Nature Reviews Molecular Cell Biology contents April 2013 Volume 14 Number 4

TABLE OF CONTENTS
April 2013 Volume 14 Number 4
Impact Factor 39.123 *	In this issue Research Highlights Reviews Also this month Article series: DNA damage  Featured article: Emerging roles for chromatin as a signal integration and storage platform Aimee I. Badeaux & Yang Shi
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RESEARCH HIGHLIGHTS Top Cell signalling: Where the mTOR action is p191 | doi:10.1038/nrm3549 mTOR regulates a Na+ channel on endolysosomes; mTOR activity is regulated by DYRK3. PDF Cell signalling: DDX3 in command of CK1ε p192 | doi:10.1038/nrm3548 DDX3 stimulates CK1ε kinase activity during WNT-β-catenin signalling. PDF Mitosis: Microtubule nucleation branches out p192 | doi:10.1038/nrm3550 Mitotic spindle formation in animal cells involves branching nucleation of microtubules. PDF Stem cells: Intestinal stem cell reserves p193 | doi:10.1038/nrm3551 Intestinal quiescent cells are committed to differentiate into secretory cells but can be called into stem cell action after injury. PDF Development: A good hair day for ROS p194 | doi:10.1038/nrm3547 Reactive oxygen species (ROS) are required for keratinocyte differentiation. PDF Cell signalling: A new Hippo pathway component p196 | doi:10.1038/nrm3534 MASK is a novel and conserved component of the Hippo pathway that is required for Yorkie activity. PDF JOURNAL CLUB Senescence: back to telomeres p196 | doi:10.1038/nrm3544 The demonstration that senescence is caused by both telomere erosion and oncogene-induced accumulation of DNA damage at telomeres. PDF IN BRIEF RNA decay: The where and when of NMD | Autophagy: Pinpointing the mysterious membrane donors | Development: SMURF2 targets ephrin B1 for degradation | Development: A biphasic push breaks symmetry | Cell signalling: Transducing mechanical signals | RNA: Circular RNAs as miRNA sponges PDF Molecular Cell Biology JOBS of the week Postdoctoral Associate in Cell Biology / Molecular Virology The Scripps Research Institute PhD Fellowships in Molecular Cell Biology Max Planck Institute of Molecular Physiology Two Lectureships / Senior Lectureships in Cell and Molecular Biology Queen Mary University of London Postdoctoral Fellow in Cancer Epigenetics University of Texas M. D. Anderson Cancer Postdoctoral Position, Developmental Therapeutics Fox Chase Cancer Center More Science jobs from
REVIEWS		Top
Article series: DNA damage The ATM protein kinase: regulating the cellular response to genotoxic stress, and more Yosef Shiloh & Yael Ziv p197 | doi:10.1038/nrm3546 Ataxia-telangiectasia mutated (ATM) is best known for its role in orchestrating the DNA damage response in response to double-strand breaks. However, it is now emerging that it is a far more versatile kinase, with roles in cell responses to other genotoxic stresses and in signalling pathways involved in cellular homeostasis. Abstract | Full Text | PDF
Emerging roles for chromatin as a signal integration and storage platform Aimee I. Badeaux & Yang Shi p211 | doi:10.1038/nrm3545 The ability of signal transduction pathways to directly modify chromatin provides a means for rapid, and potentially long-lived, responses to environmental cues. Understanding how these modifications are stored on chromatin, integrated and interpreted should provide insight into the short- and long-term control of gene expression. Abstract | Full Text | PDF
Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies Julia Ladewig, Philipp Koch & Oliver Brüstle p225 | doi:10.1038/nrm3543 During cell reprogramming and direct cell fate conversion, changes in somatic and pluripotent cell fates do not require the passage through a hierarchy of distinct cell fates that are proposed to occur during normal development and are consistent with the original Waddington model. Instead, a 'flat epigenetic disc' model might explain cell fate transitions during these processes. Abstract | Full Text | PDF
Diversity in the origins of proteostasis networks — a driver for protein function in evolution Evan T. Powers & William E. Balch p237 | doi:10.1038/nrm3542 All three domains of life - Bacteria, Archaea and Eukarya - have a proteostasis network that modulates protein folding in response to changes in the environment and to genetic variation. This proteostasis network has co-evolved with the proteome and is thought to play a part in driving evolution. Abstract | Full Text | PDF | Supplementary information
The role of transcription-independent damage signals in the initiation of epithelial wound healing João V. Cordeiro & António Jacinto p249 | doi:10.1038/nrm3541 Transcription-independent diffusible damage signals, such as Ca2+, H2O2 and ATP, are generated immediately after epithelial wounding to alert tissues to damage. Together, these signals have short-term effects on actomyosin structures and immune cell chemotaxis, and in the longer term coordinate the subsequent transcription of specific wound response genes to direct the wound healing process. Abstract | Full Text | PDF
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