Nature Reviews Genetics Contents May 2013 Volume 14 Number 5 pp 301-366

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TABLE OF CONTENTS
May 2013 Volume 14 Number 5		Advertisement
Impact Factor 38.075 *	In this issue Research Highlights Ethics Watch Reviews Perspectives Also this month Article series: Disease mechanisms Applications of next-generation sequencing  Featured article: Cancer genome-sequencing study design Jill C. Mwenifumbo & Marco A. Marra	GRANT - Staying on the cutting edge is all about collaboration. That's why Expression Analysis & Illumina have combined forces to help fuel your research. FULLY-FUNDED GRANT - Integrated Biology Approach to Genetic Research. Apply online today or call 919-405-2248 * 866-293-6094
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RESEARCH HIGHLIGHTS Top Small RNAs: Defining piRNA expression p301 | doi:10.1038/nrg3474 PDF Evolution: Replication-transcription conflict promotes gene evolution p302 | doi:10.1038/nrg3475 PDF DNA repair: Search space p302 | doi:10.1038/nrg3476 PDF Synthetic biology: Quality and quantity p303 | doi:10.1038/nrg3477 PDF Gene regulation: In charge of translation p304 | doi:10.1038/nrg3478 PDF Gene expression: Extra X expression p304 | doi:10.1038/nrg3479 PDF Pathogen sequencing: Picking and choosing p304 | doi:10.1038/nrg3480 PDF IN BRIEF Non-coding RNA: Non-coding RNA changes enzyme specificity | Cancer genetics: Focus on susceptibility to hormone-related cancers | Population genomics: Characterizing indels | DNA methylation: Placental partially methylated domains | Genome evolution: Complex fitness effects of ploidy states | DNA damage: A damaging neuronal activity | Gene regulation: Circadian control in chloroplasts | Technology: High-throughput protein interactions PDF Genetics JOBS of the week Production Editor BioMed Central Ltd (BMC) Tenure Term / Tenure-Track Faculty Positions MD Anderson Cancer Center PhD Studentship - "The role of gamma delta T cells in chronic liver inflammation" University of Birmingham UK More Science jobs from Genetics EVENT 26th Course in Medical Genetics 16.05.13 Italy More science events from
ETHICS WATCH		Top
Next-generation sequencing: does the next generation still have a right to an open future? Annelien L. Bredenoord, Martine C. de Vries & Johannes J. M. van Delden p306 | doi:10.1038/nrg3459 The use of next-generation sequencing in paediatric medicine is challenging the prevailing current ethical framework, under which only genetic information that is of immediate benefit to a child's health is disclosed. Full Text | PDF
REVIEWS		Top
Article series: Disease mechanisms A genomic view of mosaicism and human disease Leslie G. Biesecker & Nancy B. Spinner p307 | doi:10.1038/nrg3424 Mosaicism refers to genetic heterogeneity within an organism that arises from postzygotic mutational events. This Review describes our latest understanding of the diverse types and widespread nature of mosaicism that underlies normal human variation and, in particular, a wide range of clinical diseases. Abstract | Full Text | PDF
Article series: Applications of next-generation sequencing Cancer genome-sequencing study design Jill C. Mwenifumbo & Marco A. Marra p321 | doi:10.1038/nrg3445 This Review discusses the considerations for designing cancer genome-sequencing studies to fulfil different study aims, such as detecting recurrent mutations or assessing clonal evolution. For example, the cohort type and depth of sequencing can influence the downstream analysis. Abstract | Full Text | PDF | Supplementary information
Computational solutions for omics data Bonnie Berger, Jian Peng & Mona Singh p333 | doi:10.1038/nrg3433 The recent explosion of genomics data has prompted the development of advanced algorithmic techniques to aid in the analysis, storage and retrieval of these data in the hunt for answers to biological questions. In this article, several examples of these algorithms are highlighted to aid in the use and selection of such algorithms. Abstract | Full Text | PDF
From neural development to cognition: unexpected roles for chromatin Jehnna L. Ronan, Wei Wu & Gerald R. Crabtree p347 | doi:10.1038/nrg3413 Recent genome-sequencing studies in human neurodevelopmental and psychiatric disorders have revealed mutations in chromatin-modifying enzymes, such as chromatin remodellers and histone-modifying enzymes. Such studies are improving our understanding of the roles of these modifiers in human neurodevelopment, and this article discusses the emerging roles for several of these enzymes in development and disease. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION Functional and evolutionary implications of gene orthology Toni Gabaldón & Eugene V. Koonin p360 | doi:10.1038/nrg3456 The concepts of orthology and paralogy are fundamental to comparative genomics and are also frequently used for the functional annotation of uncharacterized genes. However, assumptions regarding function have recently been challenged, and the implications of assigning genes as orthologues or paralogues are far from straightforward. Abstract | Full Text | PDF
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