The EMBO Journal - Table of Contents alert Volume 32 Issue 6

TABLE OF CONTENTS 20 March 2013 | Volume 32, Issue 6 Have you seen? Articles Corrigendum Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement EMBO - Transparency in Scientific Publishing The EMBO Journal has a fair and transparent process to rapidly publish your best science. Transparent - No confidential referee remarks - Published referee reports - Detailed decisions - Source Data published alongside figures Fair - Scooping protection - Pre-decision cross-referee commenting - Fixed bar for revisions - Fast process   Have you seen? Top Struggling to let go: a non-coding RNA directs its own extension and destruction A mammalian non-coding RNA (ncRNA) templates its extension by Pol II, leading to its destabilization. This represents the first RNA-dependent RNA polymerase (RdRP) activity in higher organisms. Carrie Bernecky and Patrick Cramer The EMBO Journal (2013), 32, 771 - 772; 10.1038/emboj.2013.36 Abstract | Full text | PDF | Related article Published online: 22 February 2013 Ubc9 acetylation: a new route for achieving specificity in substrate SUMOylation Post-translational modifications are the key for generating diversity and specificity in a pathway that relies on a minimum number of components. Shen-Hsi Yang and Andrew D Sharrocks The EMBO Journal (2013), 32, 773 - 774; 10.1038/emboj.2013.21 Abstract | Full text | PDF | Related article Published online: 08 February 2013 A STUbL wards off telomere fusions A newly identified chromosome end-protection factor removes polysumoylated Rap1 from telomeres to prevent chromosomal fusions. Inn Chung and Xiaolan Zhao The EMBO Journal (2013), 32, 775 - 777; 10.1038/emboj.2013.39 Abstract | Full text | PDF | Related article Published online: 22 February 2013 Gaming the competition in microbial cell–cell interactions Mekalanos and colleagues report that bacteria ‘game’ each other in a deadly competition that involves selective deployment of the Type VI Secretion System. Jeff F Miller The EMBO Journal (2013), 32, 778 - 780; 10.1038/emboj.2013.45 Abstract | Full text | PDF| Related article Published online: 26 February 2013 Articles Top RNA polymerase II acts as an RNA-dependent RNA polymerase to extend and destabilize a non-coding RNA The non-coding RNA B2 represses transcription by binding to RNA pol II. However, RNA pol II displays RNA-dependent RNA polymerase (RdRP) activity to extend and destabilize B2. This provides the first functional role for RdRP activity in mammals. Stacey D Wagner, Petro Yakovchuk, Benjamin Gilman, Steven L Ponicsan, Linda F Drullinger, Jennifer F Kugel and James A Goodrich The EMBO Journal (2013), 32, 781 - 790; 10.1038/emboj.2013.18 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 08 February 2013 Subject Categories: Chromatin and Transcription | RNA Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response SIRT1-mediated deacetylation modulates the SUMO conjugase Ubc9 to selectively control sumoylation of substrates with an extended consensus motif. Yung-Lin Hsieh, Hong-Yi Kuo, Che-Chang Chang, Mandar T Naik, Pei-Hsin Liao, Chun-Chen Ho, Tien-Chi Huang, Jen-Chong Jeng, Pang-Hung Hsu, Ming-Daw Tsai, Tai-Huang Huang and Hsiu-Ming Shih The EMBO Journal (2013), 32, 791 - 804; 10.1038/emboj.2013.5 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 08 February 2013 Subject Categories: Proteins End-joining inhibition at telomeres requires the translocase and polySUMO-dependent ubiquitin ligase Uls1 A STUbL with DNA-dependent ATPase activity protects telomeres by preventing accumulation of poly-sumoylated Rap1 on chromosome ends. Rachel Lescasse, Sabrina Pobiega, Isabelle Callebaut and Stéphane Marcand The EMBO Journal (2013), 32, 805 - 815; 10.1038/emboj.2013.24 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 15 February 2013 Subject Categories: Proteins | Genome Stability and Dynamics I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection IKKα kinase has anti-inflammatory activity. Here, IKKα is shown to be required in dendritic cells for T-cell priming and acquired immunity to Listeria monocytogenes. IKKα thus inhibits the innate and activates the adaptive immune systems. Alessandra Mancino, Mohamed Habbeddine, Ella Johnson, Lionel