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| | | 16 April 2013 | | | Featured image: | |  | | | Yang et al. fabricate microneedle arrays for the mechanical fastening of tissue in wet environments. | | | | | | |
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Join our expanding community of scientific leaders and subscribe today! | | | | | | | Latest Articles | View all Articles | | | | | Calcium-dependent permeabilization of erythrocytes by a perforin-like protein during egress of malaria parasites | | | Swati Garg, Shalini Agarwal, Saravanan Kumar, Syed Shams Yazdani, Chetan E. Chitnis and Shailja Singh | | | Malaria parasites exit erythrocytes by triggering permeabilization and rupture of the host plasma membrane. Here, the authors identify a perforin-like protein that is secreted by the parasite in a calcium-dependent manner and mediates permeabilization through its insertion into the host membrane. | | | 16 Apr | Nat Commun 4:1736 doi:10.1038/ncomms2725 (2013) | | | Biological sciences Cell biology | | | Microbiology | | Abstract | Full Text | PDF (3,735 kB) |
Supplementary Information |
| Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals OPEN | | | Paul Koenen, Susanne Heinzel, Emma M. Carrington, Lina Happo, Warren S. Alexander, Jian-Guo Zhang, Marco J. Herold, Clare L. Scott, Andrew M. Lew, Andreas Strasser and Philip D. Hodgkin | | | Before antigen exposure, T cell survival is dependent on signalling stimulated by IL-7. Koenen et al. show that upon encountering specific antigen, T cell receptor signalling initiates a different set of survival pathways, which actively suppress those that sustain naive T cells. | | | 16 Apr | Nat Commun 4:1735 doi:10.1038/ncomms2719 (2013) | | | Biological sciences Cell biology | | | Immunology | | Abstract | Full Text | PDF (701 kB) |
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| Ballistic to diffusive crossover of heat flow in graphene ribbons | | | Myung-Ho Bae, Zuanyi Li, Zlatan Aksamija, Pierre N Martin, Feng Xiong, Zhun-Yong Ong, Irena Knezevic and Eric Pop | | | Understanding heat flow in two-dimensional nanomaterials has wide-ranging implications. Here, the authors show that the thermal conductance of quarter-micron graphene samples is quasi-ballistic, but patterning the graphene into nanoribbons leads to diffusive heat flow strongly limited by edge scattering. | | | 16 Apr | Nat Commun 4:1734 doi:10.1038/ncomms2755 (2013) | | | Physical sciences Materials science | | | Nanotechnology | | Abstract | Full Text | PDF (1,029 kB) |
Supplementary Information |
| Energetics of activation of GTP hydrolysis on the ribosome | | | Göran Wallin, Shina C. L. Kamerlin and Johan Åqvist | | | Ribosomal protein synthesis is driven by the hydrolysis of GTP. Wallin and colleagues employ molecular dynamics and computer simulations to show that a universally conserved histidine promotes GTP hydrolysis in its protonated form, and is driven into the active conformation by interactions with the ribosome. | | | 16 Apr | Nat Commun 4:1733 doi:10.1038/ncomms2741 (2013) | | | Biological sciences Biophysics | | | Chemical biology | | | Abstract | Full Text | PDF (2,435 kB) |
| High-power lithium ion microbatteries from interdigitated three-dimensional bicontinuous nanoporous electrodes | | | James H. Pikul, Hui Gang Zhang, Jiung Cho, Paul V. Braun and William P. King | | | Microbatteries offer new opportunities for microelectronics, but performance and integration remain a challenge. Pikul et al. develop a lithium ion microbattery with fully integrated nanoporous electrodes, which exceeds the power densities of most supercapacitors while retaining high-energy density. | | | 16 Apr | Nat Commun 4:1732 doi:10.1038/ncomms2747 (2013) | | | Chemical sciences Nanotechnology | | | Physical chemistry | | Abstract | Full Text | PDF (784 kB) |
Supplementary Information |
