Nature Reviews Microbiology contents May 2013 Volume 11 Number 5 pp 295-355

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TABLE OF CONTENTS
May 2013 Volume 11 Number 5
Impact Factor 21.182 *	In this issue Editorial Research Highlights News and Analysis Reviews Perspectives Also this month Article Series: New technologies: methods and applications  Featured article: Bacterial replication, transcription and translation: mechanistic insights from single-molecule biochemical studies Andrew Robinson & Antoine M. van Oijen
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Exploring Human Host-Microbiome Interactions in Health and Disease (8-10 July 2013) Fitzwilliam College, Cambridge, UK. The 2nd Wellcome Trust Microbiome conference will bring together leading scientists from the fields of microbiology, immunology, nutrition, gastroenterology and neuroscience. Abstracts due 27 May. Register by 10 June.
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EDITORIAL		Top
Less talk, more action p295 | doi:10.1038/nrmicro3025 The publication of the second volume of England's annual health report has increased pressure to prioritize strategies to tackle the antibiotic resistance crisis. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Immune evasion: UL141 keeps HCMV in charge p297 | doi:10.1038/nrmicro3018 The human cytomegalovirus protein UL141 interacts with the host proteins TRAILR1 and TRAILR2 to dampen antiviral signalling. PDF Antimicrobials: Fat chance for influenza p298 | doi:10.1038/nrmicro3012 The lipid mediator PD1 protects against lethal influenza infection by inhibiting viral replication. PDF Antimicrobials: Mismatch excels when ampicillin runs low p298 | doi:10.1038/nrmicro3017 Exposure of bacteria to subinhibitory concentrations of antibiotics induces mutagenesis by an RpoS-regulated pathway that results in reduced replication fidelity. PDF IN THE NEWS New vaccine promise p298 | doi:10.1038/nrmicro3019 PDF Fungal pathogenesis: Good copper, bad copper p299 | doi:10.1038/nrmicro3013 Cryptococcus neoformans detoxifies copper to avoid an antimicrobial host response. PDF Phage biology: Phages level the playing field p300 | doi:10.1038/nrmicro3008 The first report of a phage-encoded CRISPR-Cas system that deactivates an unrelated anti-phage system in Vibrio cholerae. PDF Bacterial virulence: IpaJ trims the fat p300 | doi:10.1038/nrmicro3023 Shigella flexneri disrupts host protein N-myristoylation to interfere with Golgi-mediated cargo sorting and secretion. PDF Biofilms: Biofilm microanatomy p300 | doi:10.1038/nrmicro3024 A new paper in mBio provides unprecedented insight into the structural and physiological complexity of Escherichia coli macrocolony biofilms. PDF IN BRIEF Techniques and applications: An impure “pure culture” | Viral therapeutics: Antisense therapy makes sense for HCV PDF Microbiology JOBS of the week Postdoc Mount Sinai School of Medicine (Marazzi lab) Bioinformatics Postdoctoral Fellow University of California, Los Angeles 2 PhD Student Positions in Bacterial Pathogenesis University of Tübingen, Germany a PhD thesis position in plasma surface treatment (m / f) Centre de Recherche Public - Gabriel Lippmann Postdoctoral Research Fellow Columbia Initiative for Systems Biology / Columbia University More Science jobs from Microbiology EVENT Molecular Approaches to Clinical Microbiology in Africa 05.25.13 Malawi More science events from
NEWS AND ANALYSIS		Top
GENOME WATCH Microbial genomes as cheat sheets Hayley M. Bennett p302 | doi:10.1038/nrmicro3014 This month's Genome Watch describes how horizontal gene transfer from bacteria and archaea has allowed an alga to live in extreme environments. PDF
Erratum: Ready, aim, fire! Lucie Wootton p301 | doi:10.1038/nrmicro3020 Full Text | PDF
REVIEWS		Top
Article series: New technologies: methods and applications Bacterial replication, transcription and translation: mechanistic insights from single-molecule biochemical studies Andrew Robinson & Antoine M. van Oijen p303 | doi:10.1038/nrmicro2994 In vitro single-molecule technologies have emerged as powerful tools for the study of complex biological phenomena. Here, Robinson and van Oijen summarize the latest insights that fluorescence-based single-molecule studies have provided for DNA replication, transcription and translation in bacterial cells. Abstract | Full Text | PDF
Exploitation of eukaryotic subcellular targeting mechanisms by bacterial effectors Stuart W. Hicks & Jorge E. Galán p316 | doi:10.1038/nrmicro3009 Many bacterial species have evolved specialized secretion systems that deliver effector proteins into host cells in order to promote bacterial survival and replication. To exert their functions in a spatially coordinated manner, effector proteins must be accurately targeted to specific subcellular compartments. Here, Hicks and Galán review how bacterial effectors exploit the host cell machinery involved in processes such as lipidation and ubiquitylation to accurately target the biochemical activities of these effectors within the host cell. Abstract | Full Text | PDF
The role of mutational robustness in RNA virus evolution Adam S. Lauring, Judith Frydman & Raul Andino p327 | doi:10.1038/nrmicro3003 RNA viruses have extremely high mutation rates, which are crucial for the ability of these viruses to adapt but can also lead to population extinction. Here, Andino and colleagues describe the mechanisms that RNA viruses use to cope with the high mutational load and discuss the impact of mutational robustness on population dynamics, pathogenicity and antiviral therapies. Abstract | Full Text | PDF
Article series: New technologies: methods and applications Going local: technologies for exploring bacterial microenvironments Aimee K. Wessel, Laura Hmelo, Matthew R. Parsek & Marvin Whiteley p337 | doi:10.1038/nrmicro3010 Microorganisms can form complex, spatially organized communities that are coordinated by both physical and chemical intercellular interactions, as well as by other molecules present in the surrounding environment. Here, Whiteley and colleagues describe a number of microscale techniques for reproducing small bacterial communities in the laboratory. They also discuss the analytical tools available to monitor the impact of spatial organization on both bacterial behaviour and the generation of phenotypic heterogeneity. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Genome architecture and global gene regulation in bacteria: making progress towards a unified model? Charles J. Dorman p349 | doi:10.1038/nrmicro3007 The bacterial nucleoid was first described more than 50 years ago, but the recent application of new imaging technologies and physical analytical methods has brought fresh insights to the structure of the DNA within the nucleoid. Here, Charles Dorman discusses these insights and argues that, in addition to DNA topology and nucleoid-associated proteins, gene regulation is an important organizing principle of nucleoid architecture. Abstract | Full Text | PDF
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*2011 Journal Citation Report (Thomson Reuters, 2012)

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