrence, N M Luheshi, J Pahle, P Mendes and D Brough

Cell Death Dis 2014 5: e1040; 10.1038/cddis.2013.547

Original Articles

Gli1 inhibition suppressed cell growth and cell cycle progression and induced apoptosis as well as autophagy depending on ERK1/2 activity in human chondrosarcoma cells

Y Sun, W Guo, T Ren, W Liang, W Zhou, Q Lu, G Jiao and T Yan

Cell Death Dis 2014 5: e979; 10.1038/cddis.2013.497

Interleukin-1β promotes hypoxia-induced apoptosis of glioblastoma cells by inhibiting hypoxia-inducible factor-1 mediated adrenomedullin production

W Sun, R Depping and W Jelkmann

Cell Death Dis 2014 5: e1020; 10.1038/cddis.2013.562

CD70-restricted specific activation of TRAILR1 or TRAILR2 using scFv-targeted TRAIL mutants

J Trebing, M El-Mesery, V Schäfer, D Weisenberger, D Siegmund, K Silence and H Wajant

Cell Death Dis 2014 5: e1035; 10.1038/cddis.2013.555

Stress-induced RNASET2 overexpression mediates melanocyte apoptosis via the TRAF2 pathway in vitro

Q Wang, M Jiang, J Wu, Y Ma, T Li, Q Chen, X Zhang and L Xiang

Cell Death Dis 2014 5: e1022; 10.1038/cddis.2013.539

JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death

S Win, T A Than, J C Fernandez-Checa and N Kaplowitz

Cell Death Dis 2014 5: e989; 10.1038/cddis.2013.522

Advanced oxidation protein products induce intestine epithelial cell death through a redox-dependent, c-jun N-terminal kinase and poly (ADP-ribose) polymerase-1-mediated pathway

F Xie, S Sun, A Xu, S Zheng, M Xue, P Wu, J H Zeng and L Bai

Cell Death Dis 2014 5: e1006; 10.1038/cddis.2013.542

Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA:cholesterol acyltransferase 1

K Yamanaka, Y Urano, W Takabe, Y Saito and N Noguchi

Cell Death Dis 2014 5: e990; 10.1038/cddis.2013.524

Prostasin may contribute to chemoresistance, repress cancer cells in ovarian cancer, and is involved in the signaling pathways of CASP/PAK2-p34/actin

B-x Yan, J-x Ma, J Zhang, Y Guo, M D Mueller, S C Remick and J J Yu

Cell Death Dis 2014 5: e995; 10.1038/cddis.2013.523

Nox4 and redox signaling mediate TGF-β-induced endothelial cell apoptosis and phenotypic switch

F Yan, Y Wang, X Wu, H M Peshavariya, G J Dusting, M Zhang and F Jiang

Cell Death Dis 2014 5: e1010; 10.1038/cddis.2013.551

The evolutionary young miR-1290 favors mitotic exit and differentiation of human neural progenitors through altering the cell cycle proteins

S V Yelamanchili, B Morsey, E B Harrison, D A Rennard, K Emanuel, I Thapa, D R Bastola and H S Fox

Cell Death Dis 2014 5: e982; 10.1038/cddis.2013.498

Adenosine 5′-monophosphate ameliorates D-galactosamine/lipopolysaccharide-induced liver injury through an adenosine receptor-independent mechanism in mice

Y Zhan, Z Wang, P Yang, T Wang, L Xia, M Zhou, Y Wang, S Wang, Z Hua and J Zhang

Cell Death Dis 2014 5: e985; 10.1038/cddis.2013.516

Galectin-1 overexpression promotes progression and chemoresistance to cisplatin in epithelial ovarian cancer

P Zhang, P Zhang, B Shi, M Zhou, H Jiang, H Zhang, X Pan, H Gao, H Sun and Z Li

Cell Death Dis 2014 5: e991; 10.1038/cddis.2013.526

Macrophages commit postnatal endothelium-derived progenitors to angiogenesis and restrict endothelial to mesenchymal transition during muscle regeneration

P Zordan, E Rigamonti, K Freudenberg, V Conti, E Azzoni, P Rovere-Querini and S Brunelli

Cell Death Dis 2014 5: e1031; 10.1038/cddis.2013.558

Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells

A de Thonel, A Hazoumé, V Kochin, K Isoniemi, G Jego, E Fourmaux, A Hammann, H Mjahed, O Filhol, O Micheau, P Rocchi, V Mezger, J E Eriksson, V M Rangnekar and C Garrido

Cell Death Dis 2014 5: e1016; 10.1038/cddis.2013.532

Correspondence

The BCL-2 database, Act 2: moving beyond dualism to diversity and pleiotropy

A Aouacheria

Cell Death Dis 2014 5: e981; 10.1038/cddis.2013.511

Methodological pitfalls in the study of DAX-1 function

E Lalli

Cell Death Dis 2014 5: e977; 10.1038/cddis.2013.446

Response to Lalli's comment: May the study of DAX-1 function just rely on its visualization?

M Lanzino and S Andò

Cell Death Dis 2014 5: e978; 10.1038/cddis.2013.476