The EMBO Journal - Table of Contents alert Volume 32 Issue 7

TABLE OF CONTENTS 03 April 2013 | Volume 32, Issue 7 Have you seen? Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement EMBO Transparency Process Referee reports published without attribution No confidential referee comments Referee cross-commenting for balanced decisions Single Round of revision - Fast process Scooping protection   Have you seen? Top Traffic COPs: rules of detection Two recent structural studies reveal how cargo proteins interact with vesicle coats, which may also explain vesicle formation of retrograde transport vesicles. Anne Spang The EMBO Journal (2013), 32, 915 - 916; 10.1038/emboj.2013.57 Abstract | Full text | PDF | Related article | Related article Published online: 12 March 2013 Oct4 shuffles Sox partners to direct cell fate Early cell fate decisions demand rapid rewiring of transcriptional circuits. Stanton and colleagues report on enhancer-dependent partnering of Oct4 with either Sox2 or Sox17 to switch from pluripotency to differentiation. Abed AlFatah Mansour and Jacob H Hanna The EMBO Journal (2013), 32, 917 - 919; 10.1038/emboj.2013.48 Abstract | Full text | PDF | Related article Published online: 08 March 2013 Synaptic requiem: a duet for Piccolo and Bassoon Piccolo and Bassoon put a brake on presynaptic protein turnover by restraining the activity of the E3 ubiquitin ligase Siah1 to prevent synaptic degeneration. Natalia Kononenko, Arndt Pechstein and Volker Haucke The EMBO Journal (2013), 32, 920 - 922; 10.1038/emboj.2013.55 Abstract | Full text | PDF Published online: 08 March 2013 Circular RNAs: splicing’s enigma variations Two recent papers published in Nature unravel general abundance of circular RNAs and offer intriguing insights into their potential biological functions. Matthias W Hentze and Thomas Preiss The EMBO Journal (2013), 32, 923 - 925; 10.1038/emboj.2013.53 Abstract | Full text | PDF | Related article | Related article Published online: 05 March 2013 Articles Top Rules for the recognition of dilysine retrieval motifs by coatomer Transmembrane proteins interact with COPI coatomers for their vesicular Golgi-ER transport. Crystal structures of the coatomers α-COP and β′-COP bound to a series of cargo retrieval motifs uncover the molecular basis of distinct recognition mechanisms. Wenfu Ma and Jonathan Goldberg The EMBO Journal (2013), 32, 926 - 937; 10.1038/emboj.2013.41 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 March 2013 Subject Categories: Membranes and Transport | Structural Biology Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm Precise, cell type-specific signal integration is crucial for developmental fate determination. The current paper elucidates enhancer-dependent Oct4 switching between Sox2 and Sox17 to govern self-renewal versus endodermal differentiation. Irene Aksoy, Ralf Jauch, Jiaxuan Chen, Mateusz Dyla, Ushashree Divakar, Gireesh K Bogu, Roy Teo, Calista Keow Leng Ng, Wishva Herath, Sun Lili, Andrew P Hutchins, Paul Robson, Prasanna R Kolatkar and Lawrence W Stanton The EMBO Journal (2013), 32, 938 - 953; 10.1038/emboj.2013.31 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 08 March 2013 Subject Categories: Chromatin and Transcription | Development Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation The presynaptic proteins Bassoon and Piccolo interact with and inhibit the activity of the E3 ubiquitin ligase Siah1 to regulate protein homeostasis and synaptic integrity. Clarissa L Waites, Sergio A Leal-Ortiz, Nathan Okerlund, Hannah Dalke, Anna Fejtova, Wilko D Altrock, Eckart D Gundelfinger and Craig C Garner The EMBO Journal (2013), 32, 954 - 969; 10.1038/emboj.2013.27 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 February 2013 Subject Categories: Proteins | Neuroscience p57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis The cyclin-dependent kinase inhibitor p57 maintains adult neural stem cells in a quiescent state to preserve their proliferative and neurogenic potential throughout life. Shohei Furutachi, Akinobu Matsumoto, Keiichi I Nakayama and Yukiko