The EMBO Journal - Table of Contents alert Volume 32 Issue 8

TABLE OF CONTENTS 17 April 2013 | Volume 32, Issue 8 Have you seen? Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement EMBO Transparency Process Referee reports published without attribution No confidential referee comments Referee cross-commenting for balanced decisions Single Round of revision - Fast process Scooping protection   Have you seen? Top Chaperoning RNA Polymerase II through repressive chromatin The histone chaperone Spt6 promotes myogenic transcription by directing UTX-dependent demethylation of repressive H3K27me3 marks. Herve Faralli and F Jeffrey Dilworth The EMBO Journal (2013), 32, 1067 - 1068; 10.1038/emboj.2013.64 Abstract | Full text | PDF | Related article Published online: 15 March 2013 TOR tour to auxin Auxin activates TOR signalling in plants, resulting in enhanced translation reinitiation of uORF-containing mRNAs and modulation of plant growth. László Bögre, Rossana Henriques and Zoltán Magyar The EMBO Journal (2013), 32, 1069 - 1071; 10.1038/emboj.2013.69 Abstract | Full text | PDF | Related article Published online: 22 March 2013 Parkin promotes cell survival via linear ubiquitination A new Molecular Cell paper by Winklhofer and colleagues shows that the Parkin ubiquitin ligase activates the linear ubiquitin chain assembly complex (LUBAC) to prevent mitochondrial dysfunction. Evgenij Fiškin and Ivan Dikic The EMBO Journal (2013), 32, 1072 - 1074; 10.1038/emboj.2013.70 Abstract | Full text | PDF | Related article Published online: 26 March 2013 Articles Top The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis The chaperone Spt6 promotes myogenesis by counteracting Polycomb-mediated gene silencing through the promotion of UTX-dependent H3K27 demethylation at muscle-specific genes. A Hongjun Wang, Hossein Zare, Kambiz Mousavi, Chaochen Wang, Cara E Moravec, Howard I Sirotkin, Kai Ge, Gustavo Gutierrez-Cruz and Vittorio Sartorelli The EMBO Journal (2013), 32, 1075 - 1086; 10.1038/emboj.2013.54 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 15 March 2013 Subject Categories: Chromatin and Transcription | Differentiation and Death TOR and S6K1 promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h The phytohormone Auxin activates the TOR pathway to dissociate inactive S6K1 from polysomes and to stimulate phosphorylation of the translation initiation factor eIF3h, resulting in the enhanced translation of uORF-containing mRNAs. Mikhail Schepetilnikov, Maria Dimitrova, Eder Mancera-Martínez, Angèle Geldreich, Mario Keller and Lyubov A Ryabova The EMBO Journal (2013), 32, 1087 - 1102; 10.1038/emboj.2013.61 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 22 March 2013 Subject Categories: Signal Transduction | Proteins OTUB1 modulates c-IAP1 stability to regulate signalling pathways The deubiquitinase OTUB1 removes ubiquitin chains from c-IAP1 within TWEAK receptor signalling complexes, to promote downstream activation of NF-kB and MAPK pathways. Tatiana Goncharov, Kyle Niessen, Maria Cristina de Almagro, Anita Izrael-Tomasevic, Anna V Fedorova, Eugene Varfolomeev, David Arnott, Kurt Deshayes, Donald S Kirkpatrick and Domagoj Vucic The EMBO Journal (2013), 32, 1103 - 1114; 10.1038/emboj.2013.62 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 22 March 2013 Subject Categories: Signal Transduction | Proteins The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing  EMBO Open This detailed characterization of membrane association in siRNA-mediated gene silencing establishes the rough ER as major site for canonical RISC loading and target RNA cleavage. Lukas Stalder, Wolf Heusermann, Lena Sokol, Dominic Trojer, Joel Wirz, Justin Hean, Anja Fritzsche, Florian Aeschimann, Vera Pfanzagl, Pascal Basselet, Jan Weiler, Martin Hintersteiner, David V Morrissey and Nicole C Meisner-Kober The EMBO Journal (2013), 32, 1115 - 1127; 10.1038/emboj.2013.52 