| Single-shot pulse duration monitor for extreme ultraviolet and X-ray free-electron lasers | | | R. Riedel, A. Al-Shemmary, M. Gensch, T. Golz, M. Harmand, N. Medvedev, M. J. Prandolini, K. Sokolowski-Tinten, S. Toleikis, U. Wegner, B. Ziaja, N. Stojanovic and F. Tavella | | | Free-electron lasers offer exciting new possibilities for X-ray studies on ultrafast timescales, but their shot-to-shot variability requires new diagnostic tools. Using a plasma switch cross-correlator, Riedel et al. present a single-shot online diagnostic to retrieve the duration of extreme ultraviolet pulses. | | | 16 Apr | Nat Commun 4:1731 doi:10.1038/ncomms2754 (2013) | | | Physical sciences Applied physics | | | Optical physics | | | Abstract | Full Text | PDF (494 kB) |
| Enhancing far-field thermal emission with thermal extraction | | | Zongfu Yu, Nicholas P. Sergeant, Torbjørn Skauli, Gang Zhang, Hailiang Wang and Shanhui Fan | | | The control of thermal radiation is important for applications such as energy conversion and radiative cooling. Here Fan et al. demonstrate a thermal extraction scheme that can enhance the emission of a finite-sized blackbody-like emitter. | | | 16 Apr | Nat Commun 4:1730 doi:10.1038/ncomms2765 (2013) | | | Physical sciences Applied physics | | | Optical physics | | Abstract | Full Text | PDF (1,214 kB) |
Supplementary Information |
| The function of fin rays as proprioceptive sensors in fish | | | Richard Williams IV, Nicole Neubarth and Melina E. Hale | | | Electrophysiological studies in some fish species suggest that proprioception is needed for fin movement. Here the authors test mechanosensory abilities of afferent nerves in pectoral fin rays, and find that the activity of fin ray nerve fibres reflects the amplitude and velocity of fin ray bending. | | | 16 Apr | Nat Commun 4:1729 doi:10.1038/ncomms2751 (2013) | | | Biological sciences Biophysics | | | Neuroscience | | | Abstract | Full Text | PDF (1,325 kB) |
| Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region OPEN | | | Xingfeng Liu, Cong Xiong, Shunji Jia, Yu Zhang, Ye-Guang Chen, Qiang Wang and Anming Meng | | | TGF-β signalling through SMAD transcription factors has been implicated in embryonic mesendoderm development. Liu and colleagues reveal that the Ras-regulated kinase Raf prevents excessive mesendoderm formation by phosphorylating and promoting the degradation of SMAD2. | | | 16 Apr | Nat Commun 4:1728 doi:10.1038/ncomms2762 (2013) | | | Biological sciences Developmental biology | | Abstract | Full Text | PDF (3,109 kB) |
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| Optical visualization of individual ultralong carbon nanotubes by chemical vapour deposition of titanium dioxide nanoparticles | | | Rufan Zhang, Yingying Zhang, Qiang Zhang, Huanhuan Xie, Haidong Wang, Jingqi Nie, Qian Wen and Fei Wei | | | The characterization and manipulation of carbon nanotubes is of relevance for a range of nanotechnology applications, but usually requires electron microscopes. Here Zhang et al. evaporate nanoparticles on carbon nanotubes to make them visible even under an optical microscope. | | | 16 Apr | Nat Commun 4:1727 doi:10.1038/ncomms2736 (2013) | | | Physical sciences Materials science | | | Nanotechnology | | Abstract | Full Text | PDF (2,491 kB) |
Supplementary Information |
| Spin wave-assisted reduction in switching field of highly coercive iron-platinum magnets | | | Takeshi Seki, Kazutoshi Utsumiya, Yukio Nozaki, Hiroshi Imamura and Koki Takanashi | | | The ideal nanomagnet in a spintronic device has a high coercive field and a low switching field—two competing goals that are hard to realize simultaneously. Here the authors achieve a major reduction of the switching field by applying a microwave magnetic field to a FePt/Ni81Fe19 bilayer. | | | 16 Apr | Nat Commun 4:1726 doi:10.1038/ncomms2737 (2013) | | | Physical sciences Materials science | | | Nanotechnology | | Abstract | Full Text | PDF (627 kB) |