Gotoh The EMBO Journal (2013), 32, 970 - 981; 10.1038/emboj.2013.50 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 March 2013 Subject Categories: Development | Neuroscience Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK4a regulation p16INK4a is a crucial determinant of cellular senescence. Gil and coworkers characterize HLX proteins as crucial co-repressor at this locus by direct interaction with polycomb and HDAC proteins. Nadine Martin, Nikolay Popov, Francesca Aguilo, Ana O’Loghlen, Selina Raguz, Ambrosius P Snijders, Gopuraja Dharmalingam, SiDe Li, Efstathia Thymiakou, Thomas Carroll, Bernd B Zeisig, Chi Wai Eric So, Gordon Peters, Vasso Episkopou, Martin J Walsh and Jesús Gil The EMBO Journal (2013), 32, 982 - 995; 10.1038/emboj.2013.37 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 01 March 2013 Subject Categories: Chromatin and Transcription | Molecular Biology of Disease Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6 The identification of UBE2O as novel E2-E3 hybrid ligase for Smad6 monoubiquitination offers a new perspective on adaptive regulation of BMP signalling. Xiaofei Zhang, Juan Zhang, Andreas Bauer, Long Zhang, Douglas W Selinger, Chris X Lu and Peter ten Dijke The EMBO Journal (2013), 32, 996 - 1007; 10.1038/emboj.2013.38 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 01 March 2013 Subject Categories: Signal Transduction | Differentiation and Death PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development  EMBO Open The conditional knockout of PDK1 in haematopoietic cells reveals an essential role in cell-cycle arrest, differentiation, IgH recombination and the survival of B cells, which is mediated by the pro-survival factor Bcl2A1 and the transcription factor Pax5. Ram K C Venigalla, Victoria A McGuire, Rosemary Clarke, Janet C Patterson-Kane, Ayaz Najafov, Rachel Toth, Pierre C McCarthy, Frederick Simeons, Laste Stojanovski and J Simon C Arthur The EMBO Journal (2013), 32, 1008 - 1022; 10.1038/emboj.2013.40 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 05 March 2013 Subject Categories: Signal Transduction | Immunology Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit Dynactin functions with dynein as a microtubule-associated motor and silences the spindle checkpoint in mitosis. Dynactin’s role in mitosis is mediated by its subunit p27, which recruits Plk1 to kinetochores upon mitotic phosphorylation by CDK1. Ting-Yu Yeh, Anna K Kowalska, Brett R Scipioni, Frances Ka Yan Cheong, Meiying Zheng, Urszula Derewenda, Zygmunt S Derewenda and Trina A Schroer The EMBO Journal (2013), 32, 1023 - 1035; 10.1038/emboj.2013.30 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 01 March 2013 Subject Categories: Cell and Tissue Architecture | Cell Cycle Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria ER signal peptides can mediate both ER and mitochondrial targeting, depending on structural features in the nascent chain. While proteins containing structured domains are imported into the ER, unstructured polypeptides are targeted to mitochondria. Natalie V Pfeiffer, Daniela Dirndorfer, Sven Lang, Ulrike K Resenberger, Lisa M Restelli, Charles Hemion, Margit Miesbauer, Stephan Frank, Albert Neutzner, Richard Zimmermann, Konstanze F Winklhofer and Jörg Tatzelt The EMBO Journal (2013), 32, 1036 - 1051; 10.1038/emboj.2013.46 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 March 2013 Subject Categories: Membranes and Transport GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation  EMBO Open GW182 proteins elicit miRNA-mediated translational repression through recruitment of the CCR4–NOT deadenylase complex, thereby displacing PABP from miRNA targets, leading to subsequent deadenylation and loss of translation initiation factors. Latifa Zekri, Duygu Kuzuoğlu-Öztürk and Elisa Izaurralde The EMBO Journal (2013), 32, 1052 - 1065; 10.1038/emboj.2013.44 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 05 March 2013 Subject Categories: RNA | Proteins Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. 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