Luron, Magali Bebien, Sylvie Memet, Carol Fong, Marc Bajenoff, Xuefeng Wu, Michael Karin, Jorge Caamano, Hongbo Chi, Michael Seed and Toby Lawrence The EMBO Journal (2013), 32, 816 - 828; 10.1038/emboj.2013.28 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 19 February 2013 Subject Categories: Signal Transduction | Immunology A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes The integrin LFA-1 mediates the adhesion of T cells to lymphatic vessels expressing the LFA-1 ligand ICAM-1, prolonging T-cell retention in lymph nodes to increase their chances of encountering foreign antigens. Peter Reichardt, Irene Patzak, Kristian Jones, Eloho Etemire, Matthias Gunzer and Nancy Hogg The EMBO Journal (2013), 32, 829 - 843; 10.1038/emboj.2013.33 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 26 February 2013 Subject Categories: Signal Transduction | Immunology pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location Genetic abrogation in POMC neurons establishes an unexpected role for Retinoblastoma (Rb) in neuronal circuits that determine the hypothalamic regulation of feeding and energy expenditure. Zhonglei Lu, Genevieve Marcelin, Frederick Bauzon, Hongbo Wang, Hao Fu, Siok Le Dun, Hongling Zhao, Xiaosong Li, Young-Hwan Jo, Sharon Wardlaw, Nae Dun, Streamson Chua Jr and Liang Zhu The EMBO Journal (2013), 32, 844 - 857; 10.1038/emboj.2013.25 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 February 2013 Subject Categories: Signal Transduction | Cellular Metabolism FOXA1 mediates p16INK4a activation during cellular senescence The transcription factor FOXA1 is induced during senescence to activate p16INK4a transcription through nucleosome repositioning, enhancer looping and antagonizing Polycomb-mediated repression. Qian Li, Yu Zhang, Jingxuan Fu, Limin Han, Lixiang Xue, Cuicui Lv, Pan Wang, Guodong Li and Tanjun Tong The EMBO Journal (2013), 32, 858 - 873; 10.1038/emboj.2013.35 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 26 February 2013 Subject Categories: Chromatin and Transcription | Molecular Biology of Disease NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15 Vesicle targeting during ciliogenesis requires binding of the GDP–GTP GEF Rabin8 to exocyst component Sec15. NDR2-mediated phosphorylation of Rabin8 switches its binding from pericentrosomal vesicles to Sec15 to regulate ciliogenesis Shuhei Chiba, Yuta Amagai, Yuta Homma, Mitsunori Fukuda and Kensaku Mizuno The EMBO Journal (2013), 32, 874 - 885; 10.1038/emboj.2013.32 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 22 February 2013 Subject Categories: Membranes and Transport | Cell and Tissue Architecture Signal recognition initiates reorganization of the presequence translocase during protein import The translocation of precursor proteins across the mitochondrial inner membrane is mediated by the presequence translocase and its associated motor complex. Presequence binding to the Tim50 subunit induces the dissociation of Tim21 and the subsequent recruitment of the motor complex. Oleksandr Lytovchenko, Jonathan Melin, Christian Schulz, Markus Kilisch, Dana P Hutu and Peter Rehling The EMBO Journal (2013), 32, 886 - 898; 10.1038/emboj.2013.23 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 February 2013 Subject Categories: Membranes and Transport Structural basis for the nuclear export activity of Importin13 Crystal structures of the nuclear import/export factor Importin 13 with and without imported and exported cargoes reveal that its conformational state determines the directionality of cargo transport. Marlene Grünwald, Daniela Lazzaretti and Fulvia Bono The EMBO Journal (2013), 32, 899 - 913; 10.1038/emboj.2013.29 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 22 February 2013 Subject Categories: Membranes and Transport | Structural Biology Corrigendum Top ROS-mediated vascular homeostatic control of root-to-shoot soil Na delivery in Arabidopsis Caifu Jiang, Eric J Belfield, Aziz Mithani, Anne Visscher, Jiannis Ragoussis, Richard Mott, J Andrew C Smith and Nicholas P Harberd The EMBO Journal (2013), 32, 914; 10.1038/emboj.2013.43 Full text | PDF Published online: 20 March 2013 Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. 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