Nature Immunology Contents: April 2013 Volume 14 pp 307 - 413

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Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Immunology ANIMATION: IMMUNOLOGY IN THE GUT MUCOSA Nature Immunology in collaboration with Arkitek Studios have produced an animation unravelling the complexities of mucosal immunology in health and disease. View the Animation for FREE at: www.nature.com/ni/multimedia/mucosal Produced with support from Janssen Pharmaceutical Companies of Johnson & Johnson   Correspondence Top Regulatory T cells: recommendations to simplify the nomenclature   pp307 - 308 Abul K Abbas, Christophe Benoist, Jeffrey A Bluestone, Daniel J Campbell, Sankar Ghosh, Shohei Hori, Shuiping Jiang, Vijay K Kuchroo, Diane Mathis, Maria Grazia Roncarolo, Alexander Rudensky, Shimon Sakaguchi, Ethan M Shevach, Dario A A Vignali and Steve F Ziegler doi:10.1038/ni.2554 News and Views Top An inside job for antibodies: tagging pathogens for intracellular sensing   pp309 - 311 Teunis B H Geijtenbeek and Sonja I Gringhuis doi:10.1038/ni.2574 Antibodies bound to pathogens that invade cells are sensed in the cytosol by the receptor TRIM21, which triggers innate signaling that leads to protective immunity. See also: Article by McEwan et al. T cell priming goes through a new phase   pp311 - 312 David A Blair and Michael L Dustin doi:10.1038/ni.2575 The priming of naive T cells requires antigen presentation by activated dendritic cells, yet the optimal generation of effector and memory CD8+ T cells requires subsequent T cell-T cell interactions during the critical differentiation period. See also: Article by Gerard et al. High-affinity IgA needs TH17 cell functional plasticity   pp313 - 315 Pierre J Milpied and Michael G McHeyzer-Williams doi:10.1038/ni.2567 The conversion of cells of the TH17 subset of helper T cells that previously expressed interleukin 17A (IL-17A) and the transcription factor RORγt into follicular helper T cells is needed to generate antigen-specific immunoglobulin A in gut mucosa, which suggests new connections in the cognate control of regional adaptive immunity. See also: Article by Hirota et al. How to become your own worst enemy   pp315 - 317 Olivier Voinnet doi:10.1038/ni.2571 Persistence is a poorly understood yet widespread outcome of viral infection. A study of RNA viruses in flies now shows that viral fragments endogenized as cDNA during the reverse transcription of retrotransposons provide immunity based on RNA-mediated interference in persistently infected cells. See also: Article by Goic et al. Immunology JOBS of the week Postdoctoral position in Immunology Singapore Immunology Network (A*STAR) Postdoctoral position-Immunology Northwestern Univeristy Senior Principal Scientist (Group Leader) Viral Immunology Roche Postdoc position in immunology Institut Pasteur Spatio-temporal Immunity in Human Intestinal Epithelium Cells University of Heidelberg More Science jobs from Immunology EVENT Immunometabolism: from mechanisms to therapy 6th Sept 2013 Toronto, Canada More science events from Research Highlights Top LncRNA regulates Ifng | Mitochondrial ROS | Tolerating iPSCs | Function of the IgM receptor | Foxp3 phosphorylation | ILC2 cells and metabolic homeostasis Perspective Top Fishing for mammalian paradigms in the teleost immune system   pp320 - 326 J Oriol Sunyer doi:10.1038/ni.2549 Articles Top Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21   pp327 - 336 William A McEwan, Jerry C H Tam, Ruth E Watkinson, Susanna R Bidgood, Donna L Mallery and Leo C James doi:10.1038/ni.2548 During pathogen infection, antibodies can be carried into the cell, where they are detected by the cytosolic antibody receptor TRIM21. McEwan and colleagues show that the recognition of intracellular antibodies by TRIM21 activates immunological signaling. See also: News and Views by Geijtenbeek & Gringhuis The protease activity of the paracaspase MALT1 is controlled by monoubiquitination   pp337 - 345 Christiane Pelzer, Katrin Cabalzar, Annette Wolf, Montserrat Gonzalez, Georg Lenz and Margot Thome doi:10.1038/ni.2540 The CARM1-MALT1-Bcl-10 complex links ligation of the antigen receptor to NF-κB activation. Thome and colleagues show that MALT1 paracaspase activity requires monoubiquitination at Lys644. Lymphomas with Lys644 mutants have diminished survival. OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7   pp346 - 355 Myeong Sup Lee, Byungil Kim, Goo Taeg Oh and Young-Joon Kim doi:10.1038/ni.2535 The production of type I interferon is regulated by the master transcription factor IRF7. Kim and colleagues show that OASL1 specifically recognizes IRF7 mRNA and inhibits its translation and the production of type I interferon. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells   pp356 - 363 Audrey Gerard, Omar Khan, Peter Beemiller, Erin Oswald, Joyce Hu, Mehrdad Matloubian and Matthew F Krummel doi:10.1038/ni.2547 CD8+ T cell are primed via recognition of cognate peptides presented by APCs. Krummel and colleagues show that optimal CD8+ T cell differentiation then occurs via T cell-T cell interactions dependent on the integrin LFA-1. See also: News and Views by Blair & Dustin The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses   pp364 - 371 Bryan D Bell, Masayuki Kitajima, Ryan P Larson, Thomas A Stoklasek, Kristen Dang, Kazuhito Sakamoto, Kay-Uwe Wagner, Boris Reizis, Lothar Hennighausen and Steven F Ziegler doi:10.1038/ni.2541 Thymic stromal lymphopoietin promotes type 2 allergic immune responses via the transcription factor STAT5. Ziegler and colleagues show that ablation of STAT5 in DCs prevents type 2 but not type 1 immunity. Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses   pp372 - 379 Keiji Hirota, Jan-Eric Turner, Matteo Villa, João H Duarte, Jocelyne Demengeot, Oliver M Steinmetz and Brigitta Stockinger doi:10.1038/ni.2552 IgA is essential in the maintenance of mucosal host defense and intestinal homeostasis. Stockinger and colleagues show that TH17 cells acquire a follicular helper T cell phenotype in Peyer's patches and induce the development of IgA-producing B cells. See also: News and Views by Milpied & McHeyzer-Williams Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms   pp380 - 388 Chuanxin Huang, Katerina Hatzi and Ari Melnick doi:10.1038/ni.2543 The transcriptional repressor Bcl-6 operates in many hematopoietic lineages. Melnick and colleagues show that Bcl-6 with a mutant BTB corepressor interaction domain selectively impairs B cell effector function. The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway   pp389 - 395 Lucille C Rankin, Joanna R Groom, Michaël Chopin, Marco J Herold, Jennifer A Walker, Lisa A Mielke, Andrew N J McKenzie, Sebastian Carotta, Stephen L Nutt and Gabrielle T Belz doi:10.1038/ni.2545 NKp46+ innate lymphoid cells are important for the control of gut microbes, but their development is unclear. Belz and colleagues show that they develop from lymphoid tissue-inducer cells in a Notch- and T-bet-dependent manner. RNA-mediated interference and reverse transcription control the persistence of RNA viruses in the insect model Drosophila    pp396 - 403 Bertsy Goic, Nicolas Vodovar, Juan A Mondotte, Clément Monot, Lionel Frangeul, Hervé Blanc, Valérie Gausson, Jorge Vera-Otarola, Gael Cristofari and Maria-Carla Saleh doi:10.1038/ni.2542 Retrotransposons are often thought of as 'selfish' genetic elements that replicate themselves without any obvious benefit to the host genome. Saleh and colleagues demonstrate that retrotransposons can be involved in generating silencing RNA species to regulate viral replication. See also: News and Views by Voinnet Resource Top Transcriptional insights into the CD8+ T cell response to infection and memory T cell formation   pp404 - 412 J Adam Best, David A Blair, Jamie Knell, Edward Yang, Viveka Mayya, Andrew Doedens, Michael L Dustin, Ananda W Goldrath and The Immunological Genome Project Consortium doi:10.1038/ni.2536 Antigenic activation induces the generation of effector and memory CD8+ T cells. Goldrath and colleagues profile gene expression at various times after infection to identify transcriptional networks unique to each population. Errata Top Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells   p413 Daniel M Andrews, Lucy C Sullivan, Nikola Baschuk, Christopher J Chan, Richard Berry, Claire L Cotterell, Jie Lin, Heloise Halse, Sally V Watt, Jennifer Poursine-Laurent, Chyung-Ru Wang, Anthony A Scalzo, Wayne M Yokoyama, Jamie Rossjohn, Andrew G Brooks and Mark J Smyth doi:10.1038/ni0413-413b Lessons learned from HIV-1 vaccine trials: new priorities and directions   p413 Andrew J McMichael and Barton F Haynes doi:10.1038/ni0413-413a Re(de)fining the dendritic cell lineage   p413 Ansuman T Satpathy, Xiaodi Wu, Jorn C Albring and Kenneth M Murphy doi:10.1038/ni0413-413c Corrigenda Top The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells   p413 Masaki Miyazaki, Richard R Rivera, Kazuko Miyazaki, Yin C Lin, Yasutoshi Agata and Cornelis Murre doi:10.1038/ni0413-413e Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling   p413 Michael P Seiler, Rebecca Mathew, Megan K Liszewski, Chauncey Spooner, Kenneth Barr, Fanyong Meng, Harinder Singh and Albert Bendelac doi:10.1038/ni0413-413d Top Advertisement Subscribe to Nature this Spring for only $60/£60/EUR60 Nature brings you the finest peer-reviewed research in all scientific disciplines, not to mention an enticing round up of news, features and commentaries by global experts. 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