Supplementary Information |
| An engineered dimeric protein pore that spans adjacent lipid bilayers | | | Shiksha Mantri, K. Tanuj Sapra, Stephen Cheley, Thomas H. Sharp and Hagan Bayley | | | An important challenge in the bottom-up fabrication of artificial tissues is communication between compartments bounded by lipid bilayers. Mantri et al. engineer a dimeric transmembrane pore that, like eukaryotic gap junctions, can form a conductive pathway between adjacent bilayers. | | | 16 Apr | Nat Commun 4:1725 doi:10.1038/ncomms2726 (2013) | | | Chemical sciences Chemical biology | | | Nanotechnology | | Abstract | Full Text | PDF (2,279 kB) |
Supplementary Information |
| Molecular mechanics of mineralized collagen fibrils in bone OPEN | | | Arun K. Nair, Alfonso Gautieri, Shu-Wei Chang and Markus J. Buehler | | | Bone is a natural composite of collagen and hydroxyapatite but, surprising, little is known about its characteristics at the molecular scale. Nair et al. conduct molecular-scale simulations of mineralized collagen networks to better understand how bone achieves superior mechanical properties to its constituents. | | | 16 Apr | Nat Commun 4:1724 doi:10.1038/ncomms2720 (2013) | | | Physical sciences Biophysics | | | Materials science | | | Abstract | Full Text | PDF (1,298 kB) |
| Codoping titanium dioxide nanowires with tungsten and carbon for enhanced photoelectrochemical performance | | | In Sun Cho, Chi Hwan Lee, Yunzhe Feng, Manca Logar, Pratap M. Rao, Lili Cai, Dong Rip Kim, Robert Sinclair and Xiaolin Zheng | | | Titanium dioxide nanowires are used as photoanodes in photoelectrochemical water splitting. Here Zheng et al. demonstrate that doping these nanowires with tungsten and carbon atom pairs considerably enhances their performance. | | | 16 Apr | Nat Commun 4:1723 doi:10.1038/ncomms2729 (2013) | | | Chemical sciences Catalysis | | | Nanotechnology Physical chemistry | | Abstract | Full Text | PDF (1,395 kB) |
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| Avalanche breakdown in GaTa4Se8–x Tex narrow-gap Mott insulators | | | V. Guiot, L. Cario, E. Janod, B. Corraze, V. Ta Phuoc, M. Rozenberg, P. Stoliar, T. Cren and D. Roditchev | | | Dielectric breakdown in Mott insulators induced by strong electric fields is thought to take place via a Zener mechanism. Guiot et al. show that the breakdown characteristics are instead similar to the avalanche breakdown in conventional semiconductors, although with much longer delay times. | | | 16 Apr | Nat Commun 4:1722 doi:10.1038/ncomms2735 (2013) | | | Physical sciences Condensed matter | | | Materials science | | Abstract | Full Text | PDF (689 kB) |
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| Arginine clustering on calix[4]arene macrocycles for improved cell penetration and DNA delivery OPEN | | | Valentina Bagnacani, Valentina Franceschi, Michele Bassi, Michela Lomazzi, Gaetano Donofrio, Francesco Sansone, Alessandro Casnati and Rocco Ungaro | | | Arginine-rich peptides act as delivery systems for the internalization of cargoes in cells. Here, the clustering of arginine units in a parallel array on a macrocyclic scaffold produces a vector with high efficiency in DNA delivery and transfection. | | | 16 Apr | Nat Commun 4:1721 doi:10.1038/ncomms2721 (2013) | | | Chemical sciences Chemical biology | | | Organic chemistry | | Abstract | Full Text | PDF (1,037 kB) |
