Nature Reviews Neuroscience contents April 2013 Volume 14 Number 4 pp 225-304

TABLE OF CONTENTS
April 2013 Volume 14 Number 4
Impact Factor 30.455 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: The changing scene of amyotrophic lateral sclerosis Wim Robberecht & Thomas Philip
Subscribe   Facebook   RSS   Recommend to library   Twitter
Advertisement
Professorship in Experimental Neuroregeneration within SCI-TReCS The Spinal Cord Injury & Tissue Regeneration Center Salzburg is a newly founded research consortium at the Paracelsus Medical University (PMU) with the goal to develop cell-based regenerative strategies for curative therapies for spinal cord injury patients. A core group will be the Research Group of Experimental Neuroregeneration focusing on spinal cord injury research. www.pmu.ac.at/spinalcord www.pmu.ac.at/service/karriere-stellenangebote-und-ausschreibungen
Advertisement
Nature Special: G protein-coupled receptors In this updated online Special we present a selection of recently published Nature papers that involve the structures of various GPCRs. Access selected content from the Special free online for two months. Produced with support from: Receptos, Inc.
RESEARCH HIGHLIGHTS Top Learning and memory: RICTOR in acti(o)n p225 | doi:10.1038/nrn3478 Mammalian target of rapamycin complex 2 regulates long-term memory formation by controlling actin polymerization. PDF Psychiatric disorders: Antidepressant epigenetic action p226 | doi:10.1038/nrn3466 An acetylating agent with fast antidepressant action in rodents acts by increasing the transcription of type 2 metabotropic glutamate receptors in the hippocampus and the prefrontal cortex. PDF Development: Microglia maketh the male p226 | doi:10.1038/nrn3473 Masculinization of the preoptic area and sexual behaviour depends on a feedforward loop of prostaglandin E2 production that requires microglial activation. PDF Psychiatric disorders: The dangers of adult-born neuron defects p227 | doi:10.1038/nrn3477 Knockdown of DISC1 levels in adult-born dentate gyrus neurons causes cognitive and other behavioural deficits in mice. PDF Neurodegenerative disease: Common routes to risk p228 | doi:10.1038/nrn3467 Interactions between two risk loci for Parkinson's disease affect protein sorting in neurons and point towards a possible common pathway to neuropathology in Parkinson's disease. PDF Learning and memory: Learning to forget p228 | doi:10.1038/nrn3474 Memories can sometimes be disrupted by pharmacological intervention during reconsolidation; a new study shows that a prediction error is required for this process. PDF IN BRIEF Taste receptors: Salt leaves a bitter taste | Gene expression: RAC1 overexpression beats depression | Neurodegenerative disease: It's translation, Jim, but not as we know it | Synaptic transmission: GABA receptor crosstalk | Signal transduction: JACOB reveals the origin of NMDAR signals | Neuroprotection: Neuronal immune signatures PDF Neuroscience JOBS of the week Postdoctoral Fellow, Neuro Science Sage Bionetworks Postdoc position in neurodegenerative disease Montreal Neurological Institute of McGill University (Tsuda Lab) Principal Investigator Institutes of Brain Science, Fudan University, Shanghai, China Postdoctoral Scientist - Functional Genomics Group The Garvan Institute of Medical Research PostDoc in Neuroimaging ( scholarship) Karolinska Instuitute More Science jobs from Neuroscience EVENT Summer Program in Neuroscience, Ethics & Survival 06.22.13 Woods Hole, US More science events from
REVIEWS		Top
Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics Matthias Kneussel & Wolfgang Wagner p233 | doi:10.1038/nrn3445 Myosins II, V and VI are actin-based cytoskeletal motors that have specific pre- and postsynaptic roles. Kneussel and Wagner review their diverse functions, which include the regulation of actin cytoskeleton dynamics in dendritic spines and powering of synaptic cargo transport. Abstract | Full Text | PDF
The changing scene of amyotrophic lateral sclerosis Wim Robberecht & Thomas Philips p248 | doi:10.1038/nrn3430 In this Review, Robberecht and Philips provide a comprehensive summary of the current understanding of the causes and mechanisms underlying the pathogenesis of amyotrophic lateral sclerosis (ALS). The emerging phenotypic heterogeneity of this neurodegenerative disease is leading to the concept that the term ALS covers several conditions and not just one disease. Abstract | Full Text | PDF | Supplementary information
Aquaporin water channels in the nervous system Marios C. Papadopoulos & Alan S. Verkman p265 | doi:10.1038/nrn3468 The aquaporins (AQPs) are a family of integral membrane proteins that are involved in water movement across cell membranes. In this Review, Papadopoulos and Verkman examine the roles of AQPs in the functioning of the mammalian nervous system and in various neurological conditions. Abstract | Full Text | PDF
Corticostriatal connectivity and its role in disease Gordon M. G. Shepherd p278 | doi:10.1038/nrn3469 Corticostriatal pathways consist of two distinct classes of cortical pyramidal cells: intratelencephalic and pyramidal tract neurons. In this Review, Shepherd explains how changes in the functional properties of these neurons result in an imbalance in activity that contributes to a wide variety of neurological disorders. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Inverse cancer comorbidity: a serendipitous opportunity to gain insight into CNS disorders Rafael Tabarés-Seisdedos & John L. Rubenstein p293 | doi:10.1038/nrn3464 Emerging evidence suggests that there is an inverse comorbidity relationship between certain neurological disorders and certain cancers. In this Opinion article, Tabares-Seisdedos and Rubenstein discuss the evidence for this intriguing association and possible underlying mechanisms. Abstract | Full Text | PDF | Supplementary information
Advertisement
Nature Neuroscience FOCUS ON MEMORY Nature Neuroscience presents a special Focus that discusses some of the most exciting recent developments and emerging ideas in our understanding of the neurobiology of learning and memory. Read this Focus online: www.nature.com/neuro/focus/memory
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2010 Journal Citation Report (Thomson Reuters, 2011)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.