Nature Reviews Genetics Contents April 2013 Volume 14 Number 4 pp 237 - 300

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TABLE OF CONTENTS
April 2013 Volume 14 Number 4
Impact Factor 30.075 *	In this issue Research Highlights Progress Reviews Perspectives Correspondence Also this month Article series: Computational tools Regulatory elements Translational genetics  Featured article: Understanding, predicting and manipulating the genotypic evolution of antibiotic resistance Adam C. Palmer & Roy Kishony
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RESEARCH HIGHLIGHTS Top Complex traits: Missing in action p237 | doi:10.1038/nrg3447 PDF Gene expression: Influences on noise p238 | doi:10.1038/nrg3448 PDF Genome organization: Supercoiled roles p238 | doi:10.1038/nrg3452 PDF Synthetic biology: A circuit to remember p239 | doi:10.1038/nrg3450 PDF Evolution: Experimental evolution probes neighbourly niches p240 | doi:10.1038/nrg3449 PDF Genetic screening: Interaction maps for mammals p240 | doi:10.1038/nrg3451 PDF Evolution: A matter of balance p240 | doi:10.1038/nrg3453 PDF IN BRIEF Regulatory RNA: Circular sponges | Gene regulation: Allosteric effects | Evolution: Tracking down human adaptations | Technology: Making mice with TALENs | RNA: New tricks for an old enzyme | Epigenetics: Plant epigenomic diversity explored | Genetic testing: New guidelines for paediatric genetics PDF Genetics JOBS of the week Lectureship in Quantitative Genetics University of Edinburgh Senior Scientist in Gene Department GenScript USA Inc. Stochastic modeling of bacterial gene expression University of Montpellier Postdoctoral Scientist, gene expression analysis in single cells University Medicine Greifswald More Science jobs from Genetics EVENT 26th Course in Medical Genetics 16.05.13 Italy More science events from
PROGRESS		Top
Understanding, predicting and manipulating the genotypic evolution of antibiotic resistance Adam C. Palmer & Roy Kishony p243 | doi:10.1038/nrg3351 The authors review new tools for studying the evolution of antibiotic resistance, including approaches to evolve resistance in the laboratory and analysis of clinical samples. Insights into pathways of evolution and the basis of resistance could inform future management of infections. Abstract | Full Text | PDF
REVIEWS		Top
Article series: Computational tools Emerging methods in protein co-evolution David de Juan, Florencio Pazos & Alfonso Valencia p249 | doi:10.1038/nrg3414 Functional interactions between proteins and within proteins results in co-evolutionary signatures in amino acid sequences that serve as clues to various forms of interdependence. This Review discusses the principles and distinctions of the large range of computational tools to analyse protein co-evolution and the biological insight that they are providing. Abstract | Full Text | PDF | Supplementary information
Genomic signatures of selection at linked sites: unifying the disparity among species Asher D. Cutter & Bret A. Payseur p262 | doi:10.1038/nrg3425 Evolution by natural selection at genomic loci sculpts the sequence features of not just each immediate locus but also nearby chromosomally linked sites. However, the way that this occurs substantially varies among different species, and this Review discusses potential reasons for these disparities. Abstract | Full Text | PDF
How cells get the message: dynamic assembly and function of mRNA-protein complexes Michaela Müller-McNicoll & Karla M. Neugebauer p275 | doi:10.1038/nrg3434 RNA-binding proteins (RBPs) are crucial for guiding mRNAs through the many steps from transcription to translation and decay. This Review discusses recent insights into the repertoire of RBPs, how they package RNA molecules and how they can connect different processing steps. Abstract | Full Text | PDF
PERSPECTIVES		Top
VIEWPOINT Article series: Regulatory elements Enhancers: five essential questions Len A. Pennacchio, Wendy Bickmore, Ann Dean, Marcelo A. Nobrega & Gill Bejerano p288 | doi:10.1038/nrg3458 Although enhancers are crucial and widespread gene-regulatory elements, we are far from a complete understanding of how they function or their importance in areas such as disease and evolution. Five prominent researchers discuss some of the key outstanding questions in enhancer biology. Abstract |Full Text | PDF
OPINION Article series: Translational genetics Disease-targeted sequencing: a cornerstone in the clinic Heidi L. Rehm p295 | doi:10.1038/nrg3463 Clinical sequencing tests that focus on genes linked to specific diseases or phenotypes are increasingly widely being used. This article discusses how disease-targeting tests retain several advantages despite moves towards the clinical application of whole-genome or exome sequencing. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Correspondence: Mixed models can correct for population structure for genomic regions under selection Jae Hoon Sul & Eleazar Eskin p300 | doi:10.1038/nrg2813-c1 Full Text | PDF
		Top
Reply: Response to Sul and Eskin Alkes L. Price, Noah A. Zaitlen, David Reich & Nick Patterson p300 | doi:10.1038/nrg2813-c2 Full Text | PDF
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