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| Louisville seamount subduction and its implication on mantle flow beneath the central Tonga–Kermadec arc | | | Christian Timm, Daniel Bassett, Ian J. Graham, Matthew I. Leybourne, Cornel E. J. de Ronde, Jon Woodhead, Daniel Layton-Matthews and Anthony B. Watts | | | Seamounts that have subducted beneath a mantle wedge allow the study of trace element recycling and mantle flow in subduction zones. Here, a geochemical analysis of central Tonga–Kermadec arc lavas suggests primarily trench-normal mantle flow in the mantle wedge beneath the central Tonga–Kermadec arc. | | | 16 Apr | Nat Commun 4:1720 doi:10.1038/ncomms2702 (2013) | | | Earth sciences Geology and geophysics | | Abstract | Full Text | PDF (4,967 kB) |
Supplementary Information |
| Optical solitons in graded-index multimode fibres | | | W. H. Renninger and F. W. Wise | | | Solitons are waves, occurring in systems such as water channels and optical fibres that preserve their shape as they travel. Here the observation of solitons in multimode optical fibres offers a platform for studying spatiotemporal wave packets, and could allow high peak power transmission along with increased data rates in low-cost telecommunications. | | | 16 Apr | Nat Commun 4:1719 doi:10.1038/ncomms2739 (2013) | | | Physical sciences Applied physics | | | Materials science Optical physics | | Abstract | Full Text | PDF (717 kB) |
Supplementary Information |
| Fish parasites resolve the paradox of missing coextinctions | | | Giovanni Strona, Paolo Galli and Simone Fattorini | | | The number of different host species that a parasite uses should affect its extinction risk, yet the number of documented host–parasite coextinctions is lower than expected. Strona et al. find that specialised parasites tend to use hosts with low vulnerability to extinction, which explains the paradox. | | | 16 Apr | Nat Commun 4:1718 doi:10.1038/ncomms2723 (2013) | | | Biological sciences | | Abstract | Full Text | PDF (244 kB) |
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| Dynamic switching of calmodulin interactions underlies Ca2+ regulation of CaV1.3 channels | | | Manu Ben Johny, Philemon S. Yang, Hojjat Bazzazi and David T. Yue | | | Calmodulin regulation of Ca2+ channels is an important Ca2+ -feedback system. The structural underpinnings of this modulation are unclear, but this study reports the molecular states underlying channel regulation. | | | 16 Apr | Nat Commun 4:1717 doi:10.1038/ncomms2727 (2013) | | | Biological sciences Biophysics | | | Neuroscience | | Abstract | Full Text | PDF (1,347 kB) |
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| Intercalation and delamination of layered carbides and carbonitrides | | | Olha Mashtalir, Michael Naguib, Vadym N. Mochalin, Yohan Dall'Agnese, Min Heon, Michel W. Barsoum and Yury Gogotsi | | | Intercalation materials are of interest for batteries because of their capability of accommodating ions in their layered structures. Mashtalir et al. develop a new battery electrode material using two-dimensional intercalated carbides, which exhibit high lithium-ion conductivity and capacity. | | | 16 Apr | Nat Commun 4:1716 doi:10.1038/ncomms2664 (2013) | | | Chemical sciences Materials science | | | Physical chemistry | | Abstract | Full Text | PDF (1,062 kB) |
Supplementary Information |
| Initialized near-term regional climate change prediction OPEN | | | F. J. Doblas-Reyes, I. Andreu-Burillo, Y. Chikamoto, J. García-Serrano, V. Guemas, M. Kimoto, T. Mochizuki, L. R. L. Rodrigues and G. J. van Oldenborgh | | | Near-term climate prediction is an information tool used in climate adaptation services. This study analyses the quality of the predictions, showing that near-term climate forecasts have good skill in predicting temperature at regional scales, where most of the skill is attributed to atmospheric composition changes. | | | 16 Apr | Nat Commun 4:1715 doi:10.1038/ncomms2704 (2013) | | | Earth sciences Atmospheric science | | | Climate science | | | Abstract | Full Text | PDF (3,392 kB) |