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 19 March 2013 Subject Categories: Membranes and Transport | RNA The splicing machinery promotes RNA-directed DNA methylation and transcriptional silencing in Arabidopsis Components of the splicing machinery are needed for siRNA generation, de novo DNA methylation, and transcriptional gene silencing in plants. Cui-Jun Zhang, Jin-Xing Zhou, Jun Liu, Ze-Yang Ma, Su-Wei Zhang, Kun Dou, Huan-Wei Huang, Tao Cai, Renyi Liu, Jian-Kang Zhu and Xin-Jian He The EMBO Journal (2013), 32, 1128 - 1140; 10.1038/emboj.2013.49 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 22 March 2013 Subject Categories: Chromatin and Transcription | RNA Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly Different organism-dependent centriole biogenesis roles have been suggested for CEP135/Bld10. Analysis of the human homologue CEP135/MCPH8 supports a key role in connecting the centriolar cartwheel hub SAS-6, the elongation factor CPAP, and outer microtubules. Yu-Chih Lin, Ching-Wen Chang, Wen-Bin Hsu, Chieh-Ju C Tang, Yi-Nan Lin, En-Ju Chou, Chien-Ting Wu and Tang K Tang The EMBO Journal (2013), 32, 1141 - 1154; 10.1038/emboj.2013.56 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 19 March 2013 Subject Categories: Cell and Tissue Architecture | Cell Cycle Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover  EMBO Open The structure-specific endonuclease Mus81-Mms4, which resolves persistent replication intermediates prior to chromosome segregation, requires tight cell-cycle restriction to not jeopardize genomic integrity during S phase. Barnabas Szakal and Dana Branzei The EMBO Journal (2013), 32, 1155 - 1167; 10.1038/emboj.2013.67 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 26 March 2013 Subject Categories: Cell Cycle | Genome Stability and Dynamics YY1 controls Igκ repertoire and B-cell development, and localizes with condensin on the Igκ locus The Polycomb Group protein YY1 interacts with the condensin complex to regulate immunoglobulin locus contraction and rearrangement during B-cell development. Xuan Pan, Madhusudhan Papasani, Yi Hao, Marco Calamito, Fang Wei, William J Quinn III, Arindam Basu, Junwen Wang, Suchita Hodawadekar, Kristina Zaprazna, Huifei Liu, Yang Shi, David Allman, Michael Cancro and Michael L Atchison The EMBO Journal (2013), 32, 1168 - 1182; 10.1038/emboj.2013.66 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 26 March 2013 Subject Categories: Immunology Epigenetic Thpok silencing limits the time window to choose CD4+ helper-lineage fate in the thymus Persistent TCR signalling during thymocyte lineage commitment prevents epigenetic silencing of the transcription factor ThPOK locus; stable Thpok expression leads to CD4+ helper cell fate commitment. Hirokazu Tanaka, Taku Naito, Sawako Muroi, Wooseok Seo, Risa Chihara, Chizuko Miyamoto, Ryo Kominami and Ichiro Taniuchi The EMBO Journal (2013), 32, 1183 - 1194; 10.1038/emboj.2013.47 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 March 2013 Subject Categories: Chromatin and Transcription | Immunology Structure of a bacterial type IV secretion core complex at subnanometre resolution  EMBO Open The core of the bacterial type IV secretion system consists of the O-layer in the outer membrane and the inner-membrane I-layer. The first high-resolution cryo-electron microscopy structure of the I-layer provides insights into T4SS secretion mechanism. Angel Rivera-Calzada, Rémi Fronzes, Christos G Savva, Vidya Chandran, Pei W Lian, Toon Laeremans, Els Pardon, Jan Steyaert, Han Remaut, Gabriel Waksman and Elena V Orlova The EMBO Journal (2013), 32, 1195 - 1204; 10.1038/emboj.2013.58 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 19 March 2013 Subject Categories: Cell and Tissue Architecture | Microbiology and Pathogens   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © European Molecular Biology Organization