Nature Reviews Immunology Contents April 2013 Volume 13 Number 4 pp 219-302

TABLE OF CONTENTS
April 2013 Volume 13 Number 4
Impact Factor 33.287 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Type 1 diabetes: translating mechanistic observations into effective clinical outcomes Kevan C. Herold, Dario A. A. Vignali, Anne Cooke & Jeffrey A. Bluestone
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RESEARCH HIGHLIGHTS Top Cytokines: [Type] I for the girls p219 | doi:10.1038/nri3428 IFNε is expressed constitutively in the female reproductive tract to protect against sexually transmitted infections. PDF Mucosal immunology: A wee immune response p220 | doi:10.1038/nri3426 IL-10 production by mast cells in the bladder suppresses adaptive immunity and promotes chronic urinary tract infections. PDF Autoimmunity: Fade out, fade in p220 | doi:10.1038/nri3434 Treatment with a mutant form of heat shock protein 70 (HSP70) can prevent and reverse vitiligo. PDF Cytokines: IRF7 lost in translation p221 | doi:10.1038/nri3425 OASL1 binds to the 5′ untranslated region of Irf7 mRNA to inhibit its translation. PDF Signal transduction: LCK regulation is hidden in details p222 | doi:10.1038/nri3429 Contrary to what was previously thought, LCK activity is increased following T cell receptor stimulation. PDF Antibody responses: An inside job p222 | doi:10.1038/nri3431 Intracellular antibodies trigger pro-inflammatory signalling pathways via TRIM21. PDF IN THE NEWS A Fragile Balance in Tuberculosis p222 | doi:10.1038/nri3438 Expression of type I interferons correlates with severe mycobacterial infections. PDF T cells: Mitochondria and T cell activation p224 | doi:10.1038/nri3424 Mitochondrial reactive oxygen species are required for antigen-specific T cell activation. PDF T cells: Salt promotes pathogenic TH17 cells p225 | doi:10.1038/nri3432 A high-salt diet triggers the development of pathogenic TH17 cells and accelerates multiple sclerosis-like disease in mice. PDF IN BRIEF Neuroimmunology: Interferon signalling in neuronal subtypes | Tumour immunology: AIRE-dependent TReg cells in tumours | Immunometabolism: CD4+ T cell activation by adipocytes in obesity | B cell responses: Self control key for maturation | Immunometabolism: ILC2s maintain metabolic homeostasis | Antiviral immunity: Visualizing the defensive lines PDF Immunology JOBS of the week Postdoctoral Research Fellow (Malaria cellular biologist / Immunologist) Nanyang Technological Univeristy, School of Biological Sciences Tumor immunology and tumor metasatasis researchers Chinese Academy of Medical Sciences Postdoctoral Fellow Mount Sinai School of Medicine (Brown Lab) Scientists Euromanager Graduate Student / Assistant Louisiana State University (LSU) More Science jobs from Immunology EVENT Tumor Immunology and Immunotherapy 10.08.13 Suzhou, China More science events from
REVIEWS		Top
Molecular mechanisms of T cell co-stimulation and co-inhibition Lieping Chen & Dallas B. Flies p227 | doi:10.1038/nri3405 The central role of co-stimulatory and co-inhibitory receptors in T cell biology has been proven by the effective therapeutic targeting of some of these molecules. However, the molecular aspects of T cell co-stimulation and co-inhibition are far from being fully understood. Here, the authors discuss emerging concepts in T cell co-signalling. Abstract | Full Text | PDF | Supplementary information
Type 1 diabetes: translating mechanistic observations into effective clinical outcomes Kevan C. Herold, Dario A. A. Vignali, Anne Cooke & Jeffrey A. Bluestone p243 | doi:10.1038/nri3422 Type 1 diabetes (T1D) was described as an autoimmune disease more than 25 years ago, but the mechanisms involved in this disease are not yet completely understood. Here, the authors review the current models of how T1D disease develops and discuss the steps that will need to be taken to develop more successful therapies for patients. Abstract | Full Text | PDF
T cell receptor signalling networks: branched, diversified and bounded Rebecca J. Brownlie & Rose Zamoyska p257 | doi:10.1038/nri3403 The first signalling molecules that are activated following T cell receptor engagement feed into an intricately branched and tightly regulated network of signalling cascades that influences T cell activation and differentiation. Perturbation of this diversified network can result in dysregulated T cell signalling and the development of autoreactivity. Abstract | Full Text | PDF
Lymphotoxin signalling in immune homeostasis and the control of microorganisms Vaibhav Upadhyay & Yang-Xin Fu p270 | doi:10.1038/nri3406 The lymphotoxin signalling pathway is best known to immunologists for its crucial roles in promoting the development and the organization of lymphoid organs. However, lymphotoxin also contributes to protective immunity against infection and can regulate the intestinal microbiota. The authors discuss these and the other lesser known immune functions of lymphotoxin. Abstract | Full Text | PDF
Population genetic tools for dissecting innate immunity in humans Lluís Quintana-Murci & Andrew G. Clark p280 | doi:10.1038/nri3421 Population genetics informs about how genes have evolved under varying selective pressures. The analysis of such selection signatures in innate immune genes, including genes encoding pattern-recognition receptors and their downstream effector molecules, provides helpful insight into the roles of these genes in host immunity and their links to disease. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Triggers and drivers of autoimmunity: lessons from coeliac disease Ludvig M. Sollid & Bana Jabri p294 | doi:10.1038/nri3407 If an exogenous antigen such as gluten can drive the autoimmune features of coeliac disease, such as the production of autoantibodies and the destruction of a specific tissue type, should we be looking more closely at the possibility that other autoimmune diseases are driven by exogenous, not self, antigens? Abstract | Full Text | PDF
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*2011 Journal Citation Report (Thomson Reuters, 2012)

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