| Cryptic variation in vulva development by cis-regulatory evolution of a HAIRY-binding site | | | Simone Kienle and Ralf J. Sommer | | | Robustness to mutations can give rise to cryptic variation—a bottled-up genetic potential, which is of undetermined importance in developmental processes. Kienle and Sommer show the occurrence of cryptic variation in nematode vulva development and identify cis-regulatory evolution of the transcription factor's HAIRY-binding site as mechanism. | | | 16 Apr | Nat Commun 4:1714 doi:10.1038/ncomms2711 (2013) | | | Biological sciences Developmental biology | | | Evolution | | Abstract | Full Text | PDF (955 kB) |
Supplementary Information |
| Nuclear retention of the transcription factor NLP7 orchestrates the early response to nitrate in plants | | | Chloé Marchive, François Roudier, Loren Castaings, Virginie Bréhaut, Eddy Blondet, Vincent Colot, Christian Meyer and Anne Krapp | | | Nitrate is both an important nutrient and a signalling molecule crucial for plant life. Here Marchive et al. report that NLP7 acts as an upstream transcriptional regulator of plant early responses to nitrate through active exportation from the nucleus in absence of nitrate. | | | 16 Apr | Nat Commun 4:1713 doi:10.1038/ncomms2650 (2013) | | | Biological sciences Molecular biology | | | Plant sciences | | Abstract | Full Text | PDF (732 kB) |
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| Self-shaping composites with programmable bioinspired microstructures | | | Randall M. Erb, Jonathan S. Sander, Roman Grisch and André R. Studart | | | Many living organisms use materials that are capable of changing their shape in response to changes in the environment. Erb et al. demonstrate an approach to synthesizing artificial shape-changing composites that replicate such behaviour. | | | 16 Apr | Nat Commun 4:1712 doi:10.1038/ncomms2666 (2013) | | | Physical sciences Materials science | | Abstract | Full Text | PDF (1,470 kB) |
Supplementary Information |
| Power-independent wavelength determination by hot carrier collection in metal-insulator-metal devices | | | Fuming Wang and Nicholas A. Melosh | | | The detection of light of different wavelengths in the same structure typically requires a complex device architecture. Here direct wavelength determination of monochromatic light is realized in a power-independent fashion with a simple metal-insulator-metal device. | | | 16 Apr | Nat Commun 4:1711 doi:10.1038/ncomms2728 (2013) | | | Physical sciences Condensed matter | | | Optical physics | | Abstract | Full Text | PDF (507 kB) |
Supplementary Information |
| Polaron hopping mediated by nuclear tunnelling in semiconducting polymers at high carrier density | | | Kamal Asadi, Auke J. Kronemeijer, Tobias Cramer, L. Jan Anton Koster, Paul W. M. Blom and Dago M. de Leeuw | | | Although polymers are widely used in electric and photonic devices, the mechanism of charge transport across polymer chains is still not well understood. Here de Leeuw and colleagues propose a model that unifies experimental observations at high carrier densities. | | | 16 Apr | Nat Commun 4:1710 doi:10.1038/ncomms2708 (2013) | | | Chemical sciences Organic chemistry | | | Physical chemistry | | | Abstract | Full Text | PDF (1,220 kB) |
| Intrinsic electrical conductivity of nanostructured metal-organic polymer chains OPEN | | | Cristina Hermosa, Jose Vicente Álvarez, Mohammad-Reza Azani, Carlos J. Gómez-García, Michelle Fritz, Jose M. Soler, Julio Gómez-Herrero, Cristina Gómez-Navarro and Félix Zamora | | | Conductive polymers are of great interest for electronic applications, but their disorder has made it difficult to realize their full electronic potential. Here transport measurements uncover the intrinsic transport properties of metal-organic polymer nanoribbons. | | | 16 Apr | Nat Commun 4:1709 doi:10.1038/ncomms2696 (2013) | | | Chemical sciences Materials science | | | Nanotechnology Physical chemistry | | Abstract | Full Text | PDF (582 kB) |
Supplementary Information |
| Highly sensitive sulphide mapping in live cells by kinetic spectral analysis of single Au-Ag core-shell nanoparticles | | | Bin Xiong, Rui Zhou, Jinrui Hao, Yanghui Jia, Yan He and Edward S. Yeung | | | H2S is an important gasotransmitter in many physiological processes but its concentrations are difficult to measure in vivo. Xiong et al. demonstrate that local variations in H2S levels in live cells can be mapped in real time via spectral shift rates of Au-Ag core-shell plasmonic nanoprobes. | | | 16 Apr | Nat Commun 4:1708 doi:10.1038/ncomms2722 (2013) | | | Chemical sciences Analytical chemistry | | | Chemical biology Nanotechnology | | Abstract | Full Text | PDF (1,064 kB) |
Supplementary Information |
| Externally controlled on-demand release of anti-HIV drug using magneto-electric nanoparticles as carriers | | | Madhavan Nair, Rakesh Guduru, Ping Liang, Jeongmin Hong, Vidya Sagar and Sakhrat Khizroev | | | Magneto-electric nanoparticles may facilitate the low-energy and dissipation-free field-triggered release of drugs across the blood–brain barrier. Here, the authors demonstrate the a.c. field-triggered release of anti-HIV drugs and confirm the in vitro drug integrity after release. | | | 16 Apr | Nat Commun 4:1707 doi:10.1038/ncomms2717 (2013) | | | Chemical sciences Inorganic chemistry | | | Medicinal chemistry Nanotechnology | | Abstract | Full Text | PDF (844 kB) |
Supplementary Information |
| Association between Gαi2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis OPEN | | | Hongyan Li, Lei Yang, Hui Fu, Jianshe Yan, Ying Wang, Hua Guo, Xishan Hao, Xuehua Xu, Tian Jin and Ning Zhang | | | Chemokines promote breast cancer metastasis by stimulating re-organization of the actin cytoskeleton. Li et al. identify the human engulfment and cell motility protein ELMO1 as an intermediary between chemokine-dependent Gαi2 signalling and small GTPase signalling mediated by Rac. | | | 16 Apr | Nat Commun 4:1706 doi:10.1038/ncomms2680 (2013) | | | Biological sciences Cancer | | | Cell biology | | Abstract | Full Text | PDF (4,018 kB) |
Supplementary Information |
| Mechanical unzipping and rezipping of a single SNARE complex reveals hysteresis as a force-generating mechanism OPEN | | | Duyoung Min, Kipom Kim, Changbong Hyeon, Yong Hoon Cho, Yeon-Kyun Shin and Tae-Young Yoon | | | Interactions between SNARE proteins on vesicle and target membranes provide the force necessary to drive membrane fusion. By applying piconewton forces to single SNARE complexes, the authors identify a partially assembled intermediate state that reveals how force is generated in a consistent direction. | | | 16 Apr | Nat Commun 4:1705 doi:10.1038/ncomms2692 (2013) | | | Biological sciences Biophysics | | | Cell biology | | Abstract | Full Text | PDF (2,294 kB) |
Supplementary Information |
| Dynamin–SNARE interactions control trans-SNARE formation in intracellular membrane fusion | | | Kannan Alpadi, Aditya Kulkarni, Sarita Namjoshi, Sankaranarayanan Srinivasan, Katherine H. Sippel, Kathryn Ayscough, Martin Zieger, Andrea Schmidt, Andreas Mayer, Michael Evangelista, Florante A. Quiocho and Christopher Peters | | | Dynamin promotes membrane fission by constricting the neck of invaginating membranes; however, it was recently shown that dynamin also regulates membrane fusion. Here the authors show that this fusogenic activity is mediated by interaction with the Qa SNARE, thereby promoting trans-SNARE formation. | | | 16 Apr | Nat Commun 4:1704 doi:10.1038/ncomms2724 (2013) | | | Biological sciences Cell biology | | Abstract | Full Text | PDF (853 kB) |
Supplementary Information |
| A troodontid dinosaur from the latest Cretaceous of India | | | A. Goswami, G. V. R. Prasad, O. Verma, J. J. Flynn and R. B. J. Benson | | | Troodontid dinosaurs share a close ancestry with birds and were distributed widely across the northern hemisphere before the extinction of non-avian dinosaurs. Goswami et al. report the discovery in South India of the first Gondwanan troodontid, extending their geographic range by nearly 10,000 km. | | | 16 Apr | Nat Commun 4:1703 doi:10.1038/ncomms2716 (2013) | | | Biological sciences Evolution | | | Palaeontology | | | Abstract | Full Text | PDF (441 kB) |
| A bio-inspired swellable microneedle adhesive for mechanical interlocking with tissue | | | Seung Yun Yang, Eoin D. O'Cearbhaill, Geoffroy C Sisk, Kyeng Min Park, Woo Kyung Cho, Martin Villiger, Brett E. Bouma, Bohdan Pomahac and Jeffrey M. Karp | | | Conventional adhesives stick poorly to wet tissue because water severely undermines the adhesive chemicals they rely on. To overcome this, Yang et al. develop a bio-inspired adhesive microneedle array whose tips swell on contact with water, forming a mechanical bond to living tissue. | | | 16 Apr | Nat Commun 4:1702 doi:10.1038/ncomms2715 (2013) | | | Physical sciences Biotechnology | | | Materials science | | Abstract | Full Text | PDF (2,255 kB) |
Supplementary Information |
| Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas | | | Il-Jin Kim, David Quigley, Minh D. To, Patrick Pham, Kevin Lin, Brian Jo, Kuang-Yu Jen, Dan Raz, Jae Kim, Jian-Hua Mao, David Jablons and Allan Balmain | | | Directly comparing patterns of gene expression in matched normal and cancerous tissues provides a powerful tool to identify drivers of tumour progression. Here the authors discover genes that are recruited into mitotic signalling networks in lung adenocarcinoma. | | | 16 Apr | Nat Commun 4:1701 doi:10.1038/ncomms2660 (2013) | | | Biological sciences Cancer | | | Cell biology | | Abstract | Full Text | PDF (1,809 kB) |
Supplementary Information |
| Theory of quantum oscillations in the vortex-liquid state of high-Tc superconductors | | | Sumilan Banerjee, Shizhong Zhang and Mohit Randeria | | | Quantum oscillations in the underdoped cuprate superconductors suggest the existence of a continuous Fermi surface, but specific heat measurements in strong magnetic fields suggest singular behaviour characteristic of point nodes. Banerjee et al. show how a vortex-liquid state could resolve this dichotomy. | | | 16 Apr | Nat Commun 4:1700 doi:10.1038/ncomms2667 (2013) | | | Physical sciences Condensed matter | | | Abstract | Full Text | PDF (411 kB) |
| Structural basis of protein phosphatase 2A stable latency OPEN | | | Li Jiang, Vitali Stanevich, Kenneth A Satyshur, Mei Kong, Guy R. Watkins, Brian E. Wadzinski, Rituparna Sengupta and Yongna Xing | | | The protein α4 is essential for the formation, stability and activity of protein phosphatase 2A (PP2A) complexes. Here the authors solve the crystal structure of a truncated PP2A bound to α4 and show that α4 binds to a partially folded form of the protein, stabilizing the enzyme in an inactive state. | | | 16 Apr | Nat Commun 4:1699 doi:10.1038/ncomms2663 (2013) | | | Biological sciences Biochemistry | | Abstract | Full Text | PDF (1,802 kB) |
Supplementary Information |
| Fathers are just as good as mothers at recognizing the cries of their baby | | | Erik Gustafsson, Florence Levréro, David Reby and Nicolas Mathevon | | | It is generally accepted that women possess innate behavioural predispositions to assess their babies’ cries. Gustaffson and colleagues compare mothers’ and fathers’ abilities to identify their babies’ cries, and find that fathers can be as good as mothers at recognizing the cries of their offspring, depending on their experience. | | | 16 Apr | Nat Commun 4:1698 doi:10.1038/ncomms2713 (2013) | | | Biological sciences Neuroscience | | Abstract | Full Text | PDF (322 kB) |
Supplementary Information |
| Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel | | | Ludovic Sauguet, Rebecca J. Howard, Laurie Malherbe, Ui S. Lee, Pierre-Jean Corringer, R. Adron Harris and Marc Delarue | | | Alcohols and anaesthetics exert their effects by potentiating ligand-gated ion channels. Here, the authors determine crystal structures of a bacterial ligand-gated ion channel in the presence of alcohols and anaesthetics, and describe a structural mechanism for stabilization of the open form of the channel. | | | 16 Apr | Nat Commun 4:1697 doi:10.1038/ncomms2682 (2013) | | | Biological sciences Biophysics | | Abstract | Full Text | PDF (1,672 kB) |
Supplementary Information |
| High-strength and thermally stable bulk nanolayered composites due to twin-induced interfaces | | | Shijian Zheng, Irene J. Beyerlein, John S. Carpenter, Keonwook Kang, Jian Wang, Weizhong Han and Nathan A. Mara | | | Nanostructured metals are known to exhibit poor thermal stability, reducing their high strength at elevated temperatures. Here, Zheng et al. fabricate a bulk two-phase bimetal composite that retains its high strength after annealing at 500 °C for 1 h. | | | 16 Apr | Nat Commun 4:1696 doi:10.1038/ncomms2651 (2013) | | | Physical sciences Materials science | | Abstract | Full Text | PDF (3,159 kB) |
Supplementary Information |
| A top–down strategy towards monodisperse colloidal lead sulphide quantum dots | | | Jing Yang, Tao Ling, Wen-Tian Wu, Hui Liu, Min-Rui Gao, Chen Ling, Lan Li and Xi-Wen Du | | | Quantum dots with a fine size dispersion offer attractive levels of functional control and manipulation. In this study, Yang et al. report an environmentally friendly top–down synthesis technique, based on laser irradiation of a polydisperse of lead sulphide nanocrystals. | | | 16 Apr | Nat Commun 4:1695 doi:10.1038/ncomms2637 (2013) | | | Chemical sciences Nanotechnology | | | Physical chemistry | | Abstract | Full Text | PDF (1,685 kB) |
Supplementary Information |
| New materials for methane capture from dilute and medium-concentration sources | | | Jihan Kim, Amitesh Maiti, Li-Chiang Lin, Joshuah K. Stolaroff, Berend Smit and Roger D. Aines | | | Methane is an important greenhouse gas but its capture presents a challenge due to its weak interactions with most materials. Here, the authors perform a systematic screening of liquid solvents and nanoporous zeolites, and identify zeolite structures with good potential for methane uptake and separation. | | | 16 Apr | Nat Commun 4:1694 doi:10.1038/ncomms2697 (2013) | | | Chemical sciences Materials science | | | Physical chemistry | | Abstract | Full Text | PDF (4,278 kB) |
Supplementary Information |
| High-coherence electron bunches produced by femtosecond photoionization | | | W. J. Engelen, M. A. van der Heijden, D. J. Bakker, E. J. D. Vredenbregt and O. J. Luiten | | | Ultrashort electron bunches are promising for diffraction measurements of structural dynamics, particularly in surfaces, thin films or membrane proteins. With this goal in mind, Engelen et al. generate high-coherence ultrafast electron bunches by photoionisation of laser-cooled atoms. | | | 16 Apr | Nat Commun 4:1693 doi:10.1038/ncomms2700 (2013) | | | Physical sciences Atomic and molecular physics | | | Optical physics | | | Abstract | Full Text | PDF (370 kB) |
| High-coherence picosecond electron bunches from cold atoms | | | A. J. McCulloch, D. V. Sheludko, M. Junker and R. E. Scholten | | | Ultrashort electron bunches are promising for diffractive imaging measurements of structural dynamics, particularly in small or delicate structures. To this end, McCulloch et al. use a two-colour photoionization process to generate high-coherence ultrafast electron bunches from laser-cooled atoms. | | | 16 Apr | Nat Commun 4:1692 doi:10.1038/ncomms2699 (2013) | | | Physical sciences Atomic and molecular physics | | | Optical physics | | | Abstract | Full Text | PDF (554 kB) | | | | | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
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